sodium-oxybate and Myocardial-Infarction

A method for computed determination of death probability was used to examine the effects of various modalities of stress-limiting therapy on mortality rates within a month after myocardial infarction. The examination was made in 591 patients with large myocardial infarction. A significant decrease in mortality rates was seen in patients on finoptin and phosphocreatine (by 9.6 and 11.2, respectively) as compared to the expected drop. Other agents given within the first hours of myocardial infarction such as beta-blockers, opioid peptides, sodium oxybutyrate, piracetam, antioxidants were demonstrated to cause no reduction in mortality rates.

Topics: Aged; Antioxidants; Clinical Trials as Topic; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Humans; Male; Myocardial Infarction; Phosphocreatine; Piracetam; Propranolol; Sodium Oxybate; Stress, Physiological; Verapamil

In the experiments on the anesthesized cats sodium hydroxybutyrate and piracetam, in contrast to glyo-6, have been shown to slow down the growth rate of creatine phosphokinase activity in the blood of the coronary sinus during 60-min occlusion of the coronary artery. At the same time, in the experiments on rats with 3-day myocardial infarction GABA derivatives like glyo-6 failed to influence the final size of cardiac necrosis. It may be concluded that anti-ischemic action of some drugs may be expressed only in the reduction of the rate of ischemic lesion development in the heart, but not in the limitation of the infarction size.

Topics: Animals; Cats; Hypoxia; Male; Myocardial Infarction; Piracetam; Pyridoxine; Rats; Sodium Oxybate

Topics: Animals; Aprotinin; Ascorbic Acid; Drug Therapy, Combination; Glutamates; Glutamic Acid; Heart Failure; Ibuprofen; Myocardial Infarction; Myocardium; Nandrolone; Nandrolone Decanoate; Nifedipine; Potassium Magnesium Aspartate; Propranolol; Rabbits; Sodium Oxybate; Vitamin E

Topics: Acid-Base Equilibrium; Acute Disease; Anesthesia, General; Animals; Dogs; Ether; Fentanyl; Hemodynamics; Myocardial Infarction; Respiration, Artificial; Sodium Oxybate; Tracheotomy

Contractile function of an isolated right auricle of the rat was studied one day after producing an experimental infarction of the left ventricle. It was disclosed that in this non-ischemized heart area there developed marked decrease in myocardial extensibility and depression of contractile function manifesting in an approximately two-fold lowering of the developing tension. These stress-induced disturbances prevented by administering GABA prior to myocardial infarction production. It is assumed that the action of GABA is accounted for by its capability to protect non-ischemized areas of the myocardium against harmful stress action.

Topics: Animals; Hydroxybutyrates; Male; Myocardial Contraction; Myocardial Infarction; Rats; Rats, Inbred Strains; Sodium Oxybate; Stress, Physiological