Page last updated: 2024-11-04

sodium fluoride and Cancer of Prostate

sodium fluoride has been researched along with Cancer of Prostate in 41 studies

Research Excerpts

ExcerptRelevanceReference
"Sodium fluoride (Na-F) PET/CT is an imaging technique which allows radiolabeled fluoride to help detect areas of bone turnover."6.52Role of sodium fluoride PET imaging for identification of bony metastases in prostate cancer patients. ( Hughes, CT; Nix, JW, 2015)
"The aim of this study was to assess coronary artery and aortic calcification in healthy controls, angina pectoris patients, and prostate cancer patients using 18F-sodium fluoride PET/computed tomography (NaF-PET/CT)."5.22Assessing Coronary Artery and Aortic Calcification in Patients with Prostate Cancer Using ( Alavi, A; Borja, AJ; Høilund-Carlsen, PF; Jin, KY; Kothekar, E; Lau, HC; Ng, SJ; Raynor, WY; Revheim, ME; Rojulpote, C; Seraj, SM; Taghvaei, R; Werner, TJ; Zhang, V, 2022)
"In a national prospective registry, we previously studied the impact of (18)F-sodium fluoride PET (NaF PET) on the intended management of cancer patients with osseous metastases."5.2018F-fluoride PET used for treatment monitoring of systemic cancer therapy: results from the National Oncologic PET Registry. ( Duan, F; Hanna, L; Hillner, BE; Quinn, B; Shields, AF; Siegel, BA, 2015)
" Fluorine 18−Sodium Fluoride (18F-NaF) PET/CT can be used as a sensitive imaging modality for detection of vascular calcification."4.12Atherogenic Indices as a Predictor of Aortic Calcification in Prostate Cancer Patients Assessed Using ( Anabaraonye, N; Chatterjee, S; Chesnais, H; Dai, M; Parente, J; Rajapakse, CS; Xu, W, 2022)
"Sixty prostate cancer patients, including 30 with and 30 without known bone metastases by conventional imaging, underwent Na(18)F PET/CT at baseline, 6 mo, and 12 mo."2.82Prospective Study Evaluating Na18F PET/CT in Predicting Clinical Outcomes and Survival in Advanced Prostate Cancer. ( Alikhani, A; Apolo, AB; Choyke, PL; Dahut, WL; Gulley, JL; Kim, JW; Kurdziel, KA; Lindenberg, L; Madan, RA; McKinney, YY; Mena, E; Park, JC; Parnes, HL; Shih, JH; Turkbey, B; Weaver, J; Wood, LV, 2016)
"In biochemical relapse of prostate cancer, 18 F-NaF PET/CT is useful in the detection of occult osseous metastases, whereas the yield of 18F-FDG PET/CT is relatively limited."2.77Prospective evaluation of 18F-NaF and 18F-FDG PET/CT in detection of occult metastatic disease in biochemical recurrence of prostate cancer. ( Conti, PS; Desai, B; Dorff, TB; Groshen, SG; Gross, ME; Jadvar, H; Ji, L; Pinski, JK; Quinn, DI, 2012)
"We reviewed the literature for prostate cancer PET tracers that are either being used for patient management or being evaluated in clinical research trials."2.58Prostate cancer PET tracers: essentials for the urologist. ( Fraum, TJ; Hope, TA; Ippolito, JE; Kim, EH; Ludwig, DR; Schroeder, P, 2018)
"Sodium fluoride (Na-F) PET/CT is an imaging technique which allows radiolabeled fluoride to help detect areas of bone turnover."2.52Role of sodium fluoride PET imaging for identification of bony metastases in prostate cancer patients. ( Hughes, CT; Nix, JW, 2015)
"Newly diagnosed high-risk prostate cancer patients who underwent radical prostatectomy from 2011 to 2018."1.72Use of ( Mogensen, AW; Nørgaard, M; Pank, MT; Petersen, LJ; Torp-Pedersen, C; Zacho, HD, 2022)
"Two hundred consecutive prostate cancer patients who had undergone 68Ga-PSMA PET/CT and 18F-NaF PET/CT at baseline evaluation (n = 80) and following suspected recurrence or disease progression (restaging) (n = 120) were analyzed retrospectively."1.72Bone metastases in prostate cancer - Gallium-68-labeled prostate-specific membrane antigen or Fluorine 18 sodium fluoride PET/computed tomography - the better tracer? ( Agrawal, A; Bakshi, G; Choudhury, S; Joshi, A; Maitre, P; Menon, S; Mithun, S; Murthy, V; Natarajan, A; Noronha, V; Pal, M; Prabhash, K; Prakash, G; Purandare, N; Puranik, A; Rangarajan, V; Shah, S, 2022)
"The patient was finally diagnosed with myelomatosis."1.46Unexpected Diffuse 18F-NaF Uptake in the Lung Parenchyma in a Patient With Severe Hypercalcemia Due to Myelomatosis. ( Asmar, A; Bülow, J; Simonsen, L; Svolgaard, B, 2017)
"Thirty patients (15 women with breast cancer and 15 men with prostate cancer) referred for standard-of-care bone scintigraphy were prospectively enrolled in this study."1.42Prospective Comparison of 99mTc-MDP Scintigraphy, Combined 18F-NaF and 18F-FDG PET/CT, and Whole-Body MRI in Patients with Breast and Prostate Cancer. ( Barkhodari, A; Gambhir, SS; Iagaru, A; Jackson, T; Jamali, M; Loening, A; Minamimoto, R; Mosci, C; Obara, P; Taviani, V; Vasanawala, S, 2015)
"Men with prostate cancer represented 72% of the cases."1.40Impact of 18F-fluoride PET in patients with known prostate cancer: initial results from the National Oncologic PET Registry. ( Coleman, RE; Duan, F; Hanna, L; Hillner, BE; Shields, AF; Siegel, BA, 2014)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-19902 (4.88)18.7374
1990's1 (2.44)18.2507
2000's0 (0.00)29.6817
2010's25 (60.98)24.3611
2020's13 (31.71)2.80

Authors

AuthorsStudies
Zacho, HD3
Ravn, S1
Ejlersen, JA1
Fledelius, J1
Dolliner, P1
Nygaard, ST1
Holdgaard, PC1
Lauridsen, JF1
Haarmark, C1
Hendel, HW2
Petersen, LJ3
Mogensen, AW1
Torp-Pedersen, C1
Nørgaard, M1
Pank, MT1
Koa, B1
Raynor, WY2
Park, PSU1
Borja, AJ2
Singhal, S1
Kuang, A1
Zhang, V2
Werner, TJ3
Alavi, A4
Revheim, ME2
Kothekar, E2
Lau, HC1
Ng, SJ1
Seraj, SM2
Rojulpote, C1
Taghvaei, R1
Jin, KY1
Høilund-Carlsen, PF2
Bénard, F1
Harsini, S1
Wilson, D1
Zukotynski, K1
Abikhzer, G1
Turcotte, E1
Cossette, M1
Metser, U1
Romsa, J1
Martin, M1
Mar, C1
Saad, F1
Soucy, JP1
Eigl, BJ1
Black, P1
Krauze, A1
Burrell, S1
Nichol, A1
Tardif, JC1
Agrawal, A1
Natarajan, A1
Mithun, S1
Bakshi, G1
Joshi, A1
Murthy, V1
Menon, S1
Purandare, N1
Shah, S1
Puranik, A1
Choudhury, S1
Prakash, G1
Pal, M1
Maitre, P1
Prabhash, K1
Noronha, V1
Rangarajan, V1
Dai, M1
Xu, W1
Chesnais, H1
Anabaraonye, N1
Parente, J1
Chatterjee, S1
Rajapakse, CS1
Sinha, P1
Lamonica, DM1
Rocha, NH1
Zacchi, SR1
Sado, HN1
Buchpiguel, CA1
Duarte, PS1
Sapienza, MT1
Toczek, J1
Chiang, J1
Gershenson, JP1
Lewis, MS1
Vahidi, K1
Berenji, GR2
Nguépy Keubo, FR1
Mboua, PC1
Djifack Tadongfack, T1
Fokouong Tchoffo, E1
Tasson Tatang, C1
Ide Zeuna, J1
Noupoue, EM1
Tsoplifack, CB1
Folefack, GO1
Kettani, M1
Bandelier, P1
Huo, J1
Li, H4
Yu, D1
Arulsamy, N1
AlAbbad, S1
Sardot, T1
Lekashvili, O1
Decato, D1
Lelj, F1
Alexander Ross, JB1
Rosenberg, E1
Nazir, H1
Muthuswamy, N1
Louis, C1
Jose, S1
Prakash, J1
Buan, MEM1
Flox, C1
Chavan, S1
Shi, X1
Kauranen, P1
Kallio, T1
Maia, G1
Tammeveski, K1
Lymperopoulos, N1
Carcadea, E1
Veziroglu, E1
Iranzo, A1
M Kannan, A1
Arunamata, A1
Tacy, TA1
Kache, S1
Mainwaring, RD1
Ma, M1
Maeda, K1
Punn, R1
Noguchi, S1
Hahn, S3
Iwasa, Y3
Ling, J2
Voccio, JP2
Kim, Y3
Song, J3
Bascuñán, J2
Chu, Y1
Tomita, M1
Cazorla, M1
Herrera, E1
Palomeque, E1
Saud, N1
Hoplock, LB1
Lobchuk, MM1
Lemoine, J1
Li, X10
Henson, MA1
Unsihuay, D1
Qiu, J1
Swaroop, S1
Nagornov, KO1
Kozhinov, AN1
Tsybin, YO1
Kuang, S1
Laskin, J1
Zin, NNINM1
Mohamad, MN1
Roslan, K1
Abdul Wafi, S1
Abdul Moin, NI1
Alias, A1
Zakaria, Y1
Abu-Bakar, N1
Naveed, A1
Jilani, K1
Siddique, AB1
Akbar, M1
Riaz, M1
Mushtaq, Z1
Sikandar, M1
Ilyas, S1
Bibi, I1
Asghar, A1
Rasool, G1
Irfan, M1
Li, XY1
Zhao, S1
Fan, XH1
Chen, KP1
Hua, W1
Liu, ZM1
Xue, XD1
Zhou, B1
Zhang, S2
Xing, YL1
Chen, MA1
Sun, Y1
Neradilek, MB1
Wu, XT1
Zhang, D2
Huang, W1
Cui, Y1
Yang, QQ1
Li, HW1
Zhao, XQ1
Hossein Rashidi, B1
Tarafdari, A1
Ghazimirsaeed, ST1
Shahrokh Tehraninezhad, E1
Keikha, F1
Eslami, B1
Ghazimirsaeed, SM1
Jafarabadi, M1
Silvani, Y1
Lovita, AND1
Maharani, A1
Wiyasa, IWA1
Sujuti, H1
Ratnawati, R1
Raras, TYM1
Lemin, AS1
Rahman, MM1
Pangarah, CA1
Kiyu, A1
Zeng, C2
Du, H1
Lin, D1
Jalan, D1
Rubagumya, F1
Hopman, WM1
Vanderpuye, V1
Lopes, G1
Seruga, B1
Booth, CM1
Berry, S1
Hammad, N1
Sajo, EA1
Okunade, KS1
Olorunfemi, G1
Rabiu, KA1
Anorlu, RI1
Xu, C2
Xiang, Y1
Xu, X1
Zhou, L2
Dong, X1
Tang, S1
Gao, XC1
Wei, CH1
Zhang, RG1
Cai, Q1
He, Y1
Tong, F1
Dong, JH1
Wu, G1
Dong, XR1
Tang, X1
Tao, F1
Xiang, W1
Zhao, Y3
Jin, L1
Tao, H1
Lei, Y1
Gan, H1
Huang, Y1
Chen, Y3
Chen, L3
Shan, A1
Zhao, H2
Wu, M2
Ma, Q1
Wang, J4
Zhang, E1
Zhang, J3
Li, Y6
Xue, F1
Deng, L1
Liu, L2
Yan, Z2
Wang, Y2
Meng, J1
Chen, G2
Anastassiadou, M1
Bernasconi, G1
Brancato, A1
Carrasco Cabrera, L1
Greco, L1
Jarrah, S1
Kazocina, A1
Leuschner, R1
Magrans, JO1
Miron, I1
Nave, S1
Pedersen, R1
Reich, H1
Rojas, A1
Sacchi, A1
Santos, M1
Theobald, A1
Vagenende, B1
Verani, A1
Du, L1
Liu, X1
Ren, Y1
Li, J7
Li, P1
Jiao, Q1
Meng, P1
Wang, F2
Wang, YS1
Wang, C3
Zhou, X2
Wang, W1
Wang, S2
Hou, J1
Zhang, A1
Lv, B1
Gao, C1
Pang, D1
Lu, K1
Ahmad, NH1
Wang, L1
Zhu, J2
Zhang, L2
Zhuang, T1
Tu, J1
Zhao, Z1
Qu, Y1
Yao, H1
Wang, X5
Lee, DF1
Shen, J3
Wen, L1
Huang, G2
Xie, X1
Zhao, Q1
Hu, W1
Zhang, Y4
Wu, X1
Lu, J2
Li, M1
Li, W2
Wu, W1
Du, F1
Ji, H1
Yang, X2
Xu, Z1
Wan, L1
Wen, Q1
Cho, CH1
Zou, C1
Xiao, Z1
Liao, J1
Su, X1
Bi, Z1
Su, Q1
Huang, H1
Wei, Y2
Gao, Y2
Na, KJ1
Choi, H1
Oh, HR1
Kim, YH1
Lee, SB1
Jung, YJ1
Koh, J1
Park, S1
Lee, HJ1
Jeon, YK1
Chung, DH1
Paeng, JC1
Park, IK1
Kang, CH1
Cheon, GJ1
Kang, KW1
Lee, DS1
Kim, YT1
Pajuelo-Lozano, N1
Alcalá, S1
Sainz, B1
Perona, R1
Sanchez-Perez, I1
Logotheti, S1
Marquardt, S1
Gupta, SK1
Richter, C1
Edelhäuser, BAH1
Engelmann, D1
Brenmoehl, J1
Söhnchen, C1
Murr, N1
Alpers, M1
Singh, KP1
Wolkenhauer, O1
Heckl, D1
Spitschak, A1
Pützer, BM1
Liao, Y1
Cheng, J1
Kong, X1
Li, S1
Zhang, M4
Zhang, H1
Yang, T2
Dong, Y1
Xu, Y1
Yuan, Z1
Cao, J1
Zheng, Y1
Luo, Z1
Mei, Z1
Yao, Y1
Liu, Z2
Liang, C1
Yang, H1
Song, Y1
Yu, K1
Zhu, C1
Huang, Z1
Qian, J1
Ge, J1
Hu, J2
Wang, H2
Liu, Y4
Mi, Y1
Kong, H1
Xi, D1
Yan, W1
Luo, X1
Ning, Q1
Chang, X2
Zhang, T2
Wang, Q2
Rathore, MG1
Reddy, K1
Chen, H1
Shin, SH1
Ma, WY1
Bode, AM1
Dong, Z1
Mu, W1
Liu, C3
Gao, F1
Qi, Y1
Lu, H1
Zhang, X4
Cai, X1
Ji, RY1
Hou, Y3
Tian, J2
Shi, Y1
Ying, S1
Tan, M1
Feng, G1
Kuang, Y1
Chen, D1
Wu, D3
Zhu, ZQ1
Tang, HX1
Shi, ZE1
Kang, J1
Liu, Q1
Qi, J2
Mu, J1
Cong, Z1
Chen, S2
Fu, D1
Li, Z2
Celestrin, CP1
Rocha, GZ1
Stein, AM1
Guadagnini, D1
Tadelle, RM1
Saad, MJA1
Oliveira, AG1
Bianconi, V1
Bronzo, P1
Banach, M1
Sahebkar, A1
Mannarino, MR1
Pirro, M1
Patsourakos, NG1
Kouvari, M1
Kotidis, A1
Kalantzi, KI1
Tsoumani, ME1
Anastasiadis, F1
Andronikos, P1
Aslanidou, T1
Efraimidis, P1
Georgiopoulos, A1
Gerakiou, K1
Grigoriadou-Skouta, E1
Grigoropoulos, P1
Hatzopoulos, D1
Kartalis, A1
Lyras, A1
Markatos, G1
Mikrogeorgiou, A1
Myroforou, I1
Orkopoulos, A1
Pavlidis, P1
Petras, C1
Riga, M1
Skouloudi, M1
Smyrnioudis, N1
Thomaidis, K1
Tsikouri, GE1
Tsikouris, EI1
Zisimos, K1
Vavoulis, P1
Vitali, MG1
Vitsas, G1
Vogiatzidis, C1
Chantanis, S1
Fousas, S1
Panagiotakos, DB1
Tselepis, AD1
Jungen, C1
Alken, FA1
Eickholt, C1
Scherschel, K1
Kuklik, P1
Klatt, N1
Schwarzl, J1
Moser, J1
Jularic, M1
Akbulak, RO1
Schaeffer, B1
Willems, S1
Meyer, C1
Nowak, JK1
Szczepanik, M1
Trypuć, M1
Pogorzelski, A1
Bobkowski, W1
Grytczuk, M1
Minarowska, A1
Wójciak, R1
Walkowiak, J1
Lu, Y1
Xi, J1
Li, C1
Chen, W2
Hu, X1
Zhang, F1
Wei, H1
Wang, Z1
Gurzu, S1
Jung, I1
Sugimura, H2
Stefan-van Staden, RI1
Yamada, H1
Natsume, H1
Iwashita, Y1
Szodorai, R1
Szederjesi, J1
Yari, D1
Ehsanbakhsh, Z1
Validad, MH1
Langroudi, FH1
Esfandiari, H1
Prager, A1
Hassanpour, K1
Kurup, SP1
Mets-Halgrimson, R1
Yoon, H1
Zeid, JL1
Mets, MB1
Rahmani, B1
Araujo-Castillo, RV1
Culquichicón, C1
Solis Condor, R1
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Zhao, K1
Sacan, O1
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Bayrak, BB1
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Akev, N1
Yanardag, R1
Gruber, S1
Kamnoedboon, P1
Özcan, M1
Srinivasan, M1
Jo, YH1
Oh, HK1
Jeong, SY1
Lee, BG1
Zheng, J1
Guan, H1
Li, D2
Tan, H1
Maji, TK1
J R, A1
Mukherjee, S1
Alexander, R1
Mondal, A1
Das, S1
Sharma, RK1
Chakraborty, NK1
Dasgupta, K1
Sharma, AMR1
Hawaldar, R1
Pandey, M1
Naik, A1
Majumdar, K1
Pal, SK1
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Ma, Y2
Gao, W1
Ma, S1
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Wu, Q1
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He, X1
Jiang, F1
Yuan, D1
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Hong, M1
Chen, K1
Hussain, M1
Razi, SS1
Yildiz, EA1
Zhao, J1
Yaglioglu, HG1
Donato, MD1
Jiang, J1
Jamil, MI1
Zhan, X1
Chen, F1
Cheng, D1
Wu, CT1
Utsunomiya, T1
Ichii, T1
Fujinami, S1
Nakajima, K1
Sanchez, DM1
Raucci, U1
Ferreras, KN1
Martínez, TJ1
Mordi, NA1
Mordi, IR1
Singh, JS1
McCrimmon, RJ1
Struthers, AD1
Lang, CC1
Wang, XW1
Yuan, LJ1
Yang, Y1
Chen, WF1
Luo, R1
Yang, K1
Amarasiri, SS1
Attanayake, AP1
Arawwawala, LDAM1
Jayatilaka, KAPW1
Mudduwa, LKB1
Ogunsuyi, O2
Akanni, O1
Alabi, O1
Alimba, C1
Adaramoye, O1
Cambier, S1
Eswara, S1
Gutleb, AC1
Bakare, A1
Gu, Z1
Cong, J1
Pellegrini, M1
Palmieri, S1
Ricci, A1
Serio, A1
Paparella, A1
Lo Sterzo, C1
Jadeja, SD1
Vaishnav, J1
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Shah, C1
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Shah, A1
Begum, R1
Song, H2
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Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
18F- Sodium Fluoride PET Imaging as a Replacement for Bone Scintigraphy[NCT01930812]Phase 3286 participants (Actual)Interventional2014-07-31Completed
The National Oncologic PET Registry[NCT00868582]333,000 participants (Anticipated)Observational2006-05-31Active, not recruiting
Combined 18F-NaF/18F-FDG PET/MRI for Detection of Skeletal Metastases[NCT00375830]Phase 2114 participants (Actual)Interventional2006-01-31Completed
The Effectiveness of Whole-body 18F-NaF PET in Detecting Metastatic Bone Lesion for Patients With Cancer: A Comparison Study With 99mTc-MDP Bone Scintigraphy.[NCT00414934]100 participants (Anticipated)Observational2006-10-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Cohort 3 - Skeletal Lesions Identified by 99mTc MDP WBBS vs 18F-NaF / 18F-FDG PET/MRI

Participants in Cohort 3 received 99mTc-methylene diphosphonate (MDP) whole-body bone scintigraphy (WBBS) and 18F-sodium fluoride (NaF) / 18F-fluorodeoxyglucose (FDG) positron emission tomography / magnetic imaging resonance (PET/MRI) scans. On the basis of the scans, participants with skeletal lesions were identified. The outcome is reported as the number of Cohort 3 participants for whom skeletal lesions were identified by each scan methodology, a number without dispersion. (NCT00375830)
Timeframe: 30 days

InterventionParticipants (Count of Participants)
Cohort 3 - 99mTc-methyl Diphosphonate (MDP) Bone Scan37
Cohort 3 - 18F-NaF / 18F-FDG PET/MRI45

Cohort 3 - Total Skeletal Lesions Identified, Tc-99m MDP WBBS vs 18F-NaF / 18F-FDG PET/MRI

Participants in Cohort 3 received 99mTc-methylene diphosphonate (MDP) whole-body bone scintigraphy (WBBS) and 18F-sodium fluoride (NaF) / 18F-fluorodeoxyglucose (FDG) positron emission tomography / magnetic imaging resonance (PET/MRI) scans. On the basis of the scans, the total number skeletal lesions identified in the participants was determined. The outcome is reported as the total number skeletal lesions identified by each scan methodology, a number without dispersion. (NCT00375830)
Timeframe: 30 days

Interventionlesions (Number)
Cohort 3 - 99mTc-methyl Diphosphonate (MDP) Bone Scan81
Cohort 3 - 18F-NaF / 18F-FDG PET/MRI140

Cohort 1 - 18F-NaF PET/CT vs 18F-FDG PET/CT

The medical value of 18F-sodium fluoride (NaF) positron emission tomography / computed tomography (PET/CT) vs 18F-fluorodeoxyglucose (FDG) positron emission tomography / computed tomography (PET/CT) was assessed on the basis of the radiation oncologist's medical assessment of image quality and detected extent of disease, for each participant diagnosed with osseous (skeletal) metastases. Per protocol, the data were collected and the outcome is reported for Cohort 1 only. The outcome is reported as the number of participants for whom the medical value of the image was superior for 18-NaF PET/CT compared to 18F-FDG PET/CT, the same between both scans, or inferior for 18-NaF PET/CT compared to 18F-FDG PET/CT. The outcome result is represented as a number without dispersion. (NCT00375830)
Timeframe: 30 days

InterventionParticipants (Count of Participants)
18F-NaF > 18F-FDG18F-NaF = 18F-FDG18F-NaF < 18F-FDG
Cohort 1 Pilot-WB-MRI & Combined 18F-NaF-CT/18F-FDG-PET Scans300

Cohort 1 - NaF PET/CT vs 99mTc-MDP Bone Scintigraphy

"The medical value of 18F-sodium fluoride (NaF) positron emission tomography / computed tomography (PET/CT) vs 99mTc-methylene diphosphonate (MDP) bone scintigraphy was assessed on the basis of the radiation oncologist's medical assessment of image quality and detected extent of disease, for each participant. Per protocol, the data were collected and the outcome is reported for Cohort 1 only. The outcome is reported as the number of participants for whom the medical value of the image was superior for 18F-NaF vs 99mTc-MDP bone scintigraphy (18F-NaF > 99mTc-MDP), the same between both scans (18F-NaF = 99mTc-MDP), or inferior for 18F-NaF vs 99mTc-MDP bone scintigraphy (18F-NaF < 99mTc-MDP)." (NCT00375830)
Timeframe: 30 days

InterventionParticipants (Count of Participants)
18F-NaF > 99mTc-MDP18F-NaF = 99mTc-MDP18F-NaF < 99mTc-MDP
Cohort 1 Pilot-WB-MRI & Combined 18F-NaF-CT/18F-FDG-PET Scans1000

Cohort 2 - 18F-NaF/18F-FDG PET/CT vs Whole-body MRI for Detection of Extraskeletal Lesions

"Sensitivity; positive predictive value (PPV); and accuracy for the detection of extraskeletal lesions was assessed for 18F-sodium fluoride (NaF) / 18F-fluorodeoxyglucose (FDG) positron emission tomography / computed tomography (PET/CT) and for whole body magnetic imaging resonance (WB-MRI).~Sensitivity is a percentage that defines the proportion of true positive participants with the disease in a total group of participants.~PPV is the probability that participants with a positive screening test truly have the disease.~Accuracy is the proportion of true results (both true positives and true negatives) among the total number of cases examined.~Per protocol, the data were collected and the outcome is reported for Cohort 2 only. Sensitivity, PPV, and accuracy are reported as a percentage, a number without dispersion. Higher numbers represent better detection." (NCT00375830)
Timeframe: 30 days

,
Interventionpercentage of particpants (Number)
SensitivityPositive predictive valueAccuracy
Cohort 2 - Combined 18F-NaF-CT/18F-FDG-PET Scan92.981.376.5
Cohort 2 - Whole Body-MRI Scan92.986.782.4

Cohort 2 - 18F-NaF/18F-FDG vs 99mTc-MDP Bone Scintigraphy for Detection of Skeletal Lesions

Sensitivity and accuracy for the detection of skeletal lesions was assessed for 18F-sodium fluoride (NaF) / 18F-fluorodeoxyglucose (FDG) positron emission tomography / computed tomography (PET/CT) and for 99mTc-methylene diphosphonate (MDP) bone scintigraphy. Per protocol, the data were collected and the outcome is reported for Cohort 2 only. Sensitivity and accuracy are reported as a percentage, a number without dispersion. Higher numbers represent better detection. (NCT00375830)
Timeframe: 30 days

,
Interventionpercentage of participants (Number)
SensitivityAccuracy
Cohort 2 - 99mTc-MDP Bone Scintigraphy Scan64.665.9
Cohort 2 Combined 18F-NaF-CT/18F-FDG-PET Scan96.289.8

Cohort 2 - 18F-NaF/18F-FDG vs Whole-body MRI for Detection of Skeletal Lesions

Sensitivity and accuracy for the detection of skeletal lesions was assessed for 18F-sodium fluoride (NaF) / 18F-fluorodeoxyglucose (FDG) positron emission tomography / computed tomography (PET/CT) and for whole body magnetic imaging resonance (WB-MRI). Per protocol, the data were collected and the outcome is reported for Cohort 2 only. Sensitivity and accuracy are reported as a percentage, a number without dispersion. Higher numbers represent better detection. (NCT00375830)
Timeframe: 30 days

,
Interventionpercentage of particpants (Number)
SensitivityAccuracy
Cohort 2 - Combined 18F-NaF-CT/18F-FDG-PET Scan96.289.8
Cohort 2 - WB-MRI Scan81.474.7

Cohort 2 - Overall Sensitivity and Accuracy for 18F-NaF/18F-FDG vs Whole-body MRI

Overall sensitivity and accuracy for the detection of tumor lesions was assessed for 18F-sodium fluoride (NaF) / 18F-fluorodeoxyglucose (FDG) positron emission tomography / computed tomography (PET/CT) and for whole body magnetic imaging resonance (WB-MRI). Per protocol, the data were collected and the outcome is reported for Cohort 2 only. Sensitivity and accuracy are reported as a percentage, a number without dispersion. Higher numbers represent better detection. (NCT00375830)
Timeframe: 30 days

,
Interventionpercentage of participants (Number)
SensitivityAccuracy
Cohort 2 - Combined 18F-NaF-CT/18F-FDG-PET Scan95.787.6
Cohort 2 - Whole Body Magnetic Resonance Imaging (WB-MRI) Scan83.376.0

Cohort 2 - Overall Sensitivity and Accuracy for 18F-NaF/18F-FDG vs Whole-body MRI/99mTc-MDP Bone Scintigraphy

Overall sensitivity and accuracy for the detection of tumor lesions was assessed for 18F-sodium fluoride (NaF) / 18F-fluorodeoxyglucose (FDG) positron emission tomography / computed tomography (PET/CT) and for 99mTc-methylene diphosphonate (MDP) bone scintigraphy. Per protocol, the data were collected and the outcome is reported for Cohort 2 only. Sensitivity and accuracy are reported as a percentage, a number without dispersion. Higher numbers represent better detection. (NCT00375830)
Timeframe: 30 days

,
Interventionpercentage of participants (Number)
SensitivityAccuracy
Cohort 2 Combined 18F-NaF-CT/18F-FDG-PET Scan95.787.6
Cohort 2 WB-MRI & 99mTc-MDP Bone Scintigraphy91.683.0

Reviews

11 reviews available for sodium fluoride and Cancer of Prostate

ArticleYear
Feasibility of Global Assessment of Bone Metastases in Prostate Cancer with
    PET clinics, 2022, Volume: 17, Issue:4

    Topics: Alkaline Phosphatase; Bone Neoplasms; Feasibility Studies; Fluorine Radioisotopes; Humans; Male; Pos

2022
Assessing Coronary Artery and Aortic Calcification in Patients with Prostate Cancer Using
    PET clinics, 2022, Volume: 17, Issue:4

    Topics: Angina Pectoris; Coronary Artery Disease; Fluorine Radioisotopes; Humans; Male; Positron Emission To

2022
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Novel imaging in advanced prostate cancer.
    Current opinion in supportive and palliative care, 2017, Volume: 11, Issue:3

    Topics: Antigens, Surface; Choline Kinase; Fluorodeoxyglucose F18; Glutamate Carboxypeptidase II; Humans; Ma

2017
Prostate cancer PET tracers: essentials for the urologist.
    The Canadian journal of urology, 2018, Volume: 25, Issue:4

    Topics: Antigens, Surface; Carbon Radioisotopes; Carboxylic Acids; Cyclobutanes; Fluorine Radioisotopes; Flu

2018
Comparison of PSMA-PET/CT, choline-PET/CT, NaF-PET/CT, MRI, and bone scintigraphy in the diagnosis of bone metastases in patients with prostate cancer: a systematic review and meta-analysis.
    Skeletal radiology, 2019, Volume: 48, Issue:12

    Topics: Bone Neoplasms; Choline; Gallium Isotopes; Gallium Radioisotopes; Humans; Magnetic Resonance Imaging

2019
[State of the art in nuclear imaging for the diagnosis of bone metastases].
    Bulletin du cancer, 2013, Volume: 100, Issue:11

    Topics: Bone Neoplasms; Breast Neoplasms; Female; Fluorodeoxyglucose F18; Humans; Kidney Neoplasms; Lung Neo

2013
¹⁸F-NaF PET/CT and ¹¹C-Choline PET/CT for the initial detection of metastatic disease in prostate cancer: overview and potential utilization.
    Oncology (Williston Park, N.Y.), 2014, Volume: 28, Issue:12

    Topics: Bone Neoplasms; Carbon Radioisotopes; Choline; Fluorine Radioisotopes; Humans; Male; Multimodal Imag

2014
Role of sodium fluoride PET imaging for identification of bony metastases in prostate cancer patients.
    Current urology reports, 2015, Volume: 16, Issue:5

    Topics: Bone Neoplasms; Early Detection of Cancer; Humans; Male; Neoplasm Metastasis; Positron-Emission Tomo

2015
PET/Computed Tomography for Radiation Therapy Planning of Prostate Cancer.
    PET clinics, 2017, Volume: 12, Issue:2

    Topics: Bone Neoplasms; Brachytherapy; Fluorine Radioisotopes; Gallium Radioisotopes; Humans; Male; Neoplasm

2017
Diagnosis of bone disease by core biopsies.
    Seminars in hematology, 1981, Volume: 18, Issue:4

    Topics: Adult; Aged; Biopsy; Bone and Bones; Bone Diseases; Bone Neoplasms; Breast Neoplasms; Female; Humans

1981

Trials

7 trials available for sodium fluoride and Cancer of Prostate

ArticleYear
Intra-individual comparison of
    The Lancet. Oncology, 2022, Volume: 23, Issue:12

    Topics: Bone Neoplasms; Breast Neoplasms; Canada; Fluorodeoxyglucose F18; Humans; Male; Multimodal Imaging;

2022
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
    Annales medico-psychologiques, 2021, Volume: 179, Issue:2

    Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli

2021
18F-fluoride PET used for treatment monitoring of systemic cancer therapy: results from the National Oncologic PET Registry.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2015, Volume: 56, Issue:2

    Topics: Aged; Aged, 80 and over; Bone Neoplasms; Breast Neoplasms; Databases, Factual; Female; Fluorodeoxygl

2015
Prospective Study Evaluating Na18F PET/CT in Predicting Clinical Outcomes and Survival in Advanced Prostate Cancer.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2016, Volume: 57, Issue:6

    Topics: Adult; Aged, 80 and over; Fluorine Radioisotopes; Humans; Male; Middle Aged; Positron Emission Tomog

2016
Molecular image-directed biopsies: improving clinical biopsy selection in patients with multiple tumors.
    Physics in medicine and biology, 2016, 10-21, Volume: 61, Issue:20

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Algorithms; Benchmarking; Bone Neoplasms; Feasibility Studi

2016
Prospective evaluation of 18F-NaF and 18F-FDG PET/CT in detection of occult metastatic disease in biochemical recurrence of prostate cancer.
    Clinical nuclear medicine, 2012, Volume: 37, Issue:7

    Topics: Fluorodeoxyglucose F18; Humans; Male; Multimodal Imaging; Neoplasm Metastasis; Positron-Emission Tom

2012
Sensitivity in detecting osseous lesions depends on anatomic localization: planar bone scintigraphy versus 18F PET.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1999, Volume: 40, Issue:10

    Topics: Bone Neoplasms; False Negative Reactions; Fluorine Radioisotopes; Humans; Lung Neoplasms; Magnetic R

1999

Other Studies

24 other studies available for sodium fluoride and Cancer of Prostate

ArticleYear
Observer experience and accuracy of 18F-sodium-fluoride PET/CT for the diagnosis of bone metastases in prostate cancer.
    Nuclear medicine communications, 2022, Jun-01, Volume: 43, Issue:6

    Topics: Bone Neoplasms; Fluorides; Fluorine Radioisotopes; Humans; Male; Positron Emission Tomography Comput

2022
Use of
    BMJ open, 2022, 06-15, Volume: 12, Issue:6

    Topics: Bone Neoplasms; Cohort Studies; Fluorine Radioisotopes; Humans; Male; Positron-Emission Tomography;

2022
Bone metastases in prostate cancer - Gallium-68-labeled prostate-specific membrane antigen or Fluorine 18 sodium fluoride PET/computed tomography - the better tracer?
    Nuclear medicine communications, 2022, Dec-01, Volume: 43, Issue:12

    Topics: Bone Neoplasms; Fluorine; Gallium Radioisotopes; Humans; Male; Positron Emission Tomography Computed

2022
Atherogenic Indices as a Predictor of Aortic Calcification in Prostate Cancer Patients Assessed Using
    International journal of molecular sciences, 2022, Oct-27, Volume: 23, Issue:21

    Topics: Humans; Male; Positron Emission Tomography Computed Tomography; Prostatic Neoplasms; Radiopharmaceut

2022
Beyond the
    AJR. American journal of roentgenology, 2023, Volume: 221, Issue:2

    Topics: Breast Neoplasms; Humans; Male; Positron Emission Tomography Computed Tomography; Prostatic Neoplasm

2023
Comparison of Oral and IV 18 F-NaF PET/CT Administration in the Assessment of Bone Metastases in Patients With Breast or Prostate Cancers.
    Clinical nuclear medicine, 2023, Sep-01, Volume: 48, Issue:9

    Topics: Bone Neoplasms; Fluorine Radioisotopes; Humans; Male; Positron Emission Tomography Computed Tomograp

2023
Reply: Off-Target Report on
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2019, Volume: 60, Issue:12

    Topics: Bone Neoplasms; Fluorine Radioisotopes; Humans; Male; Positron Emission Tomography Computed Tomograp

2019
Evolution of arterial [
    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2021, Volume: 28, Issue:5

    Topics: Aorta, Abdominal; Aortic Diseases; Fluorine Radioisotopes; Humans; Male; Positron Emission Tomograph

2021
Focal 18F-NaF PET Prostate Activity in the Setting of Prostate Adenocarcinoma.
    Clinical nuclear medicine, 2020, Volume: 45, Issue:7

    Topics: Adenocarcinoma; Aged; Androgen Antagonists; Biopsy; Fluorine Radioisotopes; Humans; Male; Neoplasm G

2020
    World journal of urology, 2018, Volume: 36, Issue:1

    Topics: Aged; Aged, 80 and over; Bone Neoplasms; Cohort Studies; Diphosphonates; Fluorine Radioisotopes; Hum

2018
Diagnostic bone imaging in patients with prostate cancer: patient experience and acceptance of NaF-PET/CT, choline-PET/CT, whole-body MRI, and bone SPECT/CT.
    Acta radiologica (Stockholm, Sweden : 1987), 2018, Volume: 59, Issue:9

    Topics: Aged; Aged, 80 and over; Bone Neoplasms; Choline; Humans; Magnetic Resonance Imaging; Male; Middle A

2018
18F-NaF Uptake in Ocular Prosthesis (Implant).
    Clinical nuclear medicine, 2020, Volume: 45, Issue:1

    Topics: Aged, 80 and over; Biological Transport; Eye, Artificial; False Positive Reactions; Fluorine Radiois

2020
Off-Target Report on
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2019, Volume: 60, Issue:12

    Topics: Bone Neoplasms; Fluorine Radioisotopes; Humans; Male; Positron Emission Tomography Computed Tomograp

2019
Ivory vertebra on 18F-sodium fluoride scan: an old sign in a new modality.
    Clinical nuclear medicine, 2014, Volume: 39, Issue:11

    Topics: Aged; Bone Neoplasms; Fluorine Radioisotopes; Humans; Male; Positron-Emission Tomography; Prostatic

2014
Impact of 18F-fluoride PET in patients with known prostate cancer: initial results from the National Oncologic PET Registry.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2014, Volume: 55, Issue:4

    Topics: Aged; Aged, 80 and over; Cohort Studies; Data Interpretation, Statistical; Fluorodeoxyglucose F18; H

2014
PET/CT with sodium 18F-fluoride for management of patients with prostate cancer.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2014, Volume: 55, Issue:4

    Topics: Humans; Male; Medical Oncology; Prostatic Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Sod

2014
PET/CT Dose Planning for Volumetric Modulated Arc Radiation Therapy (VMAT) -Comparison with Conventional Approach in Advanced Prostate Cancer Patients.
    Current radiopharmaceuticals, 2015, Volume: 8, Issue:1

    Topics: Aged; Aged, 80 and over; Choline; Fluorine Radioisotopes; Humans; Male; Middle Aged; Multimodal Imag

2015
Prospective Comparison of 99mTc-MDP Scintigraphy, Combined 18F-NaF and 18F-FDG PET/CT, and Whole-Body MRI in Patients with Breast and Prostate Cancer.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2015, Volume: 56, Issue:12

    Topics: Adult; Aged; Bone and Bones; Breast Neoplasms; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F1

2015
PSMA-Based Detection of Prostate Cancer Bone Lesions With ¹⁸F-DCFPyL PET/CT: A Sensitive Alternative to (⁹⁹m)Tc-MDP Bone Scan and Na¹⁸F PET/CT?
    Clinical genitourinary cancer, 2016, Volume: 14, Issue:1

    Topics: Antigens, Surface; Bone Neoplasms; Glutamate Carboxypeptidase II; Humans; Lysine; Male; Middle Aged;

2016
Unexpected Diffuse 18F-NaF Uptake in the Lung Parenchyma in a Patient With Severe Hypercalcemia Due to Myelomatosis.
    Clinical nuclear medicine, 2017, Volume: 42, Issue:1

    Topics: Aged, 80 and over; Amyloidosis; Bone and Bones; Calcinosis; Diagnosis, Differential; Fluorine Radioi

2017
Molecular Imaging in Neuroendocrine Differentiation of Prostate Cancer: 68Ga-PSMA Versus 68Ga-DOTA NOC PET-CT.
    Clinical nuclear medicine, 2017, Volume: 42, Issue:5

    Topics: Edetic Acid; Gallium Isotopes; Gallium Radioisotopes; Humans; Male; Middle Aged; Neuroendocrine Tumo

2017
Fluorocholine (18F) and sodium fluoride (18F) PET/CT in the detection of prostate cancer: prospective comparison of diagnostic performance determined by masked reading.
    The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of..., 2011, Volume: 55, Issue:4

    Topics: Aged; Aged, 80 and over; Bone Neoplasms; Choline; Fluorine Radioisotopes; Humans; Male; Middle Aged;

2011
Superscan pattern of F-18 sodium fluoride PET/CT study in a case of prostate cancer.
    Clinical nuclear medicine, 2011, Volume: 36, Issue:11

    Topics: Artifacts; Bone and Bones; Fluorine Radioisotopes; Humans; Male; Middle Aged; Multimodal Imaging; Po

2011
Characterization and stabilization of progesterone receptors in human benign prostatic hypertrophy.
    Journal of steroid biochemistry, 1983, Volume: 18, Issue:6

    Topics: Centrifugation, Density Gradient; Cytosol; Humans; Male; Molybdenum; Progesterone; Promegestone; Pro

1983