sodium-iodate and Inflammation

Senescent cells have been demonstrated to have lower cellular NAD

Topics: Cellular Senescence; Humans; Inflammation; Iodates; Macular Degeneration; NAD; Nicotinamide Mononucleotide; Oxidative Stress; Retinal Pigment Epithelium

Retinal degeneration (RD) is a group of serious blinding eye diseases characterized by photoreceptor cell apoptosis and progressive degeneration of retinal neurons. However, the underlying mechanism of its pathogenesis remains unclear.. In this study, retinal tissues from sodium iodate (NaIO. In total, 334 mRNAs, 77 long non-coding RNAs (lncRNAs), and 20 other RNA types were identified as differentially expressed in the retinas of NaIO. Overall, this study suggests that multiple chemokines participating in systemic inflammation may contribute to RD pathogenesis.

Topics: Animals; Chemokines; Gene Expression Profiling; Inflammation; Iodates; Rats; Retinal Degeneration; RNA, Messenger; Sequence Analysis, RNA

In most studies, the major supplement docosahexaenoic acid (DHA) is administered orally or intraperitoneally. In this study, we proposed to assess the safety and efficacy of the intravitreal injection of DHA in an age-related macular degeneration (AMD) rat model. Different concentrations of DHA were injected into the vitreous body. Histopathology and terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) analysis showed that there was no difference in thickness, observable structure, or apoptosis among the untreated, normal saline, and DHA groups (0.2, 1.0, 5.0 and 10μg). However, GFAP expression was increased in the 10μg group. To investigate whether intravitreal injection of DHA could protect photoreceptors, we developed a NaIO

Topics: Animals; Apoptosis; Disease Models, Animal; Docosahexaenoic Acids; Female; Gliosis; Inflammation; Intravitreal Injections; Iodates; Macular Degeneration; Oxidative Stress; Photoreceptor Cells; Rats; Rats, Sprague-Dawley