sodium-oxybate and Nausea

The authors performed an open-label, rater-blinded, add-on study of sodium oxybate in 20 patients with ethanol-responsive myoclonus or essential tremor. Blinded ratings of videotaped examinations showed improvements in myoclonus at rest, stimulus-sensitive myoclonus, action myoclonus, functional performance, and postural and kinetic tremor. Tolerability was acceptable, and more than half of the patients chose to continue treatment after the trial. Double-blind placebo-controlled studies in these disorders are warranted.

Topics: Adjuvants, Anesthesia; Adult; Affective Symptoms; Aged; Brain; Dizziness; Dose-Response Relationship, Drug; Essential Tremor; Ethanol; Female; Headache; Humans; Male; Middle Aged; Myoclonus; Nausea; Patient Compliance; Patient Dropouts; Sodium Oxybate; Treatment Outcome