sodium-pertechnetate-tc-99m and Dumping-Syndrome

Extracellular space and blood volume were measured using 82Br dilution and 51Cr-tagged erythrocytes in 24 tumor-free patients after total gastrectomy. Eleven of the patients suffered from early dumping. Age, blood volume, and extracellular space were significantly smaller in dumpers (P less than 0.05). The dumping score could be predicted by a multiple regression model considering blood volume per lean body mass and extracellular space (r = 0.637; P = 0.0039). Rapid (t1/2 less than 360 seconds) emptying of the gastric substitute, assessed using a 99Tc-labeled solid test meal, was significantly associated with dumping in addition to extracellular space and blood volume (r = 0.876; P = 0.0018). Both rapid emptying and a narrow extracellular space seem to contribute to the early dumping syndrome.

Topics: Blood Volume; Body Composition; Bromine Radioisotopes; Chromium Radioisotopes; Dumping Syndrome; Erythrocytes; Extracellular Space; Female; Gastric Emptying; Humans; Male; Middle Aged; Plasma Volume; Regression Analysis; Sodium Pertechnetate Tc 99m; Time Factors