sodium-pertechnetate-tc-99m and Leukemic-Infiltration

An enlarged spleen failed to accumulate Tc-99m-labeled phytate, but it showed normal perfusion and uptake of labeled and heat-denatured red blood cells. A blood cell count demonstrated moderately low hemoglobin and hematocrit levels and a markedly low platelet count, and results of direct Coombs' and antiplatelet-antibody (IgG) tests were positive. Steroid therapy resulted in normal splenic function. This case demonstrates reversible functional asplenia caused by reticuloendothelial dysfunction secondary to pure splenic chronic lymphocytic leukemia.

Topics: Anemia, Hemolytic, Autoimmune; Erythrocytes; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemic Infiltration; Middle Aged; Organotechnetium Compounds; Phytic Acid; Prednisolone; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Spleen; Splenomegaly; Thrombocytopenia