sodium-nitrite and Thymus-Neoplasms

sodium-nitrite has been researched along with Thymus-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for sodium-nitrite and Thymus-Neoplasms

Article	Year
The enhancing effect of sodium nitrite on virus-induced leukemia in mice. Cancer detection and prevention, 1997, Volume: 21, Issue:4 A study of the effect of sodium nitrite (SN) on leukemia development in mice induced by Rauscher Leukemia virus (RLV) (Balb/c mice), Mazurenko leukemia virus (MaLV) (CC57Br mice), and Gross leukemia virus (GLV) (AKR/J mice) was performed. SN was administered in water (at concentrations of 5.0, 50.0, 500.0, and 2000.0 mg/l, by NaNO2). A moderate, yet statistically significant acceleration of leukemia development was observed in some groups of SN-treated mice. Our findings and the literature provide evidence that SN has the capacity to enhance the carcinogenic effect of leukemia viruses in vivo. Topics: Animals; Female; Leukemia Virus, Murine; Leukemia, Experimental; Male; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred Strains; Rauscher Virus; Sodium Nitrite; Thymus Neoplasms	1997
Chronic toxicity of sodium nitrite in mice, with reference to its tumorigenicity. Gan, 1979, Volume: 70, Issue:2 Sodium nitrite has been widely used as one of the most effective food additives to tinge color on cured meat. However, it has been elucidated that this chemical is not merely a precursor of N-nitroso compounds, many of which are strongly carcinogenic, but also a mutagenic substance in biological tests. In order to ascertain the possible tumorigenicity of sodium nitrite itself, chronic toxicity of the agent in mice, by means of daily oral administration as drinking water for more than 18 months, in the concentration of 0.5 (maximum tolerated dose), 0.25, and 0.125%, was tested. As a result, development of various tumors, including thymic lymphoma, nonthymic lymphoid leukemia, pulmonary adenoma and carcinoma, and benign and malignant tumors in soft tissue, was seen in these mice. However, as to the incidence of tumors as well as the developmental time of each histologically classified tumor, no apparent difference was detected between those in the experimental groups and the control group. Topics: Animals; Carcinogens; Female; Leukemia; Liver Neoplasms; Lung Neoplasms; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred ICR; Nitrites; Sodium Nitrite; Soft Tissue Neoplasms; Thymus Neoplasms; Time Factors; Uterine Neoplasms	1979

Article

Year

The enhancing effect of sodium nitrite on virus-induced leukemia in mice.

Cancer detection and prevention, 1997, Volume: 21, Issue:4

A study of the effect of sodium nitrite (SN) on leukemia development in mice induced by Rauscher Leukemia virus (RLV) (Balb/c mice), Mazurenko leukemia virus (MaLV) (CC57Br mice), and Gross leukemia virus (GLV) (AKR/J mice) was performed. SN was administered in water (at concentrations of 5.0, 50.0, 500.0, and 2000.0 mg/l, by NaNO2). A moderate, yet statistically significant acceleration of leukemia development was observed in some groups of SN-treated mice. Our findings and the literature provide evidence that SN has the capacity to enhance the carcinogenic effect of leukemia viruses in vivo.

Topics: Animals; Female; Leukemia Virus, Murine; Leukemia, Experimental; Male; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred Strains; Rauscher Virus; Sodium Nitrite; Thymus Neoplasms

1997

Chronic toxicity of sodium nitrite in mice, with reference to its tumorigenicity.

Gan, 1979, Volume: 70, Issue:2

Sodium nitrite has been widely used as one of the most effective food additives to tinge color on cured meat. However, it has been elucidated that this chemical is not merely a precursor of N-nitroso compounds, many of which are strongly carcinogenic, but also a mutagenic substance in biological tests. In order to ascertain the possible tumorigenicity of sodium nitrite itself, chronic toxicity of the agent in mice, by means of daily oral administration as drinking water for more than 18 months, in the concentration of 0.5 (maximum tolerated dose), 0.25, and 0.125%, was tested. As a result, development of various tumors, including thymic lymphoma, nonthymic lymphoid leukemia, pulmonary adenoma and carcinoma, and benign and malignant tumors in soft tissue, was seen in these mice. However, as to the incidence of tumors as well as the developmental time of each histologically classified tumor, no apparent difference was detected between those in the experimental groups and the control group.

Topics: Animals; Carcinogens; Female; Leukemia; Liver Neoplasms; Lung Neoplasms; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred ICR; Nitrites; Sodium Nitrite; Soft Tissue Neoplasms; Thymus Neoplasms; Time Factors; Uterine Neoplasms

1979