sodium-pertechnetate-tc-99m and Brain-Injuries

The paper presents the experience of application of single-photon emission computed tomography (SPECT) and CT in neurosurgery. Combination of these two techniques in the single system provides higher precision of both methods. The novel technique allows assessment of tumor spread in the brain, differential diagnosis of tumor regrowth and radiation-induced necrosis, evaluation of cerebral perfusion in epilepsy, traumatic brain injury (TBI), and diagnostics of secondary CNS lesions. Examples of primary diagnosis, dynamic follow-up and differential diagnosis of cerebral neoplasms, localization of epileptogenic foci in planning of surgery, prediction of outcome after TBI and evaluation of spread of metastatic skeletal involvement and further application of acquire data are presented.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain Diseases; Brain Injuries; Brain Neoplasms; Child; Child, Preschool; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Multimodal Imaging; Neurosurgical Procedures; Positron-Emission Tomography; Sodium Pertechnetate Tc 99m; Tomography, X-Ray Computed; Treatment Outcome; Young Adult

Topics: Adult; Blood Flow Velocity; Brain Death; Brain Injuries; Cerebral Angiography; Cerebral Infarction; Cerebrovascular Circulation; Hematoma, Epidural, Cranial; Humans; Male; Nose; Radiopharmaceuticals; Sodium Pertechnetate Tc 99m; Tomography, X-Ray Computed

Comparative data of transcranial ultrasonic dopplerography (170 patients) and radionuclide antroscintigraphy (124), received during diagnostics of defeats of venous collectors of brain are analyzed. Five variants of defeats of venous collectors (cross, sigmoid, internal of jugular vein), but also unpaired sine (direct, confluent) are described. Received results permit to reveal interrelation of infringements of venous outflow and increase of intracranial pressure.

Topics: Adult; Aged; Brain Injuries; Cerebrovascular Disorders; Chronic Disease; Cranial Sinuses; Female; Humans; Male; Middle Aged; Pseudotumor Cerebri; Radionuclide Imaging; Radiopharmaceuticals; Sodium Pertechnetate Tc 99m; Technetium Tc 99m Pentetate; Ultrasonography, Doppler, Transcranial

Encephaloangioscintigraphy performed in 30 patients with a closed craniocerebral trauma has shown simultaneous inhibition of the venous cerebral blood flow both in the vascular regions of the cerebral hemispheres and in the lateral sinuses indicating the common pathogenesis of disorders of the venous circulation in these parts of the circulatory bed. The most informative characteristic feature of the venous outflow is a period of RP half-life, determined on a radiocirculogram of the brain. The diagnostic efficacy of the above method in the detection of disorders of the venous circulation of the brain in some vascular regions provides an opportunity for a purpose-oriented use of adequate methods of reflexotherapy.

Topics: Adult; Brain Concussion; Brain Injuries; Cerebral Veins; Cerebrovascular Circulation; Cerebrovascular Disorders; Female; Hemodynamics; Humans; Male; Middle Aged; Sodium Pertechnetate Tc 99m; Time Factors; Tomography, Emission-Computed; Wounds, Nonpenetrating

Of 19 adolescents (ages 10-18) admitted consecutively because of major blunt-impact trauma, 15 had head injuries (Glasgow coma scales 4-15). Eight had cardiac injury (42%), as demonstrated by cardiac wall-motion studies utilizing ECG-gated radionuclide angiography. Of the head-injured patients, 7 had cardiac injury (47%), and of these, one died in cardiac shock. Significant cardiac injury is known both experimentally and clinically to escape detection by conventional methods and a compromised cardiac output may bode ill for a damaged brain if cerebral perfusion pressure is in jeopardy.

Topics: Adolescent; Brain Injuries; Cardiac Output; Child; Contusions; Female; Heart Injuries; Humans; Radionuclide Imaging; Sodium Pertechnetate Tc 99m

Using radioindicative methods, cerebral hemodynamics was studied in 62 children aged 3 to 15 years in the acute period of head injury. The diagnostic findings of focal intracranial lesions are presented. On the basis of the clinical-neurologic findings, the patients were divided into three groups depending on the degree of the severity of traumatic lesion to the brain. Patients with mild and moderately grave craniocerebral injury were shown to have a symmetric decrease in the blood flow intensity while severe traumas were associated with disorders of vascular passage of the preparation in one cerebral hemisphere in the presence of general reduction in the cerebral blood flow.

Topics: Adolescent; Brain Concussion; Brain Injuries; Cerebrovascular Circulation; Cerebrovascular Disorders; Child; Child, Preschool; Hemodynamics; Humans; Radionuclide Imaging; Skull Fractures; Sodium Pertechnetate Tc 99m; Technetium