sodium-hypochlorite and Calcinosis

Nanomaterials have been used to create new consumer products as well as applications for life sciences and biotechnology. The aim of this study was to evaluate the tissue response to implanted polyethylene tubes filled with fibrin sponge embedded with silver nanoparticles dispersion.. Thirty rats received individually 4 polyethylene tubes filled with sponge embedded in 47 ppm, 23 ppm silver nanoparticles dispersion, 2.5% sodium hypochlorite, or with no embedding as control. The observation periods were 7, 15, 30, 60, and 90 days. After each period of time, 6 animals were killed, and the tubes and surrounding tissue were removed, fixed, and prepared to be analyzed in light microscope with glycol methacrylate embedding, 3-μm serial cutting, and hematoxylin-eosin stain. Qualitative and quantitative evaluations of the reactions were performed.. Both materials caused moderate reactions at 7 days. The response was similar to the control on the 15th day with 23 ppm silver nanoparticles dispersion and 2.5% sodium hypochlorite and on the 30th day with 47 ppm silver nanoparticles dispersion.. It was possible to conclude that silver nanoparticles dispersion was biocompatible especially in a lower concentration.

Topics: Animals; Calcinosis; Connective Tissue; Drug Carriers; Fibrin; Male; Nanoparticles; Necrosis; Neutrophil Infiltration; Rats; Rats, Wistar; Root Canal Irrigants; Silver; Sodium Hypochlorite

During an attempt to negotiate a calcified root canal in a maxillary lateral incisor, a midroot distobuccal perforation was created, and sodium hypochlorite (NaClO) was extruded through the opening into the supporting tissues. This procedural accident caused an immediate burning sensation, severe pain, and marked facial swelling, with the subsequent loss of the tooth.

Topics: Calcinosis; Female; Humans; Incisor; Middle Aged; Root Canal Irrigants; Root Canal Therapy; Sodium Hypochlorite; Tooth Root

Root surfaces, exposed by periodontal disease, were studied after treatment with sodium hypochlorite. Observations of the anorganic specimens demonstrated that substantial changes occur in root surfaces incident to periodontal disease. A mineralized surface coating was seen in all areas of the involved root surface, although local regions occurred where the coating was apparently unmineralized. These findings generally confirmed the results of a previous study where the same specimens were studied without hypochlorite treatment. It is concluded that the coating is probably identical to the dental cuticle, and stems from adsorption of components of the gingival inflammatory exudate to the root surface. The coating may also be the carrier matrix for exogenous cytotoxic substances, previously thought to be located in the cementum. The findings may have implications for the way of treating periodontitis-involved root surfaces.

Topics: Calcinosis; Dental Cementum; Dental Enamel; Humans; Microscopy, Electron, Scanning; Periodontal Diseases; Periodontal Pocket; Sodium Hypochlorite; Surface Properties; Tooth Root