sodium-pertechnetate-tc-99m and Esophagitis--Peptic

Saliva plays an important role in esophageal acid clearance. Reduction in salivary function has been considered in the pathogenesis of reflux esophagitis. Cisapride, a prokinetic agent, has been reported effective for treating mild-to-moderate grade gastroesophageal reflux disease. Some studies have shown that cisapride increases saliva volume and acid-buffering capacity. The aim of this study was to evaluate the effect of cisapride on salivary gland function by means of dynamic salivary scintigraphy.. Fifty-five patients with endoscopic reflux esophagitis (Savary-Miller Grades I-II) were enrolled in this study. In Group 1 (n = 29), patients were evaluated during the fasting state, both before and after cisapride treatment (5 mg, 3 times/day, before meals, for 2 wk). In Group 2 (n = 26), patients were evaluated during the postprandial state, both before and after cisapride treatment. Uptake ratio (UR) and excretion ratio (ER) of the salivary gland in each group were compared using the paired Student's t-test.. In Group 1, no significant differences were found in UR or ER after cisapride treatment. However, in Group 2, ER increased significantly after treatment (p < 0.01), but UR did not show any significant change.. Cisapride can increase the secretion function of salivary glands during the postprandial phase but not the fasting phase.

Topics: Cisapride; Esophagitis, Peptic; Fasting; Female; Gastrointestinal Agents; Humans; Male; Middle Aged; Piperidines; Postprandial Period; Radionuclide Imaging; Radiopharmaceuticals; Salivary Glands; Salivation; Sodium Pertechnetate Tc 99m

A case of chronic gastric organoaxial volvulus, gastroesophageal reflux, esophagitis, and chronic anemia is presented. Reflux esophagitis and chronic anemia have not been reported previously as clinical signs associated with gastric volvulus in a child. A Meckel's scan is used to diagnose the displaced stomach.

Topics: Anemia, Iron-Deficiency; Child, Preschool; Diaphragmatic Eventration; Esophagitis, Peptic; Gastroesophageal Reflux; Gastrointestinal Hemorrhage; Humans; Male; Radiography; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Stomach Volvulus

This study was designed to evaluate the utility of 99mTc pertechnetate esophageal scintigraphy for identifying Barrett's esophagus. Seventeen patients with Barrett's esophagus and seven patients with reflux esophagitis were studied. Eight of 17 patients with Barrett's esophagus had a positive image (sensitivity 47%). In contrast, none of the seven patients with esophagitis had a positive image (specificity 100%). Pentagastrin did not have a significant effect on the sensitivity. There was no correlation between the type of Barrett's epithelium and the sensitivity of the imaging results. However, the test is more frequently positive in those patients with more extensive disease. Our study indicates that technetium pertechnetate imaging should not be used as a screening test for the detection of Barrett's esophagus in patients with symptoms of gastroesophageal reflux, as the negative predictive value of the test is limited.

Topics: Barrett Esophagus; Esophagitis, Peptic; Evaluation Studies as Topic; Humans; Radionuclide Imaging; Sodium Pertechnetate Tc 99m

Topics: Esophagitis, Peptic; Esophagoplasty; Gastrostomy; Humans; Postoperative Complications; Radionuclide Imaging; Sodium Pertechnetate Tc 99m