sodium-pertechnetate-tc-99m and Hypertrophy

Topics: Choristoma; Female; Humans; Hypertrophy; Hypothyroidism; Middle Aged; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Thyroid Gland

A practical, time-saving procedure for sequential quantitative scintigraphy is introduced and 4 parameters chosen from 12 parameters by discriminant analysis are used to evaluate the function of the parotid gland. The examination was performed in 120 cases, including 16 cases with recurrent parotitis in childhood, 33 with chronic obstructive parotitis (COP), 37 with Sjögren's syndrome (SS), 4 with sialadenosis, and 30 normal controls. The scintigraphic findings were analyzed and compared with the histologic findings. The diagnostic value of this method was investigated and scaling for differential diagnosis of COP and SS was established. Scintigraphy is considered to be a useful method for evaluation of parotid function and as a diagnostic aid for SS and COP, especially in patients in whom sialography cannot be performed.

Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chronic Disease; Discriminant Analysis; Female; Humans; Hypertrophy; Male; Middle Aged; Parotid Diseases; Parotid Gland; Parotitis; Radionuclide Imaging; Secretory Rate; Sensitivity and Specificity; Sjogren's Syndrome; Sodium Pertechnetate Tc 99m

Fifty patients clinically suspected of having primary hyperparathyroidism were examined by scintigraphy (201Tl-99mTc subtraction) and sonography (5 MHz). In 28 cases, the results of subtraction scintigraphy, and in 26 cases, the results of sonography were checked by operation. In 25 patients there was a solitary parathyroid adenoma and in two, primary hyperplasia. In one patient all four parathyroid glands were normal. Subtraction scintigraphy had a sensitivity of 90% and a specificity of 98%, while sonography had a sensitivity of 82% and a specificity of 95%. The combination of 201Tl-99mTc subtraction scintigraphy as a functional investigation and sonography as a structural imaging method produced a sensitivity of 96% and is therefore superior to all other methods of localisation for normally situated glands. Diagnostic certainty is reduced by the presence of a nodular thyroid.

Topics: Humans; Hypertrophy; Parathyroid Glands; Radioisotopes; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Thallium; Ultrasonography