sodium-lactate and Melanoma

sodium-lactate has been researched along with Melanoma* in 1 studies

Other Studies

1 other study(ies) available for sodium-lactate and Melanoma

Article	Year
LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells. Cell metabolism, 2016, 11-08, Volume: 24, Issue:5 Elevated lactate dehydrogenase A (LDHA) expression is associated with poor outcome in tumor patients. Here we show that LDHA-associated lactic acid accumulation in melanomas inhibits tumor surveillance by T and NK cells. In immunocompetent C57BL/6 mice, tumors with reduced lactic acid production (Ldha Topics: Animals; Apoptosis; CD8-Positive T-Lymphocytes; Cell Count; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytokines; Glycolysis; Humans; Immunologic Surveillance; Interferon-gamma; Isoenzymes; Killer Cells, Natural; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Lactic Acid; Male; Melanoma; Mice, Inbred C57BL; NFATC Transcription Factors; Phenotype; Sodium Lactate; T-Lymphocytes; Up-Regulation	2016

Article

Year

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.

Cell metabolism, 2016, 11-08, Volume: 24, Issue:5

Elevated lactate dehydrogenase A (LDHA) expression is associated with poor outcome in tumor patients. Here we show that LDHA-associated lactic acid accumulation in melanomas inhibits tumor surveillance by T and NK cells. In immunocompetent C57BL/6 mice, tumors with reduced lactic acid production (Ldha

Topics: Animals; Apoptosis; CD8-Positive T-Lymphocytes; Cell Count; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytokines; Glycolysis; Humans; Immunologic Surveillance; Interferon-gamma; Isoenzymes; Killer Cells, Natural; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Lactic Acid; Male; Melanoma; Mice, Inbred C57BL; NFATC Transcription Factors; Phenotype; Sodium Lactate; T-Lymphocytes; Up-Regulation

2016