sodium-morrhuate and Ulcer

Ulceration at the site of injection is a common sequel of endoscopic sclerotherapy. Most postsclerotherapy ulcers heal spontaneously, usually within 3 weeks. We report a patient who developed a large esophageal ulcer after sclerotherapy, which did not heal despite 2 years of aggressive medical therapy. He bled twice from the ulcer. This is the first report in which such an ulcer has been followed sequentially for 2 years and has remained unhealed.

Topics: Aged; Chronic Disease; Esophageal and Gastric Varices; Esophageal Diseases; Esophagoscopy; Fatty Acids; Humans; Male; Sodium Morrhuate; Time Factors; Ulcer

Deep ulceration of the esophagus is the most common significant complication of endoscopic injection sclerosis of varices. Four patients with persistent bleeding from sclerotherapy-induced ulcers were treated with sucralfate. Adherence of sucralfate to the ulcerated areas was demonstrated endoscopically, and bleeding stopped in three patients. Sucralfate may be useful in the treatment of esophageal ulcers caused by sclerotherapy.

Topics: Aluminum; Anti-Ulcer Agents; Esophageal Diseases; Esophagoscopy; Fatty Acids; Gastrointestinal Hemorrhage; Humans; Sodium Morrhuate; Sucralfate; Ulcer

Three patients with portal hypertension and variceal hemorrhage were treated with flexible fiberoptic esophageal vein sclerosis by injection of sodium morrhuate. Each of these patients bled after sclerotherapy, and deep esophageal ulcers were found at the previous injection sites. Postsclerotherapy pathologic features are presented in 2 patients. It is suggested that the sclerotherapy caused esophageal ulceration and bleeding. Careful evaluation of the sclerosing technique and its histopathologic consequences is needed.

Topics: Adult; Esophageal and Gastric Varices; Esophageal Diseases; Esophagoscopes; Fatty Acids; Fiber Optic Technology; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Sodium Morrhuate; Ulcer