sodium-pertechnetate-tc-99m and Colitis--Ulcerative

The scintigraphic examination with Tc-99m pertechnetate-labeled anti-NCA 95 antigranulocyte antibodies (AGAb) was performed in a 14-year-old boy with a 7-year history of poorly controlled ulcerative colitis to estimate the spread and activity of the disease. The disturbance of the splenic function was also suspected because Howell-Jolly bodies were present in the peripheral blood smears. High AGAb uptake in the rectum, sigma, and descending colon was observed on scintigraphy scans, indicating an active inflammatory process. Slight depression of hemopoiesis was also noticed. The spleen was not visible on the scans, although it was visible on ultrasound examination performed a few years earlier. Because of the refractory disease, total colectomy was performed. The spleen was not found on surgery. This case shows all benefits of using AGAb as a diagnostic tool. With a single injection we were able to show the spread and activity of the intestinal disease, distribution and function of the granulopoietic bone marrow, and absence of the spleen.

Topics: Adolescent; Antibodies, Monoclonal; Atrophy; Colitis, Ulcerative; Granulocytes; Humans; Male; Radiopharmaceuticals; Sodium Pertechnetate Tc 99m; Spleen

The 99Tcm-labelled antigranulocyte antibody BW250/183 has been used in the detection of intestinal inflammation in patients with active ulcerative colitis and Crohn's disease. Planar images were obtained up to 24 h after intravenous injection of the antibody. Eight out of nine patients with ulcerative colitis and six out of seven patients with Crohn's disease gave positive images. In 11 patients distribution of the inflammation was confirmed by barium studies, colonoscopy or surgery, whilst in two the antibody scan suggested more extensive disease than barium enema. None of the patients had any adverse reactions. Imaging with BW250/183 appears to give an accurate indication of the extent of inflammation in inflammatory bowel disease.

Topics: Colitis, Ulcerative; Crohn Disease; Humans; Radioimmunodetection; Sodium Pertechnetate Tc 99m

Bran was labelled with 99mTc-pertechnetate, ingested as part of a normal meal and used to measure gastric emptying in 15 normal subjects and in 15 patients with ulcerative colitis. There was no significant difference between the gastric emptying curves of the normal subjects and the patients, suggesting that rapid gastric emptying does not contribute to diarrhoea in ulcerative colitis.

Topics: Animals; Colitis, Ulcerative; Diarrhea; Dietary Fiber; Gastric Emptying; Humans; Radionuclide Imaging; Rats; Sodium Pertechnetate Tc 99m; Stomach; Technetium

Two children with rectal bleeding were diagnosed as having ulcerative colitis and a bleeding colonic polyp respectively using abdominal scanning with Tc-99m pertechnetate. Early flow studies are recommended with careful attention paid to the amount of time abnormal areas of activity are seen on the abdominal scan.

Topics: Child; Colitis, Ulcerative; Female; Gastrointestinal Hemorrhage; Humans; Intestinal Neoplasms; Intestinal Polyps; Radionuclide Imaging; Rectum; Sodium Pertechnetate Tc 99m; Technetium; Time Factors