sodium-hypochlorite and Skin-Diseases--Infectious

Atopic dermatitis (AD) is considered the most prevalent chronic inflammatory condition in very young children, with a prevalence approaching 20% in some industrialized countries. Recent advances in the understanding of the aetiology and pathogenesis of AD - particularly in relation to genetically determined skin barrier dysfunction and the role of microbial infections in AD flares - have helped to galvanize thinking on approaches to treatment in young patients. Topical anti-inflammatory medicines (corticosteroids and calcineurin inhibitors) in addition to emollients are the mainstay of therapy in children, but parents need help to understand how and when to apply them and reassurance to allay their fears about the long-term effects of these treatments. At the same time, more work is required in order to identify which clinical signs, symptoms, long-term control of flares, and quality of life measures are the best outcome domains for AD clinical trials in order to continue to improve control of AD in children.

Topics: Administration, Cutaneous; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Calcineurin Inhibitors; Child; Dermatitis, Atopic; Filaggrin Proteins; Humans; Hydrotherapy; Intermediate Filament Proteins; Medication Adherence; Mutation; Patient Education as Topic; Skin Diseases, Infectious; Skin Lightening Preparations; Sodium Hypochlorite; Treatment Outcome

Under observation there were 174 patients with purulent wounds, 54 of them were treated with application of 0.06% solution of sodium hypochlorite, and 20 patients made up a control group and were treated by traditional methods. It was found that the application of the solution of sodium hypochlorite results in sharp elevation of susceptibility of wound microflora to antibiotics and facilitates more rapid debridement of the wounds and makes the treatment at the hospital 3.7 and 2.4 times shorter correspondingly (as compared with the control group).

Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Anti-Bacterial Agents; Bacterial Infections; Drug Therapy, Combination; Humans; Mastitis; Middle Aged; Proctitis; Skin Diseases, Infectious; Sodium Hypochlorite

In a small series of patients, topical treatment with dilute sodium hypochlorite hastened the resolution of cutaneous and mucosal lesions caused by herpes simplex virus. Subjective discomfort was ameliorated and vesicles healed more rapidly. Sites treated during the prodrome stage failed to vesiculate. The advantages of this therapy included ease of treatment, patient acceptance, absence of side effects, and low cost.

Topics: Administration, Topical; Female; Herpes Genitalis; Herpes Simplex; Humans; Male; Skin Diseases, Infectious; Sodium Hypochlorite; Stomatitis, Herpetic