sodium-hypochlorite and Hypersensitivity

LITERATURE REVIEW AND CASE REPORTS: The literature concerning the aetiology, symptomatology and therapy of complications during root canal irrigation is reviewed. Three cases of inadvertent injection of sodium hypochlorite and hydrogen peroxide beyond the root apex are presented. Clinical symptoms are discussed, as well as preventive and therapeutic considerations.

Topics: Animals; Burns, Chemical; Extravasation of Diagnostic and Therapeutic Materials; Eye Burns; Female; Humans; Hydrogen Peroxide; Hypersensitivity; Male; Middle Aged; Oral Hemorrhage; Root Canal Irrigants; Sodium Hypochlorite; Subcutaneous Emphysema

Chlorine bleach or sodium hypochlorite can inactivate common indoor allergens. In this cross-sectional study we evaluated to what extent regular house cleaning with bleach can influence the risks of respiratory and allergic diseases in children. We studied a group of 234 schoolchildren aged 10-13 yr among whom 78 children were living in a house cleaned with bleach at least once per week. Children examination included a questionnaire, an exercise-induced bronchoconstriction test and the measurement of exhaled nitric oxide (NO) and of serum total and aeroallergen-specific immunoglobulin (Ig)E, Clara cell protein (CC16) and surfactant-associated protein D (SP-D). Children living in a house regularly cleaned with bleach were less likely to have asthma (OR, 0.10; CI, 0.02-0.51), eczema (OR, 0.22; CI, 0.06-0.79) and of being sensitized to indoor aeroallergens (OR, 0.53; CI, 0.27-1.02), especially house dust mite (OR, 0.43; CI, 0.19-0.99). These protective effects were independent of gender, ethnicity, previous respiratory infections, total serum IgE level and of family history of allergic diseases. They were however abolished by parental smoking, which also interacted with the use of bleach to increase the risk of recurrent bronchitis (OR, 2.03; CI, 1.12-3.66). House cleaning with bleach had effect neither on the sensitization to pollen allergens, nor on the levels of exhaled NO and of serum CC16 and SP-D. House cleaning with chlorine bleach appears to protect children from the risks of asthma and of sensitization to indoor allergens while increasing the risk of recurrent bronchitis through apparently an interaction with parental smoking. As chlorine bleach is one of the most effective cleaning agent to be found, these observations argue against the idea conveyed by the hygiene hypothesis that cleanliness per se increases the risk of asthma and allergy.

Topics: Adolescent; Asthma; Bronchitis; Child; Cross-Sectional Studies; Detergents; Female; Household Work; Humans; Hypersensitivity; Male; Respiratory System; Sodium Hypochlorite; Tobacco Smoke Pollution

A 12-year-old girl, with a previous history of bronchial reaction and contact dermatitis to sodium hypochlorite, was referred for root canal treatment. Complete immunologic evaluation revealed a mild hypersensitivity condition, as it was assessed by the RAST investigation to different allergens and the DTH reactivity expressed though migration inhibition test. The absence of a serious immunologic disregulation in the patient's immunologic profile justified the term 'non-allergic hypersensitivity' to sodium hypochlorite to describe the condition.

Topics: Bronchial Hyperreactivity; Cell Migration Inhibition; Chelating Agents; Child; Dermatitis, Contact; Disinfectants; Edetic Acid; Female; Gutta-Percha; Humans; Hypersensitivity; Isotonic Solutions; Peroxides; Radioallergosorbent Test; Root Canal Filling Materials; Root Canal Irrigants; Root Canal Therapy; Sodium Chloride; Sodium Hypochlorite; T-Lymphocytes; Urea; Waxes; Zinc Oxide-Eugenol Cement