sodium-oxybate and Heart-Diseases

It has been established that sodium hydroxybutyrate, prolactin, propranolol and ionol are capable of preventing the depression of the contractile function of the heart and of decreasing the glycogen level in the myocardium, provoked by emotional stress.

Topics: Animals; Butylated Hydroxytoluene; Drug Evaluation, Preclinical; Glycogen; Heart Diseases; Humans; Male; Myocardial Contraction; Myocardium; Prolactin; Propranolol; Rats; Sodium Oxybate; Stress, Psychological

After clinical death caused by acute blood loss, hearts of rats were essentially damaged. In isolated hearts, these damages were manifested in the decrease of major contractility parameters with the preferential disturbance of relaxation, increased loss of enzymes (lactate dehydrogenase and creatine phosphokinase) into the perfusate and a significant decrease of the cardiac muscle resistance to hypoxia. All these effects could be, to a large extent, prevented by gamma-hydroxybutyric acid, an endogenous metabolite having central inhibitory effect, which was administered to the animals before the loss of blood.

Topics: Acute Disease; Animals; Creatine Kinase; Death; Heart Diseases; Heart Rate; Hemorrhage; Hydroxybutyrates; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Myocardial Contraction; Rats; Resuscitation; Sodium Oxybate; Time Factors

Studies on contractile function of the papillar muscles of the rat heart after exposure to emotional pain stress gave evidence of a significant decrease in the amplitude, rates of contraction and relaxation and in the index of contraction. These disturbances of contractile function of the heart muscle can be prevented by pretreatment of the animals with the endogenous inhibitory metabolite, gamma-hydroxybutyric acid, or by preliminary injection of the lipid hydroperoxidation inhibitor, antioxidant ionol--2,6-di(tret-butyl)-4-methylphenol.

Topics: Animals; Antioxidants; Butylated Hydroxytoluene; Heart Diseases; Humans; Hydroxybutyrates; Male; Myocardial Contraction; Papillary Muscles; Rats; Sodium Oxybate; Stress, Psychological

Topics: Animals; Female; Free Radicals; Heart Diseases; Humans; Hydroxybutyrates; Lipid Metabolism; Myocardial Contraction; Myocardium; Oxidation-Reduction; Rats; Sodium Oxybate; Stomach Ulcer; Stress, Psychological; Vitamin E