sodium-hypochlorite and Neoplasm-Metastasis

Cell suspensions of chemically induced tumors (rhabdomyosarcoma) were transplanted into the peritoneal cavities of Lewis rats. In normal animals, the greater omentum was the main site of tumor growth, and transdiaphragmatic metastases to regional lymph nodes in the mediastinum were few and small. In animals during the healing phase of a chemical peritonitis, the greater omentum was fibrotic, shrunken, and inactivated. The loss of the scavenging function of the omentum was associated with wide dissemination of the tumor in the peritoneal cavity and increased access of the tumor to the lymphatic stomata on the peritoneal surface of the diaphragm. Number and size of transdiaphragmatic metastases in draining lymph nodes were greatly increased in this postinflammatory state.

Topics: Animals; Female; Fibrosis; Liver; Lymph Nodes; Lymphatic Metastasis; Mesentery; Neoplasm Metastasis; Neoplasm Transplantation; Omentum; Peritoneal Cavity; Peritoneal Neoplasms; Peritonitis; Rats; Rats, Inbred Lew; Rhabdomyosarcoma; Sodium Hypochlorite; Spleen; Tumor Cells, Cultured

After excision of conjunctival melanomas the rate of recidivation is high. This may partly be due to local seeding of tumour cells in the excision wound, as we observed in one patient. We now use a sodiumhypochlorite solution (Dakin's solution) as tumour cell killing agent. Instead of diagnostic biopsy exfoliative cytology is performed; at surgery the tumour is not touched except for cauterisation with formaldehyde.

Topics: Conjunctival Neoplasms; Humans; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Sodium Hypochlorite

Topics: Geriatrics; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasm Transplantation; Neoplasms; Neoplastic Cells, Circulating; Pathology; Pharmacology; Rats; Sodium Hypochlorite; Surgical Procedures, Operative; Therapeutic Irrigation; Thiotepa