sodium-hypochlorite and Dermatitis

Ulcerative dermatitis (UD) is a common condition in C57BL/6 mice and strains with this background. The etiology of UD is unclear but appears to have a genetic component associated with the C57BL/6 strain and has been reported as secondary to a variety of conditions. Treatment is unrewarding, resulting in euthanasia in many cases. In the present study we compared 3 topical treatments against spontaneous UD in mice with a C57BL/6 background. In total, 301 mice of both sexes were included in this study, and the tested treatments comprised bacitracin-neomycin sulfate-polymixin B sulfate ointment twice daily, 10% povidone-iodine ointment plus 1% silver sulfadiazine cream once daily, and 0.005% sodium hypochlorite once daily. Lesion healing was defined as complete skin reepithelialization with or without hair regrowth. Sex, age, lesion location, and type and length of treatment were analyzed by using univariate and multivariate logistic regression. Of the 79 mice treated with triple-antibiotic ointment, 27 (34%) healed, compared with 43 of the 125 (34%) treated with povidone-iodine and sulfadiazine and 69 of the 97 (71%) treated with hypochlorite. Lesion size and treatment with 0.005% sodium hypochlorite were the only significant predictors of healing; all other variables were not statistically significant in multivariate analysis. We conclude that 0.005% sodium hypochlorite is an effective topical treatment alternative for UD in C57BL/6 mice and strains on this background, and a favorable prognosis depends on the early identification and treatment of those lesions.

Topics: Administration, Topical; Animal Diseases; Animals; Bacitracin; Dermatitis; Drug Combinations; Female; Logistic Models; Male; Mice; Mice, Inbred C57BL; Neomycin; Polymyxin B; Povidone-Iodine; Rodent Diseases; Silver Sulfadiazine; Skin Ulcer; Sodium Hypochlorite; Wound Healing

We report a case of Staphylococcus aureus infection of the feet that appeared after a "fish pedicure" (immersion of the feet in a tank with the fish Garra rufa, that nibbles off dead skin). Clinical picture was characterized by maceration, purulent discharge, scales, crusts, itching and burning sensation. Bacteriological examinations were positive for Staphylococcus aureus. Mycological examinations were negative. The patient was successfully treated with ciprofloxacin. Only one case of skin foot infection after fish pedicure was reported so far. Fish pedicure can be a potentially dangerous procedure in immunocompromised or diabetic patients.

Topics: Adult; Animals; Anti-Bacterial Agents; Ciprofloxacin; Cyprinidae; Dermatitis; Feeding Behavior; Female; Foot; Foot Diseases; Greece; Humans; Immersion; Sodium Hypochlorite; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome

A 13-month-old girl presented with chronic keratoconjunctivitis with dermatitis. She was initially diagnosed with corneal abrasion and mild preseptal cellulitis and was treated with topical and oral antibiotics. After failing to respond to standard therapy, she was eventually identified as a victim of abuse. We discuss key findings that could have provoked earlier recognition.

Topics: Anti-Bacterial Agents; Child Abuse; Chronic Disease; Cornea; Corneal Opacity; Dermatitis; Eyelid Diseases; Female; Humans; Infant; Keratoconjunctivitis; Orbital Cellulitis; Recurrence; Sodium Hypochlorite; Vision, Binocular; Visual Acuity