sodium-hypochlorite and Carbon-Monoxide-Poisoning

While treatment conduction of 38 patients with severe burns and poisoning with carbonic oxide in complex of antishock measures there was applied a nondirect electrochemical oxidation of blood and internal laser irradiation of blood. There was used He-Nd laser. The mortality lowering by 3.3 times in comparison with 40 patients, in whom the traditional intensive therapy was applied, was noted.

Topics: Blood; Burns; Carbon Monoxide Poisoning; Combined Modality Therapy; Critical Care; Electrochemistry; Humans; Laser Therapy; Oxidants; Oxidation-Reduction; Shock, Traumatic; Sodium Hypochlorite; Time Factors

The measurement of carboxyhemoglobin (COHb) levels in blood is a valuable procedure to confirm exposure to carbon monoxide (CO) either for forensic or occupational matters. A previously described method using spectrophotometric readings at 420 and 432 nm after reduction of oxyhemoglobin (O(2)Hb) and methemoglobin with sodium hydrosulfite solution leads to an exponential curve. This curve, used with pre-established factors, serves well for lower concentrations (1-7%) or for high concentrations (> 20%) but very rarely for both. The authors have observed that small variations on the previously described factors F1, F2, and F3, obtained from readings for 100% COHb and 100% O(2)Hb, turn into significant changes in COHb% results and propose that these factors should be determined every time COHb is measured by reading CO and O(2) saturated samples. This practice leads to an increase in accuracy and precision.

Topics: Carbon Monoxide Poisoning; Carboxyhemoglobin; Drug Stability; Forensic Toxicology; Humans; Methemoglobin; Oxidation-Reduction; Predictive Value of Tests; Reproducibility of Results; Sodium Hypochlorite; Spectrophotometry