sodium-oxybate and Dermatitis--Allergic-Contact

Topics: 4-Butyrolactone; Allergens; Dermatitis, Allergic Contact; Dermatitis, Occupational; Glycosides; Hand Dermatoses; Humans; Hydrolysis; Magnoliopsida; Occupational Exposure; Sodium Oxybate

Alstroemerias are one of the most common plants that cause allergic contact dermatitis in floral workers. This colorful plant has gained great popularity among florists and their patrons. This concise review will help dermatologists to gain familiarity with this plant and show how to diagnose problems that it may cause.

Topics: 4-Butyrolactone; Adult; Allergens; Dermatitis, Allergic Contact; Glucosides; Glycosides; Hand Dermatoses; Humans; Male; Occupational Diseases; Occupational Exposure; Patch Tests; Plant Extracts; Plants; Sodium Oxybate

The allergen tulipalin A was collected by dynamic headspace technique from cut flowers of 2 Alstroemeria hybrids and quantified and identified by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The amounts of tulipalin A released into the air were correlated with the tulipalin A and the total allergen content (tulipalin A and tuliposides) in the plant tissue, respectively. Tulipalin A was released primarily from the wounded areas, i.e. the stems, although small amounts were also emitted from the undamaged flowers in one of the hybrids. The tulipalin A concentrations in the stems of the Alstroemeria hybrids investigated were 0.06% and 0.13% of fresh weight, respectively, and the amounts directly released from the cut flowers were 0.4 and 2.2 microg (cut flower)(-1) h(-1), respectively. The content of tulipalin A exceeded that of tuliposides in leaves and flowers of both hybrids, whereas the content of tulipalin A in stems (in % fresh weight) was slightly lower than the content of tuliposides. The possibility that airborne tulipalin A from Alstroemeria could be a source of airborne contact dermatitis is discussed.

Topics: 4-Butyrolactone; Air Pollution, Indoor; Allergens; Chromatography, Gas; Chromatography, High Pressure Liquid; Dermatitis, Allergic Contact; Gas Chromatography-Mass Spectrometry; Glycosides; Humans; Plants; Sodium Oxybate

Astroemeria is an increasingly common cause of allergic contact dermatitis. We report a case of occupational contact dermatitis that was transferred with job duties. When advising patients about their risk, it is advisable to discuss the risk to others in the setting as well.

Topics: Allergens; Dermatitis, Allergic Contact; Dermatitis, Occupational; Female; Glycosides; Hand Dermatoses; Humans; Male; Middle Aged; Plants; Sodium Oxybate

Betaxolol ophthalmic solution has been associated with periocular skin hyperpigmentation. We report a case of a woman with hyperpigmentation of the fingers associated with oral betaxolol. Based on case reports associated with the topical ophthalmic product, we believe the hyperpigmentation was likely caused by oral betaxolol.

Topics: Administration, Oral; Allergens; Antihypertensive Agents; Betaxolol; Dermatitis, Allergic Contact; Dermatitis, Occupational; Female; Fingers; Glycosides; Hand Dermatoses; Humans; Hyperpigmentation; Middle Aged; Plants; Sodium Oxybate

From aqueous extracts of flowers, stems and leaves of 1 Brazilian and 15 Chilean Alstroemeria species, the content of a new tuliposide, named tuliposide D, was determined by isocratic reversed-phase high-performance liquid chromatography (RP-HPLC), using distilled water:methanol (80:20) as mobile phase. The compound was detected by a UV-detector at 208 nm. Tuliposide D was found in almost all Alstroemeria species investigated, although in very different amounts. Most species contained relatively small amounts of tuliposide D, especially in the leaves. However, A. hookeri ssp. cummingiana, A. presliana ssp. presliana, A. pseudospathulata and A. revoluta contained large amounts of tuliposide D in all plant parts. Tuliposide D was identified as 1,6-di-(4-hydroxy-2-methylenebutanoate)-beta-D-glucopyranose by UV, FAB-MS, 1H- and 13C-NMR. The content of the allergens 6-tuliposide A and tulipalin A was also determined by RP-HPLC and the possibility that tuliposide D is a further causative agent of allergic contact dermatitis in Alstroemeria is discussed.

Topics: Allergens; Brazil; Chile; Chromatography, High Pressure Liquid; Dermatitis, Allergic Contact; Glucosides; Humans; Plants; Sodium Oxybate