sodium fluoride and Dentin Hypersensitivity studies

Research Excerpts

Excerpt	Relevance	Reference
"75% (w/w) potassium chloride (KCl) in reducing dentin hypersensitivity (DH) compared with that of a standard fluoride "Reference" dentifrice after eight weeks' twice-daily brushing."	9.24	A Randomized Clinical Study to Evaluate the Efficacy of an Experimental 3.75% (w/w) Potassium Chloride Dentifrice for the Relief of Dentin Hypersensitivity. ( Mason, S; Sufi, F; Wang, N; Young, S, 2017)
"To evaluate the efficacy of an experimental mouthwash containing 3% potassium nitrate (KNO3) in the relief of dentin hypersensitivity when used as an adjunct to brushing with fluoride toothpaste compared with the use of the same toothpaste alone."	9.24	Efficacy of an experimental 3% potassium nitrate mouthwash in providing long-term relief from dentin hypersensitivity: An 8-week randomized controlled study (Study 2). ( Constantin, P; Hall, C; Sufi, F, 2017)
"To evaluate the desensitizing efficacy of 2% sodium fluoride solution (NaF), diode laser (DL), a DL and NaF association and a solution of hydroxyl-ethyl-methacrylate and glutaraldehyde (HEMA-G: Gluma desensitizer) in cervical dentin hypersensitivity (CDH)."	9.17	Efficacy of diode laser in association to sodium fluoride vs Gluma desensitizer on treatment of cervical dentin hypersensitivity. A double blind controlled trial. ( Femiano, F; Femiano, R; Festa, MV; Lanza, A; Perillo, L; Rullo, R, 2013)
"The results of this study support the conclusion that the Arginine Mouthwash provides a significant reduction in dentin hypersensitivity after eight weeks of product use as compared to a Negative Control mouthwash."	9.17	Efficacy of a mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride compared to a negative control mouthwash on dentin hypersensitivity reduction. A randomized clinical trial. ( Arvanitidou, L; De Vizio, W; Hu, D; Mateo, LR; Mello, S; Panagakos, F; Stewart, B; Yin, W; Zhang, YP, 2013)
"0% arginine, calcium carbonate, and 1000 ppm MFP provides greater efficacy in reducing dentin hypersensitivity when compared to a dentifrice containing 2% potassium ion, as potassium nitrate, after two, four, and eight weeks of product use."	9.16	Comparison of the clinical efficacy of a new dentifrice containing 8.0% arginine, calcium carbonate, and 1000 ppm fluoride to a commercially available sensitive toothpaste containing 2% potassium ion on dentin hypersensitivity: a randomized clinical trial ( DeVizio, W; Kakar, A; Kakar, K; Kohli, R; Sreenivasan, PK, 2012)
"To determine the efficacy of an in-office desensitizing paste containing 8% arginine and calcium carbonate relative to that of a commercially-available pumice prophylaxis paste in reducing dentin hypersensitivity instantly after a single application following a dental scaling procedure and to establish the duration of sensitivity relief over a period of 4 weeks and 12 weeks."	9.14	Clinical evaluation of the efficacy of an in-office desensitizing paste containing 8% arginine and calcium carbonate in providing instant and lasting relief of dentin hypersensitivity. ( Cummins, D; Delgado, E; DeVizio, W; Mateo, LR; Schiff, T; Zhang, YP, 2009)
"0% arginine and 1450 ppm MFP in a calcium carbonate base, provided a significant reduction in dentin hypersensitivity when used over a period of eight weeks."	9.14	Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight-week clinical study on Canadian ad ( Ayad, F; Ayad, N; Cummins, D; DeVizio, W; Mateo, LR; Zhang, YP, 2009)
"0% arginine calcium carbonate, and 1450 ppm fluoride as sodium monofluorophosphate (MFP) provides significantly increased dentin hypersensitivity relief (p < 0."	9.14	Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight-week clinical study in Rome, Italy ( Bartolino, M; Costacurta, M; Cummins, D; DeVizio, W; Dibart, S; Docimo, R; Mateo, LR; Maturo, P; Montesani, L; Zhang, YP, 2009)
"0% arginine and 1450 ppm fluoride as MFP in a calcium carbonate base, provided a significant reduction in dentin hypersensitivity when used over a period of eight weeks."	9.14	Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark commercial desensitizing toothpaste containing 2% potassium ion: an eight-week clinical study ( Bartolino, M; Costacurta, M; Cummins, D; Delgado, E; DeVizio, W; Dibart, S; Docimo, R; Mateo, LR; Maturo, P; Montesani, L; Zhang, YP, 2009)
"0% arginine-calcium carbonate toothpaste directly onto the hypersensitive surface of teeth provides significant immediate improvement in dentin hypersensitivity relative to an identical application of a control toothpaste and to a benchmark potassium-based desensitizing toothpaste."	9.14	Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride relative to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm ( Cummins, D; Delgado, E; DeVizio, W; Mateo, LR; Nathoo, S; Zhang, YP, 2009)
"0% arginine-calcium carbonate toothpaste directly onto the hypersensitive surface of teeth provides significant immediate improvements in dentin hypersensitivity relative to an identical application of the control toothpaste and to the benchmark potassium-based desensitizing toothpaste."	9.14	Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm fluoride, ( Ayad, F; Ayad, N; Cummins, D; Delgado, E; DeVizio, W; Mateo, LR; Zhang, YP, 2009)
"The combination of Nd:YAG laser and 5% sodium fluoride varnish seems to show an impressive efficacy, when compared to either treatment alone, in treating dentin hypersensitivity."	9.11	Short-term assessment of the Nd:YAG laser with and without sodium fluoride varnish in the treatment of dentin hypersensitivity--a clinical and scanning electron microscopy study. ( Kumar, NG; Mehta, DS, 2005)
"This investigation was conducted to evaluate the effect of chlorhexidine, sodium fluoride, and sequential rinses of chlorhexidine (Cx) and sodium fluoride (NaF) on dentin hypersensitivity."	9.07	Effectiveness of chlorhexidine and sodium fluoride in reducing dentin hypersensitivity. ( Anderson, D; Gross, KB; Lawson, K; Overman, PR, 1991)
" The aim of this study was to study the effect of sodium fluoride varnish, Gluma, and Er,Cr:YSGG laser, in the dentin hypersensitivity treatment."	8.12	Effect of sodium fluoride varnish, Gluma, and Er,Cr:YSGG laser in dentin hypersensitivity treatment: a 6-month clinical trial. ( Farhadian, M; Farmany, A; Fekrazad, R; Forouzande, M; Ganje-Khosravi, M; Rezaei-Soufi, L; Yarmohammadi, E, 2022)
"To evaluate the effectiveness in reducing dentin hypersensitivity (DH) of a commercial toothpaste containing 8% arginine, calcium carbonate and fluoride when applied by a dental professional immediately prior to a professional dental prophylaxis and again after subjects brushed twice daily with the toothpaste at home for 2 weeks, and additionally to assess whether the % reductions in DH observed in the study are comparable to those found in previously published pivotal studies."	7.88	Use of a toothpaste containing 8% arginine and calcium carbonate for immediate and lasting relief of dentin hypersensitivity: A simple and effective in-office procedure. ( Ayad, F; Ayad, N; Cummins, D; Mateo, LR; Vazquez, J; Zhang, YP, 2018)
"Additionally, the dentin hypersensitivity reductions achieved by twice-daily brushing with Sensodyne Rapid Relief are significantly improved by switching to twice-daily brushing with Colgate Sensitive Pro-Relief (elmex Sensitive Professional) for two and eight weeks."	6.76	Clinical efficacy in reducing dentin hypersensitivity of a dentifrice containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride compared to a dentifrice containing 8% strontium acetate and 1040 ppm fluoride under consumer usage conditions before ( Cummins, D; Delgado, E; DeVizio, W; Mateo, LR; Schiff, T; Zhang, YP, 2011)
"Home-use studies on dentine hypersensitivity have most commonly involved toothpastes and rarely have mouthrinses been employed."	6.69	The effects of a potassium citrate, cetylpyridinium chloride, sodium fluoride mouthrinse on dentine hypersensitivity, plaque and gingivitis. A placebo-controlled study. ( Addy, M; Marlow, I; West, N; Yates, R, 1998)
"Dentin hypersensitivity is treated using materials that occlude the dentinal tubules or release potassium ions that induce nerve desensitization."	5.42	The synthesis and characterization of a novel potassium chloride-fluoridated hydroxyapatite varnish for treating dentin hypersensitivity. ( Hirata, I; Lochaiwatana, Y; Okazaki, M; Poolthong, S; Swasdison, S; Vongsavan, N, 2015)
"To compare the desensitizing effects of two different marketed professional dentin hypersensitivity treatments, a 5% sodium fluoride varnish and an oxalic acid/potassium salt solution, in a single-center, randomized, controlled, subject-blind pilot study."	5.27	A randomized, controlled comparison of two professional dentin desensitizing agents immediately post-treatment and 2 months post-treatment. ( Anderson, CJ; Gerlach, R; Kugel, G, 2018)
"75% (w/w) potassium chloride (KCl) in reducing dentin hypersensitivity (DH) compared with that of a standard fluoride "Reference" dentifrice after eight weeks' twice-daily brushing."	5.24	A Randomized Clinical Study to Evaluate the Efficacy of an Experimental 3.75% (w/w) Potassium Chloride Dentifrice for the Relief of Dentin Hypersensitivity. ( Mason, S; Sufi, F; Wang, N; Young, S, 2017)
"A randomized, investigator-blind, five-treatment, crossover, non-inferiority study was conducted to investigate the effect of the addition of calcium sodium phosphosilicate (CSPS), an agent known to relieve dentin hypersensitivity, to a sodium monofluorophosphate (SMFP)-containing dentifrice on the enamel remineralization potential of fluoride (F), as assessed by percentage surface microhardness recovery (%SMHR) and enamel fluoride uptake (EFU) using a standard in situ caries model."	5.24	In Situ Study to Confirm the Anticaries Potential of a Sodium Monofluorophosphate Dentifrice Containing Calcium Sodium Phosphosilicate. ( Hara, AT; Lippert, F; Mason, S; Parkinson, CR; Siddiqi, M; Zero, DT, 2017)
"To evaluate the efficacy of an experimental mouthwash containing 3% potassium nitrate (KNO3) in the relief of dentin hypersensitivity when used as an adjunct to brushing with fluoride toothpaste compared with the use of the same toothpaste alone."	5.24	Efficacy of an experimental 3% potassium nitrate mouthwash in providing long-term relief from dentin hypersensitivity: An 8-week randomized controlled study (Study 2). ( Constantin, P; Hall, C; Sufi, F, 2017)
"To investigate the effect of reducing the particle size of calcium sodium phosphosilicate (CSPS) bioactive glass from ~14 µm (NovaMin®) to ~4 µm (Vitryxx®), and of changing the fluoride source in a 5% CSPS dentifrice from sodium monofluorophosphate (SMFP) to sodium fluoride (NaF) on the efficacy of CSPS-containing dentifrices in dentin hypersensitivity (DH) relief."	5.22	A Randomized Clinical Trial Investigating the Effect of Particle Size of Calcium Sodium Phosphosilicate (CSPS) on the Efficacy of CSPS-containing Dentifrices for the Relief of Dentin Hypersensitivity. ( Du, M; Hall, C; Jiang, H; Parkinson, C; Wang, N; Zang, P; Zhang, J, 2016)
"To evaluate the desensitizing efficacy of 2% sodium fluoride solution (NaF), diode laser (DL), a DL and NaF association and a solution of hydroxyl-ethyl-methacrylate and glutaraldehyde (HEMA-G: Gluma desensitizer) in cervical dentin hypersensitivity (CDH)."	5.17	Efficacy of diode laser in association to sodium fluoride vs Gluma desensitizer on treatment of cervical dentin hypersensitivity. A double blind controlled trial. ( Femiano, F; Femiano, R; Festa, MV; Lanza, A; Perillo, L; Rullo, R, 2013)
"The results of this study support the conclusion that the Arginine Mouthwash provides a significant reduction in dentin hypersensitivity after eight weeks of product use as compared to a Negative Control mouthwash."	5.17	Efficacy of a mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride compared to a negative control mouthwash on dentin hypersensitivity reduction. A randomized clinical trial. ( Arvanitidou, L; De Vizio, W; Hu, D; Mateo, LR; Mello, S; Panagakos, F; Stewart, B; Yin, W; Zhang, YP, 2013)
"0% arginine, calcium carbonate, and 1000 ppm MFP provides greater efficacy in reducing dentin hypersensitivity when compared to a dentifrice containing 2% potassium ion, as potassium nitrate, after two, four, and eight weeks of product use."	5.16	Comparison of the clinical efficacy of a new dentifrice containing 8.0% arginine, calcium carbonate, and 1000 ppm fluoride to a commercially available sensitive toothpaste containing 2% potassium ion on dentin hypersensitivity: a randomized clinical trial ( DeVizio, W; Kakar, A; Kakar, K; Kohli, R; Sreenivasan, PK, 2012)
"The test toothpaste containing 8% strontium acetate and 1040 ppm fluoride as NaF in a silica base, when used for a single topical application and twice-daily brushing for seven days, does not provide statistically significant relief of dentin hypersensitivity compared to a negative control toothpaste containing 1100 ppm fluoride as NaF in a silica base."	5.15	Comparison of clinical efficacy of three toothpastes in reducing dentin hypersensitivity. ( Delgado, E; DeVizio, W; Lee, S; Li, Y; Mateo, LR; Zhang, YP, 2011)
"An experimental stannous-containing sodium fluoride dentifrice provided significantly better dentin hypersensitivity relief relative to a positive control dentifrice both immediately and after three days of product use."	5.15	Rapid desensitizing efficacy of a stannous-containing sodium fluoride dentifrice. ( Biesbrock, AR; Chang, A; Cheng, R; He, T; Sun, L, 2011)
"0% arginine-calcium carbonate toothpaste directly onto the hypersensitive surface of teeth provides significant immediate improvements in dentin hypersensitivity relative to an identical application of the control toothpaste and to the benchmark potassium-based desensitizing toothpaste."	5.14	Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm fluoride, ( Ayad, F; Ayad, N; Cummins, D; Delgado, E; DeVizio, W; Mateo, LR; Zhang, YP, 2009)
"0% arginine calcium carbonate, and 1450 ppm fluoride as sodium monofluorophosphate (MFP) provides significantly increased dentin hypersensitivity relief (p < 0."	5.14	Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight-week clinical study in Rome, Italy ( Bartolino, M; Costacurta, M; Cummins, D; DeVizio, W; Dibart, S; Docimo, R; Mateo, LR; Maturo, P; Montesani, L; Zhang, YP, 2009)
"0% arginine and 1450 ppm MFP in a calcium carbonate base, provided a significant reduction in dentin hypersensitivity when used over a period of eight weeks."	5.14	Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight-week clinical study on Canadian ad ( Ayad, F; Ayad, N; Cummins, D; DeVizio, W; Mateo, LR; Zhang, YP, 2009)
"0% arginine-calcium carbonate toothpaste directly onto the hypersensitive surface of teeth provides significant immediate improvement in dentin hypersensitivity relative to an identical application of a control toothpaste and to a benchmark potassium-based desensitizing toothpaste."	5.14	Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride relative to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm ( Cummins, D; Delgado, E; DeVizio, W; Mateo, LR; Nathoo, S; Zhang, YP, 2009)
"0% arginine and 1450 ppm fluoride as MFP in a calcium carbonate base, provided a significant reduction in dentin hypersensitivity when used over a period of eight weeks."	5.14	Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark commercial desensitizing toothpaste containing 2% potassium ion: an eight-week clinical study ( Bartolino, M; Costacurta, M; Cummins, D; Delgado, E; DeVizio, W; Dibart, S; Docimo, R; Mateo, LR; Maturo, P; Montesani, L; Zhang, YP, 2009)
"The 8% strontium acetate, 1040 ppm fluoride dentifrice provided significant within-treatment reductions in dentin hypersensitivity for all measures at both time points (immediate and three-day brushing)."	5.14	A comparative clinical study investigating the efficacy of a dentifrice containing 8% strontium acetate and 1040 ppm fluoride in a silica base and a control dentifrice containing 1450 ppm fluoride in a silica base to provide immediate relief of dentin hyp ( Bannon, L; Holt, J; Hughes, N; Maggio, B; Mason, S; North, M; Sufi, F, 2010)
"The objective of this clinical study was to evaluate and compare the efficacy in reducing dentin hypersensitivity of an 8% strontium acetate, 1040 ppm sodium fluoride dentifrice to a marketed control 8% arginine, calcium carbonate, 1450 ppm sodium monofluorophosphate dentifrice after twice-daily brushing for two, four, and eight weeks."	5.14	A comparative clinical study investigating the efficacy of a test dentifrice containing 8% strontium acetate and 1040 ppm sodium fluoride versus a marketed control dentifrice containing 8% arginine, calcium carbonate, and 1450 ppm sodium monofluorophospha ( Browne, M; Hughes, N; Jeffery, P; Mason, S; O'Shea, C; Tobin, M; Welton, H, 2010)
"To determine the efficacy of an in-office desensitizing paste containing 8% arginine and calcium carbonate relative to that of a commercially-available pumice prophylaxis paste in reducing dentin hypersensitivity instantly after a single application following a dental scaling procedure and to establish the duration of sensitivity relief over a period of 4 weeks and 12 weeks."	5.14	Clinical evaluation of the efficacy of an in-office desensitizing paste containing 8% arginine and calcium carbonate in providing instant and lasting relief of dentin hypersensitivity. ( Cummins, D; Delgado, E; DeVizio, W; Mateo, LR; Schiff, T; Zhang, YP, 2009)
"The combination of Nd:YAG laser and 5% sodium fluoride varnish seems to show an impressive efficacy, when compared to either treatment alone, in treating dentin hypersensitivity."	5.11	Short-term assessment of the Nd:YAG laser with and without sodium fluoride varnish in the treatment of dentin hypersensitivity--a clinical and scanning electron microscopy study. ( Kumar, NG; Mehta, DS, 2005)
"To describe the development of a new dentin hypersensitivity treatment, Colgate Sensitive Maximum Strength dentifrice, containing 5% potassium nitrate as the anti-hypersensitivity active agent."	5.11	The scientific rationale and development of an optimized dentifrice for the treatment of dentin hypersensitivity. ( Blackwell, BL; Bonta, Y; Campbell, S; Darcy-Siegel, J; Fisher, SW; Miller, SE; Tavss, EA; Volpe, AR, 2004)
" The aim of this study was to study the effect of sodium fluoride varnish, Gluma, and Er,Cr:YSGG laser, in the dentin hypersensitivity treatment."	4.12	Effect of sodium fluoride varnish, Gluma, and Er,Cr:YSGG laser in dentin hypersensitivity treatment: a 6-month clinical trial. ( Farhadian, M; Farmany, A; Fekrazad, R; Forouzande, M; Ganje-Khosravi, M; Rezaei-Soufi, L; Yarmohammadi, E, 2022)
"To evaluate the effectiveness in reducing dentin hypersensitivity (DH) of a commercial toothpaste containing 8% arginine, calcium carbonate and fluoride when applied by a dental professional immediately prior to a professional dental prophylaxis and again after subjects brushed twice daily with the toothpaste at home for 2 weeks, and additionally to assess whether the % reductions in DH observed in the study are comparable to those found in previously published pivotal studies."	3.88	Use of a toothpaste containing 8% arginine and calcium carbonate for immediate and lasting relief of dentin hypersensitivity: A simple and effective in-office procedure. ( Ayad, F; Ayad, N; Cummins, D; Mateo, LR; Vazquez, J; Zhang, YP, 2018)
"A review of the literature on treatment of dentin hypersensitivity by use of fluorides and fluoride iontophoresis was presented."	3.66	Practical considerations in iontophoresis of fluoride for desensitizing dentin. ( Gangarosa, LP; Park, NH, 1978)
"Dentin hypersensitivity is common amongst older adults and negatively affects their quality of life."	3.30	Treating hypersensitivity in older adults with silver diamine fluoride: A randomised clinical trial. ( Chan, AKY; Chu, CH; Jiang, CM; Leung, KCM; Lo, ECM; Tsang, YC, 2023)
"Dentin hypersensitivity is one of the most commonly encountered clinical problems."	3.01	Comparative evaluation of fluorinol and calcium sodium phosphosilicate-containing toothpastes in the treatment of dentin hypersensitivity. ( Bhowmik, E; Pawar Chandrashekhar, D; Sharma Hareesha, M, 2021)
"They were examined for dentin hypersensitivity."	2.94	Effectiveness of Toothpaste Containing REFIX Technology against Dentin Hypersensitivity: A Randomized Clinical Study. ( Alonso, RC; D'Alpino, PH; Guiraldo, RD; Paloco, EA; Polassi, MR; Vilhena, FV, 2020)
"To examine dentin hypersensitivity (DH) at multiple time points over a 14-day period in participants who brushed twice daily with a 0."	2.87	An Exploratory Clinical Study to Monitor Clinical Efficacy of an Occluding Technology Dentifrice in Providing Short Term Relief from Dentinal Hypersensitivity. ( Krause, C; Lunau, N; Sufi, F, 2018)
"Tactile and Air-Blast dentine hypersensitivity measurements were performed at baseline, two, four, and eight weeks."	2.78	Efficacy in reducing dentine hypersensitivity of a regimen using a toothpaste containing 8% arginine and calcium carbonate, a mouthwash containing 0.8% arginine, pyrophosphate and PVM/MA copolymer and a toothbrush compared to potassium and negative contro ( De Vizio, W; Elias Boneta, AR; Mateo, LR; Naboa, J; Panagokos, F; Ramirez, K; Stewart, B, 2013)
"Dentin sensitivity was assessed at baseline and during treatment by Yeaple probe (tactile pressure; patient-reported discomfort by visual analogue scale [VAS]), as well as response to air blasts (VAS)."	2.78	Randomized trial of the clinical efficacy of a potassium oxalate-containing mouthrinse in rapid relief of dentin sensitivity. ( Amini, P; McGuire, JA; Sharma, D, 2013)
"Dentine sensitivity was assessed at baseline and after 2 and 4 weeks by Yeaple probe (tactile pressure; patient-reported discomfort by visual analogue scale [VAS]), air blast (VAS) and global subjective sensitivity (VAS)."	2.78	Randomised clinical efficacy trial of potassium oxalate mouthrinse in relieving dentinal sensitivity. ( Amini, P; Gallob, JT; McGuire, JA; Sharma, D, 2013)
"Dentine hypersensitivity was assessed by tactile stimulus (Yeaple Probe(®) ) and by air blast (Schiff scale) at baseline, immediately after and 28 days after a prophylaxis procedure."	2.78	Effectiveness of a calcium sodium phosphosilicate-containing prophylaxis paste in reducing dentine hypersensitivity immediately and 4 weeks after a single application: a double-blind randomized controlled trial. ( Clark, CE; Milleman, JL; Milleman, KR; Mongiello, KA; Neuhaus, KW; Proskin, HM; Seemann, R; Simonton, TC, 2013)
"Tooth sensitivity was measured in three ways; evaporative (Schiff score; Visual Analogue Scale) and tactile stimuli (Yeaple probe), prior to and immediately after subjects' self application of a single pea sized dose of toothpaste, and following subsequent twice daily brushing for three days with the paste."	2.78	A 3-day randomised clinical study investigating the efficacy of two toothpastes, designed to occlude dentine tubules, for the treatment of dentine hypersensitivity. ( Claydon, N; Hughes, N; Maggio, B; Mason, S; Newcombe, RG; Sufi, F; West, N, 2013)
"Tactile and air-blast dentine hypersensitivity assessments were conducted at baseline, thirty minutes post rinsing and two, four, and six weeks of twice-daily product use."	2.78	Efficacy of a mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride compared to a commercial mouthwash containing 2.4% potassium nitrate and 0.022% sodium fluoride and a control mouthwash containing 0.05% sodium f ( Arvanitidou, LS; DeVizio, W; Elías Boneta, AR; Galán Salás, RM; Mateo, LR; Mello, S; Panagakos, F; Stewart, B, 2013)
"Additionally, the dentin hypersensitivity reductions achieved by twice-daily brushing with Sensodyne Rapid Relief are significantly improved by switching to twice-daily brushing with Colgate Sensitive Pro-Relief (elmex Sensitive Professional) for two and eight weeks."	2.76	Clinical efficacy in reducing dentin hypersensitivity of a dentifrice containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride compared to a dentifrice containing 8% strontium acetate and 1040 ppm fluoride under consumer usage conditions before ( Cummins, D; Delgado, E; DeVizio, W; Mateo, LR; Schiff, T; Zhang, YP, 2011)
"To evaluate the 8-week dentin hypersensitivity efficacy of three toothpastes: (1) a dentifrice containing 0."	2.76	Assessment of hypersensitivity reduction of a dentifrice containing 0.3% triclosan, 2.0% PVM/MA copolymer, 0.243% NaF and specially-designed silica as compared to a dentifrice containing 0.454% stannous fluoride, sodium hexametaphosphate and zinc lactate ( Chaknis, P; DeVizio, W; Panagakos, FS; Petrone, D; Proskin, H; Sowinski, J, 2011)
"Shellac F reduced dentin hypersensitivity and did not differ from the two desensitizing agents used as controls."	2.74	Clinical efficiency of a natural resin fluoride varnish (Shellac F) in reducing dentin hypersensitivity. ( About, I; Camps, J; Hoang-Dao, BT; Hoang-Tu, H; Koubi, G; Tran-Thi, NN, 2009)
"Patients recorded their tooth sensitivity on a 0-to-4 scale."	2.74	Assessing the effect of a desensitizing agent used before in-office tooth bleaching. ( Kose, C; Loguercio, AD; Reis, A; Tay, LY, 2009)
"48 patients with dentine sensitivity were recruited."	2.72	Comparison of two topical treatments for dentine sensitivity. ( HeftitArthur, F; Merika, K; Preshaw, PM, 2006)
"Prior to desensitizing treatment, dentine hypersensitivity was assessed by a thermal stimulus and patients' response to the examination was considered to be a control."	2.71	Clinical evaluation of low-level laser therapy and fluoride varnish for treating cervical dentinal hypersensitivity. ( Catirse, AB; Corona, SA; Dinelli, W; Lizarelli, RF; Nascimento, TN; Palma-Dibb, RG, 2003)
" A comparable number of teeth required repeat dosage in both groups."	2.71	2% sodium fluoride-iontophoresis compared to a commercially available desensitizing agent. ( Gupta, R; Pandit, N; Singal, P, 2005)
"With respect to tolerability, tooth sensitivity and oral irritation were the most common findings."	2.70	Comparative efficacy and tolerability of two direct-to-consumer tooth whitening systems. ( Barker, ML; Gerlach, RW; Sagel, PA, 2001)
"Potassium nitrate has been used previously in a dentifrice or gel to alleviate dentinal hypersensitivity."	2.70	Efficacy of a 3% potassium nitrate desensitizing mouthwash in the treatment of dentinal hypersensitivity. ( Chava, VK; Pereira, R, 2001)
"If tooth sensitivity was experienced, the patient applied a gel containing 5% potassium nitrate and 1,000 ppm sodium fluoride in the bleaching tray for various time periods."	2.70	Tray delivery of potassium nitrate-fluoride to reduce bleaching sensitivity. ( Caughman, WF; Frazier, KB; Haywood, VB; Myers, ML, 2001)
"Home-use studies on dentine hypersensitivity have most commonly involved toothpastes and rarely have mouthrinses been employed."	2.69	The effects of a potassium citrate, cetylpyridinium chloride, sodium fluoride mouthrinse on dentine hypersensitivity, plaque and gingivitis. A placebo-controlled study. ( Addy, M; Marlow, I; West, N; Yates, R, 1998)
"Statistical analysis of dentine sensitivity was performed as a univariate study, in relation to the main factors: age, gender, and primary sensitivity or postsurgical etiology."	2.69	Intraoral fluoride releasing device: a new clinical therapy for dentine sensitivity. ( Checchi, L; Marini, I; Spiazzi, L; Vecchiet, F, 2000)
"Dentine hypersensitivity was assessed with tactile and cold air stimuli together with an overall subjective assessment."	2.68	Dentine hypersensitivity and the placebo response. A comparison of the effect of strontium acetate, potassium nitrate and fluoride toothpastes. ( Addy, M; Jackson, RJ; Ridge, DB; West, NX, 1997)
"Patients were excluded if the dentin hypersensitivity could have been caused by cervical abrasion/erosion lesions deeper than 1 mm, cracked-tooth syndrome, caries lesions, operative caries treatment, and/or periodontal surgery or root scaling within the last 6 months."	2.67	Dentin hypersensitivity treated with a fluoride-containing varnish or a light-cured glass-ionomer liner. ( Hansen, EK, 1992)
"Three studies on dental caries, eight studies on dental erosion and 11 on dentin hypersensitivity were included."	2.66	Stabilized stannous fluoride dentifrice in relation to dental caries, dental erosion and dentin hypersensitivity: A systematic review. ( Emilson, CG; Johannsen, A; Johannsen, G; Konradsson, K; Lingström, P; Ramberg, P, 2020)
"RCT of treating dentine hypersensitivity with stannous fluoride-containing toothpaste were included."	2.53	[Desensitizing effect of stannous fluoride-containing toothpaste for patients with dentine hypersensitivity: a Meta-analysis]. ( Chen, K; Wang, F; Yang, Q; Yang, S; Ying, K; Zhou, L, 2016)
"Tooth sensitivity is a common, painful dental condition."	2.49	A new treatment alternative for sensitive teeth: a desensitizing oral rinse. ( Markowitz, K, 2013)
"Dentin hypersensitivity is a painful response to external stimuli applied to exposed dentinal tubules."	1.72	Desensitizing toothpastes for dentin sealing and tertiary dentin formation in vitro and in vivo: a comparative analysis. ( Gug, H; Hwang, G; Lee, J; Lee, JH; Park, JC; Park, SJ, 2022)
"To reduce dentin hypersensitivity after these procedures the SENSODYNE Rapid Relief toothpaste was applied."	1.56	[Ways of solving the problem of dentin hypersensitivity in children after professional oral hygiene]. ( Kiselnikova, LP; Romanovskaya, VN, 2020)
"Dentine hypersensitivity can impact functional status and everyday activities such as eating and talking."	1.51	Impact of toothpaste on oral health-related quality of life in people with dentine hypersensitivity. ( Burnett, GR; Maclure, R; Mason, S; Patel, N; Patil, A, 2019)
"Dentin hypersensitivity is treated using materials that occlude the dentinal tubules or release potassium ions that induce nerve desensitization."	1.42	The synthesis and characterization of a novel potassium chloride-fluoridated hydroxyapatite varnish for treating dentin hypersensitivity. ( Hirata, I; Lochaiwatana, Y; Okazaki, M; Poolthong, S; Swasdison, S; Vongsavan, N, 2015)

Research

Studies (196)

Authors

Clinical Trials (20)

Trial Overview

Trial Outcomes

Percent Change in Mean Score of Pain Response From Baseline on Schiff Cold Air Sensitivity Scale Using Air Blast Stimulus

Timeframe	Studies, this research(%)	All Research%
pre-1990	25 (12.76)	18.7374
1990's	34 (17.35)	18.2507
2000's	50 (25.51)	29.6817
2010's	63 (32.14)	24.3611
2020's	24 (12.24)	2.80

Authors	Studies
Arshad, S	1
Zaidi, SJA	1
Farooqui, WA	1
Martins, CC	2
Riva, JJ	2
Firmino, RT	2
Schünemann, HJ	2
Rahman, B	1
El-Damanhoury, HM	1
Sheela, S	1
Ngo, HC	1
Forouzande, M	1
Rezaei-Soufi, L	1
Yarmohammadi, E	1
Ganje-Khosravi, M	1
Fekrazad, R	1
Farhadian, M	1
Farmany, A	1
Lee, J	1
Hwang, G	1
Gug, H	1
Lee, JH	1
Park, SJ	1
Park, JC	1
da Silva, A	3
Deschamps Muniz, RP	3
Almeida Lago, MC	3
da Silva Júnior, EP	3
Braz, R	3
Ramos, FS	1
Delbem, AC	1
Dos Santos, PH	1
Moda, MD	1
Briso, AL	1
Fagundes, TC	1
Jang, JH	1
Oh, S	1
Kim, HJ	1
Kim, DS	1
Chan, AKY	1
Tsang, YC	1
Jiang, CM	1
Leung, KCM	1
Lo, ECM	1
Chu, CH	2
Mason, S	9
Burnett, GR	3
Patel, N	1
Patil, A	1
Maclure, R	3
Elovikova, TM	1
Ermishina, EY	1
Uvarova, LV	1
Koshcheev, AS	1
Krikheli, NI	1
Pustovoit, EV	1
Suvkova, EI	1
Ge, L	1
Carrasco-Labra, A	1
Brignardello-Petersen, R	1
Colunga-Lozano, LE	1
Granville-Garcia, AF	1
Costa, FO	1
Yepes-Nuñez, JJ	1
Zhang, Y	2
Konradsson, K	1
Lingström, P	1
Emilson, CG	1
Johannsen, G	1
Ramberg, P	1
Johannsen, A	1
Xia, Y	1
Yang, ZY	1
Li, YH	1
Zhou, Z	1
Anderson, CJ	2
Kugel, G	2
Zou, Y	2
Ferrari, M	1
Gerlach, R	2
Tao, D	1
Ling, MR	1
Feng, XP	1
Gallob, J	4
Souverain, A	1
Yang, W	1
Alavi, A	1
Kiselnikova, LP	1
Romanovskaya, VN	1
Hu, ML	1
Zheng, G	1
Jiang, RD	1
Han, JM	1
Zhang, YD	1
Lin, H	1
Seong, J	5
Newcombe, RG	4
Matheson, JR	1
Weddell, L	1
Edwards, M	1
West, NX	4
Ding, PH	1
Dai, A	1
Hu, HJ	1
Huang, JP	1
Liu, JM	1
Chen, LL	1
Vilhena, FV	1
Polassi, MR	1
Paloco, EA	1
Alonso, RC	1
Guiraldo, RD	1
D'Alpino, PH	1
Foskett, HL	1
Davies, M	3
Creeth, JE	1
Bhowmik, E	1
Pawar Chandrashekhar, D	1
Sharma Hareesha, M	1
Abuzinadah, SH	1
Alhaddad, AJ	1
Gümüştaş, B	1
Dikmen, B	1
Zang, P	2
Parkinson, C	1
Hall, C	4
Wang, N	2
Jiang, H	1
Zhang, J	1
Du, M	1
Shaw, D	1
Young, S	2
Sufi, F	10
Siddiqi, M	3
Holt, J	3
Amini, P	4
Parkinson, CR	1
Lippert, F	1
Hara, AT	2
Zero, DT	1
Constantin, P	1
Maran, BM	1
Vochikovski, L	1
de Andrade Hortkoff, DR	1
Stanislawczuk, R	1
Loguercio, AD	3
Reis, A	3
Hiller, KA	1
Buchalla, W	1
Grillmeier, I	1
Neubauer, C	1
Schmalz, G	1
Sivaramakrishnan, G	1
Sridharan, K	1
Lynch, MC	1
Perfekt, R	1
McGuire, JA	3
Milleman, J	1
Milleman, K	1
Krause, C	1
Lunau, N	1
Ayad, F	5
Ayad, N	3
Vazquez, J	1
Zhang, YP	17
Mateo, LR	14
Cummins, D	8
Morrison, J	1
Whitworth, D	1
Hughes, AJ	1
Nehme, M	1
Sanyal, S	1
Brotherhood, AJ	1
Hall, PJ	1
Kumar, S	1
Thomas, BS	1
Gupta, K	1
Guddattu, V	1
Alexander, M	1
Milleman, JL	2
Milleman, KR	2
Bahal, P	1
He, T	6
Chapman, N	2
West, N	4
Creeth, J	3
Qaqish, J	2
Gomez-Pereira, P	2
Budhawant, C	2
Goyal, C	1
João-Souza, SH	1
Scaramucci, T	1
Bühler Borges, A	1
Lussi, A	1
Saads Carvalho, T	1
Corrêa Aranha, AC	1
Neuhaus, KW	1
Mongiello, KA	1
Simonton, TC	1
Clark, CE	1
Proskin, HM	4
Seemann, R	1
Sharma, D	2
Gallob, JT	1
Lund, RG	1
Silva, AF	1
Piva, E	1
Da Rosa, WL	1
Heckmann, SS	1
Demarco, FF	2
Femiano, F	1
Femiano, R	1
Lanza, A	1
Festa, MV	1
Rullo, R	1
Perillo, L	1
Barker, ML	2
Biesbrock, AR	2
Miner, M	1
Sharma, N	2
Lochaiwatana, Y	1
Poolthong, S	1
Hirata, I	1
Okazaki, M	1
Swasdison, S	1
Vongsavan, N	1
Antoniazzi, RP	1
Machado, ME	1
Grellmann, AP	1
Santos, RC	1
Zanatta, FB	1
Sehmi, H	1
Olley, RC	1
Yang, S	1
Ying, K	1
Wang, F	1
Chen, K	1
Zhou, L	1
Yang, Q	1
Molina, A	1
García-Gargallo, M	1
Montero, E	1
Tobías, A	1
Sanz, M	1
Martín, C	1
Cooke, J	1
Chadwick, RG	1
Mason, AG	1
Ipci, SD	1
Cakar, G	1
Kuru, B	1
Yilmaz, S	1
Hughes, N	5
Parmar, M	1
González-Cabezas, C	1
Jones, JA	1
Schiff, T	5
Delgado, E	7
DeVizio, W	18
Garcia-Godoy, F	2
Garcia-Godoy, A	1
Garcia-Godoy, C	1
Docimo, R	3
Montesani, L	3
Maturo, P	3
Costacurta, M	2
Bartolino, M	3
Dibart, S	4
Hoang-Dao, BT	2
Hoang-Tu, H	2
Tran-Thi, NN	1
Koubi, G	2
Camps, J	3
About, I	3
Kara, C	1
Orbak, R	1
Lo, E	1
Tay, LY	1
Kose, C	1
Nathoo, S	2
Day, T	1
Einwag, J	1
Hermann, JS	1
Anastasia, MK	1
Barker, M	1
Ghassemi, A	1
Hooper, W	1
Winston, AE	1
Sowinski, J	3
Bowman, J	1
Orsini, G	1
Procaccini, M	1
Manzoli, L	1
Giuliodori, F	1
Lorenzini, A	1
Putignano, A	1
Bannon, L	1
Maggio, B	2
North, M	1
Jeffery, P	1
Welton, H	1
Tobin, M	1
O'Shea, C	1
Browne, M	1
Layer, T	1
Quock, RL	1
Warren-Morris, DP	1
RIEKE, HW	1
Ni, LX	1
Chang, A	2
Sun, L	2
Yilmaz, HG	1
Kurtulmus-Yilmaz, S	1
Cengiz, E	1
Cheng, R	1
Jackson, R	1
Philip, J	1
Cox, D	1
Zaidel, L	1
Patel, R	1
Mello, S	3
Heu, R	2
Stranick, M	2
Chopra, S	1
Prencipe, M	1
Chaknis, P	5
Panagakos, FS	1
Petrone, D	1
Proskin, H	1
Zhuang, WJ	1
Cao, D	1
Macdonald, E	1
Jones, SB	1
Johnson, S	1
Li, Y	1
Lee, S	1
Perugia, C	1
Kakar, A	1
Kakar, K	1
Sreenivasan, PK	1
Kohli, R	1
Markowitz, K	1
Claydon, N	1
Pradeep, AR	1
Agarwal, E	1
Naik, SB	1
Bajaj, P	1
Kalra, N	1
Hu, D	1
Stewart, B	4
Arvanitidou, L	1
Panagakos, F	2
De Vizio, W	4
Yin, W	1
Elías Boneta, AR	2
Galán Salás, RM	1
Arvanitidou, LS	1
Ramirez, K	1
Naboa, J	1
Panagokos, F	1
Heymann, HO	1
Van Meerbeek, B	1
Franquin, JC	1
Kolker, JL	1
Vargas, MA	1
Armstrong, SR	1
Dawson, DV	1
Corona, SA	1
Nascimento, TN	1
Catirse, AB	1
Lizarelli, RF	1
Dinelli, W	1
Palma-Dibb, RG	1
Tavss, EA	1
Fisher, SW	1
Campbell, S	1
Bonta, Y	1
Darcy-Siegel, J	1
Blackwell, BL	1
Volpe, AR	6
Miller, SE	1
Browning, WD	2
Chan, DC	1
Frazier, KB	3
Callan, RS	1
Blalock, JS	2
Paes Leme, AF	1
dos Santos, JC	1
Giannini, M	1
Wada, RS	1
Pamir, T	1
Ozyazici, M	1
Baloğlu, E	1
Onal, B	1
Singal, P	1
Gupta, R	1
Pandit, N	1
Kumar, NG	1
Mehta, DS	1
Terry, DA	1
Hsu, PJ	1
Chen, JH	1
Chuang, FH	1
Roan, RT	1
Merika, K	1
HeftitArthur, F	1
Preshaw, PM	1
Hoexter, DL	1
Ritter, AV	1
de L Dias, W	1
Miguez, P	1
Caplan, DJ	1
Swift, EJ	1
Saletta, L	1
Baker, RA	1
Winston, JL	1
Downey, MC	1
Myers, ML	2
Fiocchi, MF	1
Moretti, AJ	1
Powers, JM	1
Rives, T	1
Tran-Hung, L	1
Armênio, RV	1
Fitarelli, F	1
Armênio, MF	1
Lutins, ND	1
Greco, GW	1
McFall, WT	2
Collins, JF	1
Perkins, L	1
Carlo, GT	1
Ciancio, SG	1
Seyrek, SK	1
Jadin, P	1
Vreven, J	1
Patterson, CW	1
Suge, T	2
Ishikawa, K	2
Kawasaki, A	2
Yoshiyama, M	1
Asaoka, K	1
Ebisu, S	2
Czukor, J	1
Knight, NN	1
Lie, T	1
Clark, SM	1
Adams, DF	1
Bolden, TE	1
Miller, S	1
Gaffar, A	4
Sullivan, R	1
Truong, T	1
Dotson, M	1
Cohen, S	1
McCool, J	2
Volpe, A	2
Berta, R	1
Petrone, ME	5
Silverman, G	2
Berman, E	1
Hanna, CB	1
Salvato, A	1
Fratarcangelo, P	1
Bartizek, RD	1
Bollmer, BW	1
Campbell, SL	1
Lanzalaco, AC	1
Mackay, BJ	1
McClanahan, SF	1
Perlich, MA	1
Shaffer, JB	1
Zapletalová, Z	1
Gillam, DG	3
Bulman, JS	2
Jackson, RJ	2
Newman, HN	3
Addy, M	2
Ridge, DB	1
Arends, J	1
Duschner, H	1
Ruben, JL	1
Afflitto, J	1
Nabi, N	1
Plagmann, HC	1
König, J	1
Bernimoulin, JP	1
Rudhart, AC	1
Deschner, J	1
Kielbassa, AM	1
Attin, T	1
Hellwig, E	1
Schade-Brittinger, C	1
Evans, L	1
Reddy, VV	1
Mathew, G	1
Yates, R	1
Marlow, I	1
Suzuki, K	1
Matsuo, T	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
"Immediate And Sustained Treatment Response Of Commercially Available BioMin F, Colgate Sensitive Pro-Relief And Sensodyne Rapid Action Dentifrices In Dentin Hypersensitivity - A Randomized Clinical Trial"[NCT04249336]	Phase 3	140 participants (Actual)	Interventional	2019-09-27	Completed
Study to Investigate the Impact on Oral Health Related Quality of Life of Managing Dentine Hypersensitivity With a Daily Use Anti-Sensitivity Toothpaste[NCT02752958]		75 participants (Actual)	Interventional	2016-05-23	Completed
The Effects of Different Dentin Hypersensitivity Treatment Methods on Quality of Life[NCT04887181]		69 participants (Actual)	Interventional	2020-03-04	Completed
A Randomized, 8 Week Clinical Study to Evaluate the Efficacy of an Experimental Stannous Fluoride Dentifrice in the Relief of Dentinal Hypersensitivity[NCT03310268]		185 participants (Actual)	Interventional	2017-11-18	Completed
A Medical Device Study to Measure the Efficacy of a Toothpaste Containing Calcium-silicate/Phosphate on Dentinal Hypersensitivity Compared to a Control Toothpaste Containing Fluoride.[NCT03244618]		272 participants (Actual)	Interventional	2017-06-19	Completed
A Prospective, Randomized, Proof-of-Concept Study Comparing the Efficacy of Sensi-IP Toothpaste With a Sodium Fluoride Toothpaste in the Treatment of Dentinal Hypersensitivity[NCT06166745]		46 participants (Anticipated)	Interventional	2023-11-06	Recruiting
Comparison of Dentin Hypersensitivity Reduction Over a 1-month Period Between a Single Topical Application of a Dentin-desensitizing Agent (Gluma) and Other Materials: A Randomized Clinical Trial[NCT04351412]		55 participants (Actual)	Interventional	2020-01-10	Completed
Comparison of Clinical Efficacy of a Miswak Extract-Containing Toothpaste to a Dentifrice Containing Potassium Nitrate and to a Placebo on Dentinal Hypersensitivity: A Randomized Clinical Trial[NCT04179994]		96 participants (Anticipated)	Interventional	2020-01-01	Not yet recruiting
Impact of the Daily Use of Hydroxyapatite-toothpaste on the Occurrence of Enamel Caries in the Primary Dentition (ECIPDEN17)[NCT03553966]		200 participants (Actual)	Interventional	2018-03-01	Completed
A Clinical Study Investigating the Efficacy of a Mouthwash in Providing Long Term Relief From Dentinal Hypersensitivity[NCT02226562]	Phase 2	191 participants (Actual)	Interventional	2014-09-02	Completed
A Clinical Study Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity[NCT02731833]	Phase 4	229 participants (Actual)	Interventional	2016-04-01	Completed
A Clinical Study Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity[NCT02923895]	Phase 4	197 participants (Actual)	Interventional	2016-10-11	Completed
A Clinical Study Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity[NCT02832375]	Phase 3	242 participants (Actual)	Interventional	2016-03-01	Completed
Assessment of a Potassium Oxalate-Containing Formulation for the Relief of Dentinal Hypersensitivity[NCT01345292]		226 participants (Actual)	Interventional	2011-04-30	Completed
Evaluation of the Effectiveness of Dentin Hypersensitivity Treatment Using Glass Ionomer Cements: A Randomized Clinical Trial[NCT02378129]	Phase 2/Phase 3	20 participants (Actual)	Interventional	2014-04-02	Completed
A Randomised Controlled Trial to Measure Effectiveness of Sodium Fluoride Varnish to Prevent Dental Caries in School Children Between Age of 6 and 7 Years[NCT02877888]	Phase 1/Phase 2	320 participants (Actual)	Interventional	2016-08-31	Completed
Clinical Efficacy in Relieving Dentin Hypersensitivity of Nanohydroxyapatite-Containing Toothpastes and Cream[NCT02918617]	Phase 2	203 participants (Actual)	Interventional	2015-05-31	Completed
Comparing Three Caries Prevention Products on Dentinal Hypersensitivity - A Pilot Study[NCT02136576]		39 participants (Actual)	Interventional	2014-05-31	Completed
Noncarious Cervical Lesion Treatment Outcomes: Randomized Clinical Trial[NCT00867997]	Phase 3	304 participants (Actual)	Interventional	2009-03-31	Completed
Efficacy of Seventh Generation Bonding Agents as Short-Term Desensitizers Among Patients With Hypersensitivity A Randomized Clinical Trial[NCT04225247]	Phase 3	105 participants (Actual)	Interventional	2018-03-07	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"SCHIFF cold air sensitivity scale was used to measure the intensity of pain due to dentin hypersensitivity using air blast stimulus. Patients' response of pain was assessed by the doctor according to following score range from; 0(no response of pain), 1 (pain response but no request of discontinuity of stimulus), 2(pain response with request of discontinuity of stimulus), 3(Immediate pain response for discontinuity of stimulus). Percent change in mean scores = ( one minute score-Baseline score) / Baseline score" (NCT04249336)
Timeframe: (Base line to 1 minute) (Base line to 5 minutes)(Base line to day 3)(Base line to week 4)

Percent Change in Mean Scores of Pain Response From Baseline on Visual Analog Scale Using Mechanical Stimulus

Intervention	percentage of change in mean scores (Mean)
	1- minute	5-minutes	Day-3	Week-4
BioMin F	18	27	22	58
Colgate Sensitive Pro Relief	45	56	24	55
Colgate Total	15	19	10	22
Sensodyne Rapid Action	37	51	25	45

Visual Analogue Scale was used to measure the intensity of pain due to dentin hypersensitivity using mechanical stimulus. Patient's response of pain was assessed on vertical line of 0 to 10cm by asking him to move finger on the line and stop it where he felt pain. Score range from; 0 (no pain at 0cm), 1(mild pain at 1cm), 2(mild pain at 2cm), 3(mild pain at 3cm), 4(moderate pain at 4cm), 5(moderate pain at 5cm), 6(moderate pain at 6cm), 7(severe pain at 7cm), 8(severe pain at 8cm), 9(severe pain at 9cm),10(worst imaginable pain at 10cm). Percent change in mean scores = (one minute score-Baseline score) / Baseline score (NCT04249336)
Timeframe: (Base line to 1 minute) (Base line to 5 minutes)(Base line to day 3)(Base line to week 4)

Percent Change in Mean Scores of Pain Response From Baseline on Visual Analog Scale Using Water Jet Stimulus

Intervention	percentage of change in mean scores (Mean)
	1-minute	5-minutes	Day-3	Week-4
BioMin F	25	27	28	59
Colgate Sensitive Pro Relief	56	61	38	66
Colgate Total	16	20	18	27
Sensodyne Rapid Action	46	51	32	57

Visual Analogue Scale was used to measure the intensity of pain due to dentin hypersensitivity using Water Jet Stimulus. Patient's response of pain was assessed on vertical line of 0 to 10cm by asking him to move finger on the line and stop it where he felt pain. Score range from; 0 (no pain at 0cm), 1(mild pain at 1cm), 2(mild pain at 2cm), 3(mild pain at 3cm), 4(moderate pain at 4cm), 5(moderate pain at 5cm), 6(moderate pain at 6cm), 7(severe pain at 7cm), 8(severe pain at 8cm), 9(severe pain at 9cm),10(worst imaginable pain at 10cm). Percent change in mean scores = (one minute score-Baseline score) / Baseline score (NCT04249336)
Timeframe: (Base line to 1 minute) (Base line to 5 minutes)(Base line to day 3)(Base line to week 4)

Change From Baseline in Mean DHEQ Score of Domain - Adaptation (12 Item Total From Section 2 Questions 5 to 16) at Week 12

Intervention	percentage of change in mean scores (Mean)
	1-minute	5-minutes	Day-3	Week-4
BioMin F	22	27	30	67
Colgate Sensitive Pro Relief	52	56	34	57
Colgate Total	18	21	18	29
Sensodyne Rapid Action	46	52	32	55

All participants scored first 4 questions present in Domain Adaptation of section 2 of the DHEQ using a 7-point scale, where 7= Strongly agree, 6=Agree, 5= Agree a little, 4= neither agree or disagree, 3= disagree a little, 2= disagree, and 1= strongly disagree. Adaptation domain consisted of following questions Q5: I have to change the way I eat or drink certain things, Q6: I have to be careful how I breathe on a cold day, Q7: I have leave some cold foods/drinks to warm up before having them, Q8: I have to cool some foods/drinks down before I can have them, Q9: I have to cut up some fruits before eating, Q10: I have to wear scarf over my mouth on cold days, Q11: I have avoided very cold drinks/foods, Q12: I have avoided very hot drinks/foods, Q13: when eating some foods I have made sure they don't touch certain teeth, Q14: I have changed the way I brush, Q15: I bite some foods in small pieces, and Q16: there are other foods I have avoided. (NCT02752958)
Timeframe: At Baseline and Week 12

Change From Baseline in Mean DHEQ Score of Domain - Adaptation (12 Item Total From Section 2 Questions 5 to 16) at Week 16

Intervention	Score on a scale (Mean)
	At Baseline	At Week 12	Change from Baseline at Week 12
Stannous Fluoride	53.12	45.04	-8.27

Change From Baseline in Mean DHEQ Score of Domain - Adaptation (12 Item Total From Section 2 Questions 5 to 16) at Week 20

Intervention	Score on a Scale (Mean)
	At Baseline	At Week 16	Change from Baseline at Week 16
Stannous Fluoride	53.12	42.59	-10.45

Change From Baseline in Mean DHEQ Score of Domain - Adaptation (12 Item Total From Section 2 Questions 5 to 16) at Week 24

Intervention	Score ona scale (Mean)
	At Baseline	At Week 20	Change from Baseline at Week 20
Stannous Fluoride	53.12	41.89	-11.48

Change From Baseline in Mean DHEQ Score of Domain - Adaptation (12 Item Total From Section 2 Questions 5 to 16) at Week 4

Intervention	Score on a scale (Mean)
	At Baseline	At Week 24	Change from Baseline at Week 24
Stannous Fluoride	53.12	41.67	-11.71

Change From Baseline in Mean DHEQ Score of Domain - Adaptation (12 Item Total From Section 2 Questions 5 to 16) at Week 8

Intervention	Score on a scale (Mean)
	At Baseline	At Week 4	Change from Baseline at Week 4
Stannous Fluoride	53.12	51.42	-1.46

Change From Baseline in Mean DHEQ Score of Domain - Effect on Life Overall (4 Item Total From Section 2 Questions 36 to 39) at Week 12

Intervention	Score on a scale (Mean)
	At Baseline	At Week 8	Change from Baseline at Week 8
Stannous Fluoride	53.12	46.43	-6.80

: All participants scored first 4 questions present in Domain Effect on Life Overall of section 2 of the DHEQ using a 5-point scale, 4= Very Much, 3= Quite a bit, 2= somewhat, and 1= a little, 0=not al all. Effect on Life Overall domain consisted of following questions Q36: Overall how much do the sensations in your teeth bother you? Q37: Overall, how much do the things you do to manage the sensations bother you? Q38: Overall, how much do the sensations in your teeth affect your quality of life? Q39: Overall, how much do the things you do to manage the sensations in your teeth affect your quality of life? (NCT02752958)
Timeframe: At Baseline and Week 12

Change From Baseline in Mean DHEQ Score of Domain - Effect on Life Overall (4 Item Total From Section 2 Questions 36 to 39) at Week 16

Intervention	Score on a scale (Mean)
	At Baseline	At Week 12	Change from Baseline at Week 12
Stannous Fluoride	6.56	4.70	-1.87

All participants scored first 4 questions present in Domain Effect on Life Overall of section 2 of the DHEQ using a 5-point scale, 4= Very Much, 3= Quite a bit, 2= somewhat, and 1= a little, 0=not al all. Effect on Life Overall domain consisted of following questions Q36: Overall how much do the sensations in your teeth bother you? Q37: Overall, how much do the things you do to manage the sensations bother you? Q38: Overall, how much do the sensations in your teeth affect your quality of life? Q39: Overall, how much do the things you do to manage the sensations in your teeth affect your quality of life? (NCT02752958)
Timeframe: At Baseline and Week 16

Change From Baseline in Mean DHEQ Score of Domain - Effect on Life Overall (4 Item Total From Section 2 Questions 36 to 39) at Week 20

Intervention	Score on a scale (Mean)
	At Baseline	At Week 16	Change from Baseline at Week 16
Stannous Fluoride	6.56	4.42	-2.12

Change From Baseline in Mean DHEQ Score of Domain - Effect on Life Overall (4 Item Total From Section 2 Questions 36 to 39) at Week 24

Intervention	Score on a scale (Mean)
	At Baseline	At Week 20	Change from Baseline at Week 20
Stannous Fluoride	6.56	4.29	-2.32

Change From Baseline in Mean DHEQ Score of Domain - Effect on Life Overall (4 Item Total From Section 2 Questions 36 to 39) at Week 4

Intervention	Score on a scale (Mean)
	At Baseline	At Week 24	Change from Baseline at Week 24
Stannous Fluoride	6.56	4.29	-2.32

Change From Baseline in Mean DHEQ Score of Domain - Effect on Life Overall (4 Item Total From Section 2 Questions 36 to 39) at Week 8

Intervention	Score on a scale (Mean)
	At Baseline	At Week 4	Change from Baseline at Week 4
Stannous Fluoride	6.56	5.88	-0.64

Change From Baseline in Mean DHEQ Score of Domain - Emotional Impact (8 Item Total From Section 2 Questions 22 to 29) at Week 12

Intervention	Score on a scale (Mean)
	At Baseline	At Week 8	Change from Baseline at Week 8
Stannous Fluoride	6.56	5.12	-1.43

All participants scored first 5 questions present in Domain Emotional Impact of section 2 of the DHEQ using a 7-point scale, where 7= Strongly agree, 6=Agree, 5= Agree a little, 4= neither agree or disagree, 3= disagree a little, 2= disagree, and 1= strongly disagree. Emotional Impact domain consisted of following questions Q22: I've been frustrated because I can't find anything that deals with the sensations I have in my teeth. Q23: I have been anxious that something I eat or drink might cause sensations in my teeth, Q24: The sensations in my teeth have been irritating, Q25: I have been annoyed with myself because I did something that I knew caused these sensation, Q26: I felt guilty because I might have contributed to the sensations I am having with my teeth, Q27: the sensations in my teeth have been annoying, Q28: The sensations in my teeth have been embarrassing, Q29: I have been anxious because of the sensations in my teeth. (NCT02752958)
Timeframe: At Baseline and Week 12

Change From Baseline in Mean DHEQ Score of Domain - Emotional Impact (8 Item Total From Section 2 Questions 22 to 29) at Week 16

Intervention	Score on a Scale (Mean)
	At Baseline	At Week 12	Change from Baseline at Week 12
Stannous Fluoride	35.48	28.79	-6.86

Change From Baseline in Mean DHEQ Score of Domain - Emotional Impact (8 Item Total From Section 2 Questions 22 to 29) at Week 20

Intervention	Score on a scale (Mean)
	At Baseline	At Week 16	Change from Baseline at Week 16
Stannous Fluoride	35.48	28.24	-7.33

Change From Baseline in Mean DHEQ Score of Domain - Emotional Impact (8 Item Total From Section 2 Questions 22 to 29) at Week 24

Intervention	Score on a scale (Mean)
	At Baseline	At week 20	Change from Baseline at Week 20
Stannous Fluoride	35.48	27.32	-8.17

Change From Baseline in Mean DHEQ Score of Domain - Emotional Impact (8 Item Total From Section 2 Questions 22 to 29) at Week 4

Intervention	Score on a scale (Mean)
	At Baseline	At Week 24	Change from Baseline at Week 24
Stannous Fluoride	35.48	27.03	-8.45

Change From Baseline in Mean DHEQ Score of Domain - Emotional Impact (8 Item Total From Section 2 Questions 22 to 29) at Week 8

Intervention	Score on a Scale (Mean)
	At Baseline	At Week 4	Change from Baseline at Week 4
Stannous Fluoride	35.48	32.64	-2.40

Change From Baseline in Mean DHEQ Score of Domain - Global Oral Health Rating (Response to Section 2 Question 35) at Week 12

Intervention	Score on a scale (Mean)
	At Baseline	At Week 8	Change from Baseline at Week 8
Stannous Fluoride	35.48	31.42	-4.30

All participants scored one question present in Domain Global oral health rating Global oral health rating of section 2 of the DHEQ using a 6-point scale, where, 6=Very poor, 5= poor, 4= Fair, 3= Good, 2=Very good, and 1= excellent. Global oral health rating domain consisted of following questionsQ35: overall how would you rate the health of your mouth, teeth and gums? (NCT02752958)
Timeframe: At Baseline and Week 12

Change From Baseline in Mean DHEQ Score of Domain - Global Oral Health Rating (Response to Section 2 Question 35) at Week 16

Intervention	Score on a scale (Mean)
	At Baseline	At Week 12	Change from Baseline at Week 12
Stannous Fluoride	3.38	3.27	-0.12

All participants scored one question present in Domain Global oral health rating of section 2 of the DHEQ using a 6-point scale, where, 6=Very poor, 5= poor, 4= Fair, 3= Good, 2=Very good, and 1= excellent. Global oral health rating domain consisted of following questionsQ35: overall how would you rate the health of your mouth, teeth and gums? (NCT02752958)
Timeframe: At Baseline and Week 16

Change From Baseline in Mean DHEQ Score of Domain - Global Oral Health Rating (Response to Section 2 Question 35) at Week 20

Intervention	Score on a scale (Mean)
	At Baseline	At Week 16	Change from Baseline at Week 16
Stannous Fluoride	3.38	3.24	-0.14

Change From Baseline in Mean DHEQ Score of Domain - Global Oral Health Rating (Response to Section 2 Question 35) at Week 24

Intervention	Score on a scale (Mean)
	At Baseline	At Week 20	Change from Baseline at Week 20
Stannous Fluoride	3.38	3.29	-0.11

Change From Baseline in Mean DHEQ Score of Domain - Global Oral Health Rating (Response to Section 2 Question 35) at Week 4

Intervention	Score on a scale (Mean)
	At Baseline	At Week 24	Change from Baseline at Week 24
Stannous Fluoride	3.38	3.24	-0.15

Change From Baseline in Mean DHEQ Score of Domain - Global Oral Health Rating (Response to Section 2 Question 35) at Week 8

Intervention	Score on a scale (Mean)
	At Baseline	At Week 4	Change from Baseline at Week 4
Stannous Fluoride	3.38	3.24	-0.14

Change From Baseline in Mean DHEQ Score of Domain - Identity (5 Item Total From Section 2 Questi 30 to 34) at Week 16

Intervention	Score on a scale (Mean)
	At Baseline	At Week 8	Change from Baseline at Week 8
Stannous Fluoride	3.38	3.32	-0.04

All participants scored first 4 questions present in Domain Identity of section 2 of the DHEQ using a 7-point scale, where 7= Strongly agree, 6=Agree, 5= Agree a little, 4= neither agree or disagree, 3 disagree a little, 2= disagree, and 1= strongly disagree. Identity domain consisted of following questions Q30: I find it difficult to accept that I am a person who has these sensations in my teeth, Q31: Having these sensations in my teeth makes me feel different from others, Q32:Having these sensations in my teeth makes me feel old, Q33:Having these sensations in my teeth makes me fee damaged, Q34: Having these sensations in my teeth makes me feel as though I am unhealthy. (NCT02752958)
Timeframe: At Baseline and Week 16

Change From Baseline in Mean DHEQ Score of Domain - Identity (5 Item Total From Section 2 Questions 30 to 34) at Week 12

Intervention	Score ona scale (Mean)
	At Baseline	At Week 16	Change from Baseline at Week 16
Stannous Fluoride	16.27	14.55	-2.29

All participants scored first 4 questions present in Domain Identity of section 2 of the DHEQ using a 7-point scale, where 7= Strongly agree, 6=Agree, 5= Agree a little, 4= neither agree or disagree, 3= disagree a little, 2= disagree, and 1= strongly disagree. Restriction domain consisted of following questions Q30: I find it difficult to accept that I am a person who has these sensations in my teeth, Q31: Having these sensations in my teeth makes me feel different from others, Q32:Having these sensations in my teeth makes me feel old, Q33:Having these sensations in my teeth makes me feel damaged, Q34: Having these sensations in my teeth makes me feel as though I am unhealthy. (NCT02752958)
Timeframe: At Baseline and Week 12

Change From Baseline in Mean DHEQ Score of Domain - Identity (5 Item Total From Section 2 Questions 30 to 34) at Week 20

Intervention	Score on a scale (Mean)
	At Baseline	At Week 12	Change from Baseline at Week 12
Stannous Fluoride	16.27	14.64	-1.83

All participants scored first 4 questions present in Domain Identity of section 2 of the DHEQ using a 7-point scale, where 7= Strongly agree, 6=Agree, 5= Agree a little, 4= neither agree or disagree, 3= disagree a little, 2= disagree, and 1= strongly disagree. Identity domain consisted of following questions Q30: I find it difficult to accept that I am a person who has these sensations in my teeth, Q31: Having these sensations in my teeth makes me feel different from others, Q32:Having these sensations in my teeth makes me feel old, Q33:Having these sensations in my teeth makes me feel damaged, Q34: Having these sensations in my teeth makes me feel as though I am unhealthy. (NCT02752958)
Timeframe: At Baseline and Week 20

Change From Baseline in Mean DHEQ Score of Domain - Identity (5 Item Total From Section 2 Questions 30 to 34) at Week 24

Intervention	Score on a scale (Mean)
	At Baseline	At Week 20	Change from Baseline at Week 20
Stannous Fluoride	16.27	13.82	-2.65

All participants scored first 4 questions present in Domain Identity of section 2 of the DHEQ using a 7-point scale, where 7= Strongly agree, 6=Agree, 5= Agree a little, 4= neither agree or disagree, 3= disagree a little, 2= disagree, and 1= strongly disagree. Identity domain consisted of following questions Q30: I find it difficult to accept that I am a person who has these sensations in my teeth, Q31: Having these sensations in my teeth makes me feel different from others, Q32:Having these sensations in my teeth makes me feel old, Q33:Having these sensations in my teeth makes me feel damaged, Q34: Having these sensations in my teeth makes me feel as though I am unhealthy. (NCT02752958)
Timeframe: At Baseline and Week 24

Change From Baseline in Mean DHEQ Score of Domain - Identity (5 Item Total From Section 2 Questions 30 to 34) at Week 4

Intervention	Score on a scale (Mean)
	At Baseline	At Week 24	Change from Baseline at Week 24
Stannous Fluoride	16.27	13.71	-2.76

All participants scored first 4 questions present in Domain Identity of section 2 of the DHEQ using a 7-point scale, where 7= Strongly agree, 6=Agree, 5= Agree a little, 4= neither agree or disagree, 3= disagree a little, 2= disagree, and 1= strongly disagree. Identity domain consisted of following questions Q30: I find it difficult to accept that I am a person who has these sensations in my teeth, Q31: Having these sensations in my teeth makes me feel different from others, Q32:Having these sensations in my teeth makes me feel old, Q33:Having these sensations in my teeth makes me feel damaged, Q34: Having these sensations in my teeth makes me feel as though I am unhealthy. (NCT02752958)
Timeframe: At Baseline and Week 4

Change From Baseline in Mean DHEQ Score of Domain - Identity (5 Item Total From Section 2 Questions 30 to 34) at Week 8

Intervention	Score on a scale (Mean)
	At Baseline	At Week 4	Change from Baseline at Week 4
Stannous Fluoride	16.27	15.66	-0.64

All participants scored first 4 questions present in Domain Identity of section 2 of the DHEQ using a 7-point scale, where 7= Strongly agree, 6=Agree, 5= Agree a little, 4= neither agree or disagree, 3= disagree a little, 2= disagree, and 1= strongly disagree. Identity domain consisted of following questions Q30: I find it difficult to accept that I am a person who has these sensations in my teeth, Q31: Having these sensations in my teeth makes me feel different from others, Q32:Having these sensations in my teeth makes me feel old, Q33:Having these sensations in my teeth makes me feel damaged, Q34: Having these sensations in my teeth makes me feel as though I am unhealthy. (NCT02752958)
Timeframe: At Baseline and Week 8

Change From Baseline in Mean DHEQ Score of Domain - Restrictions (4 Item Total From Section 2 Questions 1 to 4) at Week 12

Intervention	Score on a scale (Mean)
	At Baseline	At Week 8	Change from Baseline at Week 8
Stannous Fluoride	16.27	15.55	-0.81

All participants scored first 4 questions present in Domain Restriction of section 2 of the DHEQ using a 7-point scale, where 7= Strongly agree, 6=Agree, 5= Agree a little, 4= neither agree or disagree, 3= disagree a little, 2= disagree, and 1= strongly disagree. Restriction domain consisted of following questions Q1: Having sensation in my teeth takes a lot of the pleasure out of eating and drinking, Q2: there have been times when I can't finish my meal because of the sensations, Q3: It takes a long time to finish some foods and drinks because of sensations, and Q4: there have been times when I have had problems eating ice cream because if these sensations. (NCT02752958)
Timeframe: At Baseline and Week 12

Change From Baseline in Mean DHEQ Score of Domain - Restrictions (4 Item Total From Section 2 Questions 1 to 4) at Week 16

Intervention	Score on a scale (Mean)
	At Baseline	At Week 12	Change from Baseline at Week 12
Stannous Fluoride	19.55	16.31	-3.19

Change From Baseline in Mean DHEQ Score of Domain - Restrictions (4 Item Total From Section 2 Questions 1 to 4) at Week 20

Intervention	Score on a Scale (Mean)
	At Baseline	At Week 16	Change from Baseline at Week 16
Stannous Fluoride	19.55	15.55	-3.98

Change From Baseline in Mean DHEQ Score of Domain - Restrictions (4 Item Total From Section 2 Questions 1 to 4) at Week 24

Intervention	Score on a Scale (Mean)
	At Baseline	At Week 20	Change from Baseline at Week 20
Stannous Fluoride	19.55	15.50	-3.94

Change From Baseline in Mean DHEQ Score of Domain - Restrictions (4 Item Total From Section 2 Questions 1 to 4) at Week 4

Intervention	Score on a Scale (Mean)
	At Baseline	At Week 24	Change from Baseline at Week 24
Stannous Fluoride	19.55	14.91	-4.53

Change From Baseline in Mean DHEQ Score of Domain - Restrictions (4 Item Total From Section 2 Questions 1 to 4) at Week 8

Intervention	Score on a scale (Mean)
	At Baseline	At Week 4	Change from Baseline at Week 4
Stannous Fluoride	19.55	18.24	-1.21

Change From Baseline in Mean DHEQ Score of Domain - Social Impact (5 Item Total From Section 2 Questions 17 to 21) at Week 12

Intervention	Score ona scale (Mean)
	At Baseline	At Week 8	Change from Baseline at Week 8
Stannous Fluoride	19.55	16.86	-2.75

All participants scored first 5 questions present in Domain Social Impact of section 2 of the DHEQ using a 7-point scale, where 7= Strongly agree, 6=Agree, 5= Agree a little, 4= neither agree or disagree, 3= disagree a little, 2= disagree, and 1= strongly disagree. Social Impact domain consisted of following questions Q17: Because of sensations I take longer than others to finish meal, Q18: I have to be careful what I eat when I am with others because of sensation in my teeth, Q19: I hide the way I am eating with others because of sensations in my teeth, Q20: I am unable to fully take part in conversations because of sensations in my teeth., Q21: Going to dentist is hard for me because I know it is going to be painful as a result of sensations in my teeth. (NCT02752958)
Timeframe: At Baseline and Week 12

Change From Baseline in Mean DHEQ Score of Domain - Social Impact (5 Item Total From Section 2 Questions 17 to 21) at Week 16

Intervention	Score on a scale (Mean)
	At Baseline	At Week 12	Change from Baseline at Week 12
Stannous Fluoride	17.99	15.60	-2.64

Change From Baseline in Mean DHEQ Score of Domain - Social Impact (5 Item Total From Section 2 Questions 17 to 21) at Week 20

Intervention	Score ona Scale (Mean)
	At Baseline	At Week 16	Change from Baseline at Week 16
Stannous Fluoride	17.99	14.44	-3.62

Change From Baseline in Mean DHEQ Score of Domain - Social Impact (5 Item Total From Section 2 Questions 17 to 21) at Week 24

Intervention	Score on a scale (Mean)
	At Baseline	At Week 20	Change from Baseline at Week 20
Stannous Fluoride	17.99	13.79	-4.33

Change From Baseline in Mean DHEQ Score of Domain - Social Impact (5 Item Total From Section 2 Questions 17 to 21) at Week 4

Intervention	Score on a scale (Mean)
	At Baseline	At week 24	Change from Baseline at Week 24
Stannous Fluoride	17.99	13.88	-4.24

Change From Baseline in Mean DHEQ Score of Domain - Social Impact (5 Item Total From Section 2 Questions 17 to 21) at Week 8

Intervention	Score on a Scale (Mean)
	At Baseline	At Week 4	Change from Baseline at Week 4
Stannous Fluoride	17.99	17.30	-0.57

Change From Baseline in Mean Score DHEQ Section1 - Question (Q) No. 8 At Week 8

Intervention	Score on a scale (Mean)
	At Baseline	At Week 8	Change from Baseline at Week 8
Stannous Fluoride	17.99	16.32	-1.67

All the participants scored question No. 8 (Q8: on a scale of 1 to 10 how bothered are you by any sensations?) of section 1 of DHEQ on a scale of 1 to 10, where 1 =not at all bothered and 10= extremely bothered. Section 1 of DHEQ consisted questions about participant's sensitive teeth and the impact they had on participant's everyday life. (NCT02752958)
Timeframe: At Baseline and Week 8

Change From Baseline in Mean Score of Dentine Hyersensitivity Experience Questionnaire (DHEQ) Section1 - Question (Q) No. 7 At Week 4

Intervention	Score on a scale (Mean)
	At Baseline	At Week 8	Change from Baseline at Week 8
Stannous Fluoride	5.93	4.51	-1.45

All the participants scored question No. 7 (Q7: on a scale of 1 to 10 how intense are the sensations?) of section 1 of DHEQ on a scale of 1 to 10, where 1 =not at all intense and 10= worst imaginable. Section 1 of DHEQ consisted questions about participant's sensitive teeth and the impact they had on participant's everyday life. (NCT02752958)
Timeframe: At Baseline and Week 4

Change From Baseline in Mean Score of DHEQ Section1 - Question (Q) No. 7 At Week 12

Change From Baseline in Mean Score of DHEQ Section1 - Question (Q) No. 7 At Week 16

Change From Baseline in Mean Score of DHEQ Section1 - Question (Q) No. 7 At Week 20

Change From Baseline in Mean Score of DHEQ Section1 - Question (Q) No. 7 At Week 24

Change From Baseline in Mean Score of DHEQ Section1 - Question (Q) No. 7 At Week 8

Change From Baseline in Mean Score of DHEQ Section1 - Question (Q) No. 8 At Week 12

All the participants scored question No. 8 (Q8: on a scale of 1 to 10 how bothered are you by any sensations?) of section 1 of DHEQ on a scale of 1 to 10, where 1 =not at all bothered and 10= extremely bothered. Section 1 of DHEQ consisted questions about participant's sensitive teeth and impact they had on participant's everyday life. (NCT02752958)
Timeframe: At Baseline and Week 12

Change From Baseline in Mean Score of DHEQ Section1 - Question (Q) No. 8 At Week 16

Change From Baseline in Mean Score of DHEQ Section1 - Question (Q) No. 8 At Week 24

Change From Baseline in Mean Score of DHEQ Section1 - Question (Q) No. 8 At Week 4

Change From Baseline in Mean Score of DHEQ Section1 - Question (Q) No. 8 At Week20

Change From Baseline in Mean Score of DHEQ Section1 - Question (Q) No. 9 At Week 12

All the participants scored question No. 9 (Q9: on a scale of 1 to 10 how well can you tolerate sensations?) of section 1 of DHEQ on a scale of 1 to 10, where 1 =can easily tolerate and 10= cannot tolerate at all. Section 1 of DHEQ consisted questions about participant's sensitive teeth and the impact they had on participant's everyday life. (NCT02752958)
Timeframe: At Baseline and Week 12

Change From Baseline in Mean Score of DHEQ Section1 - Question (Q) No. 9 At Week 16

Change From Baseline in Mean Score of DHEQ Section1 - Question (Q) No. 9 At Week 20

Change From Baseline in Mean Score of DHEQ Section1 - Question (Q) No. 9 At Week 24

Change From Baseline in Mean Score of DHEQ Section1 - Question (Q) No. 9 At Week 4

Change From Baseline in Mean Score of DHEQ Section1 - Question (Q) No. 9 at Week 8

Change From Baseline in Mean Total Score (34 Item Total From Section 2) of Dentine Hyersensitivity Experience Questionnaire (DHEQ) at Week 12

All participants scored first 34 questions present in section 2 of the DHEQ using a 7-point scale, where 7= Strongly agree, 6=Agree, 5= Agree a little, 4= neither agree or disagree, 3= disagree a little, 2= disagree, and 1= strongly disagree. Section 2 had questions about the ways in which the sensations in the teeth affected participants in daily life. It was grouped into domains as follows: Restrictions (Section 2, Q1-4), Adaptation (Section 2, Q5-16), Social Impact (Section 2, Q17 to 21), Emotional Impact (Section 2, Q22 to 29), and Identity (Section 2, Q30 to 34). (NCT02752958)
Timeframe: At Baseline and Week 12

Change From Baseline in Mean Total Score (34 Item Total From Section 2) of Dentine Hyersensitivity Experience Questionnaire (DHEQ) at Week 16

All participants scored first 34 questions present in section 2 of the DHEQ using a 7-point scale, where 7= Strongly agree, 6=Agree, 5= Agree a little, 4= neither agree or disagree, 3= disagree a little, 2= disagree, and 1= strongly disagree. Section 2 had questions about the ways in which the sensations in the teeth affect participants in daily life. It was grouped into domains as follows: Restrictions (Section 2, Q1-4), Adaptation (Section 2, Q5-16), Social Impact (Section 2, Q17 to 21), Emotional Impact (Section 2, Q22 to 29), and Identity (Section 2, Q30 to 34). (NCT02752958)
Timeframe: At Baseline and Week 16

Change From Baseline in Mean Total Score (34 Item Total From Section 2) of Dentine Hyersensitivity Experience Questionnaire (DHEQ) at Week 20

All participants scored first 34 questions present in section 2 of the DHEQ using a 7-point scale, where 7= Strongly agree, 6=Agree, 5= Agree a little, 4= neither agree or disagree, 3= disagree a little, 2= disagree, and 1= strongly disagree. Section 2 had questions about the ways in which the sensations in the teeth affect participants in daily life. It was grouped into domains as follows: Restrictions (Section 2, Q1-4), Adaptation (Section 2, Q5-16), Social Impact (Section 2, Q17 to 21), Emotional Impact (Section 2, Q22 to 29), and Identity (Section 2, Q30 to 34). (NCT02752958)
Timeframe: At Baseline and Week 20

Change From Baseline in Mean Total Score (34 Item Total From Section 2) of Dentine Hyersensitivity Experience Questionnaire (DHEQ) at Week 24

Change From Baseline in Mean Total Score (34 Item Total From Section 2) of Dentine Hyersensitivity Experience Questionnaire (DHEQ) at Week 4

Change From Baseline in Mean Total Score (34 Item Total From Section 2) of Dentine Hyersensitivity Experience Questionnaire (DHEQ) at Week 8

Change From Baseline in Schiff Sensitivity Score After 8 Weeks of Treatment

The examiner assessed the participant's response to an evaporative air stimulus for each tooth using the Schiff Sensitivity Scale which was scored as follows - 0: Participant did not respond to air stimulation; 1: Participant responded to air stimulus but does not request discontinuation of stimulus; 2: Participant responded to air stimulus and requested discontinuation or moves from stimulus; 3: Participant responded to stimulus, considered stimulus to be painful, and requested discontinuation of the stimulus. A reduction in Schiff Sensitivity score will be indicative of an improvement in sensitivity. (NCT03310268)
Timeframe: Baseline, Week 8

Change From Baseline in Tactile Threshold After 8 Weeks of Treatment

The examiner assessed the response to tactile sensitivity using a Yeaple probe which allowed the application of a known force to the dentin surface, starting at 10 grams (g) and rising in increments of 10g until the tactile threshold or maximum force was reached. The tactile threshold for each tooth was determined by asking the participant whether the sensation caused discomfort. The pressure setting at which the participant gave two consecutive 'yes' responses was recorded as the tactile threshold. The higher the tactile threshold, the less sensitive the tooth. At baseline, the maximum force used was 20g; at all subsequent visits, it was 80g. (NCT03310268)
Timeframe: Week 8

Tactile (Yeaple Probe) Stimuli

The Yeaple score is recorded in terms of quantified reproducible force (range 10-60 grams with higher values indicating a better outcome). The Yeaple probe tip with a force of 10 grams is passed over the exposed dentin on the buccal surface of the selected teeth, apical to the cementenamel junction and the applied force in increased each time by 10 grams until the participant indicates that he/she is experiencing discomfort, or until 20 grams (baseline) or 60 grams (post product use) of force is reached. A higher value indicates lower levels of dentinal hypersensitivity. Each subject will be characterised at each visit by the average of the relevant scores for the two indicator teeth. (NCT03244618)
Timeframe: 4-weeks of product use (Day 28)

Tactile (Yeaple Probe) Stimuli

Thermo-evaporative (Schiff Air Blast) Stimuli

Air blast sensitivity assessed by directing a one-second blast of air onto the exposed buccal root surface of sensitive tooth. Sensitivity recorded: 0 = Tooth/Subject does not respond; 1 Tooth/subject responds but does not request discontinuation; 2 Tooth/subject responds and requests discontinuation or moves;3 Tooth/subject responds, considers stimulus to be painful, and requests discontinuation. Each subject will be characterised at each visit by the average of the relevant scores for the two indicator teeth. HIgher score is worse outcome. (NCT03244618)
Timeframe: 4-weeks of product use (Day 28)

Thermo-evaporative (Schiff Air Blast) Stimuli

Air blast sensitivity assessed by directing a one-second blast of air onto the exposed buccal root surface of sensitive tooth. Sensitivity will be recorded: 0 = Tooth/Subject does not respond; 1 Tooth/subject responds but does not request discontinuation; 2 Tooth/subject responds and requests discontinuation or moves;3 Tooth/subject responds, considers stimulus to be painful, and requests discontinuation. Each subject will be characterised at each visit by the average of the relevant scores for the two indicator teeth. (NCT03244618)
Timeframe: Day 29, 12 hours after product use has ceased

Visual Analogue Scale

Visual Analogue Scale values of the same teeth will be also be recorded to give the outcome variable per subject at the same time of Schiff assessment. The VAS values will be assigned a numerical value in the conventional order from 0 (no pain) to 100 (extremely pain). (NCT03244618)
Timeframe: Day 29, 12 hours after product use has ceased

Visual Analogue Scale

Visual Analogue Scale values were recorded to give the outcome variable per subject at the same time asSchiff assessment. The VAS values were assigned a numerical value in the conventional order from 0 (no pain) to 100 (extremely pain). (NCT03244618)
Timeframe: 4-weeks of product use (Day 28)

Mean Change From Baseline in Schiff Sensitivity Score at Week 4

The examiner indicated the participant's response to an evaporaitve air stimulus for each tooth using the Schiff Sensitivity Scale scored as follows - 0: Participant does not respond to air stimulation; 1: responds to air stimulus but does not request discontinuation of stimulus; 2: Participant responds to air stimulus and requests discontinuation or moves from stimulus; 3: Participant responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus. A reduction in Schiff Sensitivity score is indicative of an imrpovement in sensitivity. (NCT02226562)
Timeframe: Baseline to 4 week

Mean Change From Baseline in Schiff Sensitivity Score at Week 8

Mean Change From Baseline in Tactile Threshold at Week 4

The examiner assessed the response to tactile sensitivity using a Yeaple probe which allowed application of a known force to the dentin surface, starting at 10g and rising in increments of 10g until the tactile threshold or maximum force was reached. The tactile threshold for each tooth was determined by asking the subject whether the sensation caused discomfort. The pressure setting at which the subject gave two consecutive 'yes' responses was recorded as the tactile threshold. The higher the tactile threshold, the less sensitive the tooth. At baseline, the maximum force used was 20g; at all subsequent visits, it was 80g. (NCT02226562)
Timeframe: Baseline to 4 week

Mean Change From Baseline in Tactile Threshold at Week 8

Mean Change From Baseline in Visual Rating Scale (VRS) at Week 8

Participants rated the intensity of their response to an evaporative air stimulus using a 10 point VRS scale with 1 indicating 'no pain' and 10 indicating 'Intense pain'. A reduction in the score is indicative of an improvement in sensitivity. (NCT02226562)
Timeframe: Baseline to 8 week

Mean Change From Baseline in VRS at Week 4

Change From Baseline in Schiff Sensitivity Score on Day 3

The examiner assessed the participant's response to an evaporative air stimulus for each tooth using the Schiff Sensitivity Scale which was scored as follows - 0: Participant does not respond to air stimulation; 1: Participant responded to air stimulus but does not request discontinuation of stimulus; 2: Participant responded to air stimulus and requests discontinuation or moves from stimulus; 3: Participant responded to stimulus, considered stimulus to be painful, and requested discontinuation of the stimulus. A reduction in Schiff Sensitivity score was indicative of an improvement in sensitivity. (NCT02731833)
Timeframe: Baseline to Day 3

Change From Baseline in Schiff Sensitivity Score Post First Treatment by Direct Application

Change From Baseline in Tactile Threshold on Day 3

The examiner assessed the response to tactile sensitivity using a Yeaple probe which allowed application of a known force to the dentin surface, starting at 10g and rising in increments of 10g until the tactile threshold or maximum force was reached. The tactile threshold for each tooth was determined by asking the participant whether the sensation caused discomfort. The pressure setting at which the participant gives two consecutive 'yes' responses was recorded as the tactile threshold. The higher the tactile threshold, the less sensitive the tooth. (NCT02731833)
Timeframe: Baseline to Day 3

Change From Baseline in Tactile Threshold Post First Treatment by Direct Application

The examiner assessed the response to tactile sensitivity using a Yeaple probe which allowed application of a known force to the dentin surface, starting at 10g and rising in increments of 10g until the tactile threshold or maximum force was reached. The tactile threshold for each tooth was determined by asking the participant whether the sensation caused discomfort. The pressure setting at which the participant gives two consecutive 'yes' responses was recorded as the tactile threshold. The higher the tactile threshold, the less sensitive the tooth. (NCT02731833)
Timeframe: Baseline to 60 seconds post first treatment

Change From Baseline in Schiff Sensitivity Score After a Single Use

The examiner assessed the participant's response to an evaporative air stimulus for each of the two test tooth using the Schiff Sensitivity Scale which was scored as follows: 0 Participant does not respond to air stimulation, 1 Participant responds to air stimulus but does not request discontinuation of stimulus, 2 Participant responds to air stimulus and requests discontinuation or moves from stimulus, 3 Participant responds to stimulus, considers stimulus to be painful and requests discontinuation of the stimulus. The Schiff sensitivity score was calculated as the average of individual test teeth score. Change from baseline in Schiff sensitivity was calculated as participant level mean change from baseline of the 2 test teeth. A reduction in Schiff Sensitivity score was indicative of an improvement in sensitivity. (NCT02923895)
Timeframe: Baseline to 60 seconds post first treatment

Change From Baseline in Schiff Sensitivity Score on Day 3

Change From Baseline in Tactile Threshold After a Single Use

Tactile threshold was assessed by examiner using a constant pressure probe (Yeaple probe) which allowed application of a known force to the dentin surface from 10 g to an upper threshold of 80g in increments of 10 g. The tactile threshold is the maximum pressure applied at which participant do not report any pain or discomfort. The tactile threshold for each tooth was determined by asking the participant whether the sensation caused discomfort. The pressure setting at which the participant gave two consecutive 'yes' responses was recorded as the tactile threshold. The higher the tactile threshold, the less sensitive the tooth. (NCT02923895)
Timeframe: Baseline to 60 seconds post first treatment

Change From Baseline in Tactile Threshold on Day 3

Tactile threshold was assessed by examiner using a constant pressure probe (Yeaple probe) which allowed application of a known force to the dentin surface from 10 gram[g] to an upper threshold of 80g in increments of 10 g. The tactile threshold is the maximum pressure applied at which participant do not report any pain or discomfort. The tactile threshold for each tooth was determined by asking the participant whether the sensation caused discomfort. The pressure setting at which the participant gave two consecutive 'yes' responses was recorded as the tactile threshold. The higher the tactile threshold, the less sensitive the tooth. (NCT02923895)
Timeframe: Baseline and Day 3

Change From Baseline in Schiff Sensitivity Score After Single Use

Schiff sensitivity score was assessed by examiner as participant's response to an evaporative (air) stimulus after the stimulation of each individual tooth. Response of participant was scored using Schiff sensitivity scale range of 0-3; 0=Participant does not respond to air stimulation; 1=Participant responds to air stimulus but does not request discontinuation of stimulus; 2=Participant responds to air stimulus and requests discontinuation or moves from stimulus; 3= Participant responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus. A reduction in Schiff Sensitivity score indicates improvement in sensitivity. (NCT02832375)
Timeframe: Baseline, after single use (after 5 minutes)

Change From Baseline in Schiff Sensitivity Score on Day 3

Change From Baseline in Tactile Threshold Immediately After Single Use and on Day 3

Tactile threshold was assessed by examiner using a constant pressure probe (Yeaple probe) which allowed application of a known force to the dentin surface from 10 g to an upper threshold of 80g in increments of 10 g. The tactile threshold is the maximum pressure applied at which participant do not report any pain or discomfort. The tactile threshold for each tooth was determined by asking the participant whether the sensation caused discomfort. The pressure setting at which the participant gave two consecutive 'yes' responses was recorded as the tactile threshold. The higher the tactile threshold, the less sensitive the tooth. (NCT02832375)
Timeframe: Baseline, after single use (after 5 minutes) and on Day 3

Global Subjective VAS Score at Week 2

"At each visit, participants rated their perception of the pain/discomfort experienced by marking a single vertical line on a VAS scale from 0 to 100 mm, where 0 = No Pain/Discomfort and 100 = Intense Pain/Discomfort. Participants were instructed as follows: Please rate the intensity of the pain/discomfort you have experienced in the last two weeks when drinking cold/hot beverages and/or foods, eating sweet and sour foods, breathing cold air, brushing your teeth or performing any habits/behaviors that solicit your dentinal hypersensitivity pain/discomfort since you first started using the product. The dental recorder measured the length of the line from 0 to the participant's line and recorded the VAS score in mm." (NCT01345292)
Timeframe: 2 weeks

Global Subjective VAS Score at Week 4

Mean Cold Air Stimulus VAS Score at Week 2

Tooth sensitivity was measured using a Cold Air Stimulus. When being assessed, participants rated their perception of the pain/discomfort experienced when cold air was directed at the exposed root of each tooth by marking a single vertical line on a VAS scale from 0 to 100 mm, where 0 = No Pain/Discomfort and 100 = Intense Pain/Discomfort. The dental recorder measured the length of the line from 0 to the participant's line and recorded the VAS score in mm. The score for each participant was calculated by averaging the scores for all study teeth for that participant. (NCT01345292)
Timeframe: 2 weeks

Mean Cold Air Stimulus VAS Score at Week 4

Mean Tactile Sensitivity Score at Week 2

Tooth sensitivity was measured using a Yeaple probe. The force at which discomfort was felt by the participant was recorded on a scale of 10-80 grams. The score for each participant was calculated by averaging the scores for all study teeth for that participant. (NCT01345292)
Timeframe: 2 weeks

Mean Tactile Sensitivity Score at Week 4

Mean Tactile Sensitivity VAS Score at Week 4

Tooth sensitivity was measured using a VAS. At each visit, participants rated their perception of the pain/discomfort experienced from the Yeaple probe by marking a single vertical line on a VAS scale from 0 to 100 mm, where 0 = No Pain/Discomfort and 100 = Intense Pain/Discomfort. The dental recorder measured the length of the line from 0 to the participant's line and recorded the VAS score in mm. The investigator recorded a VAS score of 0 mm for participants who did not experience discomfort at the maximum force of 80 grams. The score for each participant was calculated by averaging the scores for all study teeth for that participant. (NCT01345292)
Timeframe: 4 weeks

Mean Tactile Sensitivity Visual Analog Scale (VAS) Score at Week 2

Percentage Change From Baseline in DPS (Dental Pain Scale) With Air Stimulation

Patient's response to an air stimulus is recorded on a Dental Pain Scale (none[1]-mild[2]-moderate[3]-severe[4]). (NCT02918617)
Timeframe: Baseline to 8 weeks

Percentage Change From Baseline in DPS (Dental Pain Scale) With Cold Stimulation

Patient's response to an cold stimulus is recorded on a Dental Pain Scale (none[1]-mild[2]-moderate[3]-severe[4]). (NCT02918617)
Timeframe: Baseline to 8 weeks

Percentage Change From Baseline in VAS (Visual Analog Scale) With Air Stimulation

Patient's response to an air stimulus is recorded on a Visual Analog Scale of 0-100 with 0 representing no pain and 100 representing the worst possible pain. (NCT02918617)
Timeframe: Baseline to 8 weeks

Percentage Change From Baseline in VAS (Visual Analog Scale) With Cold Stimulation

Patient's response to cold stimulus is recorded on a Visual Analog Scale of 0-100 with 0 signifying no pain and 100 signifying the worst possible pain (NCT02918617)
Timeframe: Baseline to 8 weeks

Dentinal Hypersensitivity

"The primary analysis will be to compare the dentinal hypersensitivity between the 3 groups.~Air test: A 1 second blast of air from the air-water syringe was applied to the tooth.~Water test: Three drops of ice water were be placed on the tooth.~Schiff Score~Investigator observed participant reaction to test and scored on following scale:~0-Tooth/Subject does not respond to stimulus.~Tooth/Subject responds to stimulus, but does not request discontinuation of stimulus.~Tooth/Subject responds to stimulus and requests discontinuation or moves from stimulus.~Tooth/Subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus~VAS (visual analog scale):~The participant reported sensitivity on a scale of 0-10. 0 being no pain and 10 being worst pain imaginable." (NCT02136576)
Timeframe: 8 weeks after baseline

Intervention	Score on Scale (Mean)
	Schiff score at baseline	Schiff score at Week 8	Change from baseline in Schiff score at Week 8
Negative Control (1400 Ppm Fluoride as SMFP)	2.23	1.50	-0.72
Positive Control (SnCl2 and 0.15% NaF [1450 Ppm Fluoride])	2.18	1.70	-0.48
Test Product (0.454% SnF2 and 0.072% NaF [1450 Ppm Fluoride])	2.22	1.69	-0.53

Intervention	Grams (Mean)
	Tactile threshold at baseline	Tactile threshold at Week 8	Change from baseline at Week 8
Negative Control (1400 Ppm Fluoride as SMFP)	11.42	36.49	25.00
Positive Control (SnCl2 and 0.15% NaF [1450 Ppm Fluoride])	11.80	33.93	22.31
Test Product (0.454% SnF2 and 0.072% NaF [1450 Ppm Fluoride])	11.13	28.52	17.38

Intervention	score on a scale (Mean)
	Baseline	Week 4
CSSP Toothpaste	17.5	38.2
Fluoride Toothpaste	16.6	27.5

Intervention	score on a scale (Mean)
	Baseline	Day 29, 12hr after last product use
CSSP Toothpaste	17.5	41.5
Fluoride Toothpaste	16.6	29.7

Intervention	Score on a scale (Mean)
	At Baseline (Day 0, Pre-treatment)	Day 0 (Post-treatment)	Change from Baseline
Control Dentifrice	2.49	2.40	-0.09
Test Dentifrice	2.44	1.76	-0.68

Intervention	Score on a scale (Mean)
	At Baseline (Day 0, Pre-treatment)	At Day 3	Change from Baseline
Control Dentifrice	2.49	2.37	-0.13
Test Dentifrice	2.44	1.01	-1.44

Intervention	g (Mean)
	At Baseline (Day 0, Pre-treatment)	Day 0, Post-treatment	Change from Baseline
Control Dentifrice	13.58	14.63	1.05
Test Dentifrice	13.40	22.47	9.07

Intervention	score on a scale (Mean)
Experimental: Stannous Fluoride(SnF)	-0.46
Standard: Sodium Monofluorophosphate(SMFP)	-0.45

Intervention	score on a scale (Mean)
Experimental: Stannous Fluoride(SnF)	-0.82
Control: Sodium Monofluorophosphate(SMFP)	-0.39

Intervention	g (Mean)
	Change from baseline post treatment	Change from baseline on Day 3
Experimental: Stannous Fluoride(SnF)	4.01	15.25
Standard: Sodium Monofluorophosphate(SMFP)	3.60	3.88

Intervention	units on a scale (mm) (Least Squares Mean)
Negative Control (Crest Regular Toothpaste)	44.94
Positive Control (Sensodyne Toothpaste)	43.68
12027-027 (1.40% Potassium Oxalate Mouth Rinse)	43.64

Intervention	units on a scale (mm) (Least Squares Mean)
Negative Control (Crest Regular Toothpaste)	41.32
Positive Control (Sensodyne Toothpaste)	32.79
12027-027 (1.40% Potassium Oxalate Mouth Rinse)	35.19

Intervention	units on a scale (mm) (Least Squares Mean)
Negative Control (Crest Regular Toothpaste)	43.65
Positive Control (Sensodyne Toothpaste)	38.74
12027-027 (1.40% Potassium Oxalate Mouth Rinse)	40.22

Intervention	units on a scale (mm) (Least Squares Mean)
Negative Control (Crest Regular Toothpaste)	39.54
Positive Control (Sensodyne Toothpaste)	28.36
12027-027 (1.40% Potassium Oxalate Mouth Rinse)	29.30

Intervention	grams of force (Least Squares Mean)
Negative Control (Crest Regular Toothpaste)	10.10
Positive Control (Sensodyne Toothpaste)	13.16
12027-027 (1.40% Potassium Oxalate Mouth Rinse)	12.51

Intervention	grams of force (Least Squares Mean)
Negative Control (Crest Regular Toothpaste)	10.39
Positive Control (Sensodyne Toothpaste)	21.83
12027-027 (1.40% Potassium Oxalate Mouth Rinse)	18.72

Intervention	units on a scale (mm) (Least Squares Mean)
Negative Control (Crest Regular Toothpaste)	39.49
Positive Control (Sensodyne Toothpaste)	30.94
12027-027 (1.40% Potassium Oxalate Mouth Rinse)	29.32

Intervention	units on a scale (mm) (Least Squares Mean)
Negative Control (Crest Regular Toothpaste)	41.59
Positive Control (Sensodyne Toothpaste)	39.52
12027-027 (1.40% Potassium Oxalate Mouth Rinse)	37.16

Intervention	percentage change from baseline (Mean)
Control Toothpaste Containing Novamin® Technology	-35.14
Control Toothpaste Containing 1500 Ppm Fluoride as MFP	-43.35
Test Toothpaste With Nano-HAP (High Concentration)	-34.15
Test Toothpaste With Nano-HAP (Low Concentration)	-38.63
Test Toothpaste With Nano-HAP and Potassium Nitrate (KNO3)	-43.95
Control Toothpaste Without Nano-HAP	-33.63
Test Toothpaste With Nano-HAP (Medium Concentration)	-49.35
Test Cream With Nano-HAP (Higher Concentration)	-17.47
Control Cream Without Nano-HAP	-28.54

Intervention	percentage change from baseline (Mean)
Control Toothpaste Containing Novamin® Technology	-35.37
Control Toothpaste Containing 1500 Ppm Fluoride as MFP	-30.18
Test Toothpaste With Nano-HAP (High Concentration)	-39.81
Test Toothpaste With Nano-HAP (Low Concentration)	-38.41
Test Toothpaste With Nano-HAP and Potassium Nitrate (KNO3)	-35.03
Control Toothpaste Without Nano-HAP	-34.07
Test Toothpaste With Nano-HAP (Medium Concentration)	-46.21
Test Cream With Nano-HAP (Higher Concentration)	-15.30
Control Cream Without Nano-HAP	-25.57

Intervention	percentage change from baseline (Mean)
Control Toothpaste Containing Novamin® Technology	-51.44
Control Toothpaste Containing 1500 Ppm Fluoride as MFP	-51.59
Test Toothpaste With Nano-HAP (High Concentration)	-41.59
Test Toothpaste With Nano-HAP (Low Concentration)	-38.64
Test Toothpaste With Nano-HAP and Potassium Nitrate (KNO3)	-53.16
Control Toothpaste Without Nano-HAP	-47.19
Test Toothpaste With Nano-HAP (Medium Concentration)	-56.85
Test Cream With Nano-HAP (Higher Concentration)	-38.99
Control Cream Without Nano-HAP	-50.67

Intervention	percentage change from baseline (Mean)
Control Toothpaste Containing Novamin® Technology	-48.14
Control Toothpaste Containing 1500 Ppm Fluoride as MFP	-34.96
Test Toothpaste With Nano-HAP (High Concentration)	-44.71
Test Toothpaste With Nano-HAP (Low Concentration)	-31.95
Test Toothpaste With Nano-HAP and Potassium Nitrate (KNO3)	-42.49
Control Toothpaste Without Nano-HAP	-35.67
Test Toothpaste With Nano-HAP (Medium Concentration)	-48.80
Test Cream With Nano-HAP (Higher Concentration)	-34.90
Control Cream Without Nano-HAP	-39.36

Intervention	units on a scale (Median)
	Air Schiff	Air VAS	Water Schiff	Water VAS
Clinpro 5000	0	2	1	2
Crest Cavity Protection & MI Paste Plus	1	2	1	2
Sensodyne	1	3	1	4

Article	Year
Formulations of desensitizing toothpastes for dentin hypersensitivity: a scoping review. Journal of applied oral science : revista FOB, 2022, Volume: 30 Topics: Dentin Desensitizing Agents; Dentin Sensitivity; Double-Blind Method; Fluorides; Humans; Potassium C	2022
Clinical Efficacy of Mouthwashes with Potassium Salts in the Treatment of Dentinal Hypersensitivity: A Systematic Review and Meta-analysis. Operative dentistry, 2023, Jan-01, Volume: 48, Issue:1 Topics: Dentin Desensitizing Agents; Dentin Sensitivity; Double-Blind Method; Fluorides; Humans; Mouthwashes	2023
Clinical Efficacy of Mouthwashes with Potassium Salts in the Treatment of Dentinal Hypersensitivity: A Systematic Review and Meta-analysis. Operative dentistry, 2023, Jan-01, Volume: 48, Issue:1 Topics: Dentin Desensitizing Agents; Dentin Sensitivity; Double-Blind Method; Fluorides; Humans; Mouthwashes	2023
Clinical Efficacy of Mouthwashes with Potassium Salts in the Treatment of Dentinal Hypersensitivity: A Systematic Review and Meta-analysis. Operative dentistry, 2023, Jan-01, Volume: 48, Issue:1 Topics: Dentin Desensitizing Agents; Dentin Sensitivity; Double-Blind Method; Fluorides; Humans; Mouthwashes	2023
Clinical Efficacy of Mouthwashes with Potassium Salts in the Treatment of Dentinal Hypersensitivity: A Systematic Review and Meta-analysis. Operative dentistry, 2023, Jan-01, Volume: 48, Issue:1 Topics: Dentin Desensitizing Agents; Dentin Sensitivity; Double-Blind Method; Fluorides; Humans; Mouthwashes	2023
Desensitizing Toothpastes for Dentin Hypersensitivity: A Network Meta-analysis. Journal of dental research, 2020, Volume: 99, Issue:5 Topics: Bayes Theorem; Dentin Desensitizing Agents; Dentin Sensitivity; Double-Blind Method; Fluorides; Huma	2020
Stabilized stannous fluoride dentifrice in relation to dental caries, dental erosion and dentin hypersensitivity: A systematic review. American journal of dentistry, 2020, Volume: 33, Issue:2 Topics: Cariostatic Agents; Dental Caries; Dentifrices; Dentin Sensitivity; Double-Blind Method; Humans; Pho	2020
[Desensitizing effect of stannous fluoride-containing toothpaste for patients with dentine hypersensitivity: a Meta-analysis]. Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2016, Volume: 34, Issue:2 Topics: Dentin Desensitizing Agents; Dentin Sensitivity; Humans; Randomized Controlled Trials as Topic; Sodi	2016
Clinical efficacy of desensitizing mouthwashes for the control of dentin hypersensitivity and root sensitivity: a systematic review and meta-analysis. International journal of dental hygiene, 2017, Volume: 15, Issue:2 Topics: Aluminum Compounds; Dentin Desensitizing Agents; Dentin Sensitivity; Double-Blind Method; Follow-Up	2017
A new treatment alternative for sensitive teeth: a desensitizing oral rinse. Journal of dentistry, 2013, Volume: 41 Suppl 1 Topics: Arginine; Calcium Carbonate; Dentin Desensitizing Agents; Dentin Sensitivity; Dentinal Fluid; Diphos	2013
Cervical hypersensitivity...a review of the literature. The Journal of the Michigan Dental Association, 1981, Volume: 63, Issue:5 Topics: Dentin Sensitivity; Humans; Prednisolone; Sodium Fluoride	1981
A desensitizing dentifrice with multiple oral health benefits formulated for daily use. The Journal of clinical dentistry, 1994, Volume: 5 Spec No Topics: Dental Calculus; Dentifrices; Dentin Sensitivity; Diphosphates; Drug Combinations; Gingival Recessio	1994
Chemical agents for the control of plaque and plaque microflora: an overview. European journal of oral sciences, 1997, Volume: 105, Issue:5 Pt 2 Topics: Anti-Infective Agents, Local; Bacteria; Bacterial Adhesion; Cariostatic Agents; Cations; Chemopreven	1997
Treating hypersensitivity with fluoride varnishes. Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 1998, Volume: 19, Issue:11 Topics: Administration, Topical; Adult; Dentin Sensitivity; Dentinal Fluid; Female; Fluorides, Topical; Huma	1998
Chlorhexidine varnishes: a review. Journal of clinical periodontology, 2002, Volume: 29, Issue:1 Topics: Aggregatibacter actinomycetemcomitans; Anti-Infective Agents, Local; Chlorhexidine; Dental Caries; D	2002
Iontophoresis in the treatment of cervical dentinal sensitivity--a review. The Journal of the Western Society of Periodontology/Periodontal abstracts, 1990, Volume: 38, Issue:4 Topics: Dentin Sensitivity; Humans; Iontophoresis; Sodium Fluoride	1990
Chemotherapeutic agents and periodontal therapy. Their impact on clinical practice. Journal of periodontology, 1986, Volume: 57, Issue:2 Topics: Administration, Topical; Anti-Bacterial Agents; Cetylpyridinium; Chlorhexidine; Dental Plaque; Denti	1986
Dentinal sensation and hypersensitivity. A review of mechanisms and treatment alternatives. Journal of periodontology, 1985, Volume: 56, Issue:4 Topics: Calcium Hydroxide; Dental Pulp; Dentifrices; Dentin; Dentin Sensitivity; Glucocorticoids; Humans; Ni	1985