sodium hydroxide has been researched along with Disease Models, Animal in 157 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 9 (5.73) | 18.7374 |
1990's | 32 (20.38) | 18.2507 |
2000's | 39 (24.84) | 29.6817 |
2010's | 68 (43.31) | 24.3611 |
2020's | 9 (5.73) | 2.80 |
Authors | Studies |
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Li, Q; Wu, X; Xin, M | 1 |
Feng, H; Pan, Y; Tan, Y; Xie, L; Zhang, M | 1 |
Appel, EA; Grosskopf, AK; Li, B; Stapleton, LM; Subramaniam, VR; Swarup, A; Weissman, IL; Wu, AY | 1 |
Ameredes, BT; Gupta, PK; Karediya, N; Kraft, ER; Lin, JL; Luisi, J; Merkley, KH; Motamedi, M; Schmitz-Brown, ME; Sharifi, A; Zhang, W | 1 |
Duan, F; Huang, Y; Lin, L; Lin, X; Lou, B; Yang, Y; Yuan, M | 1 |
Chen, L; Du, S; Gao, L; Han, J; Li, J; Niu, Z; Shi, Y; Tian, H; Wei, L; Yang, P | 1 |
Basu, S; Bokara, KK; Damala, M; Kethiri, AR; Rao, CM; Singh, V; Singh, VK | 1 |
Cai, J; Li, Y; Liu, Y; Shu, Y; Wang, W; Wang, X; Wang, Y; Wei, T; Xie, T; Yang, X; Yao, Y; Yin, L; Zhan, P; Zhu, L; Zou, J | 1 |
Andrade, N; Araújo E Silva, PM; Crispim Ribeiro, J; de Moraes, MO; Fechine, FV; Savio, D | 1 |
Cejka, C; Cejkova, J; Hermankova, B; Holan, V; Kossl, J | 1 |
Chodosh, J; Dana, R; Dohlman, CH; Kapoulea, V; Lei, F; Paschalis, EI; Robert, MC; Scott, N; Vavvas, D; Zhou, C | 1 |
Choi, H; Fulcher, S; Kim, DK; Oh, JY; Phillips, C; Stock, EM; Won, JK | 1 |
Kim, B; Kim, JW; Lim, CW | 1 |
Coulson-Thomas, VJ; Coulson-Thomas, YM; Gesteira, TF; Hascall, V; Sun, M; Yamaguchi, Y; Yeh, LK | 1 |
Gao, F; Manyande, A; Tian, X; Tian, Y; Wang, P; Xiang, H; Xiang, Y; Yang, H; Zhou, W | 1 |
Huang, Z; Lu, Y; Wu, Y; Xue, C | 1 |
Halim, WHWA; Hwei, NM; Idrus, RBH; Man, RC; Ramli, R; Saim, AB; Yong, TK; Zahidin, AZM | 1 |
Cornell, LE; Griffith, GL; Johnson, AJ; Lee, HK; McDaniel, JS; Wirostko, B; Zamora, DO | 1 |
Chen, D; Chen, Q; Cheng, R; Larrick, JW; Ma, JX; Mendelson, AR; Qiu, F; Shin, Y; Zhou, K | 1 |
Chen, P; Ge, J; Qiu, J; Tang, M; Wang, Q; Wu, Y; Xu, Z; Yang, Y; Yu, J; Yu, K; Zhuang, J | 1 |
Bian, F; Chen, H; Chi, W; Deng, Y; Gu, J; Hong, Y; Li, Y; Su, L; Yin, L | 1 |
Arefian, E; Atyabi, F; Dinarvand, R; Heydari, M; Khonsari, F; Mahbod, M; Shahhosseini, S; Soleimani, M; Zahir-Jouzdani, F | 1 |
Fernández, I; Gallego-Muñoz, P; Herrero-Pérez, C; Lorenzo-Martín, E; Martínez-García, MC | 1 |
Chen, J; Jin, J; Su, SB; Wang, Y; Zhang, J; Zhao, R; Zhou, H | 1 |
Bermudez, MA; Eiro, N; Gonzalez, F; Martinez-Ordoñez, A; Perez-Fernandez, R; Saa, J; Sendon-Lago, J; Seoane, S; Vizoso, FJ | 1 |
Gao, R; Lu, F; Qi, Y; Ren, J; Weng, W; Zhang, W; Zhu, B | 1 |
Chan, AM; Diaz-Aguilar, D; Duarte, S; Gordon, LK; Law, SM; Sun, MM; Wadehra, M | 1 |
Basu, S; Bokara, KK; Kethiri, AR; Mishra, DK; Raju, E; Rao, CM; Sangwan, VS; Singh, V | 1 |
Akdogan, RA; Kalkan, Y; Kurt, A; Pergel, A; Sehitoglu, İ; Tomak, Y; Tumkaya, L; Yucel, AF | 1 |
Lang, W; Li, X; Lv, X; Ma, J; Yang, H; Zhang, Y; Zhao, S | 1 |
Cai, W; Cheng, R; Gao, G; Gu, X; Li, C; Li, L; Ma, J; Wei, L; Yang, X; Yang, Z; Yao, Y; Zhang, Y | 1 |
Garrett, Q; Pattamatta, U; Stapleton, F; Willcox, M | 1 |
Hwang, JC; Jin, B; Kim, JH; Kim, SS; Lee, KM; Lim, SG; Shin, SJ; Yang, MJ | 1 |
Cade, F; Dana, R; Dohlman, CH; Paschalis, EI; Regatieri, CV; Vavvas, DG | 1 |
Bignami, F; Ferrari, G; Giacomini, C; Rama, P | 1 |
Ambrecht, LA; Bouchard, CS; Bu, P; Nikolic, N; Qiao, L; Sethupathi, P; Vin, AP; Zhai, Y | 1 |
Anderson, C; Wang, S; Zhou, Q | 1 |
Kim, CE; Lee, HS; Lee, JH; Yang, JW | 1 |
Jin, J; Shen, M; Yuan, F; Yuan, Y | 1 |
Cevik, M; Demir, T; Elmas, O; Ketani, MA | 1 |
Aksit, H; Ermis, SS; Sahin, G; Sari, ES; Seyrek, K; Yalcin, B; Yay, A; Yazici, A; Yildiz, O | 1 |
Chen, Z; He, X; Liu, G; Lu, P; Xiao, Y; Zhou, W | 1 |
Bucak, YY; Erdurmus, M; Kükner, AŞ; Önder, Hİ; Simavli, H; Terzi, EH | 1 |
Acar, DE; Acar, U; Beyazyildiz, E; Delibasi, T; Ozgermen, BB; Pinarli, FA; Sobaci, G; Sonmez, AA | 1 |
Choi, CW; Kim, SC; Koo, JM; Oh, S; Park, HJ; Vinod, N | 1 |
Cai, J; Dou, G; Huang, Y; Jia, X; Li, X; Tang, L; Wang, X; Wu, W; Yang, T; Zheng, L | 1 |
Almaliotis, D; Gounari, E; Karampatakis, V; Koliakos, G; Komnenou, A; Nakos, I; Papakonstantinou, E; Petrakis, S; Thomas, A | 1 |
Guo, Q; Li, X; Tang, W; Zhang, Y; Zhou, H | 1 |
Castermans, K; Kindt, N; Moons, L; Sijnave, D; Stalmans, I; Stassen, JM; Van Bergen, T; Vandewalle, E | 1 |
Chen, T; Geng, N; Jiang, N; Liu, D; Liu, L; Peng, C; Wang, H; Wu, Y; Zhang, S | 1 |
Liu, J; Liu, JY; Qin, CY; Shang, L | 1 |
Bunyak, F; Giuliano, EA; Gronkiewicz, KM; Hamm, CW; Kuroki, K; Mohan, RR; Sharma, A; Teixeira, LB | 1 |
Cheng, YH; Chiou, SH; Liu, KT; Sung, YJ; Tsai, CY; Tseng, PC; Woung, LC; Yen, JC | 1 |
Arikan, S; Comez, AT; Demirtas, S; Elmas, S; Ersan, I; Ertekin, YH; Karaca, T; Tufan, HA; Turkon, H | 1 |
Kalinski, T; Nass, N; Paulsen, F; Sel, S; Stangl, GI; Trau, S | 1 |
Cejka, C; Cejkova, J; Holan, V; Sykova, E; Trosan, P; Zajicova, A | 1 |
Celik, A; Cinar, E; Karahan, E; Karti, O; Kucukerdonmez, C; Tutuncu, M; Zengin, MO | 1 |
Dan, L; Hong-jie, M; Miao-li, L; Shi-long, Y; Xiang-gui, W; Ying, Z; Yong-ping, L | 1 |
Chen, J; Chu, PH; Jung, SM; Lin, HC; Ma, DH; Shiu, TF; Wang, IJ; Wu, HH; Yeh, LK | 1 |
Cole, N; Garrett, Q; Pattamatta, U; Stapleton, F; Willcox, M | 1 |
Bayol, U; Erkan, N; Makay, O; Ozütemiz, O; Vardar, E; Vardar, R; Yükselen, V | 1 |
Li, L; Liu, G; Lu, P; Mukaida, N; Zhang, X | 1 |
Atli, Y; Bakan, V; Ciralik, H; Garipardic, M; Okumuş, M; Ozbağ, D; Tolun, FI | 1 |
Meteoglu, I; Pabuccu, E; Sen, S; Senturk, E; Unsal, C | 1 |
Li, W; Liang, L; Ling, S; Qi, C; Yan, H | 1 |
Ceylan, H; Ceylan, NO; Demiryurek, AT; Tarakçıoğlu, M; Tutar, E; Yapici, S | 1 |
Ishida, S; Kato, N; Kubota, M; Kubota, S; Kurihara, T; Miyashita, H; Noda, K; Ozawa, Y; Shimmura, S; Tsubota, K; Umezawa, K; Usui, T | 1 |
Hasegawa, T; Hisamatsu, C; Nishijima, E; Okata, Y; Okita, Y | 1 |
Fang, D; Fang, J; Lin, Q; Liu, X; Ren, X; Su, SB; Wang, JM; Wen, F; Yang, XP; Yao, X; Zhou, H; Zhou, S | 1 |
Pabuscu, E; Sen, S; Senturk, E; Unsal, C | 1 |
Akbal, E; Astarcı, MH; Can, M; Güven, B; Karaca, G; Koçak, E; Köklü, S; Taş, A | 1 |
Atinkaya, C; Cavuşoğlu, T; Dıkmen, E; Han, S; Han, Ü; Osmanoğlu, G | 1 |
Bargagna-Mohan, P; Lau, DL; Mohan, R; Paranthan, RR | 1 |
Budel, V; Mello, GR; Moreira, H; Pizzolatti, ML; Santhiago, MR; Wasilewski, D | 1 |
Kim, MK; Lee, SM; Shin, MS; Wee, WR | 1 |
Bredehorn-Mayr, T; Ehrich, D; Garreis, F; Kaiser, M; Kalinski, T; Knak, M; Nass, N; Paulsen, F; Schilling, UM; Sel, S; Simm, A; Storsberg, J | 1 |
Ishimori, A; Sakimoto, T; Sawa, M; Sugaya, S | 1 |
Gebert, A; Gehlsen, U; Huettmann, G; Koop, N; Oetke, A; Paulsen, F; Steven, P; Szaszák, M | 1 |
Jang, JY; Li, Z; Oh, HJ; Park, SH; Yoon, KC | 1 |
Baratta, F; Battaglia, L; Bussano, R; Chirio, D; Gallarate, M; Peira, E; Trotta, M | 1 |
Kim, EC; Kim, MS; Kim, TK; Park, SH | 1 |
Bustamante, TF; Higa, KL; Lourenção, PL; Ortolan, EV; Silva, AP | 1 |
Al-Howiriny, TA; Al-Rehaily, AJ; Al-Sohaibani, MO; Rafatullah, S | 1 |
Dana, MR; Kinoshita, S; Sotozono, C; Yamada, J | 1 |
Al-Howiriny, T; Al-Sohaibani, M; El-Tahir, K; Rafatullah, S | 1 |
Den, S; Ikeda, T; Kinoshita, S; Sotozono, C | 1 |
Aksu, B; Altinok, G; Bingol-Kologlu, M; Dindar, H; Fitoz, S; Gokcora, IH; Renda, N; Yagmurlu, A | 1 |
Li, G; Yan, J; Yang, J; Yang, T; Zeng, Y; Zhang, Y | 1 |
Colvin, RB; Foster, CS; Havrlikova, K; Kaufman, AH; Loredo, GA; Mellott, M; Peters, JH | 1 |
Choi, SB; Kim, JS; Kwon, JW; Lee, JH; Wee, WR | 1 |
Chen, MY; Jiang, TA; Zhao, QY; Zheng, SS | 1 |
Barrett, RP; Christopherson, PL; Fridman, R; Sosne, G | 1 |
Bari, F; Domoki, F; Farkas, E; Luiten, PG; Mihály, A; Timmer, NM | 1 |
Hilgers, C; Kompa, S; Redbrake, C; Remky, A; Schrage, N; Wüstemeyer, H | 1 |
Chen, J; Gao, G; Jiang, A; Kuang, W; Li, C; Liu, Z; Luo, L; Ma, JX; Xu, L; Yang, W; Zhang, M; Zhang, Z | 1 |
Burzenski, LM; Gott, B; Lyons, BL; Roopenian, DC; Shaffer, DJ; Shultz, LD; Ueno, M | 1 |
Bazan, HE; Bazan, NG; He, J | 1 |
Karaoglu, AO; Ozutemiz, O; Vardar, E; Yenisey, C; Yukselen, O; Yukselen, V | 1 |
Lopes, DD; Mamede, RC; Mattos, GM; Mello-Filho, FV; Neto, JB; Ricz, H | 1 |
Krahenbuhl, JL; Lahiri, R; Randhawa, B | 1 |
Pfister, RR; Sommers, CI | 1 |
Cole, N; Hume, EB; Jalbert, I; Krishnan, R; Vijay, AK; Willcox, MD | 1 |
Becker, J; Frentz, M; Reim, M; Rihawi, S; Schrage, NF | 1 |
Bourghardt Peebo, B; Fagerholm, P; Gan, L; Knutsen, A; Rearden, A; Sun, XF | 1 |
Flanders, KC; Ikeda, K; Kao, WW; Kitano, A; Miyamoto, T; Nakajima, Y; Ohnishi, Y; Okada, Y; Saika, S; Yamanaka, O | 1 |
Hemmati, AA; Idani, E; Sharifipour, F; Zamani, M | 1 |
Duarte, ME; Filho, OH; Fraga, JC; Hanauer, AD; Sanches, PR; Saueressig, MG; Sousa, JK; Ulbrich-Kulczynski, J | 1 |
Correa, L; Croxatto, JO; Gallo, JE; Gatto, S; Lavigne, V; Luengo Gimeno, F | 1 |
Hosseini, H; Mehryar, M; Nejabat, M; Noori, F; Sedaghat, A; Yazdchi, T | 1 |
Amano, S; Hasegawa, G; Ishida, S; Kawakami, Y; Mochimaru, H; Nagahama, Y; Shimmura, S; Tsubota, K; Usui, T; Usui, Y; Yaguchi, T | 1 |
Denhardt, DT; Ikeda, K; Kao, WW; Kitano, A; Kon, S; Miyazaki, K; Okada, Y; Rittling, SR; Saika, S; Uede, T; Yamanaka, O | 1 |
Du, LQ; Li, MC; Pang, KP; Wang, SG; Wu, XY | 1 |
Dutrieux, RP; Hoeksema, H; Hoekstra, MJ; Kamperdijk, EW; Kreis, RW; Monstrey, S; Pirayesh, A; Richters, CD | 1 |
al-Gharably, NM; al-Harbi, MM; al-Shabanah, OA; Islam, MW | 1 |
Copin, MC; Desmidt, A; Freitag, L; Marquette, CH; Mensier, E; Petyt, L; Ramon, P; Witt, C | 1 |
Docherty, AJ; Higgs, GA; Koklitis, PA; Paterson, CA; Wells, JG | 1 |
Alio, JL; Artola, A; Ayala, MJ; Mulet, ME; Ruiz, JM | 1 |
Alio, JL; Artola, A; Ayala, MJ; Bellot, JL; Mulet, E; Ruiz-Moreno, JM | 1 |
Kao, CW; Kao, WW; Zhu, G | 1 |
Hashizume, N; Kobata, S; Okada, Y; Saika, S; Yamanaka, O | 1 |
Donnenfeld, ED; Golub, LM; Hodes, LW; McNamara, TF; Perry, HD; Seedor, JA | 1 |
Bahrke, C; Kuckelkorn, R; Kuwert, T; Reim, M | 1 |
Dandona, L; Nirankari, VS; Rodrigues, MM | 1 |
Haddox, JL; Pfister, RR; Sommers, CI | 2 |
Alio, JL; Artola, A; Ayala, MJ; Bellot, J; Mulet, ME; Ruiz, JM | 1 |
Afzal, M; Ahmed, MM; al-Harbi, MM; Qureshi, S; Raza, M; Shah, AH | 1 |
Charton-Picard, F; Eloy, R; Gabard, B; Treffel, P | 1 |
Henry, MC; Homan, CS; Singer, AJ; Thode, HC | 1 |
Doughty, MJ | 1 |
Fukunaga, S; Hotei, H; Koura, Y; Matsuura, Y; Orihashi, K; Sueda, T | 1 |
Conners, MS; Dunn, MW; Schwartzman, ML; Stoltz, RA; Urbano, F; Vafeas, C | 1 |
Al Moutaery, AR; Tariq, M | 1 |
Ishizaki, M; Kao, WW; Matsunami, T; Saiga, T; Shimizu, Y; Wakamatsu, K; Yamanaka, N; Zhu, G | 1 |
Berenshtein, E; Chevion, M; Ever-Hadani, P; Frucht-Pery, J; Muallem, MS; Naoumidi, I; Pallikaris, IG; Siganos, CS; Siganos, DS | 1 |
Burchard, WG; Lorenz, U; Reim, M; Schrage, NF; von Fischern, T | 1 |
Cheon, HG; Lee, DH; Lee, SS; Lim, H | 1 |
Al-Attas, A; Chan, K; Chen, HB; Islam, MW; Ismail, A; Liu, XM; Radhakrishnan, R; Zakaria, MN | 1 |
Cağlayan, F; Cağlayan, O; Canbilen, A; Günel, E; Tosun, M | 1 |
Hirsch, M; Pouliquen, Y; Renard, G | 1 |
Fromer, CH; Klintworth, GK | 1 |
Dohlman, CH; Henriquez, AS; Pihlaja, DJ | 1 |
Fagerholm, P; Fitzsimmons, T; Härfstrand, A; Schenholm, M | 1 |
Haseba, T; Ishizaki, M; Kao, WW; Sun, TT; Wu, RL; Zhu, G | 1 |
Haddox, JL; John, G; Pfister, RR | 1 |
Nirankari, VS | 1 |
Brent, BD; Karcioglu, ZA | 1 |
Hayashi, K; Ishibashi, T | 1 |
Colvin, RB; Foster, CS; Phan, TM; Shaw, CD; Zagachin, LM | 1 |
Chung, JH | 1 |
Kontos, HA; Patterson, JL; Raper, AJ; Richardson, DW | 1 |
Boden, K; Fehring, G; Turss, R | 1 |
Dawson, CR; Naidoff, MA; Stein, MR | 1 |
De Souza, SW; Dobbing, J | 1 |
Gehanno, P; Guedon, C | 1 |
Bingöl-Kologlu, M; Büyükpamukçu, N; Cakar, N; Hiçsönmez, A; Müftüoğlu, S; Renda, N; Tanyel, FC | 1 |
Butler, C; Davis, WM; Madden, JW; Peacock, EE | 1 |
157 other study(ies) available for sodium hydroxide and Disease Models, Animal
Article | Year |
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Strengthened rebamipide ocular nanoformulation to effectively treat corneal alkali burns in mice through the HMGB1 signaling pathway.
Topics: Alanine; Animals; Antioxidants; Blotting, Western; Burns, Chemical; Chickens; Chorioallantoic Membrane; Disease Models, Animal; Drug Carriers; Enzyme-Linked Immunosorbent Assay; Epithelium, Corneal; Eye Burns; Glycyrrhizic Acid; HMGB1 Protein; Humans; Mice; Ophthalmic Solutions; Quinolones; Rabbits; Signal Transduction; Sodium Hydroxide; Wound Healing | 2021 |
Suppression of the caspase-1/GSDMD-mediated pyroptotic signaling pathway through dexamethasone alleviates corneal alkali injuries.
Topics: Administration, Ophthalmic; Animals; Blotting, Western; Burns, Chemical; Caspase 1; Corneal Injuries; Dexamethasone; Disease Models, Animal; Eye Burns; Female; Fluorescent Antibody Technique, Indirect; Glucocorticoids; Immunohistochemistry; Interleukin-18; Interleukin-1beta; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Ophthalmic Solutions; Phosphate-Binding Proteins; Pore Forming Cytotoxic Proteins; Pyroptosis; Real-Time Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sodium Hydroxide | 2022 |
PNP Hydrogel Prevents Formation of Symblephara in Mice After Ocular Alkali Injury.
Topics: Alkalies; Animals; Collagen; Conjunctival Diseases; Disease Models, Animal; Eye Injuries; Fibrosis; Hydrogels; Mice; Nanoparticles; Polymers; Sodium Hydroxide | 2022 |
Concentration-associated pathology of alkali burn in a mouse model using anterior segment optical coherence tomography with angiography.
Topics: Animals; Biomarkers; Burns, Chemical; Corneal Edema; Disease Models, Animal; Fluorescein Angiography; Humans; Mice; Mice, Inbred C57BL; Sodium Hydroxide; Tomography, Optical Coherence | 2022 |
Effect of Tauroursodeoxycholic Acid on Inflammation after Ocular Alkali Burn.
Topics: Animals; Apoptosis; Burns, Chemical; Disease Models, Animal; Endoplasmic Reticulum Stress; Inflammation; Infliximab; Mice; Mice, Inbred C57BL; Protein Serine-Threonine Kinases; RNA, Messenger; Sodium Hydroxide; Taurochenodeoxycholic Acid; Tumor Necrosis Factor-alpha | 2022 |
Rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse TSC1 and mTOR genes.
Topics: Actins; Animals; Blotting, Western; Burns, Chemical; Chromones; Corneal Injuries; Disease Models, Animal; DNA Methylation; Eye Burns; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation; Immunosuppressive Agents; Male; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Real-Time Polymerase Chain Reaction; Sirolimus; Sodium Hydroxide; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 1 Protein; Vascular Endothelial Growth Factor A | 2021 |
Long term observation of ocular surface alkali burn in rabbit models: Quantitative analysis of corneal haze, vascularity and self-recovery.
Topics: Animals; Burns, Chemical; Caustics; Conjunctiva; Cornea; Corneal Injuries; Corneal Neovascularization; Corneal Opacity; Disease Models, Animal; Eye Burns; Follow-Up Studies; Limbus Corneae; Rabbits; Recovery of Function; Sodium Hydroxide; Stem Cell Transplantation; Wound Healing | 2021 |
Protective roles of the TIR/BB-loop mimetic AS-1 in alkali-induced corneal neovascularization by inhibiting ERK phosphorylation.
Topics: Angiogenesis Inhibitors; Animals; Biomarkers; Blotting, Western; Burns, Chemical; Corneal Neovascularization; Disease Models, Animal; Epithelium, Corneal; Extracellular Signal-Regulated MAP Kinases; Eye Burns; Eye Proteins; Humans; Immunoprecipitation; Lymphangiogenesis; Mice; Mice, Inbred C57BL; Phosphorylation; Pyrrolidines; Real-Time Polymerase Chain Reaction; Sodium Hydroxide; Valine | 2021 |
Effect of Topical Instillation of Pegaptanib Sodium Upon Inflammatory Corneal Neovascularization in Rabbits.
Topics: Administration, Topical; Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents; Aptamers, Nucleotide; Caustics; Cornea; Corneal Injuries; Corneal Neovascularization; Disease Models, Animal; Inflammation; Instillation, Drug; Male; Neovascularization, Pathologic; Prednisolone; Rabbits; Sodium Hydroxide; Treatment Outcome; Vascular Endothelial Growth Factor A | 2021 |
Molecular Hydrogen Effectively Heals Alkali-Injured Cornea via Suppression of Oxidative Stress.
Topics: Actins; Animals; Cornea; Corneal Injuries; Cytokines; Disease Models, Animal; Female; Gene Expression; Hydrogen; Immunohistochemistry; Interleukin-1beta; Keratin-12; Keratin-3; Malondialdehyde; Oxidative Stress; Peroxynitrous Acid; Rabbits; Sodium Hydroxide; Vascular Endothelial Growth Factor A | 2017 |
Mechanisms of Retinal Damage after Ocular Alkali Burns.
Topics: Alkalies; Animals; Apoptosis; Burns, Chemical; Cornea; Corneal Injuries; Disease Models, Animal; Drug Evaluation, Preclinical; Eye Burns; Hydrogen-Ion Concentration; Infliximab; Mice, Inbred C57BL; Mice, Knockout; Neuroprotective Agents; Oxidation-Reduction; Rabbits; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Retina; Retinal Ganglion Cells; Sodium Hydroxide; Tumor Necrosis Factor-alpha; Uvea; Uveitis, Anterior | 2017 |
Comprehensive Modeling of Corneal Alkali Injury in the Rat Eye.
Topics: Animals; Burns, Chemical; Cornea; Corneal Neovascularization; Corneal Opacity; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eye Burns; Fibrosis; Gene Expression; Inflammation; Lymphangiogenesis; Macrophages; Male; Neutrophils; Rats; Rats, Inbred Lew; Real-Time Polymerase Chain Reaction; RNA, Messenger; Sodium Hydroxide; Wound Healing | 2017 |
Effects of nicotine on corneal wound healing following acute alkali burn.
Topics: Actins; Animals; Burns, Chemical; Cell Line; Collagen Type I; Cornea; Corneal Injuries; Cotinine; Disease Models, Animal; Eye Burns; Female; Fibroblasts; Humans; Mice, Inbred BALB C; Nicotine; Protective Agents; Random Allocation; Receptors, Nicotinic; Sodium Hydroxide; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A; Wound Healing | 2017 |
Hyaluronan Rich Microenvironment in the Limbal Stem Cell Niche Regulates Limbal Stem Cell Differentiation.
Topics: Animals; Burns, Chemical; Cell Differentiation; Cellular Microenvironment; Disease Models, Animal; Epithelium, Corneal; Eye Burns; Glucuronosyltransferase; Hyaluronan Synthases; Hyaluronic Acid; Immunohistochemistry; Limbus Corneae; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microscopy, Confocal; Microscopy, Electron, Transmission; Real-Time Polymerase Chain Reaction; RNA, Messenger; Sodium Hydroxide; Stem Cell Niche; Stem Cells; Wound Healing | 2017 |
Alkali Burn Induced Corneal Spontaneous Pain and Activated Neuropathic Pain Matrix in the Central Nervous System in Mice.
Topics: Animals; Burns, Chemical; Caustics; Central Nervous System Diseases; Cornea; Corneal Diseases; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Eye Burns; Eye Pain; Male; Mice; Mice, Inbred C57BL; Neuralgia; Pain Measurement; Pain Threshold; Phosphorylation; Sodium Hydroxide | 2017 |
The inhibitory effect of different concentrations of KH902 eye drops on corneal neovascularization induced by alkali burn.
Topics: Administration, Topical; Animals; Burns, Chemical; Corneal Neovascularization; Disease Models, Animal; Eye Burns; Immunohistochemistry; Microscopy, Confocal; Ophthalmic Solutions; Rabbits; Recombinant Fusion Proteins; Sodium Hydroxide; Vascular Endothelial Growth Factor A | 2017 |
Corneal regeneration by induced human buccal mucosa cultivated on an amniotic membrane following alkaline injury.
Topics: Amnion; Animals; Biomarkers; Burns, Chemical; Cell Differentiation; Cell Engineering; Cell Lineage; Cells, Cultured; Cornea; Corneal Diseases; Disease Models, Animal; Epithelial Cells; Eye Burns; Humans; Integrin beta1; Keratin-3; Mouth Mucosa; Phosphoproteins; Rats; Rats, Nude; Real-Time Polymerase Chain Reaction; Regeneration; Sodium Hydroxide; Stem Cells; Tissue Scaffolds; Tomography, Optical Coherence; Trans-Activators; Transplantation, Heterologous | 2017 |
Treatment of corneal chemical alkali burns with a crosslinked thiolated hyaluronic acid film.
Topics: Alkalies; Animals; Burns, Chemical; Caustics; Cornea; Corneal Edema; Corneal Injuries; Corneal Opacity; Disease Models, Animal; Epithelium, Corneal; Eye Burns; Hyaluronic Acid; Intravital Microscopy; Male; Microscopy, Confocal; Rabbits; Re-Epithelialization; Sodium Hydroxide; Sulfhydryl Compounds; Tomography, Optical Coherence; Viscosupplements | 2018 |
Anti-angiogenic effect of a humanized antibody blocking the Wnt/β-catenin signaling pathway.
Topics: Angiogenesis Inhibitors; Angiogenic Proteins; Animals; Antibodies, Monoclonal, Humanized; Burns, Chemical; Cells, Cultured; Corneal Neovascularization; Disease Models, Animal; Epithelium, Corneal; Eye Burns; Humans; Inflammation Mediators; Male; Neovascularization, Pathologic; Rats, Sprague-Dawley; Sodium Hydroxide; Wnt Signaling Pathway | 2018 |
Tetramethylpyrazine in a Murine Alkali-Burn Model Blocks NFκB/NRF-1/CXCR4-Signaling-Induced Corneal Neovascularization.
Topics: Animals; Blotting, Western; Burns, Chemical; Corneal Neovascularization; Disease Models, Animal; Eye Burns; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Inbred C57BL; NF-kappa B; Nuclear Respiratory Factor 1; Pyrazines; Real-Time Polymerase Chain Reaction; Receptors, CXCR4; Sodium Hydroxide; Vasodilator Agents | 2018 |
TLR4-MyD88 pathway promotes the imbalanced activation of NLRP3/NLRP6 via caspase-8 stimulation after alkali burn injury.
Topics: Animals; Blotting, Western; Burns, Chemical; Caspase 8; Disease Models, Animal; Eye Injuries; Fluorescent Antibody Technique, Indirect; Glyburide; Humans; Hypoglycemic Agents; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88; NLR Family, Pyrin Domain-Containing 3 Protein; Real-Time Polymerase Chain Reaction; Receptors, Cell Surface; RNA, Small Interfering; Signal Transduction; Sodium Hydroxide; Toll-Like Receptor 4 | 2018 |
Nanostructured lipid carriers containing rapamycin for prevention of corneal fibroblasts proliferation and haze propagation after burn injuries: In vitro and in vivo.
Topics: Administration, Ophthalmic; Animals; Burns, Chemical; Cell Proliferation; Cells, Cultured; Cornea; Corneal Injuries; Corneal Neovascularization; Corneal Opacity; Disease Models, Animal; Drug Carriers; Drug Compounding; Eye Burns; Fibroblasts; Fibrosis; Humans; Lipids; Male; Mice, Inbred BALB C; Nanomedicine; Nanoparticles; Sirolimus; Sodium Hydroxide; Wound Healing | 2019 |
Nidogen-2: Location and expression during corneal wound healing.
Topics: Actins; Animals; Burns, Chemical; Cell Count; Corneal Injuries; Corneal Keratocytes; Corneal Stroma; Disease Models, Animal; Endothelium, Corneal; Epithelium, Corneal; Eye Burns; Female; Immunohistochemistry; Membrane Glycoproteins; Rabbits; Re-Epithelialization; Real-Time Polymerase Chain Reaction; RNA, Messenger; Sodium Hydroxide; Wound Healing | 2019 |
Activation of Toll-like receptor 3 promotes pathological corneal neovascularization by enhancement of SDF-1-mediated endothelial progenitor cell recruitment.
Topics: Administration, Ophthalmic; Animals; Burns, Chemical; Cell Movement; Chemokine CXCL12; Cornea; Corneal Neovascularization; Disease Models, Animal; Endothelial Progenitor Cells; Eye Burns; Fluorescent Antibody Technique, Indirect; Mice; Mice, Inbred C57BL; Poly I-C; Real-Time Polymerase Chain Reaction; Signal Transduction; Sodium Hydroxide; Toll-Like Receptor 3 | 2019 |
Corneal regeneration by conditioned medium of human uterine cervical stem cells is mediated by TIMP-1 and TIMP-2.
Topics: Animals; Apoptosis; Atropine; Blotting, Western; Cell Movement; Cell Proliferation; Cervix Uteri; Culture Media, Conditioned; Cytokines; Disease Models, Animal; Dry Eye Syndromes; Epithelium, Corneal; Female; Ki-67 Antigen; Male; Rabbits; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Regeneration; Sodium Hydroxide; Stem Cells; Tandem Mass Spectrometry; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Wound Healing | 2019 |
Two methods for modeling of sick sinus syndrome in rats: Ischemia reperfusion and sodium hydroxide induced injury.
Topics: Animals; Disease Models, Animal; Heart Rate; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sick Sinus Syndrome; Sodium Hydroxide | 2019 |
Epithelial Membrane Protein-2 (EMP2) Antibody Blockade Reduces Corneal Neovascularization in an In Vivo Model.
Topics: Animals; Antibodies, Blocking; Antigens, CD34; Blotting, Western; Burns, Chemical; Cell Movement; Cells, Cultured; Corneal Neovascularization; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Eye Burns; Female; Human Umbilical Vein Endothelial Cells; Humans; Immunotherapy; Limbus Corneae; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Platelet Endothelial Cell Adhesion Molecule-1; Sodium Hydroxide; Vascular Endothelial Growth Factor A | 2019 |
Inflammation, vascularization and goblet cell differences in LSCD: Validating animal models of corneal alkali burns.
Topics: Animals; Burns, Chemical; Corneal Diseases; Corneal Neovascularization; Disease Models, Animal; Epithelial Cells; Epithelium, Corneal; Eye Burns; Female; Fluorescent Antibody Technique, Indirect; Goblet Cells; Humans; Immunophenotyping; Inflammation; Keratin-19; Keratin-3; Keratitis; Limbus Corneae; Male; Mice; Mice, Inbred C57BL; Mucins; Rabbits; Sodium Hydroxide | 2019 |
A novel model approach for esophageal burns in rats: A comparison of three methods.
Topics: Animals; Burns, Chemical; Catheterization, Peripheral; Caustics; Disease Models, Animal; Esophagus; Euthanasia, Animal; Male; Rats; Sodium Chloride; Sodium Hydroxide | 2015 |
Blockade of the intermediate-conductance Ca(2+)-activated K+ channel inhibits the angiogenesis induced by epidermal growth factor in the treatment of corneal alkali burn.
Topics: Animals; Blotting, Western; Burns, Chemical; Cell Movement; Cell Proliferation; Cornea; Corneal Neovascularization; Cyclin-Dependent Kinase 4; Disease Models, Animal; Epidermal Growth Factor; Eye Burns; Flavonoids; Flow Cytometry; Human Umbilical Vein Endothelial Cells; Humans; Intermediate-Conductance Calcium-Activated Potassium Channels; Male; Matrix Metalloproteinase 2; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyrazoles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium Hydroxide; Up-Regulation; Vimentin; Wound Healing | 2013 |
The artemisinin derivative artesunate inhibits corneal neovascularization by inducing ROS-dependent apoptosis in vascular endothelial cells.
Topics: Angiogenesis Inhibitors; Animals; Annexin A5; Antimalarials; Apoptosis; Artemisinins; Artesunate; bcl-2-Associated X Protein; Blotting, Western; Burns, Chemical; Corneal Neovascularization; Disease Models, Animal; Endothelial Cells; Eye Burns; Female; Flow Cytometry; In Situ Nick-End Labeling; Membrane Potential, Mitochondrial; Mitochondria; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sodium Hydroxide | 2013 |
Bovine lactoferrin promotes corneal wound healing and suppresses IL-1 expression in alkali wounded mouse cornea.
Topics: Alkalies; Animals; Burns, Chemical; Carrier Proteins; Cattle; Caustics; Cells, Cultured; Corneal Diseases; Disease Models, Animal; Eye Burns; Humans; Intercellular Signaling Peptides and Proteins; Interleukin-1alpha; Interleukin-1beta; Lactoferrin; Male; Mice; Mice, Inbred BALB C; Sodium Hydroxide; Wound Healing | 2013 |
Esophageal stricture induced by an ultraslim upper endoscope in a novel rabbit model of corrosive injury.
Topics: Animals; Burns, Chemical; Caustics; Disease Models, Animal; Esophageal Stenosis; Esophagoscopes; Esophagoscopy; Esophagus; Rabbits; Radiography; Sodium Hydroxide | 2014 |
Alkali burn to the eye: protection using TNF-α inhibition.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Burns, Chemical; Corneal Diseases; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eye Burns; Hydrogen-Ion Concentration; In Situ Nick-End Labeling; Infliximab; Injections, Intraperitoneal; Leukocyte Common Antigens; Male; Mice; Mice, Inbred BALB C; Retinal Diseases; Retinal Ganglion Cells; Sodium Hydroxide; Tumor Necrosis Factor-alpha | 2014 |
Alkali burn versus suture-induced corneal neovascularization in C57BL/6 mice: an overview of two common animal models of corneal neovascularization.
Topics: Animals; Burns, Chemical; Corneal Neovascularization; Corneal Stroma; Disease Models, Animal; Eye Burns; Fluorescent Antibody Technique, Indirect; Glycoproteins; Lymphangiogenesis; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Nylons; Platelet Endothelial Cell Adhesion Molecule-1; Retrospective Studies; Sodium Hydroxide; Sutures; Time Factors | 2014 |
Effects of activated omental cells on rat limbal corneal alkali injury.
Topics: Animals; Burns, Chemical; Cell Transplantation; Corneal Neovascularization; Corneal Opacity; Disease Models, Animal; Eye Burns; Leukocyte Count; Limbus Corneae; Male; Neutrophils; Omentum; Rats; Rats, Inbred F344; Sodium Hydroxide; Wound Healing | 2014 |
An alkali-burn injury model of corneal neovascularization in the mouse.
Topics: Animals; Burns, Chemical; Corneal Neovascularization; Disease Models, Animal; Mice; Sodium Hydroxide | 2014 |
Anti-neovascular effect of chondrocyte-derived extracellular matrix on corneal alkaline burns in rabbits.
Topics: Amnion; Animals; Biomarkers; Burns, Chemical; Chondrocytes; Corneal Neovascularization; Disease Models, Animal; Extracellular Matrix; Eye Burns; Humans; Immunoenzyme Techniques; Male; NF-kappa B; Protein Kinase C; Proto-Oncogene Proteins c-akt; Rabbits; Sodium Hydroxide | 2014 |
The effect of TC14012 on alkali burn-induced corneal neovascularization in mice.
Topics: Animals; Burns, Chemical; Conjunctiva; Corneal Neovascularization; Disease Models, Animal; Eye Burns; Gene Expression Regulation; Injections, Intraocular; Male; Matrix Metalloproteinases; Mice; Mice, Inbred BALB C; Oligopeptides; Real-Time Polymerase Chain Reaction; Receptors, CXCR; Receptors, CXCR4; RNA, Messenger; Sodium Hydroxide; Vascular Endothelial Growth Factor A | 2014 |
Effect of oral tamoxifen on the healing of corrosive oesophageal burns in an experimental rat model.
Topics: Administration, Oral; Animals; Burns, Chemical; Caustics; Collagen; Disease Models, Animal; Esophageal Stenosis; Esophagitis; Esophagus; Fibrosis; Male; Rats, Wistar; Sodium Hydroxide; Tamoxifen; Time Factors; Wound Healing | 2014 |
Inhibitory effect of sub-conjunctival tocilizumab on alkali burn induced corneal neovascularization in rats.
Topics: Animals; Antibodies, Monoclonal, Humanized; Burns, Chemical; Conjunctiva; Corneal Neovascularization; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eye Burns; Injections, Intraocular; Male; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-6; Sodium Hydroxide; Vascular Endothelial Growth Factor A; Wound Healing | 2015 |
[Inhibited experimental mouse corneal neovascularization by CCR3 antagonist].
Topics: Animals; Burns, Chemical; Corneal Neovascularization; Disease Models, Animal; Gene Expression; Humans; Male; Mice; Mice, Inbred BALB C; Random Allocation; Real-Time Polymerase Chain Reaction; Receptors, CCR3; RNA, Messenger; Sodium Hydroxide; Vascular Endothelial Growth Factor A | 2014 |
The effect of β receptor blockade through propranolol on corneal neovascularization.
Topics: Adrenergic beta-Antagonists; Animals; Burns, Chemical; Caspase 3; Caustics; Corneal Neovascularization; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Eye Burns; Glucocorticoids; Instillation, Drug; Male; Propranolol; Rats, Wistar; Sodium Hydroxide; Treatment Outcome; Vascular Endothelial Growth Factor A | 2014 |
Effect of allogeneic limbal mesenchymal stem cell therapy in corneal healing: role of administration route.
Topics: Animals; Bromodeoxyuridine; Burns, Chemical; Cell Culture Techniques; Corneal Diseases; Disease Models, Animal; Eye Burns; Limbus Corneae; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley; Sodium Hydroxide; Transplantation, Homologous; Wound Healing | 2015 |
Generation of a Novel Staphylococcus aureus Ghost Vaccine and Examination of Its Immunogenicity against Virulent Challenge in Rats.
Topics: Administration, Oral; Animals; Antibodies, Bacterial; Bacterial Load; Blood Bactericidal Activity; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Disease Models, Animal; Electrons; Immunoglobulin G; Injections, Intravenous; Injections, Subcutaneous; Male; Microscopy, Electron, Scanning; Rats, Sprague-Dawley; Sodium Hydroxide; Staphylococcal Infections; Staphylococcal Vaccines; Staphylococcus aureus; Vaccination; Vaccines, Inactivated | 2015 |
Pharmacokinetics of topically applied recombinant human keratinocyte growth factor-2 in alkali-burned and intact rabbit eye.
Topics: Administration, Topical; Animals; Anterior Eye Segment; Burns, Chemical; Chromatography, High Pressure Liquid; Disease Models, Animal; Eye Burns; Fibroblast Growth Factor 10; Ophthalmic Solutions; Rabbits; Recombinant Proteins; Sclera; Sodium Hydroxide; Tissue Distribution; Vitreous Body | 2015 |
Mesenchymal stem cells improve healing of the cornea after alkali injury.
Topics: Actins; Alanine Transaminase; Animals; Biomarkers; Burns, Chemical; Corneal Neovascularization; Corneal Opacity; Disease Models, Animal; Eye Burns; Flow Cytometry; Ki-67 Antigen; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Rabbits; Re-Epithelialization; Sodium Hydroxide; Vascular Endothelial Growth Factor A; Wound Healing | 2015 |
Transient downregulation of microRNA-206 protects alkali burn injury in mouse cornea by regulating connexin 43.
Topics: Animals; Burns, Chemical; Connexin 43; Cornea; Corneal Injuries; Corneal Neovascularization; Corneal Opacity; Disease Models, Animal; Down-Regulation; HEK293 Cells; Humans; Injections, Intraocular; Keratitis; Male; Mice, Inbred C57BL; MicroRNAs; Oligonucleotides; RNA Interference; RNA, Small Interfering; Sodium Hydroxide; Time Factors; Transfection; Wound Healing | 2015 |
Inhibition of Rho-Associated Kinase Prevents Pathological Wound Healing and Neovascularization After Corneal Trauma.
Topics: Animals; Burns, Chemical; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Collagen Type III; Corneal Opacity; Dexamethasone; Disease Models, Animal; Drug Combinations; Drug Synergism; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Eye Burns; Glucocorticoids; Human Umbilical Vein Endothelial Cells; Male; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Protein Kinase Inhibitors; rho-Associated Kinases; Sodium Hydroxide; Wound Healing | 2015 |
Sodium Hydroxide Pinpoint Pressing Permeation Method for the Animal Modeling of Sick Sinus Syndrome.
Topics: Animals; Disease Models, Animal; Electrophysiologic Techniques, Cardiac; Female; Formaldehyde; Heart Rate; Male; Rats; Rats, Wistar; Sick Sinus Syndrome; Sinoatrial Node; Sodium Hydroxide; Thoracotomy; Time Factors | 2015 |
Newly designed "pieced" stent in a rabbit model of benign esophageal stricture.
Topics: Alloys; Animals; Burns, Chemical; Device Removal; Dilatation; Disease Models, Animal; Esophageal Stenosis; Esophagoscopy; Esophagus; Foreign-Body Migration; Male; Materials Testing; Nickel; Prosthesis Design; Prosthesis Failure; Rabbits; Radiography; Sodium Hydroxide; Stents; Suture Techniques; Time Factors; Titanium | 2015 |
Development of a novel in vivo corneal fibrosis model in the dog.
Topics: Actins; Animals; Biomarkers; Burns, Chemical; Cornea; Corneal Diseases; Disease Models, Animal; Dogs; Eye Burns; Female; Fibrosis; Histone Deacetylase Inhibitors; Hydroxamic Acids; Immunohistochemistry; Sodium Hydroxide; Tomography, Optical Coherence; Vorinostat | 2016 |
Thermosensitive chitosan-based hydrogels for sustained release of ferulic acid on corneal wound healing.
Topics: Animals; Antioxidants; Apoptosis; Burns, Chemical; Cell Line; Cell Survival; Chitosan; Cornea; Coumaric Acids; Delayed-Action Preparations; Disease Models, Animal; Drug Liberation; Epithelial Cells; Eye Burns; Hydrogels; Hydrogen Peroxide; Rabbits; Sodium Hydroxide; Temperature; Wound Healing | 2016 |
Effect of Topically Applied Azithromycin on Corneal Epithelial and Endothelial Apoptosis in a Rat Model of Corneal Alkali Burn.
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Apoptosis; Azithromycin; Burns, Chemical; Disease Models, Animal; Endothelium, Corneal; Epithelium, Corneal; Eye Burns; In Situ Nick-End Labeling; Male; Rats; Rats, Wistar; Sodium Hydroxide; Tumor Necrosis Factor-alpha | 2016 |
1,25-dihydroxyvitamin D3 inhibits corneal wound healing in an ex-vivo mouse model.
Topics: Administration, Topical; Animals; Burns, Chemical; Calcitriol; Cell Line; Corneal Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelium, Corneal; Eye Burns; Humans; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Re-Epithelialization; Real-Time Polymerase Chain Reaction; Receptor for Advanced Glycation End Products; Receptors, Calcitriol; Retinoid X Receptors; RNA, Messenger; Sodium Hydroxide; Vitamin D3 24-Hydroxylase; Vitamins; Wound Healing | 2016 |
Transfer of mesenchymal stem cells and cyclosporine A on alkali-injured rabbit cornea using nanofiber scaffolds strongly reduces corneal neovascularization and scar formation.
Topics: Animals; Caustics; Cicatrix; Corneal Injuries; Corneal Neovascularization; Cyclosporine; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Female; Immunosuppressive Agents; Mesenchymal Stem Cell Transplantation; Nanofibers; Rabbits; Sodium Hydroxide; Tissue Scaffolds; Wound Healing | 2016 |
Effect of 1- and 6-Hour-Delayed Corneal Collagen Cross-Linking on Corneal Healing in a Rabbit Alkali-Burn Model: Clinical and Histological Observations.
Topics: Animals; Burns, Chemical; Collagen; Corneal Diseases; Corneal Stroma; Cross-Linking Reagents; Disease Models, Animal; Epithelium, Corneal; Eye Burns; Male; Photosensitizing Agents; Rabbits; Re-Epithelialization; Riboflavin; Sodium Hydroxide; Time Factors; Ultraviolet Rays; Wound Healing | 2016 |
Inhibitory effect of oral doxycycline on neovascularization in a rat corneal alkali burn model of angiogenesis.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Burns, Chemical; Corneal Neovascularization; Dexamethasone; Disease Models, Animal; Doxycycline; Eye Burns; Female; Glucocorticoids; Rats; Rats, Sprague-Dawley; Sodium Hydroxide; Treatment Outcome; Wound Healing | 2008 |
Deletion of the FHL2 gene attenuating neovascularization after corneal injury.
Topics: Animals; Blotting, Western; Burns, Chemical; Corneal Injuries; Corneal Neovascularization; Cyclooxygenase 2; Disease Models, Animal; Eye Burns; Gene Deletion; Gene Expression Regulation; Homeodomain Proteins; LIM-Homeodomain Proteins; Male; Mice; Mice, Inbred C57BL; Muscle Proteins; Platelet Endothelial Cell Adhesion Molecule-1; Sodium Hydroxide; Transcription Factors; Up-Regulation; Vascular Endothelial Growth Factor A | 2008 |
Bovine lactoferrin stimulates human corneal epithelial alkali wound healing in vitro.
Topics: Animals; Burns, Chemical; Cell Movement; Cell Proliferation; Cells, Cultured; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Epithelium, Corneal; Eye Burns; Fibronectins; Fluorescent Antibody Technique, Indirect; Humans; Lactoferrin; Limbus Corneae; Male; Mice; Mice, Inbred BALB C; Sodium Hydroxide; Tyrphostins; Wound Healing | 2009 |
Image-based assessment of esophageal stricture in experimental corrosive esophagitis in animals: an objective, adjunct diagnostic tool.
Topics: Animals; Burns, Chemical; Caustics; Disease Models, Animal; Esophageal Stenosis; Esophagitis; Image Processing, Computer-Assisted; Laparotomy; Male; Pathology, Clinical; Rats; Rats, Wistar; Sodium Hydroxide | 2009 |
Enhanced experimental corneal neovascularization along with aberrant angiogenic factor expression in the absence of IL-1 receptor antagonist.
Topics: Animals; Antigens, Differentiation; Burns, Chemical; Cornea; Corneal Neovascularization; Disease Models, Animal; Eye Burns; Fluorescent Antibody Technique, Indirect; Interleukin 1 Receptor Antagonist Protein; Interleukin-1alpha; Interleukin-1beta; Macrophages; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Mice, Knockout; Neutrophils; Nitric Oxide Synthase Type II; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium Hydroxide; Vascular Endothelial Growth Factor A | 2009 |
The protective effect of erythropoietin on the acute phase of corrosive esophageal burns in a rat model.
Topics: Acute-Phase Reaction; Animals; Burns, Chemical; Catalase; Caustics; Disease Models, Animal; Dose-Response Relationship, Drug; Erythropoietin; Esophagus; Female; Injections, Subcutaneous; Malondialdehyde; Nitric Oxide; Oxidative Stress; Rats; Rats, Sprague-Dawley; Sodium Hydroxide; Superoxide Dismutase; Trauma Severity Indices; Treatment Outcome | 2010 |
New experimental corrosive esophagitis model in rats.
Topics: Animals; Burns, Chemical; Caustics; Chi-Square Distribution; Disease Models, Animal; Esophageal Stenosis; Female; Laparotomy; Rats; Rats, Wistar; Sodium Hydroxide; Statistics, Nonparametric | 2010 |
Lymphatic vessels correlate closely with inflammation index in alkali burned cornea.
Topics: Adult; Animals; Burns, Chemical; Disease Models, Animal; Eye Burns; Female; Fluorescent Antibody Technique, Indirect; Humans; Immunoenzyme Techniques; Inflammation; Keratitis; Lymphangiogenesis; Lymphatic Vessels; Male; Middle Aged; Neutrophils; Rats; Rats, Inbred Lew; Receptors, Cell Surface; Sodium Hydroxide | 2010 |
Protective effects of dexpanthenol and y-27632 on stricture formation in a rat model of caustic esophageal injury.
Topics: Amides; Animals; Caustics; Collagen; Disease Models, Animal; Enzyme Inhibitors; Esophageal Stenosis; Esophagus; Hydroxyproline; Male; Malondialdehyde; Pantothenic Acid; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Sodium Hydroxide; Vitamin B Complex | 2011 |
Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model.
Topics: Acetylcysteine; Animals; Antioxidants; Benzamides; Blindness; Burns, Chemical; Chemokine CCL2; Corneal Neovascularization; Cyclohexanones; Deuterium Oxide; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eye Burns; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Microscopy, Fluorescence; NF-kappa B; Oxidative Stress; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Sodium Hydroxide; Superoxide Dismutase; Superoxide Dismutase-1; Vascular Endothelial Growth Factor A | 2011 |
Development of a model of benign esophageal stricture in rats: the optimal concentration of sodium hydroxide for stricture formation.
Topics: Animals; Burns, Chemical; Caustics; Disease Models, Animal; Esophageal Stenosis; Esophagus; Male; Rats; Rats, Sprague-Dawley; Sodium Hydroxide; Survival Analysis | 2011 |
High-mobility group box-1 mediates toll-like receptor 4-dependent angiogenesis.
Topics: Angiogenic Proteins; Animals; Chemotaxis; Cornea; Corneal Neovascularization; Disease Models, Animal; Endothelial Cells; Female; HMGB1 Protein; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Physiologic; Peptide Fragments; Signal Transduction; Sodium Hydroxide; Time Factors; Toll-Like Receptor 2; Toll-Like Receptor 4 | 2011 |
Comparison of mitomycin-c and heparin affects in experimental corrosive esophagitis on rats.
Topics: Alkylating Agents; Animals; Burns, Chemical; Caustics; Disease Models, Animal; Esophagitis; Female; Fibrinolytic Agents; Heparin; Mitomycin; Rats; Rats, Wistar; Sodium Hydroxide | 2011 |
NaOH-induced Crohn's colitis in rats: a novel experimental model.
Topics: Animals; Body Weight; Colon; Crohn Disease; Disease Models, Animal; Male; Malondialdehyde; Nitric Oxide; Rats; Rats, Wistar; Sodium Hydroxide | 2011 |
Management of gastrostomy to prevent perforation in acute severe corrosive esophagitis and gastritis: an experimental study.
Topics: Acute Disease; Animals; Caustics; Disease Models, Animal; Esophageal Perforation; Esophagitis; Gastrostomy; Necrosis; Rats; Risk Factors; Severity of Illness Index; Sodium Hydroxide; Time Factors | 2011 |
A robust model for simultaneously inducing corneal neovascularization and retinal gliosis in the mouse eye.
Topics: Animals; Blotting, Western; Cornea; Corneal Injuries; Corneal Neovascularization; Disease Models, Animal; Eye Injuries; Glial Fibrillary Acidic Protein; Gliosis; Humans; Immunochemistry; Injections, Intraperitoneal; Macular Degeneration; Mice; Mice, Inbred C57BL; Neuroglia; Platelet Endothelial Cell Adhesion Molecule-1; Retina; Sodium Hydroxide; Withanolides | 2011 |
The effect of subconjunctival bevacizumab on corneal neovascularization, inflammation and re-epithelization in a rabbit model.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Bevacizumab; Burns, Chemical; Caustics; Corneal Neovascularization; Disease Models, Animal; Endothelium, Corneal; Eye Burns; Inflammation; Injections, Intraocular; Keratitis; Male; Prospective Studies; Rabbits; Random Allocation; Severity of Illness Index; Sodium Hydroxide | 2011 |
Matrix metalloproteinase-9 expression in the Seoul-type keratoprosthesis implanted corneas with concurrent cultivated autologous oral mucosal epithelial cell transplantation.
Topics: Animals; Burns, Chemical; Cell Transplantation; Cells, Cultured; Combined Modality Therapy; Corneal Diseases; Disease Models, Animal; Epithelial Cells; Eye Burns; Fluorescent Antibody Technique, Indirect; Keratin-4; Male; Matrix Metalloproteinase 9; Mouth Mucosa; Prostheses and Implants; Prosthesis Implantation; Rabbits; Sodium Hydroxide; Transplantation, Autologous | 2013 |
Bone marrow cells and CD117-positive haematopoietic stem cells promote corneal wound healing.
Topics: Animals; Bone Marrow Transplantation; Burns, Chemical; Cell Separation; Cells, Cultured; Corneal Ulcer; Disease Models, Animal; Epithelium, Corneal; Eye Burns; Female; Fluorescent Antibody Technique, Indirect; Hematopoietic Stem Cell Transplantation; Keratin-12; Keratin-3; Male; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Organ Culture Techniques; Proto-Oncogene Proteins c-kit; Regeneration; Sodium Hydroxide; Wound Healing | 2012 |
Anti-inflammatory effect of IL-6 receptor blockade in corneal alkali burn.
Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Neutralizing; Burns, Chemical; Cells, Cultured; Chemokine CCL2; Corneal Keratocytes; Corneal Neovascularization; Disease Models, Animal; Eye Burns; Immunoenzyme Techniques; Intercellular Adhesion Molecule-1; Interleukin-6; Keratitis; Male; Mice; Mice, Inbred BALB C; Phosphorylation; Receptors, Interleukin-6; Reverse Transcriptase Polymerase Chain Reaction; Sodium Hydroxide; STAT3 Transcription Factor; Vascular Endothelial Growth Factor A | 2012 |
Two-photon fluorescence lifetime imaging monitors metabolic changes during wound healing of corneal epithelial cells in vitro.
Topics: Animals; Burns, Chemical; Cells, Cultured; Disease Models, Animal; Epithelium, Corneal; Eye Burns; Female; Humans; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence, Multiphoton; NADP; Organ Culture Techniques; Sodium Hydroxide; Tomography, Optical Coherence; Wound Healing | 2012 |
Effects of umbilical cord serum eye drops in a mouse model of ocular chemical burn.
Topics: Animals; Burns, Chemical; Corneal Diseases; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Epithelium, Corneal; Eye Burns; Fetal Blood; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Ophthalmic Solutions; Sodium Hydroxide; Wound Healing | 2012 |
Development of O/W nanoemulsions for ophthalmic administration of timolol.
Topics: Administration, Ophthalmic; Adrenergic beta-Antagonists; Animals; Biological Availability; Chitosan; Corneal Opacity; Disease Models, Animal; Drug Delivery Systems; Drug Stability; Emulsions; In Vitro Techniques; Nanotechnology; Rabbits; Sodium Hydroxide; Succinates; Timolol | 2013 |
The wound healing effects of vitamin A eye drops after a corneal alkali burn in rats.
Topics: Animals; Burns, Chemical; Corneal Ulcer; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eye Burns; Fluorescent Antibody Technique, Indirect; Male; Matrix Metalloproteinase 9; Ophthalmic Solutions; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA, Messenger; Sodium Hydroxide; Thrombospondins; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A; Vitamin A; Vitamins; Wound Healing | 2012 |
The use of mitomycin C in caustic esophagitis in rats.
Topics: Animals; Burns, Chemical; Caustics; Dilatation; Disease Models, Animal; Esophageal Stenosis; Male; Mitomycin; Nucleic Acid Synthesis Inhibitors; Rats; Rats, Wistar; Sodium Hydroxide | 2013 |
Gastroprotective effects of 'Amla' Emblica officinalis on in vivo test models in rats.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Female; Fruit; Gastric Mucosa; Indomethacin; Male; Peptic Ulcer; Phyllanthus emblica; Phytotherapy; Plant Extracts; Pylorus; Rats; Rats, Wistar; Sodium Chloride; Sodium Hydroxide | 2002 |
Local suppression of IL-1 by receptor antagonist in the rat model of corneal alkali injury.
Topics: Animals; Burns, Chemical; Cornea; Corneal Opacity; Disease Models, Animal; Eye Burns; Female; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Interleukins; Keratitis; Rats; Rats, Wistar; Receptors, Interleukin-1; Recombinant Proteins; Sialoglycoproteins; Sodium Hydroxide; Wound Healing | 2003 |
Prevention of experimentally-induced gastric ulcers in rats by an ethanolic extract of "Parsley" Petroselinum crispum.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Gastric Mucosa; Hydrochloric Acid; Hypothermia, Induced; Indomethacin; Petroselinum; Plant Extracts; Pylorus; Rats; Rats, Wistar; Sodium Hydroxide; Stomach Ulcer; Time Factors | 2003 |
Efficacy of early systemic betamethasone or cyclosporin A after corneal alkali injury via inflammatory cytokine reduction.
Topics: Animals; Betamethasone; Burns, Chemical; Cornea; Cyclosporine; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eye Burns; Female; Glucocorticoids; Immunosuppressive Agents; Injections, Intramuscular; Injections, Subcutaneous; Interleukins; Rats; Rats, Wistar; Sodium Hydroxide | 2004 |
A novel approach for preventing esophageal stricture formation: sphingosylphosphorylcholine-enhanced tissue remodeling.
Topics: Animals; Burns, Chemical; Caustics; Collagen; Contrast Media; Disease Models, Animal; Esophageal Stenosis; Esophagus; Female; Hydroxyproline; Mucous Membrane; Muscle, Smooth; Phosphorylcholine; Radiography; Rats; Rats, Wistar; Second Messenger Systems; Sodium Hydroxide; Sphingosine; Treatment Outcome; Wound Healing | 2004 |
Changes of uPA and uPA-R expression in the cornea after alkali burn.
Topics: Animals; Burns, Chemical; Cornea; Disease Models, Animal; Epithelium; Eye Burns; Rabbits; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Sodium Hydroxide; Time Factors; Urokinase-Type Plasminogen Activator | 2004 |
Expression of fibronectin isoforms bearing the alternatively spliced EIIIA, EIIIB, and V segments in corneal alkali burn and keratectomy wound models in the rat.
Topics: Alternative Splicing; Animals; Burns, Chemical; Cornea; Corneal Injuries; Disease Models, Animal; Eye Burns; Eye Injuries; Female; Fibronectins; Fluorescent Antibody Technique, Indirect; Protein Isoforms; Rats; Rats, Long-Evans; Sodium Hydroxide | 2004 |
Experimental study of an automated system for the delivery of eyedrops using a microinfusion pump.
Topics: Animals; Burns, Chemical; Cornea; Corneal Injuries; Disease Models, Animal; Drug Delivery Systems; Eye Burns; Feasibility Studies; Fluorometholone; Glucocorticoids; Infusion Pumps; Ophthalmic Solutions; Rabbits; Sodium Hydroxide; Tears | 2005 |
Low-concentration sodium hydroxide solution injection in normal liver parenchyma of rabbits.
Topics: Analysis of Variance; Animals; Biopsy, Needle; Disease Models, Animal; Female; Immunohistochemistry; Injections, Intralesional; Liver; Male; Necrosis; Probability; Rabbits; Random Allocation; Sclerotherapy; Sensitivity and Specificity; Sodium Hydroxide; Ultrasonography, Doppler | 2005 |
Thymosin-beta4 modulates corneal matrix metalloproteinase levels and polymorphonuclear cell infiltration after alkali injury.
Topics: Animals; Burns, Chemical; Chemokines; Corneal Diseases; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eye Burns; Matrix Metalloproteinases; Mice; Mice, Inbred BALB C; Neutrophil Infiltration; Neutrophils; Reverse Transcriptase Polymerase Chain Reaction; Sodium Hydroxide; Thymosin; Tissue Inhibitor of Metalloproteinases; Wound Healing | 2005 |
Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain after permanent carotid artery occlusion.
Topics: Animals; Brain Infarction; Brain Ischemia; Carotid Stenosis; CD11 Antigens; Cerebrovascular Circulation; Diazoxide; Dimethyl Sulfoxide; Disease Models, Animal; Drug Interactions; Encephalitis; Gliosis; Hippocampus; Learning Disabilities; Male; Maze Learning; Memory Disorders; Microglia; Neuroprotective Agents; Rats; Rats, Wistar; Sodium Hydroxide; Treatment Outcome; Vasodilator Agents | 2005 |
Effect of different irrigating solutions on aqueous humour pH changes, intraocular pressure and histological findings after induced alkali burns.
Topics: Animals; Aqueous Humor; Burns, Chemical; Cornea; Corneal Edema; Disease Models, Animal; Electrodes, Implanted; Eye Burns; Female; Hydrogen-Ion Concentration; Intraocular Pressure; Isotonic Solutions; Microelectrodes; Ophthalmic Solutions; Osmolar Concentration; Rabbits; Sodium Chloride; Sodium Hydroxide; Therapeutic Irrigation; Water | 2005 |
Plasminogen kringle 5 inhibits alkali-burn-induced corneal neovascularization.
Topics: Administration, Topical; Angiogenesis Inhibitors; Animals; Apoptosis; Blotting, Western; Burns, Chemical; Cattle; Cell Proliferation; Corneal Neovascularization; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Eye Burns; Female; Flow Cytometry; Immunohistochemistry; In Situ Nick-End Labeling; Male; Peptide Fragments; Plasminogen; Rabbits; Sodium Hydroxide; Vascular Endothelial Growth Factor A | 2005 |
Accelerated wound healing of alkali-burned corneas in MRL mice is associated with a reduced inflammatory signature.
Topics: Animals; Bone Marrow Transplantation; Burns, Chemical; Carrier Proteins; Collagenases; Corneal Diseases; Disease Models, Animal; Epithelium, Corneal; Eye Burns; Flow Cytometry; Gene Expression Regulation; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Neutrophils; Oligonucleotide Array Sequence Analysis; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium Hydroxide; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling Proteins; Wound Healing | 2005 |
Alkali-induced corneal stromal melting prevention by a novel platelet-activating factor receptor antagonist.
Topics: Animals; Apoptosis; Burns, Chemical; Corneal Stroma; Corneal Ulcer; Dihydropyridines; Disease Models, Animal; Eye Burns; Female; In Situ Nick-End Labeling; Male; Platelet Membrane Glycoproteins; Rabbits; Receptors, G-Protein-Coupled; Rupture, Spontaneous; Sodium Hydroxide | 2006 |
Colchicine in experimental alkaline burns of the rat esophagus: an old drug, a new indication?
Topics: Analysis of Variance; Animals; Burns, Chemical; Caustics; Colchicine; Disease Models, Animal; Dose-Response Relationship, Drug; Esophagus; Fibrosis; Hydroxyproline; Protective Agents; Rats; Rats, Wistar; Sodium Hydroxide; Treatment Outcome; Wound Healing | 2006 |
Effects of time of contact and concentration of caustic agent on generation of injuries.
Topics: Animals; Burns, Chemical; Caustics; Disease Models, Animal; Dose-Response Relationship, Drug; Esophageal Stenosis; Esophagus; Female; Follow-Up Studies; Male; Rats; Sodium Hydroxide; Time Factors; Trauma Severity Indices | 2006 |
Effects of purification and fluorescent staining on viability of Mycobacterium leprae.
Topics: Animals; Cell Membrane; Disease Models, Animal; Fluorescent Dyes; Foot; Leprosy; Macrophages, Peritoneal; Mice; Mice, Nude; Microscopy, Electron, Scanning; Mycobacterium leprae; Organic Chemicals; Oxidation-Reduction; Palmitic Acid; Sodium Hydroxide; Staining and Labeling | 2005 |
L-arginine-threonine-arginine (RTR) tetramer peptide inhibits ulceration in the alkali-injured rabbit cornea.
Topics: Animals; Burns, Chemical; Chemotactic Factors; Chemotaxis, Leukocyte; Cornea; Corneal Ulcer; Disease Models, Animal; Eye Burns; Female; Humans; Isomerism; Male; Neutrophils; Oligopeptides; Proline; Rabbits; Sodium Hydroxide | 2006 |
Effects of topical administration of 12-methyl tetradecanoic acid (12-MTA) on the development of corneal angiogenesis.
Topics: Administration, Topical; Angiogenesis Inhibitors; Animals; Cornea; Corneal Neovascularization; Dexamethasone; Disease Models, Animal; Eye Burns; Eye Infections, Bacterial; Fatty Acids; Glucocorticoids; Male; Mice; Mice, Inbred BALB C; Pseudomonas Infections; Sodium Hydroxide | 2007 |
The consequences of delayed intervention when treating chemical eye burns.
Topics: Animals; Anterior Chamber; Biological Transport, Active; Burns, Chemical; Cornea; Decontamination; Disease Models, Animal; Emergency Medical Services; Eye Burns; Hydrogen-Ion Concentration; Permeability; Practice Guidelines as Topic; Sodium Hydroxide; Swine; Therapeutic Irrigation; Time Factors | 2007 |
Expression of the focal adhesion protein PINCH in normal and alkali-injured corneas and the role of PMNs.
Topics: Animals; Anticoagulants; Azepines; Burns, Chemical; Cornea; Corneal Injuries; Disease Models, Animal; DNA-Binding Proteins; Endothelium, Vascular; Eye Burns; Focal Adhesions; Immunoenzyme Techniques; Lidocaine; Neutrophils; Polysaccharides; Rabbits; Sodium Hydroxide; Wound Healing; Zinc Fingers | 2007 |
Effect of overexpression of PPARgamma on the healing process of corneal alkali burn in mice.
Topics: Adenoviridae; Animals; Basement Membrane; Burns, Chemical; Cell Movement; Cell Proliferation; Cells, Cultured; Cicatrix; Cornea; Corneal Diseases; Disease Models, Animal; Epithelium, Corneal; Eye Burns; Fibroblasts; Fibrosis; Gelatinases; Genetic Therapy; Genetic Vectors; Inflammation; Intercellular Signaling Peptides and Proteins; Macrophages; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; PPAR gamma; RNA, Messenger; Signal Transduction; Smad Proteins; Sodium Hydroxide; Transfection; Up-Regulation; Wound Healing | 2007 |
Oxygen therapy for severe corneal alkali burn in rabbits.
Topics: Animals; Burns, Chemical; Corneal Opacity; Corneal Ulcer; Disease Models, Animal; Double-Blind Method; Eye Burns; Oxygen; Rabbits; Randomized Controlled Trials as Topic; Sodium Hydroxide; Wound Healing | 2007 |
Electrocautery versus 23% NaOH infiltration to induce subglottic stenosis in a canine experimental model.
Topics: Animals; Catheter Ablation; Caustics; Disease Models, Animal; Dogs; Injections; Laryngostenosis; Sodium Hydroxide; Treatment Outcome | 2007 |
Advances in corneal stem-cell transplantation in rabbits with severe ocular alkali burns.
Topics: Animals; Biopsy; Burns, Chemical; Cells, Cultured; Coculture Techniques; Corneal Neovascularization; Disease Models, Animal; Epithelium, Corneal; Eye Burns; Immunohistochemistry; Keratin-12; Keratin-19; Keratin-3; Laser Coagulation; Limbus Corneae; Rabbits; Sodium Hydroxide; Stem Cell Transplantation; Transplantation, Autologous | 2007 |
Bevacizumab inhibits corneal neovascularization in an alkali burn induced model of corneal angiogenesis.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevacizumab; Burns, Chemical; Conjunctiva; Corneal Neovascularization; Disease Models, Animal; Eye Burns; Injections; Rabbits; Sodium Hydroxide; Vascular Endothelial Growth Factor A | 2007 |
Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2.
Topics: Animals; Burns, Chemical; CD8-Positive T-Lymphocytes; Corneal Neovascularization; Cytokines; Cytotoxicity Tests, Immunologic; Dendritic Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Epitopes; Eye Burns; Flow Cytometry; Lymphocyte Depletion; Lymphocyte Subsets; Male; Mice; Mice, Inbred C57BL; Peptide Fragments; Sodium Hydroxide; Vaccination; Vascular Endothelial Growth Factor Receptor-2 | 2008 |
Corneal wound healing in an osteopontin-deficient mouse.
Topics: Animals; Burns, Chemical; Cell Adhesion; Cell Culture Techniques; Cell Movement; Corneal Stroma; Debridement; Disease Models, Animal; Eye Burns; Fibroblasts; Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; Sodium Hydroxide; Transforming Growth Factor beta1; Wound Healing | 2008 |
Effect of different biomedical membranes on alkali-burned cornea.
Topics: Animals; Burns, Chemical; Chitosan; Collagen; Corneal Diseases; Disease Models, Animal; Epithelium, Corneal; Eye Burns; Lactic Acid; Membranes, Artificial; Polyesters; Polymers; Rabbits; Sodium Hydroxide; Wound Healing | 2008 |
Development of a dermal matrix from glycerol preserved allogeneic skin.
Topics: Animals; Dermis; Disease Models, Animal; Glycerol; Humans; Inflammation; Preservation, Biological; Prosthesis Implantation; Rats; Skin, Artificial; Sodium Hydroxide; Sus scrofa; Time Factors; Transplantation, Homologous | 2008 |
Effect of acute administration of fish oil (omega-3 marine triglyceride) on gastric ulceration and secretion induced by various ulcerogenic and necrotizing agents in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Ethanol; Female; Fish Oils; Gastric Acid; Gastric Mucosa; Hydrochloric Acid; Hypothermia; Indomethacin; Male; Pylorus; Rats; Rats, Wistar; Reserpine; Sodium Hydroxide; Stomach Ulcer | 1995 |
Experimental models of tracheobronchial stenoses: a useful tool for evaluating airway stents.
Topics: Animals; Bronchial Diseases; Bronchoscopy; Cartilage; Caustics; Cicatrix; Constriction, Pathologic; Dilatation; Disease Models, Animal; Equipment Design; Evaluation Studies as Topic; Fibrosis; Follow-Up Studies; Materials Testing; Mucous Membrane; Necrosis; Recurrence; Sodium Hydroxide; Stents; Swine; Swine, Miniature; Tracheal Stenosis | 1995 |
Recombinant tissue inhibitor of metalloproteinases type 1 suppresses alkali-burn-induced corneal ulceration in rabbits.
Topics: Administration, Topical; Animals; Burns, Chemical; Cornea; Corneal Ulcer; Disease Models, Animal; Eye Burns; Female; Glycoproteins; Incidence; Male; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Rabbits; Random Allocation; Recombinant Proteins; Sodium Hydroxide; Tissue Inhibitor of Metalloproteinases | 1994 |
Topical treatment of experimental acute corneal inflammation by dexamethasone and nonsteroidal drugs.
Topics: Acute Disease; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Corneal Ulcer; Dexamethasone; Disease Models, Animal; Keratitis; Ophthalmic Solutions; Rabbits; Sodium Hydroxide | 1994 |
Treatment of experimental acute corneal inflammation with inhibitors of the oxidative metabolism.
Topics: 6-Aminonicotinamide; Adenosine; Administration, Topical; Animals; Corneal Ulcer; Disease Models, Animal; Free Radicals; Keratitis; Luminescent Measurements; Ophthalmic Solutions; Oxidation-Reduction; Rabbits; Sodium Hydroxide | 1993 |
Effects of polymorphonuclear neutrophils on protein synthesis by alkali-injured rabbit corneas. A preliminary study.
Topics: Animals; Burns, Chemical; Cells, Cultured; Cornea; Corneal Injuries; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Eye Burns; Eye Proteins; Female; Male; Methionine; Neutrophils; Organ Culture Techniques; Rabbits; Sodium Hydroxide; Sulfur Radioisotopes; Wound Healing | 1993 |
Epithelial basement membrane in alkali-burned corneas in rats. Immunohistochemical study.
Topics: Animals; Basement Membrane; Burns, Chemical; Cell Division; Cornea; Corneal Injuries; Corneal Stroma; Disease Models, Animal; Endothelium, Corneal; Epithelium; Extracellular Matrix Proteins; Eye Burns; Female; Immunoenzyme Techniques; Male; Rats; Rats, Wistar; Sodium Hydroxide; Wound Healing | 1993 |
Effect of doxycycline hyclate on corneal epithelial wound healing in the rabbit alkali-burn model. Preliminary observations.
Topics: Administration, Oral; Animals; Burns, Chemical; Cell Division; Collagenases; Cornea; Corneal Injuries; Disease Models, Animal; Doxycycline; Epithelium; Eye Burns; Female; Male; Rabbits; Sodium Hydroxide; Wound Healing | 1993 |
Investigation of enzyme activities in severe burns of the anterior eye segment.
Topics: Acetylglucosaminidase; Animals; Anterior Eye Segment; Burns, Chemical; Cathepsin D; Disease Models, Animal; Eye Burns; L-Lactate Dehydrogenase; Rabbits; Sodium Hydroxide; Wound Healing | 1993 |
Laser photocoagulation of experimental corneal stromal vascularization. Efficacy and histopathology.
Topics: Animals; Corneal Neovascularization; Corneal Stroma; Disease Models, Animal; Endothelium, Vascular; Fluorescein Angiography; Fluorophotometry; Follow-Up Studies; Laser Coagulation; Rabbits; Sodium Hydroxide | 1993 |
Alkali-degraded cornea generates a low molecular weight chemoattractant for polymorphonuclear leukocytes.
Topics: Animals; Burns, Chemical; Cattle; Chemotactic Factors; Chemotaxis, Leukocyte; Cornea; Diffusion Chambers, Culture; Disease Models, Animal; Eye Burns; Humans; Image Processing, Computer-Assisted; Molecular Weight; Neutrophils; Sodium Hydroxide | 1993 |
Antioxidant therapy in the treatment of experimental acute corneal inflammation.
Topics: Acute Disease; Administration, Topical; Animals; Antioxidants; Burns, Chemical; Cornea; Corneal Ulcer; Disease Models, Animal; Eye Burns; Free Radical Scavengers; Ophthalmic Solutions; Rabbits; Sodium Hydroxide; Superoxide Dismutase; Thiourea | 1995 |
Gastric antiulcer and cytoprotective effect of Commiphora molmol in rats.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Gastric Mucosa; Indomethacin; Male; Malondialdehyde; Nucleic Acids; Plant Extracts; Proteins; Rats; Rats, Wistar; Sodium Chloride; Sodium Hydroxide; Stomach Ulcer; Sulfhydryl Reagents; Tissue Preservation | 1997 |
Irritant reactions on hairless micropig skin: a model for testing barrier creams?
Topics: Alopecia; Animals; Body Water; Dermatitis, Irritant; Disease Models, Animal; Drug Evaluation, Preclinical; Erythema; Female; Histamine Release; Industrial Oils; Intradermal Tests; Irritants; Male; Nicotinic Acids; Ointments; Patch Tests; Permeability; Sodium Dodecyl Sulfate; Sodium Hydroxide; Swine; Swine, Miniature; Toluene | 1995 |
Thermal effects of neutralization therapy and water dilution for acute alkali exposure in canines.
Topics: Acids; Analysis of Variance; Animals; Body Temperature; Burns, Chemical; Caustics; Disease Models, Animal; Dogs; Gastric Mucosa; Sodium Hydroxide; Water | 1997 |
Changes in lactate dehydrogenase activity in bovine corneal stroma and epithelium in response to in vitro toxic challenges in the enucleated eye test.
Topics: Animals; Benzalkonium Compounds; Biomarkers; Burns, Chemical; Cattle; Caustics; Corneal Stroma; Descemet Membrane; Detergents; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelium; Eye Burns; Eye Enucleation; In Vitro Techniques; L-Lactate Dehydrogenase; Microscopy, Electron; Sodium Hydroxide; Spectrophotometry | 1997 |
Development of a direct mechanical left ventricular assist device for left ventricular failure.
Topics: Animals; Blood Pressure; Cardiac Output; Caustics; Disease Models, Animal; Dogs; Electrocardiography; Heart; Heart-Assist Devices; Sodium Hydroxide; Ventricular Dysfunction, Left | 1997 |
Alkali burn-induced synthesis of inflammatory eicosanoids in rabbit corneal epithelium.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonic Acid; Burns, Chemical; Chromatography, High Pressure Liquid; Cornea; Corneal Neovascularization; Cytochrome P-450 Enzyme System; Disease Models, Animal; Epithelium; Eye Burns; Lipoxygenase; NADP; Rabbits; Sodium Hydroxide; Time Factors; Wound Healing | 1997 |
Studies on the antisecretory, gastric anti-ulcer and cytoprotective properties of glycine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Caustics; Disease Models, Animal; Ethanol; Female; Gastric Acid; Gastric Mucosa; Glycine; Hydrochloric Acid; Indomethacin; Male; Mucus; Pylorus; Rats; Rats, Wistar; Sodium Hydroxide; Solvents; Stomach Ulcer; Sulfhydryl Compounds | 1997 |
Dynamics of the expression of cytoskeleton components and adherens molecules by fibroblastic cells in alkali-burned and lacerated corneas.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; Burns, Chemical; Cornea; Corneal Injuries; Cytoskeletal Proteins; Disease Models, Animal; Eye Burns; Eye Injuries; Female; Fibroblasts; Fibronectins; Immunoenzyme Techniques; Male; Rabbits; Sodium Hydroxide; Wound Healing | 1994 |
Topical use of zinc desferrioxamine for corneal alkali injury in a rabbit model.
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Burns, Chemical; Cornea; Corneal Injuries; Corneal Ulcer; Deferoxamine; Disease Models, Animal; Eye Burns; Gentamicins; Ophthalmic Solutions; Organometallic Compounds; Rabbits; Random Allocation; Sodium Hydroxide | 1998 |
Changes in mineral composition of rabbit corneas after alkali burn.
Topics: Animals; Body Water; Burns, Chemical; Cations; Chlorides; Cornea; Corneal Edema; Disease Models, Animal; Electron Probe Microanalysis; Eye Burns; Female; Follow-Up Studies; Prospective Studies; Rabbits; Sodium Hydroxide; Wound Healing | 1998 |
Injection of chemoattractants into normal cornea: a model of inflammation after alkali injury.
Topics: Animals; Burns, Chemical; Chemotactic Factors; Chemotaxis, Leukocyte; Corneal Stroma; Disease Models, Animal; Eye Burns; Humans; Injections; Keratitis; Leukocyte Count; Leukotriene B4; Neutrophils; Oligopeptides; Rabbits; Sodium Hydroxide | 1998 |
Pharmacological properties of a newly synthesized H(+)/K(+) ATPase inhibitor, 1-(2-methyl-4-methoxyphenyl)-4-.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cysteamine; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Gastric Acid; Gastric Mucosa; H(+)-K(+)-Exchanging ATPase; Indomethacin; Omeprazole; Perfusion; Proton Pump Inhibitors; Pyrroles; Quinolines; Rats; Rats, Sprague-Dawley; Sodium Hydroxide; Stomach; Stomach Ulcer; Time Factors | 2001 |
Anti-inflammatory and anti-ulcer activity of Calligonum comosum in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Ethanol; Female; Gossypium; Granuloma, Foreign-Body; Indomethacin; Male; Phenylbutazone; Plant Extracts; Plants, Medicinal; Polygonaceae; Rats; Rats, Wistar; Sodium Hydroxide; Stomach Ulcer | 2001 |
Effect of antioxidant therapy on collagen synthesis in corrosive esophageal burns.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Burns, Chemical; Collagen; Disease Models, Animal; Esophagus; Malondialdehyde; Methylprednisolone; Rats; Rats, Sprague-Dawley; Sodium Hydroxide; Statistics, Nonparametric; Vitamin E | 2002 |
Corneal changes due to alkali burns.
Topics: Animals; Burns, Chemical; Cornea; Disease Models, Animal; Endothelium; Epithelium; Eye Burns; Microscopy, Electron, Scanning; Rabbits; Sodium Hydroxide; Wound Healing | 1978 |
An evaluation of the role of leukocytes in the pathogenesis of experimentally induced corneal vascularization.
Topics: Administration, Topical; Alloxan; Animals; Antigen-Antibody Complex; Cattle; Cautery; Cornea; Corneal Opacity; Disease Models, Animal; Eye Diseases; Female; Hemocyanins; Inflammation; Leukocytes; Male; Rabbits; Rats; Rats, Inbred BN; Riboflavin Deficiency; Serum Albumin, Bovine; Silver Nitrate; Sodium Hydroxide; Vitamin A Deficiency | 1975 |
Surface ultrastructure in alkali-burned rabbit corneas.
Topics: Alkalies; Animals; Basement Membrane; Cornea; Corneal Ulcer; Disease Models, Animal; Epithelial Cells; Epithelium; Eye Burns; Rabbits; Regeneration; Sodium Hydroxide | 1976 |
Reactive formation of hyaluronic acid in the rabbit corneal alkali burn.
Topics: Animals; Burns, Chemical; Cornea; Corneal Injuries; Disease Models, Animal; Epithelium; Eye Burns; Fibroblasts; Histocytochemistry; Hyaluronic Acid; Rabbits; Sodium Hydroxide; Wound Healing | 1992 |
Expression of K12 keratin in alkali-burned rabbit corneas.
Topics: Animals; Autoradiography; Burns, Chemical; Cells, Cultured; Cornea; Corneal Injuries; Disease Models, Animal; DNA Probes; Epithelium; Eye Burns; Female; Gene Expression; In Situ Hybridization; Keratins; Male; Rabbits; RNA, Messenger; Sodium Hydroxide; Wound Healing | 1992 |
Subconjunctival injection of purified blood mononuclear cells into alkali-injured rabbit eyes.
Topics: Animals; Burns, Chemical; Cell Separation; Conjunctiva; Corneal Ulcer; Disease Models, Animal; Eye Burns; Injections; Monocytes; Rabbits; Sodium Hydroxide; Wound Healing | 1992 |
Laser photocoagulation for corneal stromal vascularization.
Topics: Adult; Aged; Aged, 80 and over; Animals; Corneal Neovascularization; Corneal Stroma; Disease Models, Animal; Female; Fluorophotometry; Humans; Laser Coagulation; Male; Middle Aged; Rabbits; Sodium Hydroxide | 1992 |
Effect of topical corticosteroids on goblet-cell density in an alkali-burn model.
Topics: Administration, Topical; Animals; Burns, Chemical; Cell Count; Conjunctiva; Disease Models, Animal; Eye Burns; Prednisolone; Prospective Studies; Rabbits; Random Allocation; Sodium Hydroxide | 1991 |
In vivo observations on experimental corneal neovascularization with a newly developed macroscope.
Topics: Animals; Burns, Chemical; Cornea; Corneal Neovascularization; Disease Models, Animal; Equipment Design; Eye Burns; Male; Microscopy; Photography; Rabbits; Sodium Hydroxide; Video Recording | 1991 |
Topical fibronectin in an alkali burn model of corneal ulceration in rabbits.
Topics: Administration, Topical; Animals; Autoantigens; Burns, Chemical; Carrier Proteins; Cell Movement; Collagen; Collagen Type XVII; Corneal Ulcer; Cytoskeletal Proteins; Disease Models, Animal; Dystonin; Eye Burns; Female; Fibronectins; Fluorescent Antibody Technique; Male; Nerve Tissue Proteins; Non-Fibrillar Collagens; Rabbits; Random Allocation; Sodium Hydroxide; Wound Healing | 1991 |
Healing of rabbit corneal alkali wounds in vitro.
Topics: Animals; Burns, Chemical; Cornea; Corneal Diseases; Disease Models, Animal; Endothelium, Corneal; Epithelium; Eye Burns; In Vitro Techniques; Photography; Rabbits; Sodium Hydroxide; Wound Healing | 1990 |
Mechanisms of action of hypocapnic alkalosis on limb blood vessels in man and dog.
Topics: Alkalosis; Alkalosis, Respiratory; Animals; Blood Pressure; Carbon Dioxide; Diphenhydramine; Disease Models, Animal; Dogs; Epinephrine; Forearm; Hindlimb; Histamine H1 Antagonists; Histamine Release; Humans; Hyperventilation; Injections, Intra-Arterial; Muscle, Smooth; Muscles; Phenoxybenzamine; Promethazine; Propranolol; Regional Blood Flow; Sodium Hydroxide; Tromethamine; Vascular Resistance | 1972 |
[Corneal nutrition in alkali burns and the effect of tolazoline (author's transl)].
Topics: Animals; Aqueous Humor; Burns, Chemical; Ciliary Body; Conjunctiva; Cornea; Corneal Ulcer; Disease Models, Animal; Eye Burns; Glucose; Ischemia; Sodium Hydroxide; Tolazoline | 1974 |
Intraocular pressure response to experimental alkali burns.
Topics: Animals; Burns, Chemical; Ciliary Body; Conjunctiva; Corneal Injuries; Descemet Membrane; Disease Models, Animal; Eye Burns; In Vitro Techniques; Intraocular Pressure; Iris; Rabbits; Retinal Vessels; Sclera; Sodium Hydroxide; Time Factors | 1973 |
Cerebral edema in developing brain. II. Asphyxia in the five-day-old rat.
Topics: Animals; Animals, Newborn; Asphyxia; Asphyxia Neonatorum; Body Temperature; Brain; Brain Damage, Chronic; Brain Edema; Brain Stem; Calcium; Cerebellum; Chlorides; Disease Models, Animal; Humans; Hypoxia, Brain; Infant, Newborn; Iodoacetates; Oxides; Potassium; Rats; Sodium; Sodium Hydroxide; Water-Electrolyte Balance | 1973 |
Inhibition of experimental esophageal lye strictures by penicillamine.
Topics: Animals; Burns, Chemical; Caustics; Disease Models, Animal; Esophageal Stenosis; Lathyrism; Lye; Penicillamine; Rats | 1981 |
The preventive effect of heparin on stricture formation after caustic esophageal burns.
Topics: Animals; Burns, Chemical; Caustics; Disease Models, Animal; Esophageal Stenosis; Esophagus; Heparin; Hydroxyproline; Lye; Rats; Statistics, Nonparametric | 1999 |
Morphologic aspects of experimental esophageal lye strictures. II. Effect of steroid hormones, bougienage, and induced lathyrism on acute lye burns.
Topics: Adrenal Cortex Hormones; Aminopropionitrile; Animals; Burns, Chemical; Dilatation; Disease Models, Animal; Dogs; Esophageal Stenosis; Lathyrism; Lye; Wound Healing | 1977 |