sodium-pertechnetate-tc-99m and Diarrhea

Enteric coating of a capsule has been used to deliver a bolus of radioisotope to the ileocecal region. This has allowed quantitative assessment of regional colonic transit in a group of healthy subjects whose proximal colonic transit was accelerated by lactulose 20 ml thrice daily. In this experimental model of diarrhea, codeine delayed transit from mouth to terminal ileum and also delayed transit through the ascending colon from 5.3 +/- 2.5 hr to 7.4 +/- 2.5 hr, N = 11, P < 0.05. Furthermore, codeine delayed whole colon transit, as assessed by geometric center analysis, which showed the delay to be most marked in the right colon with little effect noted in the left colon. In addition, codeine significantly reduced the number of retrograde movements observed and reduced the colonic response to eating. The antidiarrheal effect of codeine appears to be due to a combination of delayed mouth-cecum transit plus an additional delay in the ascending colon. This colonic delay may be partially explained by a reduction in postprandial propulsive movements that were seen in this model of diarrhea.

Topics: Adult; Capsules; Codeine; Colon; Diarrhea; Female; Gastrointestinal Transit; Humans; Lactulose; Male; Particle Size; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Tablets, Enteric-Coated; Time Factors

Topics: Abdominal Pain; Anorexia; Appendicitis; Child; Diagnosis, Differential; Diarrhea; Diverticulitis; Fever; Humans; Male; Meckel Diverticulum; Peritonitis; Radionuclide Imaging; Radiopharmaceuticals; Sodium Pertechnetate Tc 99m; Tomography, Spiral Computed; Vomiting

The diagnosis of a symptomatic Meckel's diverticulum in an adult is uncommon. Still more infrequent is the presentation of a bleeding Meckel's diverticulum after childhood. We present a case report of a 24-year-old male with gastrointestinal hemorrhage secondary to a Meckel's diverticulum containing ectopic gastric mucosa. With the exception of a Meckel's Tc 99m pertechnetate scan, all other diagnostic procedures including Tc 99m-labeled red cell scan and angiography were negative.

Topics: Adult; Diarrhea; Gastrointestinal Hemorrhage; Humans; Laparotomy; Male; Meckel Diverticulum; Sodium Pertechnetate Tc 99m

Bran was labelled with 99mTc-pertechnetate, ingested as part of a normal meal and used to measure gastric emptying in 15 normal subjects and in 15 patients with ulcerative colitis. There was no significant difference between the gastric emptying curves of the normal subjects and the patients, suggesting that rapid gastric emptying does not contribute to diarrhoea in ulcerative colitis.

Topics: Animals; Colitis, Ulcerative; Diarrhea; Dietary Fiber; Gastric Emptying; Humans; Radionuclide Imaging; Rats; Sodium Pertechnetate Tc 99m; Stomach; Technetium