sodium-pertechnetate-tc-99m and Meibomian-Gland-Dysfunction

To measure tear clearance values in patients with meibomian gland dysfunction (MGD) with a dynamic nuclear medicine method, namely, dacryoscintigraphy (DSCI).. Twenty-four MGD patients and 24 healthy volunteers were examined. During DSCI one drop of a solution with 100 MBq/mL. The T½ values were 29.91 ± 11.61 min in MGD patients and 6.26 ± 1.5 min in healthy controls. Tear osmolarity parameters were 308 ± 9.41 mOsm/L and 288.9 ± 6.4 mOsm/L, tBUT values were 5.54 ± 2.73 s and 11.4 ± 2.7 s, while the ST. Although the MGD patients' lacrimal drainage systems were patent their tear clearance values were significantly higher than those of healthy volunteers, which may be caused by decreased drainage of tears from the eyes towards the nasal cavity. The understanding of new features regarding the altered physico-chemical characteristics of MGD tears has been augmented by the results of this study.

Topics: Adult; Aged; Aged, 80 and over; Female; Healthy Volunteers; Humans; Lacrimal Apparatus; Lacrimal Duct Obstruction; Male; Meibomian Gland Dysfunction; Middle Aged; Osmolar Concentration; Radiopharmaceuticals; Sodium Pertechnetate Tc 99m; Tears; Tomography, Emission-Computed