sodium-hypochlorite and Acute-Disease

Bacterial colonization and infection are important factors in compromised wound healing, particularly in chronic wounds. Although "best practice" for controlling these factors currently is not defined, systemic antibiotics are generally accepted as the preferred choice for treating infection, provided ischemia does not reduce their bioavailability. However, widespread use of systemic and topical antibiotics is associated with the emergence of resistant bacterial strains such as methicillin-resistant Staphylococcus aureus. Colonization of wounds presents a double problem--potentially delayed healing and a potential source for cross-contamination. The judicious use of dressings, notably those containing certain antiseptic agents, can be a valuable option to control infection and promote healing. A review of the literature underscores the importance of considering the antiseptic route as part of a concerted approach to wound management and infection control.

Topics: Acute Disease; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bandages; Benchmarking; Biofilms; Biological Availability; Chlorhexidine; Chronic Disease; Colony Count, Microbial; Evidence-Based Medicine; Honey; Humans; Infection Control; Iodine Compounds; Potassium Permanganate; Risk Factors; Severity of Illness Index; Silver Compounds; Skin Care; Sodium Hypochlorite; Wound Healing; Wound Infection

This is a case of a 36-year-old Spanish-speaking Hispanic man who was brought to a busy suburban New Jersey emergency department (ED) by family members for altered mental status. By report, patient was noted by family to be "not acting normal" at home, when he went into his bathroom and locked the door. A brief time thereafter, he emerged smelling of bleach and with confused speech. The family surmised that he tried to commit suicide by drinking bleach and emergently brought the patient to the ED.

Topics: Acute Disease; Adult; Humans; Male; Neurocysticercosis; Sodium Hypochlorite; Suicide, Attempted; Tomography, X-Ray Computed

Presented are the results of experimental research on 144 animals (the rats Wistar), on whom was carried out resection of a part of large intestine and a intestinal anastamosis was formed in the presents of acute intestinal obstruction and peritonitis. The sanitation of abdominal cavity in the basic group of animals (74) was performed using sodium hypochlorite solution and dissolved ozone. The intestinal lavage was carried out by dissolved ozone with the subsequent introduction of ozonized oil Ozonide in the area of intestinal anastamosis. The combined application of ozone and sodium produces an expressed samative effect which leads to healing of intestinal anastamosis and decreases unstability of intestinal sutures and mortality.

Topics: Abdominal Cavity; Acute Disease; Animals; Disease Models, Animal; Intestinal Obstruction; Oxidants, Photochemical; Ozone; Peritonitis; Rats; Rats, Wistar; Remission Induction; Sodium Hypochlorite

Acute irritant contact dermatitis induced by cutaneous exposure to chemicals is a common dermatologic problem in the workplace. In severe cases, irritant contact responses can result in a caustic burn. Chemical burn induced by concentrated sodium hypochlorite (the active ingredient in bleach) has been reported infrequently in the literature, with no previously reported cases of chemical burn due to an alkyl sulfate (a common surfactant in cleaning fluids). Here we describe a chemical burn in a 16-year-old girl resulting from exposure to a solution of concentrated sodium hypochlorite and alkyl sulfate applied as a sanitizer to the interior of roller skates worn at work.. The diagnosis was made on the basis of the patient's exposure history, clinical appearance, and laboratory results. On physical examination, the erythematous plaque, located at the site of chemical exposure, had intact skin lines, surrounding edema, and decreased sensitivity to touch. The peripheral white blood cell count was within normal limits and bacterial and fungal cultures from the lesion were negative.. The irritant effect of exposure to chemicals, including those that usually are not major irritants, and the possible additive effect of simultaneous exposure to different chemicals, should be considered in the differential diagnosis of acute dermatitis of unknown etiology. Moreover, increased reporting of cases of chemical-induced acute irritant contact dermatitis will help lead to crucial early and appropriate treatment.

Topics: Acute Disease; Adolescent; Anti-Infective Agents, Local; Burns, Chemical; Dermatitis, Irritant; Detergents; Diagnosis, Differential; Female; Humans; Silver Sulfadiazine; Skin; Skin Transplantation; Sodium Hypochlorite; Sulfuric Acid Esters; Therapeutic Irrigation; Wound Healing

Topics: Acute Disease; Aged; Cholangiopancreatography, Endoscopic Retrograde; Cholangitis; Cholecystectomy, Laparoscopic; Combined Modality Therapy; Drainage; Humans; Sodium Hypochlorite; Sphincterotomy, Endoscopic

Caustic products are responsible for the most serious cases of poisoning, which are always emergency cases. Application of current intervention procedures has decreased both morbidity and mortality. Water-diluted bleach, the ingestion of which remains extremely frequent, is a moderate irritant rather than a caustic product. Emission of gas produced when mixing bleach with other agents can be responsible for choking gas poisoning. Anionic and nonionic detergents are mostly dangerous because of their foam-producing properties. Mercury vapours and methanol are other potentially hazardous products.

Topics: Acute Disease; Adult; Aged; Burns, Chemical; Caustics; Child; Detergents; Esophageal Stenosis; Household Products; Humans; Middle Aged; Poisoning; Sodium Hypochlorite; Stomach

Treatment results in 61 patients with acute mediastinitis are analyzed. Combined treatment of acute mediastinitis, including cryoplasma-antienzymic complex use and indirect electrochemical blood plasma detoxication, promotes disappearance of microcirculation disorders, to earlier decreasing of endogenic intoxication, outcomes improvement.

Topics: Acute Disease; Adolescent; Adult; Aged; Combined Modality Therapy; Disinfectants; Electrochemistry; Female; Humans; Male; Mediastinitis; Middle Aged; Oxidants; Oxidation-Reduction; Physical Therapy Modalities; Plasmapheresis; Protease Inhibitors; Sodium Hypochlorite

A previously undocumented complication of root canal therapy is reported. A dilute solution of 5-10 mls sodium hypochlorite was inadvertently injected into the maxillary sinus during root canal therapy of a right upper second premolar (5). The patient developed acute, sudden, severe facial pain and swelling necessitating emergency admission to hospital and operative intervention under general anaesthesia. A diagnosis of acute chemical sinusitus was made, further management and discussion follow.

Topics: Accidents; Acute Disease; Adult; Anti-Infective Agents, Local; Bicuspid; Edema; Facial Pain; Humans; Injections; Male; Maxillary Sinus; Maxillary Sinusitis; Root Canal Irrigants; Root Canal Therapy; Sodium Hypochlorite

NaClO effect on rat central neuron morphology and transcription after injection of high doses (500 mg/kg b.w.) of nembutal (NB) was studied. Cortical pyramids, Purkinje, basket and granule cells were examined. NaClO (3 mg/kg b.w) was injected 45 min after NB injection, and 45 min later animals were sacrificed. Intact rats and rats injected NB or NaClO alone were controls. NB treatment resulted in toxic-hypoxic injury of cerebral and cerebellar neurons. Transcription in all types of neurons was lower than in control cells. NaClO injected alone had virtually no effect on neuronal morphology while transcription in the middle pyramids and Purkinje cells was activated. NaClO injected after NB normalized morphology and transcription in all neuronal populations under study. In cortical pyramids transcription was even higher than in control group.

Topics: Acute Disease; Animals; Brain; Drug Evaluation, Preclinical; Male; Neurons; Pentobarbital; Poisoning; Rats; Sodium Hypochlorite; Time Factors; Transcription, Genetic

The effect of electrolysis sodium hypochlorite solution (ENaClO) on the course of an inflammatory process in 233 patients with purulent pathology of different etiology was studied. ENaClO was obtained by means of electrolysis of the isotonic sodium chloride solution in the electrochemical cell. It was established that ENaClO had a pronounced bactericidal action contributing to acceleration of an inflammatory focus clearance of purulent-necrotic masses, stimulation of local immunity, activation of reparative processes.

Topics: Acute Disease; Anti-Infective Agents; Combined Modality Therapy; Drug Evaluation; Electrolysis; Humans; Hydrogen-Ion Concentration; Intraoperative Care; Isotonic Solutions; Sodium Hypochlorite; Suppuration; Therapeutic Irrigation