sodium-pertechnetate-tc-99m and Parotid-Diseases

Rosai-Dorfman disease (RDD) is an unusual clinical entity characterized by benign pseudolymphomatous proliferation with significant histiocytic infiltration. In the present paper, extranodal RDD of the major salivary glands causing salivary hypofunction and the results of salivary gland scintigraphy and ultrasound are presented in two siblings. Case 1: a 10-year-old boy with bilateral painless masses around the parotid and submandibular glands was referred. Ultrasound examination showed bilateral, well-defined, hypoechoic solid mass lesions within both parotid glands with minimal normal parenchyma in the upper poles. Both submandibular glands were markedly hypoechoic and heterogeneous. Mass lesions within the parotid glands appeared as cold lesions with regular contours on scintigraphy. Dynamic images showed normal uptake and normal response to secretion in the upper poles of the parotid glands, corresponding with ultrasonographically normal parenchyma. Both submandibular glands showed markedly diminished uptake and secretion. Case 2: a 9-year-old boy presented with mass lesions around the submandibular glands. Ultrasound examination showed normal parotid glands and markedly hypoechoic and heterogeneous submandibular glands. Salivary gland scintigraphy showed normal uptake and secretion of parotid glands with markedly diminished uptake and secretion in both submandibular glands. There were severe carious lesions in both patients due to salivary hypofunction. Treatments of the two patients' teeth were performed. Major salivary gland involvement of RDD is important for dentists as it may cause xerostomia and can mimic dental abscess. Functional evaluation of salivary glands with scintigraphy, besides radiological and pathological techniques, will help to explain whether salivary glands are affected or not and improve the diagnostic effectiveness.

Topics: Biopsy; Child; Dental Caries; Gingivitis; Histiocytosis, Sinus; Humans; Male; Parotid Diseases; Parotid Gland; Radionuclide Imaging; Radiopharmaceuticals; Sodium Pertechnetate Tc 99m; Submandibular Gland; Submandibular Gland Diseases; Tooth, Deciduous; Ultrasonography; Xerostomia

This study reviews the results of sialolithectomy performed with the CO2 laser.. Forty-nine patients were treated under local anesthesia at initial presentation in the outpatient clinic.. All patients had immediate relief after surgery. Clinical and scintographic follow-up of up to 28 months on 27 patients showed that all but 1 were asymptomatic. The single exception required excision of the submandibular gland because of two recurrences of sialoliths in Wharton's duct. Although some glands had no function clinically and scintigraphically, they were asymptomatic and needed no further treatment.. Salivary glands that are nonfunctioning clinically and scintigraphically should only be removed when there is a recurrence of symptoms.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Anesthesia, Local; Carbon Dioxide; Female; Follow-Up Studies; Humans; Laser Therapy; Male; Middle Aged; Parotid Diseases; Parotid Gland; Radionuclide Imaging; Recurrence; Salivary Duct Calculi; Salivary Gland Calculi; Sodium Pertechnetate Tc 99m; Submandibular Gland; Submandibular Gland Diseases

The salivary disease in two patients with human immunodeficiency virus infection was investigated by technetium pertechnetate scintiscanning. Although there was good histologic evidence of benign lymphoepithelial disease, scintiscanning failed to delineate any salivary lesions. Technetium pertechnetate scintiscanning seems to be of little value in the detailed investigation of salivary disease in human immunodeficiency virus infection, though gallium scanning can help. Fine needle aspiration or biopsy remain the main diagnostic tools.

Topics: Adult; AIDS-Related Opportunistic Infections; Evaluation Studies as Topic; Female; Gallium; Humans; Male; Parotid Diseases; Radionuclide Imaging; Salivary Gland Diseases; Salivary Glands, Minor; Sodium Pertechnetate Tc 99m

A practical, time-saving procedure for sequential quantitative scintigraphy is introduced and 4 parameters chosen from 12 parameters by discriminant analysis are used to evaluate the function of the parotid gland. The examination was performed in 120 cases, including 16 cases with recurrent parotitis in childhood, 33 with chronic obstructive parotitis (COP), 37 with Sjögren's syndrome (SS), 4 with sialadenosis, and 30 normal controls. The scintigraphic findings were analyzed and compared with the histologic findings. The diagnostic value of this method was investigated and scaling for differential diagnosis of COP and SS was established. Scintigraphy is considered to be a useful method for evaluation of parotid function and as a diagnostic aid for SS and COP, especially in patients in whom sialography cannot be performed.

Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chronic Disease; Discriminant Analysis; Female; Humans; Hypertrophy; Male; Middle Aged; Parotid Diseases; Parotid Gland; Parotitis; Radionuclide Imaging; Secretory Rate; Sensitivity and Specificity; Sjogren's Syndrome; Sodium Pertechnetate Tc 99m

Unilateral radionuclide accumulation in salivary glands is an uncommon finding on gallium scintigraphy. The differential diagnosis includes malignant tumors and inflammatory processes of these organs. Two cases of unilateral gallium uptake of the parotid and submandibular gland respectively, verified as solitary tuberculosis, are presented, together with the correlative findings of Tc-99m pertechnetate scintigraphy, sialography, and sonography. None of these imaging modalities is specific enough to provide pathognomonic signs for tuberculosis. When assessing unilateral gallium uptake of the salivary glands, one should be aware of the possibility of tuberculosis.

Topics: Adult; Female; Gallium Radioisotopes; Humans; Parotid Diseases; Radionuclide Imaging; Salivary Gland Diseases; Sialography; Sodium Pertechnetate Tc 99m; Submandibular Gland Diseases; Tuberculosis; Tuberculosis, Oral

Topics: Adult; Gallium Radioisotopes; Humans; Male; Parotid Diseases; Radionuclide Imaging; Sarcoidosis; Sodium Pertechnetate Tc 99m; Technetium

Topics: Aged; False Negative Reactions; Female; Humans; Male; Middle Aged; Parotid Diseases; Parotid Gland; Radioactivity; Radionuclide Imaging; Sialography; Sodium Pertechnetate Tc 99m; Technetium

Topics: Adolescent; Adult; Aged; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Parotid Diseases; Parotid Gland; Parotid Neoplasms; Radionuclide Imaging; Salivation; Sialography; Sodium Pertechnetate Tc 99m; Technetium

Salivary gland imaging with 99mTc as pertechnetate provides functional information concerning trapping and excretion of the parotid and submandibular glands. Anatomic information gained often adds little to clinical evaluation. On the other hand, functional information may detect subclinical involvement, which correlates well with biopsy of the minor labial salivary glands. Salivary gland abnormalities in systemic disease such as sarcoidosis, rheumatoid arthritis, lupus erythematosus, and other collagenvascular disorders may be detected before they result in the clinical manifestaions of Sjögren's syndrome. Such glands, after initially demonstrating increased trapping in the acute phase, tend to have decreased trapping and failure to discharge pertechnetate in response to an appropriate physiologic stimulus. Increased uptake of gallium-67 citrate often accompanies these findings. Inflammatory parotitis can be suspected when increased perfusion is evident on radionuclide angiography with any agent. The ability of the salivary gland image to detect and categorize mass lesions, which result in focal areas of diminished activity such as tumors, cysts, and most other masses, is disappointing, while its ability to detect and categorize Warthin's tumor, which concentrates pertechnetate, is much more valuable, although not specific.

Topics: Adenolymphoma; Humans; Lymphangioma; Parotid Diseases; Parotid Neoplasms; Radionuclide Imaging; Salivary Gland Diseases; Sjogren's Syndrome; Sodium Pertechnetate Tc 99m; Submandibular Gland Diseases; Submandibular Gland Neoplasms; Technetium