sodium-hypochlorite and Rhabdomyosarcoma

Exodontia of extremely carious teeth leads to a significant risk of osteoradionecrosis in patients who have undergone radiotherapy. In these patients, endodontic treatment could be an alternative. Successful root canal therapy in a girl who had been irradiated for head and neck neoplasms is reported. The results indicated that use of calcium hydroxide to obturate the root canals is a viable method of postirradiation endodontics in primary teeth.

Topics: Animals; Calcium Hydroxide; Child; Cranial Irradiation; Dental Care for Chronically Ill; Dental Caries; Dental Pulp Necrosis; Female; Head and Neck Neoplasms; Humans; Hydrogen Peroxide; Osteoradionecrosis; Patient Care Planning; Periapical Abscess; Rhabdomyosarcoma; Root Canal Filling Materials; Root Canal Irrigants; Root Canal Therapy; Sodium Hypochlorite; Tooth, Deciduous

Cell suspensions of chemically induced tumors (rhabdomyosarcoma) were transplanted into the peritoneal cavities of Lewis rats. In normal animals, the greater omentum was the main site of tumor growth, and transdiaphragmatic metastases to regional lymph nodes in the mediastinum were few and small. In animals during the healing phase of a chemical peritonitis, the greater omentum was fibrotic, shrunken, and inactivated. The loss of the scavenging function of the omentum was associated with wide dissemination of the tumor in the peritoneal cavity and increased access of the tumor to the lymphatic stomata on the peritoneal surface of the diaphragm. Number and size of transdiaphragmatic metastases in draining lymph nodes were greatly increased in this postinflammatory state.

Topics: Animals; Female; Fibrosis; Liver; Lymph Nodes; Lymphatic Metastasis; Mesentery; Neoplasm Metastasis; Neoplasm Transplantation; Omentum; Peritoneal Cavity; Peritoneal Neoplasms; Peritonitis; Rats; Rats, Inbred Lew; Rhabdomyosarcoma; Sodium Hypochlorite; Spleen; Tumor Cells, Cultured