sodium-pertechnetate-tc-99m and Meningioma

We present the case of a 64-year-old man with a presumed diagnosis of extracerebral cavernous hemangioma involving the cavernous sinus. The diagnosis was made on the basis of labeled red cell blood pool scintigraphy findings in conjunction with those of MR imaging. This lesion was not altered in appearance at 6-year follow-up MR imaging. We also present the labeled red cell blood pool scintigraphy findings obtained in three other patients with similar-appearing cavernous sinus lesions at MR imaging who underwent subsequent biopsy; histologic findings confirmed chondrosarcoma, chordoma, and meningioma, respectively.

Topics: Adult; Brain Neoplasms; Carotid Artery, Internal; Cavernous Sinus; Chondrosarcoma; Chordoma; Diagnosis, Differential; Erythrocytes; Female; Hemangioma, Cavernous, Central Nervous System; Humans; Magnetic Resonance Imaging; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Sensitivity and Specificity; Sodium Pertechnetate Tc 99m; Tomography, Emission-Computed, Single-Photon

A single photon emission computed tomographic method was designed for the measurement of radiopharmaceutical uptake in brain tumors. Results of phantom studies showed a correlation coefficient of .99 when measured volume was compared with actual volume. The correlation coefficient for measured radioactivity concentration compared with the actual concentration was .97. In 13 meningiomas the correlation between in vivo SPECT measurements of uptake and in vitro measurements in samples of the same tumors removed surgically was .84; when two tumors that contained regions of necrosis and fibrosis were excluded it was .93. This method can be used for in vivo quantitative assessment of pharmacokinetics of labeled drug uptake in human brain tumors.

Topics: Evaluation Studies as Topic; Humans; Meningeal Neoplasms; Meningioma; Models, Structural; Organotechnetium Compounds; Sodium Pertechnetate Tc 99m; Sugar Acids; Technetium; Time Factors; Tomography, Emission-Computed

Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; Cerebrovascular Disorders; Diagnosis, Differential; Female; Glioma; Humans; Male; Meningioma; Middle Aged; Radionuclide Imaging; Sodium Pertechnetate Tc 99m

Topics: Brain; Brain Abscess; Brain Diseases; Brain Neoplasms; Cerebrovascular Disorders; Glioblastoma; Humans; Meningioma; Organotechnetium Compounds; Pentetic Acid; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Sugar Acids; Technetium; Tomography, X-Ray Computed; Wounds and Injuries

Topics: Adenocarcinoma; Brain; Brain Neoplasms; Cerebrovascular Disorders; Humans; Meningeal Neoplasms; Meningioma; Radioisotopes; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Technetium