sodium-nitrite has been researched along with Glucosephosphate-Dehydrogenase-Deficiency* in 1 studies
1 other study(ies) available for sodium-nitrite and Glucosephosphate-Dehydrogenase-Deficiency
| Article | Year |
|---|---|
The effect of ascorbic acid on sodium nitrite-induced methemoglobin formation in glucose-6-phosphate dehydrogenase-deficient erythrocytes.
Ascorbic acid significantly reduced the occurrence of sodium nitrite-induced methemoglobin (METHB) formation in a dose-dependent manner in erythrocytes from glucose-6-phosphate dehydrogenase (G-6-PD)-deficient humans in vitro. The ascorbic acid treatment, however, also decreased levels of reduced GSH in a dose-dependent manner, a response indicative of oxidant stress to the erythrocyte membrane. The latter findings are inconsistent with the hypothesis that ascorbic acid supplementation in G-6-PD-deficient humans may help compensate for inherently low levels of erythrocyte GSH. Finally, the ascorbic acid-induced reduction of METHB values, while of statistical significance, does not appear to be of clinical significance. Topics: Ascorbic Acid; Erythrocytes; Glucosephosphate Dehydrogenase Deficiency; Glutathione; Humans; Methemoglobin; Nitrites; Oxidation-Reduction; Sodium Nitrite | 1983 |