sodium-pertechnetate-tc-99m and Coronary-Artery-Disease

Ventricular stroke work (SW) is one of the best indices to evaluate ventricular function, however, the SW monitoring mainly depends on the invasive method with the artery catheter. In this paper, our aim is to develop a new semi-quantitative non-invasive method for evaluating ventricular SW.. The multiple gated cardiac blood pool imaging was done in 25 patients with coronary artery disease and 12 normal controls. A new parameter, the relative stroke work (RSW) of left ventricle, was calculated using an equation derived from the principle of hydrodynamics. The left ventricular SW was analyzed by stroke volume (SV) and mean arterial pressure. Ejected fraction (EF), peak ejected rate (PER) and peak filling rate (PFR) were gotten with the routine software in imaging device.. The left ventricular RSW was linearly correlated with the SW. The RSW was related to the SV, EF, PER and PFR of the left ventricle. The RSW had regressive relation with SV and PER. The RSW in patients, same as SW, SV, EF, PFR and PER, was noticeably lower than that in normal controls, P<0.01.. The RSW is a potential and valuable clinical index for evaluation of the ventricular function.

Topics: Blood Pressure; Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography; Coronary Artery Disease; Electrocardiography; Female; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Radiopharmaceuticals; Reproducibility of Results; Sodium Pertechnetate Tc 99m; Software; Stroke Volume; Tin Polyphosphates; Ventricular Function

This report is a prospective study of 33 male patients who underwent both contrast ventriculography (CVG) and radionuclide ventriculography (RVG) within a 24-hour period. Expert, blinded observers graded the left ventricle's regional wall motion (RWM) in the left anterior descending (LAD), left circumflex (LCx), and posterior descending arterial (PDA) distributions on right anterior oblique (RAO), and left anterior oblique (LAO) CVGs, and on anterior (ANT), LAO, 70 degrees left anterior oblique (LAO70), and left posterior oblique (LPO) RVGs. When statistically compared with CVG RWM standard data, RVG studies composed of LAO and LPO views were equal to the RVG studies composed of ANT, LAO, and LAO70 views in assessment of the LAD and LCx distributions. The RVG with LAO and LPO views was superior to the RVG with ANT, LAO, LAO70 in the detection of the posterior descending artery RWM. The authors conclude that accurate assessment of RWM is efficiently performed with the RVG composed of LAO and LPO views.

Topics: Coronary Artery Disease; Humans; Male; Middle Aged; Myocardial Contraction; Observer Variation; Radionuclide Ventriculography; Sodium Pertechnetate Tc 99m; Ventricular Function, Left

Left ventricular diastolic filling measurements were determined by means of standard consecutive R-wave gating, list mode acquisition, and alternate R-wave gating. Time-activity curves obtained by the latter two methods were equally accurate in quantifying rapid, slow, and atrial left ventricular filling, whereas curves obtained by means of standard gating were inadequate for this purpose.

Topics: Cardiomegaly; Coronary Artery Disease; Diastole; Electrocardiography; Heart Ventricles; Humans; Hypertension; Male; Middle Aged; Myocardial Contraction; Radionuclide Angiography; Sodium Pertechnetate Tc 99m; Stroke Volume; Time Factors