sodium-pertechnetate-tc-99m and Foot-Ulcer

In 12 patients with trophic foot-lesions (diabetic feet) retrograde intravenous pressure infusions (150 ml) containing radioactive tracers (99m Tc, 99m Tc labelled human serum albumin) were carried out. With the veins emptied time-activity curves over the legs reflect tissue concentrations after release of the occlusion. Tissue-concentration is about 3 times higher than after intraarterial and 7 times higher than after intravenous injection of the same dose. The high count-rates which can be measured in the wound-secretion demonstrate the "rinsing effect" of the injected fluid. Hemodynamic investigations have been performed in a double blind study. 8 patients received buflomedil and 9 got placebo 3 times per week by retrograde intravenous pressure infusions. After 3 weeks there was an increase of the peak-flow on the lower leg (venous occlusion plethysmography), an increase of transcutaneous oxygen pressure and a fall of peak flow-time and of plasma-viscosity, both for buflomedil and for placebo (without statistical significance). Preliminary investigations after an arterial occlusion for 1 hour showed an increase of flow-values measured by venous occlusion plethysmography which reached a maximum after 4 to 5 days.

Topics: Aged; Aged, 80 and over; Blood Flow Velocity; Chemotherapy, Cancer, Regional Perfusion; Diabetic Angiopathies; Diabetic Neuropathies; Double-Blind Method; Female; Foot; Foot Ulcer; Humans; Infusions, Intravenous; Male; Microspheres; Middle Aged; Pyrrolidines; Radionuclide Imaging; Regional Blood Flow; Reperfusion; Serum Albumin, Radio-Iodinated; Sodium Pertechnetate Tc 99m; Tourniquets; Vasodilator Agents