sodium-pertechnetate-tc-99m and Mucocutaneous-Lymph-Node-Syndrome

Twenty-eight children ranging in age from 1-6 years (11 girls, 17 boys) with Kawasaki disease and, for comparison, 30 normal children ranging in age from 1-8 years (8 girls, 22 boys) without any cardiovascular disease were included in this study. The left ventricular functions of the children were evaluated by equilibrium multigated blood pooling ventriculography (EMBPV), which was performed after in vivo labeling of red blood cells using 10 mCi Tc-99m pertechnetate. Scintigraphy was performed using a digital gamma camera with the aid of an electrocardiogram gate. The left ventricular functions were determined by Fourier analysis of the time-activity curve in the left ventricles. The parameters of the left ventricular functions included: 1) systolic phase--[a] ejection fraction (EF), [b] ejection time (ET), [c] peak ejection rate (PER), and [d] first 1/3 ejection rate mean (1/3ERM), and 2) diastolic phase--[a] peak filling rate (PFR), [b] fast filling fraction (FFF), [c] time to peak filling rate (TPFR), and [d] first 1/3 filling rate mean (1/3FRM). The results showed that no significant differences existed between the two groups in any parameter of the left ventricular function. The authors suggest that the left ventricular functions in children with Kawasaki disease are not apparently impaired. The results were proven by the presentation of the EMBPV in this study.

Topics: Case-Control Studies; Child; Child, Preschool; Erythrocytes; Female; Gated Blood-Pool Imaging; Humans; Infant; Male; Mucocutaneous Lymph Node Syndrome; Sodium Pertechnetate Tc 99m; Ventricular Dysfunction, Left; Ventricular Function, Left

Twenty-one patients with acute state Kawasaki disease (15 boys, 6 girls; age range, 1-8 years) had equilibrium multigated blood pool ventriculography (EMBPV) before treatment. The symptoms and signs subsided after the administration of aspirin and the intravenous injection of high-dose (400 mg/kg per day x 5 days) gamma-globulin (IVGG) treatment. Then, a second EMBPV was arranged to evaluate the effects of the treatment on left ventricular functions. Left ventricular function was analyzed based on the following parameters: (systolic phase) ejection fraction, ejection time, peak ejection rate, first 1/3 ejection rate mean; and (diastolic phase) peak filling rate, fast filling fraction, time to peak filling rate, first 1/3 filling rate mean. The results showed that there were no significant differences in the parameters of left ventricular function before and after treatment (P > 0.05, paired Student's t-tests).

Topics: Aspirin; Child; Child, Preschool; Erythrocytes; Female; Gated Blood-Pool Imaging; Humans; Immunoglobulins, Intravenous; Infant; Male; Mucocutaneous Lymph Node Syndrome; Sodium Pertechnetate Tc 99m; Ventricular Function, Left

First pass radionuclide angiocardiography was utilized to calculate right and left ventricular ejection fraction in 74 infants and children. For the synchronization of radionuclide imaging with the cardiac cycle, the peaks and valleys of corrected ventricular time activity curve were adopted as the time reference points instead of R wave of electrocardiogram. Left ventricular ejection fractions obtained by the radionuclide technique correlated well with those derived from the contrast angiographic technique (r = 0.90), but right ventricular ejection fractions correlated less well (r = 0.74). This noninvasive technique appeared useful for evaluation of right and left ventricular ejection fraction.

Topics: Aortic Valve Insufficiency; Aortic Valve Stenosis; Cardiac Output; Cardiomyopathies; Child; Child, Preschool; Female; Heart Defects, Congenital; Heart Diseases; Humans; Infant; Male; Mitral Valve Insufficiency; Mucocutaneous Lymph Node Syndrome; Pulmonary Valve Insufficiency; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Stroke Volume; Syndrome; Technetium