sodium-pertechnetate-tc-99m and Mediastinal-Neoplasms

Topics: Aged; Aged, 80 and over; Diagnosis, Differential; Female; Goiter, Substernal; Humans; Mediastinal Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Sodium Pertechnetate Tc 99m; Thymoma; Thymus Neoplasms

Topics: Adenoma; Aged; Humans; Hypercalcemia; Hyperparathyroidism; Intraoperative Care; Male; Mediastinal Neoplasms; Parathyroid Glands; Parathyroid Neoplasms; Parathyroidectomy; Radionuclide Imaging; Radiopharmaceuticals; Reoperation; Sodium Pertechnetate Tc 99m; Subtraction Technique; Technetium Tc 99m Sestamibi

Topics: Adenoma; Adult; Choristoma; Humans; Male; Mediastinal Diseases; Mediastinal Neoplasms; Parathyroid Glands; Radionuclide Imaging; Radiopharmaceuticals; Sodium Pertechnetate Tc 99m; Tomography, X-Ray Computed

Topics: Adenoma; Adult; Humans; Hypercalcemia; Male; Mediastinal Neoplasms; Organophosphorus Compounds; Organotechnetium Compounds; Parathyroid Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Sodium Pertechnetate Tc 99m

A 37-year-old male with a persistent increased parathyroid hormone level, after subtotal thyroidectomy and parathyroidectomy, was referred for scintigraphic localization of a possible ectopic parathyroid adenoma. Tc-99m pertechnetate and Tc-99m MIBI scintigraphy were performed on separate days. There was marked uptake of both tracers in the mediastinum, which at surgery was confirmed to be an extrathyroidal parathyroid adenoma. Hypervascularity was suggested as a possible explanation for rare cases of pertechnetate avid parathyroid adenomas. And Tc-99m MIBI scintigraphy proved to be a successful imaging procedure for ectopic parathyroid tissue.

Topics: Adenoma; Adult; Choristoma; Humans; Male; Mediastinal Neoplasms; Mediastinum; Parathyroid Glands; Parathyroid Neoplasms; Radioactive Tracers; Radionuclide Imaging; Radiopharmaceuticals; Sodium Pertechnetate Tc 99m; Technetium Tc 99m Sestamibi

Topics: Adult; False Positive Reactions; Female; Humans; Mediastinal Neoplasms; Parathyroid Neoplasms; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Subtraction Technique; Thallium Radioisotopes

A 53-yr-old man with hypercalcemia was referred after an unsuccessful operative attempt to find a parathyroid adenoma. Metabolic evaluation showed relatively suppressed levels of parathyroid hormone with an elevation of serum 1,25-dihydroxyvitamin D. Thallium-technetium dual isotope imaging revealed localized mediastinal thallium uptake. A vascular mediastinal lesion was then demonstrated by arteriography, with subsequent surgical removal of a mass that proved to be lymphocyte predominant Hodgkin's disease. This case is noteworthy for the finding of isolated lymphocyte predominant Hodgkin's disease in the chest, the association of elevated serum 1,25-dihydroxyvitamin D with hypercalcemia that resolved postoperatively, and the uptake of thallium by the tumor.

Topics: Calcitriol; Calcium; Hodgkin Disease; Humans; Hypercalcemia; Male; Mediastinal Neoplasms; Middle Aged; Parathyroid Neoplasms; Radioisotopes; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Thallium

Topics: Adult; Choristoma; Diagnosis, Differential; Female; Humans; Mediastinal Neoplasms; Parathyroid Glands; Radioisotopes; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Subtraction Technique; Thallium

Among numerous methods utilized for preoperative localization of hyperfunctioning ectopic parathyroid tissue, the technetium-thallium scan appears to be a major advance. Eight patients are presented where this method located ectopic parathyroid tissue in the neck, in the mediastinum, within the pericardium, and within the thyroid gland. To date, these findings have been confirmed operatively in five of the eight patients. On the basis of our limited experience, the authors believe that this is a valuable method in the preoperative localization of ectopic parathyroid tissue, especially in patients with persistent or recurrent hyperparathyroidism following a thorough neck exploration.

Topics: Adenoma; Aged; Female; Head and Neck Neoplasms; Humans; Male; Mediastinal Neoplasms; Middle Aged; Parathyroid Neoplasms; Radioisotopes; Radionuclide Imaging; Reoperation; Sodium Pertechnetate Tc 99m; Subtraction Technique; Thallium

201Tl-thallous chloride/99mTc sodium pertechnetate subtraction scanning is a simple and accurate means to demonstrate enlarged parathyroid glands. We report a case in which the intra-operative location of a mediastinal adenoma was greatly facilitated by using a probe radiation detector following intravenous injection of 201Tl-thallous chloride. We believe this is the first reported use of this technique in parathyroid surgery.

Topics: Adenoma; Female; Humans; Mediastinal Neoplasms; Middle Aged; Parathyroid Neoplasms; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Subtraction Technique; Thallium

Topics: Adenoma; Aged; Humans; Male; Mediastinal Neoplasms; Parathyroid Glands; Parathyroid Neoplasms; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Technetium