sodium-oxybate and Fetal-Hypoxia

The protective effect of the narcoanalgetics, viadril (hydroxydione sodium succinate) and administered intraperitoneally in doses of 5 and 20 mg/kg was studied in the experiment on 146 pregnant noninbred white rats with simulated hemic hypoxia in the late pregnancy (the 19th day). The aforementioned rats were studied for the composition of the peripheral blood, their weight gain oxidative isoenzymes (LDH), pH and pO2 in the blood. Wilson's technique was used for the assessment of the fetal status. The offspring was studied with regard to the weight increment, the rate of postnatal mortality, behavioral reactions, etc. It was stated that viadril strengthened the resistance of pregnant animals to hypoxia and contributed to the alleviation of late sequela of posthypoxic changes in the fetus and newborn.

Topics: Animals; Animals, Newborn; Female; Fetal Hypoxia; Fetus; Hydroxybutyrates; Hypoxia; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complications; Pregnanediones; Rats; Sodium Oxybate