sodium-pertechnetate-tc-99m and Orbital-Neoplasms

Topics: Bleomycin; Chlormerodrin; Eye Neoplasms; Gallium Radioisotopes; Humans; Melanoma; Mercury Radioisotopes; Methods; Orbital Neoplasms; Phosphorus Radioisotopes; Radionuclide Imaging; Selenomethionine; Serum Albumin, Radio-Iodinated; Sodium Pertechnetate Tc 99m; Technetium

Topics: Aged; Carcinoma, Signet Ring Cell; Eyelid Neoplasms; Fluorodeoxyglucose F18; Frozen Sections; Humans; Lymph Node Excision; Lymphatic Metastasis; Magnetic Resonance Imaging; Male; Orbital Neoplasms; Positron-Emission Tomography; Radiopharmaceuticals; Sentinel Lymph Node Biopsy; Sodium Pertechnetate Tc 99m

To evaluate technetium Tc 99m (99mTc) red blood cell scintigraphy as a diagnostic tool for orbital cavernous hemangioma and to differentiate between orbital masses on the basis of their vascularization.. We performed 99mTc red blood cell scintigraphy on 23 patients (8 female and 15 male; mean age, 47 years) affected by an orbital mass previously revealed with computed tomography (CT) and magnetic resonance imaging (MRI) and suggesting cavernous hemangioma. In our diagnosis, we considered the orbital increase delayed uptake with the typical scintigraphic pattern known as perfusion blood pool mismatch. The patients underwent biopsy or surgical treatment with transconjunctival cryosurgical extraction when possible.. Single-photon emission tomography (SPET) showed intense focal uptake in the orbit corresponding to radiologic findings in 11 patients who underwent surgical treatment and pathologic evaluation (9 cavernous hemangiomas, 1 hemangiopericytoma, and 1 lymphangioma). Clinical or histologic examination of the remaining 22 patients revealed the presence of 5 lymphoid pseudotumors, 2 lymphomas, 2 pleomorphic adenomas of the lacrimal gland, 1 astrocytoma, 1 ophthalmic vein thrombosis, and 1 orbital varix.. The confirmation of the preoperative diagnosis by 99mTc red blood cell scintigraphy shows that this technique is a reliable tool for differentiating cavernous hemangiomas from other orbital masses (sensitivity, 100%; specificity, 86%) when ultrasound, CT, and MRI are not diagnostic. Unfortunately, 99mTc red blood cell scintigraphy results were positive in 1 patient with hemangiopericytoma and 1 patient with lymphangioma, which showed increased uptake in the lesion on SPET images because of the vascular nature of these tumors. Therefore, in these cases, the SPET images have to be integrated with data regarding clinical preoperative evaluation and CT scans or MRI studies. On the basis of our study, a complete diagnostic picture, CT scans or MRI studies, and scintigraphic patterns can establish the preoperative diagnosis of vascular orbital tumors such as cavernous hemangioma, adult-type lymphangioma, and hemangiopericytoma.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Diagnosis, Differential; Erythrocytes; Female; Hemangioma, Cavernous; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Orbital Neoplasms; Preoperative Care; Radiopharmaceuticals; Retrospective Studies; Sodium Pertechnetate Tc 99m; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

Topics: Diagnosis, Differential; Erythrocytes; Hemangioma, Cavernous; Humans; Orbital Neoplasms; Radiopharmaceuticals; Sodium Pertechnetate Tc 99m; Tomography, Emission-Computed, Single-Photon

Preoperative accumulation of Tc-99m pertechnetate and radioiodine in metastases of well-differentiated thyroid carcinoma is uncommon. The authors report the case of a 51-year-old woman with follicular thyroid carcinoma revealed by a right orbital metastasis. I-131 scintigraphy performed before thyroidectomy showed intense uptake in an orbital metastasis despite the presence of an intact thyroid gland.

Topics: Adenocarcinoma, Follicular; Diagnosis, Differential; Iodine Radioisotopes; Orbital Neoplasms; Preoperative Care; Radionuclide Imaging; Radiopharmaceuticals; Sodium Pertechnetate Tc 99m; Thyroid Nodule

The cavernous hemangioma is the most common benign orbital tumor in adults. Its presentation is during the forth to fifth decades with a slowly progressive unilateral proptosis. Intraconal cavernous hemangiomas may be difficult to differentiate from other intraconal lesions such as schwannomas, meningiomas and hemangiopericytomas. We report a case of orbital cavernous hemangioma diagnosed by Tc-99m RBC scintigraphy. Tc-99m RBC scintigraphy revealed a typical scintigraphic pattern in which there is intense focally increased uptake on the delayed image. We conclude that Tc-99m RBC scintigraphy can be a useful method in the differential diagnosis of orbital cavernous hemangioma as in hepatic hemangioma.

Topics: Diagnosis, Differential; Erythrocytes; Female; Hemangioma, Cavernous; Humans; Middle Aged; Orbital Neoplasms; Radiopharmaceuticals; Sodium Pertechnetate Tc 99m; Tomography, Emission-Computed, Single-Photon

A case of intraorbital ectopic lacrimal gland was evaluated with various radionuclides. CT and MRI with contrast enhancement showed a soft-tissue mass in the orbit. The lesion was gallium-avid, but 18F-FDG PET demonstrated very faint uptake. On early and delayed 201Tl-Cl images, mildly increased uptake and mild retention were observed. Technetium-99m-(V)-DMSA SPECT showed intense accumulation on both the early and delayed images. Technetium-99m-pertechnetate SPECT, demonstrating marked uptake in the lesion, was useful for the differential diagnosis between intraorbital malignancy and this benign lesion. These scintigraphic variations played an important role in the tissue characterization of this uncommon lesion.

Topics: Child; Deoxyglucose; Diagnosis, Differential; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Gallium Radioisotopes; Humans; Lacrimal Apparatus; Male; Orbital Neoplasms; Radiopharmaceuticals; Sodium Pertechnetate Tc 99m; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon

The authors analyzed the results of combined investigation of 103 patients with primary, secondary, benign and malignant orbital tumors and pseudotumors. CT high efficacy in the above tumors was shown. The results of gamma-topography (GT) of the orbit were shown to depend on the volume of a tumor and its histological type. The combined use of CT and GT made it possible to raise the significance of preoperative diagnosis and to predict organ-sparing therapy.

Topics: Adult; Aged; Humans; Middle Aged; Orbital Neoplasms; Sodium Pertechnetate Tc 99m; Tomography, X-Ray Computed

A gamma-topographic study of the orbit was performed in 64 patients with unilateral exophthalmus using 99m Tc-pertechnetate. Some peculiarities in the RP distribution in the focus of lesion in malignant and benign neoplasms and inflammatory processes in the orbit were revealed. Correlation between RP accumulation intensity in the focus and the degree of RP vascularization and volume was shown. The method does not allow assessment of the morphological nature of a process however its use extends the diagnostic potentialities in specifying the genesis of unilateral exophthalmus and facilitates the choice of appropriate therapy.

Topics: Adult; Aged; Exophthalmos; Humans; Middle Aged; Orbital Neoplasms; Radionuclide Imaging; Sodium Pertechnetate Tc 99m