sodium-pertechnetate-tc-99m and Neurilemmoma

A 31-year-old man is reported with the rare occurrence of a neurogenic tumor simulating a thyroid nodule. A growing nodule of the right neck was the only clinical symptom. Ultrasonography revealed a hypoechogenic nodule on the right side of the thyroid gland. Technetium (Tc)-99m pertechnetate showed a normal thyroid scintiscan. Due to ultrasonography-guided fine-needle aspiration biopsy, a schwannoma (neurilemmoma) was suspected. Surgical intervention removed the nodule and histology confirmed a schwannoma with Antoni A structures. To avoid unnecessary or inappropriate surgical intervention in cases of hypoechogenic nodules in connection with the thyroid gland, other nonthyroidal structures that may cause hypoechogenic patterns with ultrasonography should also be considered. The key preoperative investigations in such cases are ultrasonography and sonographically guided fine-needle aspiration biopsy.

Topics: Adult; Diagnosis, Differential; Head and Neck Neoplasms; Humans; Male; Neurilemmoma; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Thyroid Nodule; Tomography, X-Ray Computed; Ultrasonography

The purpose of this study was to investigate the accumulation of technetium-99m pertechnetate (99mTc) in malignant soft-tissue tumors. Twenty-one patients with malignant soft-tissue tumors were subjected to 99mTc scintigraphic studies. In 19 of 21 patients (90%), 99mTc accumulated extensively in the tumors. 99mTc accumulation was especially thorough in all cases of MFH and liposarcoma. Therefore, 99mTc is useful for the local evaluation of malignant soft-tissue tumors.

Topics: Adolescent; Adult; Aged; Female; Histiocytoma, Benign Fibrous; Humans; Liposarcoma; Male; Middle Aged; Neurilemmoma; Radionuclide Imaging; Rhabdomyosarcoma; Sodium Pertechnetate Tc 99m; Soft Tissue Neoplasms

Three soft tissue tumors were studied with 99mTc-pertechnetate scintigraphy, 67Ga-citrate scintigraphy and MRI. These tumors included schwannoma, neurofibromatosis and malignant fibrous histiocytoma. On 99mTc-pertechnetate scintigram all patients showed more increased accumulation corresponding to the tumor than on 67Ga-citrate scintigram. In conclusion, 99mTc-pertechnetate scintigraphy may be useful in detection of soft tissue tumors.

Topics: Adolescent; Citrates; Citric Acid; Evaluation Studies as Topic; Female; Histiocytoma, Benign Fibrous; Humans; Middle Aged; Neurilemmoma; Neurofibromatoses; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Soft Tissue Neoplasms

Technetium-99m pertechnetate scintigraphy in three patients with pathologically proven peripheral nerve tumors (six in total) demonstrated its ability to assess accurately the size, location, and the extent of all lesions. Pertechnetate localized only in areas of abnormal nerve involvement and all lesions were better seen in delayed images than the earlier ones. Pertechnetate imaging appears to be a promising method of noninvasive evaluation of clinically evident and occult tumors of peripheral nerve origin.

Topics: Adult; Female; Humans; Male; Neurilemmoma; Neurofibroma; Peripheral Nervous System Neoplasms; Sodium Pertechnetate Tc 99m; Tomography, Emission-Computed