sodium-morrhuate and Chronic-Disease

Chronic lateral epicondylosis is common, debilitating, and often refractory. Prolotherapy (PrT) is an injection therapy for tendinopathy. The efficacy of two PrT solutions for chronic lateral epicondylosis was evaluated.. This study is a three-arm randomized controlled trial. Twenty-six adults (32 elbows) with chronic lateral epicondylosis for 3 mos or longer were randomized to ultrasound-guided PrT with dextrose solution, ultrasound-guided PrT with dextrose-morrhuate sodium solution, or watchful waiting ("wait and see"). The primary outcome was the Patient-Rated Tennis Elbow Evaluation (100 points) at 4, 8, and 16 wks (all groups) and at 32 wks (PrT groups). The secondary outcomes included pain-free grip strength and magnetic resonance imaging severity score.. The participants receiving PrT with dextrose and PrT with dextrose-morrhuate reported improved Patient-Rated Tennis Elbow Evaluation composite and subscale scores at 4, 8, and/or 16 wks compared with those in the wait-and-see group (P < 0.05). At 16 wks, compared with baseline, the PrT with dextrose and PrT with dextrose-morrhuate groups reported improved composite Patient-Rated Tennis Elbow Evaluation scores by a mean (SE) of 18.7 (9.6; 41.1%) and 17.5 (11.6; 53.5%) points, respectively. The grip strength of the participants receiving PrT with dextrose exceeded that of the PrT with dextrose-morrhuate and the wait and see at 8 and 16 wks (P < 0.05). There were no differences in magnetic resonance imaging scores. Satisfaction was high; there were no adverse events.. PrT resulted in safe, significant improvement of elbow pain and function compared with baseline status and follow-up data and the wait-and-see control group. This pilot study suggests the need for a definitive trial.

Topics: Adult; Chronic Disease; Drug Therapy, Combination; Female; Follow-Up Studies; Glucose Solution, Hypertonic; Humans; Injections, Intra-Articular; Male; Middle Aged; Pain Measurement; Pilot Projects; Quality of Life; Range of Motion, Articular; Reference Values; Risk Assessment; Severity of Illness Index; Single-Blind Method; Sodium Morrhuate; Tennis Elbow; Treatment Outcome; Ultrasonography, Doppler

To compare the efficacy of prolotherapy versus corticosteroid injection for the treatment of chronic lateral epicondylosis.. A prospective, randomized controlled, double-blinded study.. Academic, tertiary, outpatient, rehabilitation hospital.. Twenty-four subjects with clinically determined chronic (ie, lasting 3 months or longer) lateral epicondylosis were recruited. All subjects noted pain intensity levels significant enough to prevent the participation in activities, such as playing racquet sports or lifting heavy objects.. Subjects were assigned to receive either prolotherapy or corticosteroid injection for treatment of chronic lateral epicondylosis. Each subject underwent injection at baseline followed by a second injection 1 month later.. Visual analog scale (VAS) self-rating of pain, quadruple visual analog scale (QVAS), and the Disabilities of the Arm, Shoulder, and Hand questionnaire (DASH) were measured at baseline and at 1, 3, and 6 months' follow-up.. Within each group, the analysis demonstrated statistically significant improvements in both VAS and DASH within the prolotherapy group with significant changes noted from baseline to 3 months (VAS: Δ2.38; 95% confidence interval [95% CI] 1.04-3.71, P = .004 and DASH: Δ19.89; 95% CI 5.73-34.04, P = .01), and baseline to 6 months (VAS: Δ2.63; 95% CI 0.61-4.62, P = .017 and DASH: Δ21.76; 9% CI 7.43-36.09, P = .009) after initial treatment, as well as in the QVAS from baseline to 3 months. The steroid group demonstrated a clinically and statistically significant change for DASH only at both 3-month (Δ13.33; 95% CI 0.68-25.99, P = .04) and 6-month (Δ15.56; 95% CI 1.30-29.81, P = .04) follow-up. Comparison of the subjects completing the study revealed no significant differences between the prolotherapy and the corticosteroid group for change in VAS, QVAS, or DASH, although the study lacked sufficient power to draw conclusions from this finding. Eighty-three percent of the subjects were satisfied with their overall improvement during the course of the study, without significant differences revealed between groups. Aside from injection-associated pain, no adverse reactions were reported. Seventeen subjects completed study protocol.. Both prolotherapy and corticosteroid therapy were generally well tolerated and appeared to provide benefit of long duration. Small sample size precludes determining whether one therapy is superior to the other. Larger, controlled trials appear feasible and warranted on the basis of these findings.

Topics: Anti-Inflammatory Agents; Chronic Disease; Double-Blind Method; Glucocorticoids; Hand Strength; Humans; Injections, Intra-Articular; Methylprednisolone; Methylprednisolone Acetate; Muscle Strength Dynamometer; Pain Measurement; Prospective Studies; Sclerosing Solutions; Sodium Morrhuate; Tennis Elbow

Ampicillin/sulbactam was used for the treatment of experimental osteomyelitis due to Staphylococcus aureus in rabbits. Treatment with 200 mg/kg (ampicillin) three times a day sterilized 40% of infected rabbit bones. The results of 4 weeks of treatment with ampicillin/sulbactam for chronic experimental staphylococcal osteomyelitis were comparable to those obtained previously with cephalothin and with oxacillin in previous studies and were not as good as those with clindamycin alone or combination therapy that included rifampin.

Topics: Ampicillin; Animals; Chronic Disease; Disease Models, Animal; Drug Therapy, Combination; Microbial Sensitivity Tests; Osteomyelitis; Rabbits; Sodium Morrhuate; Staphylococcal Infections; Sulbactam

Ulceration at the site of injection is a common sequel of endoscopic sclerotherapy. Most postsclerotherapy ulcers heal spontaneously, usually within 3 weeks. We report a patient who developed a large esophageal ulcer after sclerotherapy, which did not heal despite 2 years of aggressive medical therapy. He bled twice from the ulcer. This is the first report in which such an ulcer has been followed sequentially for 2 years and has remained unhealed.

Topics: Aged; Chronic Disease; Esophageal and Gastric Varices; Esophageal Diseases; Esophagoscopy; Fatty Acids; Humans; Male; Sodium Morrhuate; Time Factors; Ulcer