sodium-pertechnetate-tc-99m and Lymphoma--Non-Hodgkin

To comparatively assess the capabilities of currently available instrumental studies in the diagnosis of early cardiac performance changes in patients with lymph tumors at different stages of treatment and to study the myocardial histomorphological pattern in relation to the intensity of the therapy performed (as evidenced by sectional studies).. 44 patients, including 26 with various types of lymphogranulomatosis (LGM) and 18 with lymphosarcomas were examined at different stages of antitumor treatment. Radionuclide equilibrium ventriculography (REVG), echocardiography (EchoCG), and electrocardiography (ECG) were used. Postmortem studies of the myocardial histological pattern were conducted in 20 patients (archive data).. No significant pathological REVG, EchoCG, and ECG changes were found in 10 patients examined prior to treatment. In a group of 17 patients receiving a total dose of doxorubicine of 240 +/- 30 mg/m2, there was a significant decrease in diastolic duration, a reduction in diastolic volume, end systolic volume, stroke volume, stroke index, filling fraction over 1/3 diastole. In a group of 17 patients receiving a total dose of doxorubicine of 250 +/- 30 mg/m2 and radiotherapy applied to the mediastinum, the above changes were more marked. There were myocardial histomorphological changes whose magnitude progressed as therapy became more intensive. CONCLUSION. The findings have indicated that by using relatively small cumulative dose of anthracyclines, cardiovascular dysfunction can occur at the early stages of programmed treatment for LGM and lymphosarcomas. REVG has the greatest advantage in their detection.

Topics: Adult; Anthracyclines; Antibiotics, Antineoplastic; Cardiomyopathies; Diagnosis, Differential; Echocardiography; Electrocardiography; Female; Heart; Hodgkin Disease; Humans; Lymphoma, Non-Hodgkin; Male; Middle Aged; Myocardium; Radionuclide Ventriculography; Sodium Pertechnetate Tc 99m; Time Factors

Three cases of imaging with 99mTc-pertechnetate (99mTcO4) and unusual positive lymph node uptake in the neck are reported hereby. Two cases were later diagnosed to be well-differentiated thyroid carcinoma, (DTC) with nodal metastasis. The third was a confirmed case of carcinoma thyroid that had presented with mass in the neck soon after surgery, being prepared for ablative dose of radioactive iodine (131I). All three were young females under 40 years of age. These 3 cases signify that extra thyroidal areas of uptake on a routine thyroid scan with 99mTcO4 can some time be due to thyroid carcinoma with regional metastases. Foci of metastasis in patients with DTC may be incidentlly detected with 99mTcO4 scan. Multinodular goiter with palpable lymph node should always be investigated for exclusion of malignancy. The patients underwent near total thyroidectomy and radical neck dissection; histopathology confirmed the scan findings.

Topics: Adult; Female; Humans; Immunohistochemistry; Lymphoma, Non-Hodgkin; Neoplasm Metastasis; Radiopharmaceuticals; Sodium Pertechnetate Tc 99m; Thyroid Function Tests; Thyroid Neoplasms; Thyroidectomy; Tomography, Emission-Computed; Treatment Outcome; Ultrasonography

Topics: Aerosols; Bronchial Neoplasms; Diagnosis, Differential; Female; Humans; Lymphoma, Non-Hodgkin; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Sodium Pertechnetate Tc 99m

Topics: Adult; Citrates; Diagnosis, Differential; Female; Gallium; Humans; Lymphoma, Non-Hodgkin; Palpation; Radionuclide Imaging; Radiopharmaceuticals; Sodium Pertechnetate Tc 99m; Thyroid Nodule