sodium-oxybate and Postural-Orthostatic-Tachycardia-Syndrome

Although there are reports of narcolepsy type 1 caused by lesions of the central nervous system, there are far fewer reports of narcolepsy type 2 (NT2) caused by discrete brain lesions. We report a case of a patient in whom NT2 was diagnosed after a viral illness, and inflammatory lesions in the right thalamus and amygdala were found. In addition, symptoms of autonomic impairment developed and postural tachycardia syndrome was subsequently diagnosed in this patient. To our knowledge this is the first reported case of NT2 resulting from central nervous system lesions in these discrete locations, as well as the first reported case of postural tachycardia syndrome associated with narcolepsy.

Topics: Adolescent; Adrenergic beta-Antagonists; Amphetamine; Amygdala; Central Nervous System Stimulants; Dextroamphetamine; Female; Humans; Magnetic Resonance Imaging; Narcolepsy; Postural Orthostatic Tachycardia Syndrome; Propranolol; Sodium Oxybate; Thalamus