Page last updated: 2024-11-04

sodium fluoride and Xerostomia

sodium fluoride has been researched along with Xerostomia in 31 studies

Xerostomia: Decreased salivary flow.

Research Excerpts

ExcerptRelevanceReference
"30% triclosan/copolymer) in 440 medication-induced xerostomic adults identified in a 1-year, run-in phase (no treatment) as high risk for periodontitis and root caries."9.12Comparative efficacy of stabilized stannous fluoride/sodium hexametaphosphate dentifrice and sodium fluoride/triclosan/copolymer dentifrice for the prevention of periodontitis in xerostomic patients: a 2-year randomized clinical trial. ( Bartizek, RD; Biesbrock, AR; He, T; Martuscelli, G; Papas, A; Singh, M, 2007)
"30% triclosan/copolymer) in 440 medication-induced xerostomic adults identified in a 1-year, run-in phase (no treatment) as high risk for periodontitis and root caries."5.12Comparative efficacy of stabilized stannous fluoride/sodium hexametaphosphate dentifrice and sodium fluoride/triclosan/copolymer dentifrice for the prevention of periodontitis in xerostomic patients: a 2-year randomized clinical trial. ( Bartizek, RD; Biesbrock, AR; He, T; Martuscelli, G; Papas, A; Singh, M, 2007)
" Safety was assessed as adverse events from clinical examination and interview."2.87Safety and effectiveness of a two-step dentifrice/gel sequence with medication-associated hyposalivation: A randomized controlled trial in a vulnerable population. ( Gerlach, RW; Papas, A; Singh, M, 2018)
"Xerostomia is a common chronic health condition that affects a great number of adults and significantly deteriorates quality of life, such that treatment is necessary."2.77Evaluation of the efficacy of two mouthrinses formulated for the relief of xerostomia of diverse origin in adult subjects. ( Espinoza, I; Lozano, C; Morales-Bozo, I; Ortega-Pinto, A; Plaza, A; Rojas, G; Soto, L; Urzúa, B, 2012)
"Pre-existing carious lesions were restored prior to the beginning of the study."2.73Erratum to "Clinical evaluation of the intraoral fluoride releasing system in radiation-induced xerostomic subjects. Part 2: Phase I study". ( Bouwsma, OJ; Chambers, MS; Craven, TE; Espeland, MA; Fleming, TJ; Garden, AS; Keene, HJ; Lemon, JC; Martin, JW; Sipos, T; Toth, BB, 2007)
"Pre-existing carious lesions were restored prior to the beginning of the study."2.72Clinical evaluation of the intraoral fluoride releasing system in radiation-induced xerostomic subjects. Part 2: Phase I study. ( Bouwsma, OJ; Chambers, MS; Fleming, TJ; Garden, AS; Keene, HJ; Mellberg, JR; Sipos, T, 2006)
" Acute and chronic side effects from established and recommended mouthrinsing routines are extremely rare but ethanol containing products should not be recommended to children for long-term use or to individuals with alcohol problems."2.41Mouthrinses and dental caries. ( , 2002)
" Oral examinations were conducted before radiotherapy, after dosage of 2000 cGy irradiation, immediately after the termination of radiotherapy, and 1 month and 6 months after termination of the radiotherapy."1.36Progress of oral sequelae during head-neck radiotherapy. ( Deng, J; Gao, XJ; Li, NY; Lu, HJ; Sun, HB, 2010)
" There were some significant differences in the maximum F concentration, the area under the salivary fluoride concentration curve (AUC) when plotted against time, and the salivary stimulating effect among the four products, but as a whole they were small and probably of minor clinical importance."1.29Salivary fluoride clearance after a single intake of fluoride tablets and chewing gums in children, adults, and dry mouth patients. ( Birkhed, D; Norén, JG; Persson, LG; Sjögren, K, 1993)
"In this clinical study of irradiated head and neck cancer patients at M."1.27Prevalence of caries-associated microflora after radiotherapy in patients with cancer of the head and neck. ( Fleming, TJ; Keene, HJ, 1987)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19908 (25.81)18.7374
1990's7 (22.58)18.2507
2000's8 (25.81)29.6817
2010's8 (25.81)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jose, A1
Ward, J1
Shneyer, L1
Skinner, J1
Jeal, N1
Cronin, M1
Bosma, ML1
Singh, M2
Papas, A2
Gerlach, RW1
Borges, AB1
Scaramucci, T1
Lippert, F1
Zero, DT2
Hara, AT1
Skrinjar, I1
Vucicevic Boras, V1
Bakale, I1
Andabak Rogulj, A1
Brailo, V1
Vidovic Juras, D1
Alajbeg, I1
Vrdoljak, DV1
Singh, ML1
Papas, AS1
De Moor, RJ1
Stassen, IG1
van 't Veldt, Y1
Torbeyns, D1
Hommez, GM1
Sun, HB1
Gao, XJ1
Deng, J1
Li, NY1
Lu, HJ1
Su, N1
Marek, CL1
Ching, V1
Grushka, M2
Morales-Bozo, I1
Rojas, G1
Ortega-Pinto, A1
Espinoza, I1
Soto, L1
Plaza, A1
Lozano, C1
Urzúa, B1
Haveman, CW1
Summitt, JB1
Burgess, JO1
Carlson, K1
Chambers, MS3
Mellberg, JR2
Keene, HJ4
Bouwsma, OJ3
Garden, AS3
Sipos, T3
Fleming, TJ4
He, T1
Martuscelli, G1
Bartizek, RD1
Biesbrock, AR1
Toth, BB1
Lemon, JC1
Craven, TE1
Espeland, MA1
Martin, JW1
Swango, PA1
Edmonds, EJ1
Shannon, IL1
Weisz, AS1
Hutton, J1
Koulourides, T1
Borden, L1
Markitziu, A1
Gedalia, I1
Stabholz, A1
Shuval, J1
Sjögren, K1
Birkhed, D1
Persson, LG1
Norén, JG1
Stevenson-Moore, P1
Epstein, JB1
Chin, EA1
Jacobson, JJ1
Rishiraj, B1
Le, N1
Hay, KD1
Thomson, WM1
Tavss, EA1
Bontá, CY1
Joziak, MT1
Fisher, SW1
Campbell, SK1
Reznik, DA1
Giertsen, E1
Bowen, WH1
Pearson, SK1
Meyerowitz, C1
Featherstone, JD1
Billings, RJ1
Eisenberg, AD1
Fu, J1
Shariati, M1
Macan, D1
Rukavina, K1
Virag, M1
Krajina, Z1
Grad, H1
Yanover, L1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparing Three Caries Prevention Products on Dentinal Hypersensitivity - A Pilot Study[NCT02136576]39 participants (Actual)Interventional2014-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Dentinal Hypersensitivity

"The primary analysis will be to compare the dentinal hypersensitivity between the 3 groups.~Air test: A 1 second blast of air from the air-water syringe was applied to the tooth.~Water test: Three drops of ice water were be placed on the tooth.~Schiff Score~Investigator observed participant reaction to test and scored on following scale:~0-Tooth/Subject does not respond to stimulus.~Tooth/Subject responds to stimulus, but does not request discontinuation of stimulus.~Tooth/Subject responds to stimulus and requests discontinuation or moves from stimulus.~Tooth/Subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus~VAS (visual analog scale):~The participant reported sensitivity on a scale of 0-10. 0 being no pain and 10 being worst pain imaginable." (NCT02136576)
Timeframe: 8 weeks after baseline

,,
Interventionunits on a scale (Median)
Air SchiffAir VASWater SchiffWater VAS
Clinpro 50000212
Crest Cavity Protection & MI Paste Plus1212
Sensodyne1314

Reviews

5 reviews available for sodium fluoride and Xerostomia

ArticleYear
Mouthrinses and dental caries.
    International dental journal, 2002, Volume: 52, Issue:5

    Topics: Adolescent; Anti-Infective Agents, Local; Cariostatic Agents; Child; Dental Caries; Dental Caries Su

2002
Clinical evaluation of the intraoral fluoride releasing system in radiation-induced xerostomic subjects. Part 1: Fluorides.
    Oral oncology, 2006, Volume: 42, Issue:9

    Topics: Anti-Bacterial Agents; Delayed-Action Preparations; Dental Caries; Fluoridation; Humans; Mouth Neopl

2006
The use of topical fluorides to prevent dental caries in adults: a review of the literature.
    Journal of the American Dental Association (1939), 1983, Volume: 107, Issue:3

    Topics: Adolescent; Adult; Aged; Cost-Benefit Analysis; Dental Caries; Female; Fluorides, Topical; Humans; M

1983
Replacement therapy in a dry mouth patient: a review.
    Journal of hospital dental practice, 1980, Volume: 14, Issue:1

    Topics: Carboxymethylcellulose Sodium; Drug Combinations; Glycerol; Humans; Minerals; Mouthwashes; Radiother

1980
High-potency sodium fluoride: a literature review.
    Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 1997, Volume: 18, Issue:2 Spec No

    Topics: Adult; Cariostatic Agents; Child; Dental Caries; Dental Caries Susceptibility; Dentifrices; Fluoride

1997

Trials

9 trials available for sodium fluoride and Xerostomia

ArticleYear
Evaluation of the Oral Tolerance of Three Fluoride Toothpaste Formulations in a Dry Mouth Population: Results from Two Randomized Studies.
    The Journal of clinical dentistry, 2016, Volume: 27, Issue:1

    Topics: Biofilms; Dental Plaque; Double-Blind Method; Fluorides; Humans; Mouth; Sodium Fluoride; Toothpastes

2016
Safety and effectiveness of a two-step dentifrice/gel sequence with medication-associated hyposalivation: A randomized controlled trial in a vulnerable population.
    American journal of dentistry, 2018, Volume: 31, Issue:Sp Is A

    Topics: Adult; Aged; Aged, 80 and over; Dental Plaque; Dentifrices; Double-Blind Method; Female; Humans; Hyd

2018
Comparison between three different saliva substitutes in patients with hyposalivation.
    Clinical oral investigations, 2015, Volume: 19, Issue:3

    Topics: Aged; Althaea; Betaine; Cellulose; Drug Combinations; Female; Humans; Male; Middle Aged; Plant Extra

2015
Two-year clinical performance of glass ionomer and resin composite restorations in xerostomic head- and neck-irradiated cancer patients.
    Clinical oral investigations, 2011, Volume: 15, Issue:1

    Topics: Adult; Carcinoma; Cariostatic Agents; Chi-Square Distribution; Composite Resins; Cranial Irradiation

2011
Evaluation of the efficacy of two mouthrinses formulated for the relief of xerostomia of diverse origin in adult subjects.
    Gerodontology, 2012, Volume: 29, Issue:2

    Topics: Adult; Aloe; Arthritis; Burning Mouth Syndrome; Cetylpyridinium; Citric Acid; Cross-Over Studies; De

2012
Clinical evaluation of the intraoral fluoride releasing system in radiation-induced xerostomic subjects. Part 2: Phase I study.
    Oral oncology, 2006, Volume: 42, Issue:9

    Topics: Administration, Topical; Anti-Bacterial Agents; Delayed-Action Preparations; Dental Caries; Humans;

2006
Comparative efficacy of stabilized stannous fluoride/sodium hexametaphosphate dentifrice and sodium fluoride/triclosan/copolymer dentifrice for the prevention of periodontitis in xerostomic patients: a 2-year randomized clinical trial.
    Journal of periodontology, 2007, Volume: 78, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Local; Cariostatic Agents; Dentifrices; Doubl

2007
Erratum to "Clinical evaluation of the intraoral fluoride releasing system in radiation-induced xerostomic subjects. Part 2: Phase I study".
    Oral oncology, 2007, Volume: 43, Issue:1

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Delayed-Action Prepa

2007
A clinical trial of the anticaries efficacy of casein derivatives complexed with calcium phosphate in patients with salivary gland dysfunction.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2002, Volume: 93, Issue:3

    Topics: Adult; Cariostatic Agents; Caseins; Cranial Irradiation; Dental Caries; Drug Combinations; Female; H

2002

Other Studies

17 other studies available for sodium fluoride and Xerostomia

ArticleYear
Erosion protection by calcium lactate/sodium fluoride rinses under different salivary flows in vitro.
    Caries research, 2014, Volume: 48, Issue:3

    Topics: Animals; Calcium Compounds; Cattle; Citric Acid; Dental Enamel; Dentin; Diffusion Chambers, Culture;

2014
Long-term clinical observation of dental caries in salivary hypofunction patients using a supersaturated calcium-phosphate remineralizing rinse.
    The Journal of clinical dentistry, 2009, Volume: 20, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Calcium Phosphates; Dental Caries; Female; Humans; Male;

2009
Progress of oral sequelae during head-neck radiotherapy.
    The Chinese journal of dental research, 2010, Volume: 13, Issue:1

    Topics: Aged; Analysis of Variance; Cariostatic Agents; Cranial Irradiation; Dental Caries; Disease Progress

2010
Caries prevention for patients with dry mouth.
    Journal (Canadian Dental Association), 2011, Volume: 77

    Topics: Calcium Phosphates; Cariostatic Agents; Caseins; Dental Caries; Glass; Humans; Mouthwashes; Saliva;

2011
Three restorative materials and topical fluoride gel used in xerostomic patients: a clinical comparison.
    Journal of the American Dental Association (1939), 2003, Volume: 134, Issue:2

    Topics: Analysis of Variance; Cariostatic Agents; Dental Amalgam; Dental Caries; Dental Marginal Adaptation;

2003
The use of a saliva substitute as treatment for xerostomia in Sjögren's syndrome--a case report.
    Oral surgery, oral medicine, and oral pathology, 1981, Volume: 52, Issue:4

    Topics: Carboxymethylcellulose Sodium; Drug Combinations; Female; Fluorides; Humans; Methylcellulose; Middle

1981
Evaluation of cariostatic disciplines for postradiation caries.
    Caries research, 1982, Volume: 16, Issue:5

    Topics: Animals; Bacteria; Cattle; Dental Caries; Dental Enamel; Dental Plaque; Fluorides; Gels; Humans; Rad

1982
Prevention of caries progress in xerostomic patients by topical fluoride applications: a study in vivo and in vitro.
    Journal of dentistry, 1982, Volume: 10, Issue:3

    Topics: Acidulated Phosphate Fluoride; Adolescent; Adult; Amines; Dental Caries; Dental Enamel; Diamines; Fl

1982
Salivary fluoride clearance after a single intake of fluoride tablets and chewing gums in children, adults, and dry mouth patients.
    Scandinavian journal of dental research, 1993, Volume: 101, Issue:5

    Topics: Adult; Age Factors; Aged; Chewing Gum; Child; Fluorides; Humans; Middle Aged; Saliva; Secretory Rate

1993
FluoriSHIELD.
    Journal (Canadian Dental Association), 1998, Volume: 64, Issue:1

    Topics: Buffers; Cariostatic Agents; Fluorides, Topical; Humans; Hydrogen-Ion Concentration; Sodium Fluoride

1998
The relationships among fluoride, cariogenic oral flora, and salivary flow rate during radiation therapy.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 1998, Volume: 86, Issue:3

    Topics: Adult; Aged; Candida albicans; Colony Count, Microbial; Cranial Irradiation; Female; Fluorides, Topi

1998
Case reports. 1. Xerostomia.
    Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 1997, Volume: 18, Issue:2 Spec No

    Topics: Cariostatic Agents; Dentifrices; Disease Progression; Fluorides, Topical; Follow-Up Studies; Humans;

1997
Combined effects of Zn(2+)-chlorhexidine and Zn(2+)-cetylpyridinium chloride on caries incidence in partially desalivated rats.
    Scandinavian journal of dental research, 1991, Volume: 99, Issue:4

    Topics: Acetates; Administration, Topical; Animals; Cetylpyridinium; Chlorhexidine; Dental Caries; Drug Comb

1991
Use of an intra-oral model to evaluate 0.05% sodium fluoride mouthrinse in radiation-induced hyposalivation.
    Journal of dental research, 1991, Volume: 70, Issue:5

    Topics: Bacteria; Dental Caries; Dental Enamel; Dental Plaque; Evaluation Studies as Topic; Hardness; Humans

1991
[Evaluation of artificial saliva developed for the treatment of postradiation xerostomia. 1. Preliminary results].
    Chirurgia maxillofacialis & plastica, 1986, Volume: 16, Issue:3

    Topics: Adult; Aged; Consumer Behavior; Female; Humans; Male; Middle Aged; Mouthwashes; Radiotherapy; Saliva

1986
Prevalence of caries-associated microflora after radiotherapy in patients with cancer of the head and neck.
    Oral surgery, oral medicine, and oral pathology, 1987, Volume: 64, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Dental Caries; Female; Gels; Head and Neck Neoplasms; Humans; Lactob

1987
Drug induced xerostomia. The effects and treatment.
    Journal (Canadian Dental Association), 1985, Volume: 51, Issue:4

    Topics: Carboxymethylcellulose Sodium; Dental Care; Drug Combinations; Drug-Related Side Effects and Adverse

1985