sodium-oxybate and Shock--Traumatic

The mitotic regimen analysis in rat bone marrow cells was conducted 1, 3, 7, 14, 21 and 35 days after shock trauma. A sharp impairment of myelocyte reproductive function was registered against an increase in the mitotic index. It confirms a universal character of normal mitosis impairment in strong stresses, which was earlier established for epithelial tissues. Cell division disturbances in the bone marrow may be considered an pathogenic factor of a number of pathological processes occurring in the blood system in traumatic disease (anemia, immunodepression). A complex of drugs (sodium oxybutyrate, sodium oxiferriscarbon, Laevamizolum) is offered for the correction of proliferative processes in the bone marrow. This complex has no significant influence on mitotic index and causes relative reduction of pathological mitosis level, ensuring its earlier normalization.

Topics: 2,3-Diketogulonic Acid; Alloxan; Animals; Bone Marrow; Drug Combinations; Ferric Compounds; Levamisole; Male; Mitosis; Mitotic Index; Rats; Shock, Traumatic; Sodium Oxybate

Topics: Abdominal Injuries; Animals; Guinea Pigs; Hydroxybutyrates; Kidney; Shock, Traumatic; Sodium Oxybate; Thoracic Injuries