sodium-oxybate and Lung-Diseases

Clinical examination of patients with diseases of the lungs and locomotor system during the surgical treatment and experiments in animals has shown that sodium hydroxybutyrate used as an anesthetizing drug under conditions of the neuroleptic analgesia fails to provide an effective defense against the surgical trauma. This is shown by the instability in the hemodynamic indices, metabolic shifts and the presence of nociceptive viscero-somatic reflexes.

Topics: Aged; Anesthesia, Intravenous; Animals; Bone and Bones; Clinical Trials as Topic; Drug Evaluation, Preclinical; Hemodynamics; Humans; Hydroxybutyrates; Joints; Lung Diseases; Middle Aged; Pneumonectomy; Preanesthetic Medication; Reflex; Sodium Oxybate; Time Factors

The investigation of gas exchange, central hemodynamics and real oxygen transport has shown expediency of using ether and fluothane as main anesthetic drugs in operations on the lungs in patients with a compensated form of chronic pulmonary respiratory insufficiency. Neuroleptoanalgesia decreased the operative risk as compared with ether and fluothane. A combined anesthesia with sodium hydroxybutyrate in association with drugs for NLA and tranquilizers is thought to be the method of choice in patients with a pronounced respiratory insufficiency.

Topics: Anesthesia, General; Chronic Disease; Ether; Fentanyl; Halothane; Hemodynamics; Humans; Lung Diseases; Neuroleptanalgesia; Nitrous Oxide; Pulmonary Circulation; Pulmonary Gas Exchange; Respiratory Insufficiency; Sodium Oxybate