sodium fluoride and Age-Related Osteoporosis studies

Research Excerpts

Excerpt	Relevance	Reference
"The findings of the present study show that both sodium fluoride and ibandronate are effective in combination with calcium and vitamin D substitution in the management of osteopenia and osteoporosis in patients with Crohn's disease."	9.10	Therapy of osteoporosis in patients with Crohn's disease: a randomized study comparing sodium fluoride and ibandronate. ( Adler, G; Boehm, BO; Hofbauer, LC; Klaus, J; Kratzer, W; Mason, R; Reinshagen, M; Steinkamp, M; von Tirpitz, C, 2003)
"To investigate whether administration of sodium fluoride (NaF) in addition to cyclical etidronate has a positive effect on bone mineral density (BMD) in patients with established osteoporosis during continued treatment with corticosteroids."	9.08	Is addition of sodium fluoride to cyclical etidronate beneficial in the treatment of corticosteroid induced osteoporosis? ( Bijlsma, JW; Gerrits, MI; Haanen, HC; Houben, HH; Jacobs, JW; Lems, WF; van Rijn, HJ; van Veen, GJ, 1997)
"To investigate whether sodium fluoride (NaF) is able to prevent bone loss in patients treated with corticosteroids (Cs), we performed a randomized double-masked, placebo-controlled trial with 44 Cs-treated patients without established osteoporosis, defined as the absence of previous peripheral fractures and vertebral deformities on radiographs."	9.08	Effect of sodium fluoride on the prevention of corticosteroid-induced osteoporosis. ( Bijlsma, JW; Croone, A; Gerrits, MI; Haanen, HC; Houben, HH; Jacobs, WG; Lems, WF; van Rijn, HJ, 1997)
"The value of intermittent slow release sodium fluoride treatment in the management of osteoporosis was studied by a comprehensive metabolic and clinical assessment during a long term trial."	9.06	Safe and effective treatment of osteoporosis with intermittent slow release sodium fluoride: augmentation of vertebral bone mass and inhibition of fractures. ( Johnson, K; Pak, CY; Parcel, C; Peterson, R; Sakhaee, K; Zerwekh, JE, 1989)
"Nineteen patients suffering from primary osteoporosis, all having at least one vertebral collapse, initially received 50 mg of sodium fluoride alone per day for 6-18 months."	9.05	Extended treatment of primary osteoporosis by sodium fluoride combined with 25 hydroxycholecalciferol. ( Kuntz, D; Marie, P; Maziere, B; Naveau, B; Ryckewaert, A; Tubiana, M, 1984)
"To evaluate a therapeutic effect, biochemical parameters of bone metabolism and photonabsorption densitometry have been compared in patients with senile osteoporosis under long-term continuous or intermittent sodium fluoride treatment."	9.04	[Therapy of senile osteoporosis using sodium fluoride--continuous and intermittent long-term therapy]. ( Haber, P; Willvonseder, R, 1979)
"A histomorphometric and dynamic study of non-decalcified transiliac biopsies was carried out in 51 cases of osteoporosis who had received double marking with tetracycline before and after two years treatment with association of sodium fluoride (50 mg/day) vitamin, D2 (8,000 IU/day) and calcium (1 g/day)."	8.76	[Histological effects of the treatment of osteoporosis with the combination of sodium fluoride, vitamin D and calcium]. ( Briançon, D; Charhon, S; Edouard, C; Meunier, PJ, 1980)
"In a 5-year observational study we have compared sodium fluoride (NaF) with different treatments commonly used in the treatment of osteoporosis: calcium, estrogens, androgens, and calcitonin, referred to as non-NaF."	7.69	Sodium fluoride treatment is a major protector against vertebral and nonvertebral fractures when compared with other common treatments of osteoporosis: a longitudinal, observational study. ( Armadans, L; Farrerons, J; Guañabens, N; López-Navidad, A; Renau, A; Rodríguez de la Serna, A; Vaqué, J; Yoldi, B, 1997)
"Recent studies have suggested that sodium fluoride therapy may be an effective treatment for vertebral osteoporosis."	7.68	Exacerbation of rheumatoid arthritis by sodium fluoride treatment of osteoporosis. ( Chesnut, CH; Duell, PB, 1991)
"To evaluate the need for a randomised study of treatment of spinal osteoporosis with human parathyroid peptide in the secondary prevention of crush fractures; to study the effect of human parathyroid hormone peptide 1-34 plus sex hormones on vertebral body cancellous bone; and, separately, to determine the effect of relatively low doses of sodium fluoride plus calcium on spinal bone mineral density."	7.68	Treatment of osteoporosis with human parathyroid peptide and observations on effect of sodium fluoride. ( Davies, UM; Hesp, R; Katz, D; McNally, E; Reeve, J, 1990)
"This article contains a report of the results of a study of 10 postmenopausal women with uncomplicated osteoporosis who were treated with sodium fluoride, calcium supplementation, and vitamin D."	7.67	Treatment of osteoporosis with sodium fluoride and calcium: effects on vertebral fracture incidence and bone histomorphometry. ( Einhorn, TA; Healey, JH; Lane, JM; Robbins, WC; Schneider, R; Schwartz, E; Suda, M; Vigorita, VJ, 1984)
"Thirty seven female patients with osteoporosis underwent iliac bone biopsy after 10 to 23 months of continuous or discontinuous treatment with sodium fluoride, calcium, and vitamin D."	7.67	[Microradiographic study of iliac bone biopsies taken after treatment of postmenopausal osteoporosis with sodium fluoride. Histomorphometric correlations]. ( Duriez, J; Duriez, R; Flautre, B, 1989)
"Thirteen cases of spontaneous fissure or fracture of the lower limbs observed in 8 patients under treatment with sodium fluoride are reported; 7 of these patients were being treated for osteoporosis."	7.67	[Spontaneous fissures and fractures of the legs in patients with osteoporosis treated with sodium fluoride]. ( Crouzet, J; Kaplan, G; Orcel, P; Prier, A, 1987)
" The fluorosis is only rarely observed as a sequel of the sodium fluoride therapy of osteoporosis."	7.67	[Fluorosis following the long-term treatment of osteoporosis with sodium fluoride]. ( Hasert, V; Matzkowski, H; Meseg, S, 1986)
"During an 8-year period, 163 consecutive patients with spinal crush fracture osteoporosis started a 5-year treatment with a combination of sodium fluoride (60 mg/day), calcium phosphate (45 mmol/day) and vitamin D2 (18,000 IU/day), and were followed in the outpatient clinic every 3 months."	7.67	Safety of osteoporosis treatment with sodium fluoride, calcium phosphate and vitamin D. ( Hasling, C; Melsen, F; Mosekilde, L; Nielsen, HE, 1987)
"Calcium and phosphorus balances and 47Ca turnover studies were performed before and after 12-27 months of daily treatment with sodium fluoride (60 mg), calcium (30-45 mmol), phosphate (29-44 mmol), and vitamin D2 (18,000 IU) in 20 postmenopausal women with spinal crush fracture osteoporosis."	7.67	The effects of sodium fluoride, calcium phosphate, and vitamin D2 for one to two years on calcium and phosphorus metabolism in postmenopausal women with spinal crush fracture osteoporosis. ( Charles, P; Jensen, FT; Mosekilde, L, 1985)
"Thirteen patients with primary osteoporosis were treated for two years with sodium fluoride (NaF), calcium and dihydrotachysterol (group A)."	7.66	Fluoride in serum and bone during treatment of osteoporosis with sodium fluoride, calcium and vitamin D. ( Backer Dirks, O; Duursma, SA; van der Sluys Veer, J; van Kesteren, RG; Visser, WJ, 1982)
"26 women were treated for osteoporosis with 40 mg of sodium fluoride twice a day (equivalent 36 mg of fluorine) for a longer period."	7.66	[Osteoporosis therapy and thyroid function. Influence of 6 months of sodium fluoride treatment on thyroid function and bone density]. ( Börner, W; Eichner, R; Henschler, D; Köhler, W; Moll, E, 1981)
" This constant concentration of ionised fluorine in the plasma contrasted with the marked and rapid variations which follow the ingestion of sodium fluoride, which is usually prescribed in the treatment of osteoporosis."	7.66	[Change in the plasma and urine levels of ionized fluorine under the influence of low doses of niflumic acid. Possible application to the treatment of osteoporosis]. ( Audran, M; Boiteau, HL; Caumon, JP; Prost, A; Rossel-Renac, F, 1980)
"25 female patients with different forms of osteoporosis (progredient form in elderly patients, steroid osteoporosis, involutive osteoporosis) treated during a period varying between 1 to 24 months with a new compound preparation containing 25 mg sodium fluoride and 200 mg L-ascorbic acid per tablet."	7.66	[Treatment of osteoporosis with a new retard-preparation of sodium fluoride (author's transl)]. ( Bröll, H; Eberl, R; Falkensamer, C; Fischer, M; Petera, P; Tausch, G, 1979)
"Twenty-three patients with primary osteoporosis were treated with sodium fluoride over 25 months."	7.66	[Results of long-term treatment of primary osteoporosis with sodium fluoride (author's transl)]. ( Kruse, HP; Kuhlencordt, F; Ringe, JD, 1978)
"Treatment with sodium fluoride did not impair liver function or cholestasis in PBC."	6.67	Sodium fluoride prevents bone loss in primary biliary cirrhosis. ( del Rio, L; Gómez, R; Guañabens, N; Muñoz, J; Parés, A; Roca, M; Rodés, J, 1992)
"Osteosclerosis was achieved in 69% of the cases who had a radiological followup of at least four years (average period of appearance: 1."	6.67	Treatment of the vertebral crush fracture syndrome with enteric-coated sodium fluoride tablets and calcium supplements. ( Depresseux, G; Devogelaer, JP; Maldague, B; Malghem, J; Nagant de Deuxchaisnes, C, 1990)
"Osteoporosis is a systemic disease characterized by bone degradation and decreased bone mass that promotes increased bone fragility and eventual fracture risk."	5.43	Effect of Sodium Fluoride on Bone Biomechanical and Histomorphometric Parameters and on Insulin Signaling and Insulin Sensitivity in Ovariectomized Rats. ( Buzalaf, MA; Chiba, FY; de Cássia Alves Nunes, R; de Lima Coutinho Mattera, MS; Ervolino, E; Louzada, MJ; Pereira, AG; Pereira, RF; Silva, CA; Sumida, DH, 2016)
"76 years, were treated in the course of one year with sodium fluoride (Fluosen) in a dose of 45 mg/24 h in combination with calcium gluconate (2 g/24 h) and oil solution of vit D2 (2 mg/week)."	5.28	[Treatment of patients with postmenopausal and steroid-induced osteoporosis using sodium fluoride combined with vitamin D2 and calcium gluconate]. ( Andreeva, M; Diankova, L; Kamenova, P; Khristova, D; Todorova, S; Tsachev, K, 1990)
" In the described series of investigations this compound, with which treatment by gradual dosage is possible, has proved its effectiveness."	5.26	[Sodium fluoride in the therapy of osteoporosis]. ( Krokowski, E, 1979)
"The findings of the present study show that both sodium fluoride and ibandronate are effective in combination with calcium and vitamin D substitution in the management of osteopenia and osteoporosis in patients with Crohn's disease."	5.10	Therapy of osteoporosis in patients with Crohn's disease: a randomized study comparing sodium fluoride and ibandronate. ( Adler, G; Boehm, BO; Hofbauer, LC; Klaus, J; Kratzer, W; Mason, R; Reinshagen, M; Steinkamp, M; von Tirpitz, C, 2003)
"Sodium fluoride in combination with vitamin D and calcium is an effective, well-tolerated and inexpensive treatment to increase lumbar bone density in patients with chronic active Crohn's disease and osteoporosis."	5.09	Increase of bone mineral density with sodium fluoride in patients with Crohn's disease. ( Adler, G; Böhm, BO; Brückel, J; Klaus, J; Reinshagen, M; Rieber, A; Scholer, A; von Tirpitz, C, 2000)
"To investigate whether administration of sodium fluoride (NaF) in addition to cyclical etidronate has a positive effect on bone mineral density (BMD) in patients with established osteoporosis during continued treatment with corticosteroids."	5.08	Is addition of sodium fluoride to cyclical etidronate beneficial in the treatment of corticosteroid induced osteoporosis? ( Bijlsma, JW; Gerrits, MI; Haanen, HC; Houben, HH; Jacobs, JW; Lems, WF; van Rijn, HJ; van Veen, GJ, 1997)
"To investigate whether sodium fluoride (NaF) is able to prevent bone loss in patients treated with corticosteroids (Cs), we performed a randomized double-masked, placebo-controlled trial with 44 Cs-treated patients without established osteoporosis, defined as the absence of previous peripheral fractures and vertebral deformities on radiographs."	5.08	Effect of sodium fluoride on the prevention of corticosteroid-induced osteoporosis. ( Bijlsma, JW; Croone, A; Gerrits, MI; Haanen, HC; Houben, HH; Jacobs, WG; Lems, WF; van Rijn, HJ, 1997)
" To determine the relationships between parathyroid hormone activity and long-term sodium fluoride therapy in osteoporosis, cytochemical bioassays (for biologically active parathyroid hormone) were performed in 22 osteoporotic control patients and in 18 patients after 15 +/- 10 months of treatment (60 mg of sodium fluoride daily)."	5.06	Fluoride therapy and parathyroid hormone activity in osteoporosis. ( Goldstein, AJ; Jenkins, MV; Katakity, M; Kelsey, CR; Loveridge, N; Rose, GA; Saphier, PW; Stamp, TC, 1990)
"Long-term clinical effects of intermittent sodium fluoride (slow-release) therapy were assessed in 71 patients with primary osteoporosis."	5.06	Effect of intermittent therapy with a slow-release fluoride preparation. ( Pak, CY; Sakhaee, K; Zerwekh, JE, 1990)
"The value of intermittent slow release sodium fluoride treatment in the management of osteoporosis was studied by a comprehensive metabolic and clinical assessment during a long term trial."	5.06	Safe and effective treatment of osteoporosis with intermittent slow release sodium fluoride: augmentation of vertebral bone mass and inhibition of fractures. ( Johnson, K; Pak, CY; Parcel, C; Peterson, R; Sakhaee, K; Zerwekh, JE, 1989)
"Daily treatment with 30 mg of sodium fluoride (NaF) and 1 g of calcium over a 3-year period increased the bone mineral content (BMC) in the spines of women (n = 25) with osteoporosis."	5.06	The effect of fluoride and calcium on spinal bone mineral content: a controlled, prospective (3 years) study. ( Hansson, T; Roos, B, 1987)
"Nineteen patients suffering from primary osteoporosis, all having at least one vertebral collapse, initially received 50 mg of sodium fluoride alone per day for 6-18 months."	5.05	Extended treatment of primary osteoporosis by sodium fluoride combined with 25 hydroxycholecalciferol. ( Kuntz, D; Marie, P; Maziere, B; Naveau, B; Ryckewaert, A; Tubiana, M, 1984)
"To evaluate a therapeutic effect, biochemical parameters of bone metabolism and photonabsorption densitometry have been compared in patients with senile osteoporosis under long-term continuous or intermittent sodium fluoride treatment."	5.04	[Therapy of senile osteoporosis using sodium fluoride--continuous and intermittent long-term therapy]. ( Haber, P; Willvonseder, R, 1979)
" The similarities of primary osteoporosis and osteoporosis in multiple myeloma raised a hope that sodium fluoride will help to prevent or to slow down the osteoporotic process in multiple myeloma patients."	4.79	[Bone manifestations of multiple myeloma and therapeutic possibilities]. ( Adam, Z; Vorlícek, J, 1994)
" Sodium fluoride has been used to treat established osteoporosis for nearly 30 years."	4.79	Water fluoridation and osteoporotic fracture. ( Coggon, D; Cooper, C; Hillier, S; Inskip, H, 1996)
"A histomorphometric and dynamic study of non-decalcified transiliac biopsies was carried out in 51 cases of osteoporosis who had received double marking with tetracycline before and after two years treatment with association of sodium fluoride (50 mg/day) vitamin, D2 (8,000 IU/day) and calcium (1 g/day)."	4.76	[Histological effects of the treatment of osteoporosis with the combination of sodium fluoride, vitamin D and calcium]. ( Briançon, D; Charhon, S; Edouard, C; Meunier, PJ, 1980)
"To determine whether sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) can be used to monitor decreased bone turnover with aging in the spine."	4.31	The Utility of 18 F-NaF-Positron Emission Tomography/Computed Tomography in Measuring the Metabolic Activity of the Aging Spine : Implications for Osteoporosis. ( Alavi, A; Høilund-Carlsen, PF; Khurana, N; Park, PSU; Raynor, WY; Resto, DA; Werner, TJ, 2023)
" In this report, we examine the data from our clinical trial of sodium fluoride in spinal osteoporosis to assess critically the plausibility of two hypotheses: (1) The "rebound" phenomenon results from measurement error."	3.69	Reversal of vertebral deformities in osteoporosis: measurement error or "rebound"? ( Kleerekoper, M; Nelson, DA; Peterson, EL, 1994)
"In a 5-year observational study we have compared sodium fluoride (NaF) with different treatments commonly used in the treatment of osteoporosis: calcium, estrogens, androgens, and calcitonin, referred to as non-NaF."	3.69	Sodium fluoride treatment is a major protector against vertebral and nonvertebral fractures when compared with other common treatments of osteoporosis: a longitudinal, observational study. ( Armadans, L; Farrerons, J; Guañabens, N; López-Navidad, A; Renau, A; Rodríguez de la Serna, A; Vaqué, J; Yoldi, B, 1997)
"The long-term effects of low concentrations of sodium fluoride (0, 1 and 5 mg/l) in drinking water on bone metabolism were examined in the growing senescence accelerated mouse (SAM-P/6) as a spontaneous experimental model of senile osteoporosis."	3.68	[The effects of long-term intake of a low concentration of sodium fluoride on bone loss in the growing senescence-accelerated mouse (SAM-P/6)]. ( Imai, T; Niwa, M; Takeki, Y; Yagoori, A; Yamazaki, S, 1992)
"The effect of sodium fluoride therapy on iliac trabecular bone has been studied in 15 patients with primary osteoporosis by comparing bone biopsies taken before and after two years of treatment."	3.68	The effect of sodium fluoride on trabecular architecture. ( Aaron, JE; de Vernejoul, MC; Kanis, JA, 1991)
"Recent studies have suggested that sodium fluoride therapy may be an effective treatment for vertebral osteoporosis."	3.68	Exacerbation of rheumatoid arthritis by sodium fluoride treatment of osteoporosis. ( Chesnut, CH; Duell, PB, 1991)
" Transiliac crest bone biopsies were obtained from 16 patients with osteoporosis and vertebral compression fractures (12 women and 4 men, mean age 56 years) before and after approximately 2 years of intermittent slow-release sodium fluoride therapy (25 mg twice a day) combined with continuous calcium citrate supplementation."	3.68	Assessment by reflection ultrasound method of the effect of intermittent slow-release sodium fluoride-calcium citrate therapy on material strength of bone. ( Antich, PP; Gonzales, J; Gottschalk, F; Pak, CY; Sakhaee, K; Zerwekh, JE, 1991)
"To evaluate the need for a randomised study of treatment of spinal osteoporosis with human parathyroid peptide in the secondary prevention of crush fractures; to study the effect of human parathyroid hormone peptide 1-34 plus sex hormones on vertebral body cancellous bone; and, separately, to determine the effect of relatively low doses of sodium fluoride plus calcium on spinal bone mineral density."	3.68	Treatment of osteoporosis with human parathyroid peptide and observations on effect of sodium fluoride. ( Davies, UM; Hesp, R; Katz, D; McNally, E; Reeve, J, 1990)
"This article contains a report of the results of a study of 10 postmenopausal women with uncomplicated osteoporosis who were treated with sodium fluoride, calcium supplementation, and vitamin D."	3.67	Treatment of osteoporosis with sodium fluoride and calcium: effects on vertebral fracture incidence and bone histomorphometry. ( Einhorn, TA; Healey, JH; Lane, JM; Robbins, WC; Schneider, R; Schwartz, E; Suda, M; Vigorita, VJ, 1984)
"In order to find out whether the response of osteoporosis to sodium fluoride treatment or complications arising from this treatment are related to the retention of fluoride in bones, we measured bone fluoride concentrations in 30 patients with primary osteoporosis who had been treated with sodium fluoride for 1 to 8 years."	3.67	[Value of bone fluoride determination in osteoporotic patients treated with sodium fluoride]. ( Brouard, A; de Vernejoul, MC; Kuntz, D; Laurent, V; Miravet, L; Terrier, JL, 1989)
"Thirty seven female patients with osteoporosis underwent iliac bone biopsy after 10 to 23 months of continuous or discontinuous treatment with sodium fluoride, calcium, and vitamin D."	3.67	[Microradiographic study of iliac bone biopsies taken after treatment of postmenopausal osteoporosis with sodium fluoride. Histomorphometric correlations]. ( Duriez, J; Duriez, R; Flautre, B, 1989)
"Thirteen cases of spontaneous fissure or fracture of the lower limbs observed in 8 patients under treatment with sodium fluoride are reported; 7 of these patients were being treated for osteoporosis."	3.67	[Spontaneous fissures and fractures of the legs in patients with osteoporosis treated with sodium fluoride]. ( Crouzet, J; Kaplan, G; Orcel, P; Prier, A, 1987)
" The fluorosis is only rarely observed as a sequel of the sodium fluoride therapy of osteoporosis."	3.67	[Fluorosis following the long-term treatment of osteoporosis with sodium fluoride]. ( Hasert, V; Matzkowski, H; Meseg, S, 1986)
"Forty-one women with idiopathic postmenopausal osteoporosis have been followed for 2 years after initiation of sodium fluoride at 40-50 mg/day, given together with a daily calcium supplement of 1 gram and vitamin D2, at 50,000 IU weekly."	3.67	The effect of fluoride on bone histology in postmenopausal osteoporosis depends on adequate fluoride absorption and retention. ( Bayley, TA; Budden, FH; Goodwin, S; Harrison, JE; Josse, RG; Kandel, R; Murray, TM; Strauss, AL; Sturtridge, WC; Vieth, R, 1988)
"Twenty-one patients with postmenopausal osteoporosis were studied for 4 years after initiation with sodium fluoride (NaF), 20-25 mg b."	3.67	The relationship between fluoride effects on bone histology and on bone mass in patients with postmenopausal osteoporosis. ( Bayley, TA; Fornasier, V; Goodwin, S; Harrison, JE; Josse, RG; Murray, TM; Sturtridge, W; Tam, C; Williams, C, 1986)
"Patients with osteoporosis were treated for two years with sodium fluoride."	3.67	Responders and non-responders after fluoride therapy in osteoporosis. ( Bosch, R; Duursma, SA; Glerum, JH; Kerkhoff, H; Raymakers, JA; van Dijk, A; van Putten, J, 1987)
"During an 8-year period, 163 consecutive patients with spinal crush fracture osteoporosis started a 5-year treatment with a combination of sodium fluoride (60 mg/day), calcium phosphate (45 mmol/day) and vitamin D2 (18,000 IU/day), and were followed in the outpatient clinic every 3 months."	3.67	Safety of osteoporosis treatment with sodium fluoride, calcium phosphate and vitamin D. ( Hasling, C; Melsen, F; Mosekilde, L; Nielsen, HE, 1987)
"The benefit of sodium fluoride (NaF) in the therapy of osteoporosis is still controversial."	3.67	Long-term fluoride therapy of postmenopausal osteoporosis. ( Dambacher, MA; Ittner, J; Ruegsegger, P, 1986)
"Report on 3 female patients who, after treatment of an osteoporosis with sodium fluoride, have developed a skeletal fluorosis."	3.67	[Therapy-induced fluorosis--damage or goal?]. ( Eisengarten, K; Leuschke, W; Schmidt, CW, 1986)
"Calcium and phosphorus balances and 47Ca turnover studies were performed before and after 12-27 months of daily treatment with sodium fluoride (60 mg), calcium (30-45 mmol), phosphate (29-44 mmol), and vitamin D2 (18,000 IU) in 20 postmenopausal women with spinal crush fracture osteoporosis."	3.67	The effects of sodium fluoride, calcium phosphate, and vitamin D2 for one to two years on calcium and phosphorus metabolism in postmenopausal women with spinal crush fracture osteoporosis. ( Charles, P; Jensen, FT; Mosekilde, L, 1985)
"Thirteen patients with primary osteoporosis were treated for two years with sodium fluoride (NaF), calcium and dihydrotachysterol (group A)."	3.66	Fluoride in serum and bone during treatment of osteoporosis with sodium fluoride, calcium and vitamin D. ( Backer Dirks, O; Duursma, SA; van der Sluys Veer, J; van Kesteren, RG; Visser, WJ, 1982)
"26 women were treated for osteoporosis with 40 mg of sodium fluoride twice a day (equivalent 36 mg of fluorine) for a longer period."	3.66	[Osteoporosis therapy and thyroid function. Influence of 6 months of sodium fluoride treatment on thyroid function and bone density]. ( Börner, W; Eichner, R; Henschler, D; Köhler, W; Moll, E, 1981)
"Thirty-six patients with primary osteoporosis were treated for up to six years with sodium fluoride, calcium supplements, and, in 24 patients, vitamin D."	3.66	Treatment of primary osteoporosis with fluoride and calcium. Clinical tolerance and fracture occurrence. ( Hodgson, SF; Hoffman, DL; Johnson, KA; Kelly, PJ; Riggs, BL; Taves, D, 1980)
" This constant concentration of ionised fluorine in the plasma contrasted with the marked and rapid variations which follow the ingestion of sodium fluoride, which is usually prescribed in the treatment of osteoporosis."	3.66	[Change in the plasma and urine levels of ionized fluorine under the influence of low doses of niflumic acid. Possible application to the treatment of osteoporosis]. ( Audran, M; Boiteau, HL; Caumon, JP; Prost, A; Rossel-Renac, F, 1980)
" She was asthmatic and had been treated with 60 mg sodium fluoride and three Calcium Sandoz tablets daily for three years in an attempt to minimize steroid-induced osteoporosis."	3.66	Iatrogenic fluorosis. ( de Silva, RT; Grennan, DM; Malthus, RS; Matagni, MF; Palmer, DG, 1978)
"25 female patients with different forms of osteoporosis (progredient form in elderly patients, steroid osteoporosis, involutive osteoporosis) treated during a period varying between 1 to 24 months with a new compound preparation containing 25 mg sodium fluoride and 200 mg L-ascorbic acid per tablet."	3.66	[Treatment of osteoporosis with a new retard-preparation of sodium fluoride (author's transl)]. ( Bröll, H; Eberl, R; Falkensamer, C; Fischer, M; Petera, P; Tausch, G, 1979)
"Twenty-three patients with primary osteoporosis were treated with sodium fluoride over 25 months."	3.66	[Results of long-term treatment of primary osteoporosis with sodium fluoride (author's transl)]. ( Kruse, HP; Kuhlencordt, F; Ringe, JD, 1978)
" Two groups of patients with either low (osteoporosis), (n = 15) or high (Paget's disease, n = 6) bone turnover were studied before and after sodium fluoride (NaF) and diphosphonate (EHDP) treatment, respectively."	3.65	Bone remodeling and calcium metabolism: a correlated histomorphometric, calcium kinetic, and biochemical study in patients with osteoporosis and Paget's Disease. ( Dambacher, MA; Guncaga, J; Haas, HG; Lauffenburger, T; Lentner, C; Olah, AJ, 1977)
"Osteoporosis is a metabolic bone disorder that leads to a decline in bone microarchitecture, predisposing individuals to catastrophic fractures."	3.01	Emerging Role of ( Collins, MT; Farhadi, F; Osamor, CC; Paravastu, SS; Saboury, B; Sheppard, AJ; Wojnowski, NM, 2023)
"Osteoporosis commonly afflicts Crohn's disease (CD) patients."	2.76	Intravenous ibandronate or sodium-fluoride--a 3.5 years study on bone density and fractures in Crohn's disease patients with osteoporosis. ( Adler, G; Herdt, K; Klaus, J; Reinshagen, M; von Boyen, GB; von Tirpitz, C, 2011)
" Australian randomized study of 50 patients is described where NaF dosage is varied proportional to the osteoblast response, and duration is dependent on densitometric and radiographic response."	2.67	Fluoride treatment of osteoporosis: cyclical non-blinded or continuous blinded studies? ( Bhagat, CI; Gutteridge, DH; Jones, CE; Kent, GN; Nicholson, GC; Prince, RL; Retallack, RW; Stewart, GO; Stuckey, BG, 1993)
"Treatment with sodium fluoride did not impair liver function or cholestasis in PBC."	2.67	Sodium fluoride prevents bone loss in primary biliary cirrhosis. ( del Rio, L; Gómez, R; Guañabens, N; Muñoz, J; Parés, A; Roca, M; Rodés, J, 1992)
"Osteosclerosis was achieved in 69% of the cases who had a radiological followup of at least four years (average period of appearance: 1."	2.67	Treatment of the vertebral crush fracture syndrome with enteric-coated sodium fluoride tablets and calcium supplements. ( Depresseux, G; Devogelaer, JP; Maldague, B; Malghem, J; Nagant de Deuxchaisnes, C, 1990)
"Osteoporosis is one of the most important problems in developed societies."	2.43	[Anabolic therapy in osteoporosis--part 1]. ( Herman, ZS; Krysiak, R; Labuzek, K; Okopień, B, 2005)
"Osteoporosis is one of the most important problems in developed societies."	2.43	[Anabolic therapy of osteoporosis]. ( Herman, ZS; Krysiak, R; Labuzek, K; Okopień, B, 2005)
"Osteoporosis is a frequent complication in the course of various gastrointestinal disorders."	2.42	Management of osteoporosis in patients with gastrointestinal diseases. ( Reinshagen, M; von Tirpitz, C, 2003)
"Osteoporosis is not a significant problem in the majority of patients with primary biliary cirrhosis (PBC)."	2.41	Management of osteoporosis in primary biliary cirrhosis. ( Schalm, SW; van Buuren, HR; Vleggaar, FP; Wolfhagen, FH, 2000)
"Osteoporosis is a public health scourge that is usually eminently preventable."	2.40	Osteoporosis: prevention, diagnosis, and management. ( Deal, CL, 1997)
"Risk fractures for osteoporosis are numerous."	2.39	Osteoporotic fractures: background and prevention strategies. ( Wark, JD, 1996)
" With this in mind, the bioavailability of the drug has to be taken into account, particularly its gastrointestinal absorption which is dramatically enhanced if a plain non entericoated (EC) capsule is used, as compared to that of an EC tablet with the same face value."	2.39	Fluoride therapy of type I osteoporosis. ( Devogelaer, JP; Nagant de Deuxchaisnes, C, 1995)
"Osteoporosis is an increasingly prevalent chronic and debilitating disease."	2.39	Update on pharmacologic therapies for osteoporosis. ( Kessenich, CR, 1996)
"Osteoporosis is a leading cause of disability and death in older Americans; women are at higher risk than men."	2.39	Alternatives to estrogen replacement therapy for preventing osteoporosis. ( Cáceres, B; Haines, ST; Yancey, L, 1996)
"Women are the most common victims of involutional osteoporosis because of post-menopausal bone loss induced by oestrogenic deficit."	2.38	Osteoporosis. ( Devogelaer, JP; Nagant de Deuxchaisnes, C, 1993)
"Osteoporosis is a major public health problem."	2.38	Treatment of osteoporosis and Paget's disease. ( Nicholson, GC; Stewart, GO, 1991)
"Osteoporosis is a skeletal condition in which there is a loss of bone mass, evident radiographically by diffuse rarefaction or clinically by overt fractures."	2.37	Osteoporosis. ( Lane, JM; Vigorita, VJ, 1984)
"It has proved worthwhile to treat osteoporosis simultaneously in two ways."	2.37	[Drug therapy of osteoporosis]. ( Dambacher, MA, 1988)
"Osteoporosis is a major public health problem, particularly for the postmenopausal woman."	2.37	Postmenopausal osteoporosis. ( Lindsay, R; Silverberg, SJ, 1987)
"Osteoporosis is a common disorder in women."	2.36	Osteoporosis--a review and update. ( Lukert, BP, 1982)
"Osteoporosis is a systemic disease characterized by bone degradation and decreased bone mass that promotes increased bone fragility and eventual fracture risk."	1.43	Effect of Sodium Fluoride on Bone Biomechanical and Histomorphometric Parameters and on Insulin Signaling and Insulin Sensitivity in Ovariectomized Rats. ( Buzalaf, MA; Chiba, FY; de Cássia Alves Nunes, R; de Lima Coutinho Mattera, MS; Ervolino, E; Louzada, MJ; Pereira, AG; Pereira, RF; Silva, CA; Sumida, DH, 2016)
"Osteoporosis was induced by ovariectomy and a calcium restricted diet."	1.40	Preliminary evaluation of different biomaterials for defect healing in an experimental osteoporotic rat model with dynamic PET-CT (dPET-CT) using F-18-sodium fluoride (NaF). ( Alt, V; Cheng, C; Dimitrakopoulou-Strauss, A; Gelinsky, M; Pan, L; Schnettler, R; Schumacher, M; Strauss, LG; Thormann, U, 2014)
"Osteoporosis was induced by ovariectomy and a calcium-restricted diet."	1.40	Application of F-18-sodium fluoride (NaF) dynamic PET-CT (dPET-CT) for defect healing: a comparison of biomaterials in an experimental osteoporotic rat model. ( Alt, V; Cheng, C; Dimitrakopoulou-Strauss, A; Gelinsky, M; Heinemann, S; Nies, B; Pan, L; Schnettler, R; Schumacher, M; Strauss, LG; Thormann, U, 2014)
"Osteoporosis affects the craniofacial and oral structures and has been associated with periodontal bone loss, tooth loss and reduced jaw bone mass."	1.38	Oral bone loss induced by mineral deficiency in a rat model: effect of a synthetic bone mineral (SBM) preparation. ( Dias, R; Kulkarni, A; LeGeros, RZ; Lewis, K; Mijares, D; Tannous, S; Xi, Q; Yao, F, 2012)
"Osteoporosis was induced in 10 rats via injection with an excess of dexamethasone phosphate sodium, and the biodistribution of (18)-NaF in the rats was studied, with another 10 normal rats as the control group."	1.35	[Biodistribution of (18)F-NaF as an imaging agent in osteoporotic rats for position emission tomography]. ( Li, QZ; Wang, MF; Wang, P, 2008)
"Osteoporosis is a frequent complication in patients with inflammatory bowel disease."	1.35	Cost effectiveness of ibandronate for the prevention of fractures in inflammatory bowel disease-related osteoporosis: cost-utility analysis using a Markov model. ( Klaus, J; König, HH; Konnopka, A; Kreck, S; Leidl, R; Matschinger, H; von Tirpitz, C, 2008)
"After treatment with NaF, bone resorption was not inhibited, but bone formation was significantly increased."	1.31	[Effect of sodium fluoride on bone turnover and bone loss of vertebrae and tibia in ovariectomized rats]. ( Huang, F; Jin, M; Ma, S; Tan, Y; Zhang, M; Zhao, H, 2000)
"Osteoporosis is a metabolic bone disease characterized by an increased risk of fractures, especially hip, wrist and vertebral fractures."	1.30	[Osteoporosis: its diagnosis, its consequences]. ( Hardouin, P, 1997)
" The results of this study indicate that long-term administration of sodium fluoride may be detrimental to bone quality, at least as measured in non-loaded iliac crest trabecular bone."	1.29	[Loss of trabecular bone strength and bone quality after 5 years of fluoride therapy for osteoporosis]. ( Mosekilde, L; Richards, A; Søgaard, CH, 1995)
"Osteoporosis has major medical and economic costs and consequences for society, yet the most effective strategies to pursue in reducing these costs and consequences are uncertain."	1.29	Outcomes assessment in osteoporosis: strategies for improvement. ( Chrischilles, E, 1996)
"In Paget's disease and fluoride-treated osteoporosis a thickening of rarefied trabeculae in both was associated in Paget's disease only with an increase in the trabecular number and the transformation of a discontinuous arrangement into a more continuous network."	1.28	Bone hypertrophy and trabecular generation in Paget's disease and in fluoride-treated osteoporosis. ( Aaron, JE; de Vernejoul, MC; Kanis, JA, 1992)
"Osteoporosis is the most common metabolic bone disorder in the United States."	1.28	The prevention of osteoporosis. ( Levin, RM, 1991)
"Under these conditions microfractures are likely to heal poorly and propagate to develop into full stress fractures."	1.28	Iliac bone biopsies at the time of periarticular stress fractures during fluoride therapy: comparison with pretreatment biopsies. ( Gear, KA; Mesquita, JM; Moodley, GP; Robson, HJ; Schnitzler, CM; Smyth, AE, 1990)
"Finally, stress fractures were found in less than 2% of our patients."	1.28	The causes of bone scintigram hot spots in fluoride-treated osteoporotic patients. ( Baylink, DJ; Brin, BN; Flowers, C; Sauser, DD; Schulz, EE; Wergedal, JE, 1990)
" It is suggested that improvements of the clinical benefit of fluoride therapy in osteoporosis might be achieved if the dosage regimen were based on the pharmacokinetic properties of the fluoride preparation used as well as plasma fluoride monitoring."	1.28	Fluoride pharmacokinetics: its implications in the fluoride treatment of osteoporosis. ( Ekstrand, J; Spak, CJ, 1990)
"76 years, were treated in the course of one year with sodium fluoride (Fluosen) in a dose of 45 mg/24 h in combination with calcium gluconate (2 g/24 h) and oil solution of vit D2 (2 mg/week)."	1.28	[Treatment of patients with postmenopausal and steroid-induced osteoporosis using sodium fluoride combined with vitamin D2 and calcium gluconate]. ( Andreeva, M; Diankova, L; Kamenova, P; Khristova, D; Todorova, S; Tsachev, K, 1990)
"Osteomalacia is caused by inadequate or delayed mineralization of bone and is treated by correcting the abnormal intake, loss, or metabolism of vitamin D, phosphate, and calcium."	1.27	Osteoporosis, osteomalacia, rickets, and Paget's disease. ( Gall, EP; Nugent, CA; Pitt, MJ, 1984)
"As bilateral femoral neck fractures are very rare these data suggest a causal link between fractures and fluoride in patients with renal failure."	1.27	Bilateral fractures of femoral neck in patients with moderate renal failure receiving fluoride for spinal osteoporosis. ( Baud, CA; Boivin, G; Briancon, D; Charhon, SA; Gerster, JC; Jaeger, P; Meunier, PJ; Rostan, A, 1983)
"Osteoporosis is a serious metabolic bone disorder that results in fractures of the wrist, hip and vertebrae."	1.27	Osteoporosis: significance, risk factors and treatment. ( Coralli, CH; Raisz, LG; Wood, CL, 1986)
"Osteoporosis is the most common bone disorder in the United States."	1.27	Osteoporosis. ( Davies, R; Saha, S, 1985)
" The effect of long-term administration of parathyroid hormone (PTH) on whole-body calcium and ash weight of individual bones has been studied in normal and osteoporotic adult female rats in order to examine whether such a treatment could induce a positive calcium balance."	1.26	Increase of whole-body calcium and skeletal mass in normal and osteoporotic adult rats treated with parathyroid hormone. ( Bonjour, JP; Fleisch, H; Hefti, E; Schenk, R; Trechsel, U, 1982)
" In the described series of investigations this compound, with which treatment by gradual dosage is possible, has proved its effectiveness."	1.26	[Sodium fluoride in the therapy of osteoporosis]. ( Krokowski, E, 1979)
"The bioavailability of Ossin, a drug for the treatment of osteoporosis, containing 40 mg of NaF, was investigated."	1.26	[Biological availability of Ossin, a sodium-fluoride dragee for osteoporosis therapy]. ( Becker, R, 1979)
""Osteoporosis" is no disease by itself, but solely an anatomically equal result of various etiologic and pathogenetic influences on the bone structure or parts of same."	1.26	[Principles in the therapy of osteoporosis. 2. Therapy]. ( Jesserer, H, 1977)
"The incidence of senile osteoporosis is not known because of the various criteria used for the diagnosis of this disorder by different authors."	1.26	Senile osteoporosis. ( Targovnik, J, 1977)

Research

Studies (278)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Changes in Femoral Neck BMD +/- Treatment With Alendronate

Timeframe	Studies, this research(%)	All Research%
pre-1990	168 (60.43)	18.7374
1990's	82 (29.50)	18.2507
2000's	18 (6.47)	29.6817
2010's	7 (2.52)	24.3611
2020's	3 (1.08)	2.80

Authors	Studies
Sheppard, AJ	3
Paravastu, SS	3
Wojnowski, NM	3
Osamor, CC	3
Farhadi, F	3
Collins, MT	3
Saboury, B	3
Park, PSU	1
Resto, DA	1
Khurana, N	1
Raynor, WY	3
Werner, TJ	4
Høilund-Carlsen, PF	2
Alavi, A	4
Zhang, V	1
Koa, B	1
Borja, AJ	1
Padmanhabhan, S	1
Bhattaru, A	1
Rojulpote, C	1
Seraj, SM	1
Rajapakse, C	1
Revheim, ME	1
Reilly, CC	1
Hong, AL	1
Kargilis, DC	1
Lee, JS	1
Alecxih, AG	1
Gupta, N	1
Lim, MK	1
Al-Zaghal, A	1
Rhodes, SS	1
Rajapakse, CS	2
Cheng, C	2
Alt, V	2
Pan, L	2
Thormann, U	2
Schnettler, R	2
Strauss, LG	2
Schumacher, M	2
Gelinsky, M	2
Dimitrakopoulou-Strauss, A	2
Heinemann, S	1
Nies, B	1
de Cássia Alves Nunes, R	1
Chiba, FY	1
Pereira, AG	1
Pereira, RF	1
de Lima Coutinho Mattera, MS	1
Ervolino, E	1
Louzada, MJ	1
Buzalaf, MA	1
Silva, CA	1
Sumida, DH	1
Raynor, W	1
Houshmand, S	1
Gholami, S	1
Emamzadehfard, S	1
Blomberg, BA	1
Baker, JF	1
Klaus, J	4
Reinshagen, M	4
Herdt, K	1
Adler, G	3
von Boyen, GB	1
von Tirpitz, C	5
Mijares, D	1
Kulkarni, A	1
Lewis, K	1
Yao, F	1
Xi, Q	1
Tannous, S	1
Dias, R	1
LeGeros, RZ	1
Steinkamp, M	1
Hofbauer, LC	1
Kratzer, W	1
Mason, R	1
Boehm, BO	1
ARMSTRONG, WD	1
SINGER, L	1
ENSINCK, J	1
RICH, C	1
GEALL, MG	1
BEILIN, LJ	1
Hough, S	1
Pepene, CE	1
Seck, T	1
Diel, I	1
Minne, HW	2
Ziegler, R	2
Pfeilschifter, J	1
Simon, LS	1
Okopień, B	2
Krysiak, R	2
Labuzek, K	2
Herman, ZS	2
Galus, K	4
Wang, P	1
Li, QZ	1
Wang, MF	1
Kreck, S	1
Leidl, R	1
Konnopka, A	1
Matschinger, H	1
König, HH	1
Gardner, FH	1
Kanis, JA	4
Reeve, J	3
Lukert, BP	1
Selby, J	1
Nugent, CA	1
Gall, EP	1
Pitt, MJ	1
Christiansen, C	2
Mazess, RB	1
Transbøl, I	1
Jensen, GF	1
Riggs, BL	6
Seeman, E	2
Hodgson, SF	2
Taves, DR	1
O'Fallon, WM	1
Gerster, JC	1
Charhon, SA	1
Jaeger, P	1
Boivin, G	2
Briancon, D	4
Rostan, A	1
Baud, CA	3
Meunier, PJ	11
Leroux, JL	1
Blotman, F	1
Claustre, J	1
Simon, L	2
Lane, JM	5
Vigorita, VJ	4
Baylink, DJ	9
Duane, PB	1
Farley, SM	2
Farley, JR	2
Dixon, AS	1
Grove, O	1
Halver, B	1
Chesnut, CH	5
Hefti, E	1
Trechsel, U	1
Bonjour, JP	1
Fleisch, H	1
Schenk, R	1
Kuntz, D	4
Marie, P	1
Naveau, B	1
Maziere, B	1
Tubiana, M	1
Ryckewaert, A	2
Spencer, H	4
Kramer, L	3
Wiatrowski, E	2
Lender, M	1
Gruber, HE	2
Brautbar, N	1
Healey, JH	2
Schwartz, E	1
Schneider, R	1
Einhorn, TA	1
Suda, M	1
Robbins, WC	1
Schmidt, CW	3
Gaborit, P	1
Dobbels, E	1
Bonnefoy-Cudraz, M	1
Roux, H	1
Pantůcek, MB	2
Karpas, K	2
Milhaud, G	1
Gallagher, C	2
Chesnut, C	1
Parfitt, A	1
Dempster, DW	1
Edouard, C	3
Chapuy, MC	1
Arlot, M	1
Charhon, S	2
Schulz, EE	3
Libanati, CR	1
Kirk, GA	1
Harrison, JE	5
McNeill, KG	2
Sturtridge, WC	2
Bayley, TA	4
Murray, TM	5
Williams, C	2
Tam, C	2
Fornasier, V	2
El-Khoury, GY	1
Moore, TE	1
Albright, JP	1
Huang, HK	1
Martin, RK	1
Williams, CC	1
Kocián, J	3
Stauffer, ME	1
Thompson, ER	1
Ringe, JD	4
Kruse, HP	3
Kuhlencordt, F	2
Rico Lenza, H	2
Espinós Pérez, D	2
Maheshwari, UR	1
Schneider, VS	1
McDonald, JT	1
Brunetti, AJ	1
Leybin, L	1
Newbrun, E	1
Hodge, H	1
Rüegsegger, P	2
Stebler, B	1
Dambacher, M	1
van Kesteren, RG	2
Duursma, SA	6
Visser, WJ	3
van der Sluys Veer, J	2
Backer Dirks, O	1
Lie, H	1
Malde, K	1
Sorteberg, K	1
Hasvold, O	1
Ekren, T	1
Malm, OJ	1
Glimet, T	1
de Vernejoul, MC	5
Eichner, R	1
Börner, W	1
Henschler, D	1
Köhler, W	1
Moll, E	1
Nemec, M	1
Kovác, M	1
Varga, G	1
Nemec, P	1
Hoffman, DL	1
Kelly, PJ	1
Johnson, KA	1
Taves, D	1
Balink, DJ	1
Ivey, JL	1
Compston, JE	1
Chadha, S	1
Merrett, AL	1
Pizio, Z	1
Machácek, P	2
Marat, V	2
Prost, A	2
Boiteau, HL	1
Rossel-Renac, F	1
Audran, M	1
Caumon, JP	1
Van Gastel, C	1
Becker, H	1
Bonne, A	1
Megens, JG	1
Mundy, GR	1
Adam, Z	1
Vorlícek, J	1
Søgaard, CH	1
Mosekilde, L	8
Richards, A	1
Neuhaus, R	1
Lohmann, R	1
Platz, KP	1
Guckelberger, O	1
Schön, M	1
Lang, M	1
Hierholzer, J	1
Neuhaus, P	1
Bucsi, L	2
Ashton, BA	1
Nelson, DA	2
Kleerekoper, M	7
Peterson, EL	2
Antich, PP	5
Pak, CY	9
Gonzales, J	3
Anderson, J	1
Sakhaee, K	8
Rubin, C	1
Gutteridge, DH	2
Kent, GN	1
Prince, RL	1
Nicholson, GC	2
Stewart, GO	2
Jones, CE	1
Bhagat, CI	1
Stuckey, BG	1
Retallack, RW	1
Devogelaer, JP	4
Nagant de Deuxchaisnes, C	4
Nakahara, H	1
Wark, JD	1
Turner, CH	1
Kessenich, CR	1
Hillier, S	1
Inskip, H	1
Coggon, D	1
Cooper, C	1
Price, RI	1
Haines, ST	1
Cáceres, B	1
Yancey, L	1
Rubin, CD	1
Zerwekh, JE	8
Adachi, JD	1
Farrerons, J	1
Rodríguez de la Serna, A	1
Guañabens, N	2
Armadans, L	1
López-Navidad, A	1
Yoldi, B	1
Renau, A	1
Vaqué, J	1
Roschger, P	1
Fratzl, P	1
Klaushofer, K	1
Rodan, G	1
Deal, CL	1
Lems, WF	2
Jacobs, JW	1
Bijlsma, JW	2
van Veen, GJ	1
Houben, HH	2
Haanen, HC	2
Gerrits, MI	2
van Rijn, HJ	2
Schnitzler, CM	5
Wing, JR	2
Raal, FJ	1
van der Merwe, MT	1
Mesquita, JM	3
Gear, KA	2
Robson, HJ	3
Shires, R	1
Mehta, S	1
Gottschalk, F	3
Hardouin, P	1
Gibaldi, M	1
Shiflett, S	1
Cooke, CE	1
Jacobs, WG	1
Croone, A	1
Balena, R	1
Foldes, JA	1
Shih, MS	1
Rao, DS	1
Schober, HC	1
Parfitt, AM	2
Chrischilles, E	1
Brückel, J	1
Rieber, A	1
Scholer, A	1
Böhm, BO	1
Blank, RD	1
Bockman, RS	1
Wolfhagen, FH	1
van Buuren, HR	1
Vleggaar, FP	1
Schalm, SW	1
Lin, CL	1
Moniz, C	1
Chow, JW	1
Rosen, CJ	1
Bilezikian, JP	1
Lane, NE	1
Antich, P	1
Zhang, M	1
Huang, F	1
Tan, Y	1
Zhao, H	1
Jin, M	1
Ma, S	1
Compston, J	1
Jowsey, J	1
Haber, P	2
Willvonseder, R	2
Krokowski, E	2
Grennan, DM	1
Palmer, DG	1
Malthus, RS	1
Matagni, MF	1
de Silva, RT	1
Münzenberg, KJ	1
Femppel, J	1
Heidelmann, G	4
Lauffenburger, T	2
Olah, AJ	2
Dambacher, MA	4
Guncaga, J	1
Lentner, C	1
Haas, HG	4
Vokrouhlická, O	1
Hrba, J	1
Horn, V	1
Pacovský, V	1
Tausch, G	1
Petera, P	1
Bröll, H	1
Eberl, R	1
Falkensamer, C	1
Fischer, M	1
del Rio Vázquez, A	1
Vázquez Salamanica, E	1
Vose, GP	1
Keele, DK	1
Milner, AM	1
Rawley, R	2
Roach, TL	1
Sprinkle, EE	1
Wallach, S	1
Avioli, LV	1
Becker, R	1
Baer, HP	1
Bech, R	1
Franke, J	2
Grunewald, A	1
Kochmann, W	1
Melson, F	1
Runge, H	1
Wiedner, W	1
Jesserer, H	1
Targovnik, J	1
Manzke, E	1
Vose, G	1
Roginsky, M	1
Rader, JI	1
Osis, D	2
Geidel, H	1
Fuchs, C	1
Dorn, D	1
Hauswaldt, C	1
Henning, HV	1
Köbberling, J	1
Kubosch, J	1
Mc Intosh, C	1
Unger, HD	1
Scheler, F	1
Ambrus, JL	1
Hoffman, M	1
Ambrus, CM	1
Hreshchyshyn, MM	1
Moore, D	1
Munschauer, FE	1
Pankow, W	1
Ehlenz, K	1
Buhr, T	1
Pflüger, KH	1
von Wichert, P	1
Greenwald, M	1
Brandli, D	1
Spector, S	1
Silverman, S	1
Golde, G	1
Prior, J	1
Parés, A	1
del Rio, L	1
Roca, M	1
Gómez, R	1
Muñoz, J	1
Rodés, J	1
Treves, R	2
Harang, H	1
Bertin, P	2
Bonnet, C	1
Arnaud, M	2
Desproges-Gotteron, R	2
Imai, T	1
Takeki, Y	1
Yamazaki, S	1
Yagoori, A	1
Niwa, M	1
Tałałaj, M	1
Smogorzewski, M	1
Madej, K	1
Karolak, M	1
Wall, W	1
Greep, N	1
Anderson, AL	1
Gallagher, JC	2
Aaron, JE	2
Verlooy, H	1
Westhovens, R	1
Mortelmans, L	1
De Roo, M	1
Hesch, RD	1
Rittinghaus, EF	1
Levin, RM	1
Long, K	1
Long, R	1
Kuska, J	1
Wiecek, A	1
Czech, U	1

Trial	Enrollment	Study Type	Start Date	Status
CT-Based Changes in Bone and Marrow Among Patients on Oral Steroids[NCT04518722]	12 participants (Anticipated)	Observational	2020-12-01	Recruiting
Changes in Bone Density, Radiographic Texture Analysis and Bone Turnover During Two Years of Antiresorptive Therapy for Postmenopausal Osteoporosis[NCT00145977]	36 participants (Actual)	Interventional	2001-07-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Percent Change in femoral neck BMD from Baseline to Month 24 (NCT00145977)
Timeframe: Baseline to Month 24

Changes in Lumbar Spine BMD +/- Treatment With Alendronate

Intervention	Percent Change (Mean)
Alendronate	-4.21
Control	0.04

Percent Change in lumbar spine BMD from Baseline to Month 24 (NCT00145977)
Timeframe: Baseline to Month 24

Changes in Peripheral Heel BMD +/- Treatment With Alendronate

Intervention	Percent Change (Mean)
Alendronate	5.28
Control	-1.48

Percent Change in peripheral heel BMD from Baseline to Month 24 (NCT00145977)
Timeframe: Baseline to Month 24

Changes in Radiographic Texture Analysis (RTA) Feature Integrated First Moment of the Power Spectrum (iFMP) From Baseline to Month 24

Intervention	Percent Change (Mean)
Alendronate	1.02
Control	-1.99

To derive a measure of variability and directionality in the first moment of the power spectrum (FMP) in the region of interest of the bone image, the power spectrum is divided into 24 angular sectors at 15 degree intervals, and FMP is calculated for each segment. We use iFMP (integrated FMP) as a measure of overall special frequency of the radiographic pattern. FMP characterizes spatial frequency in the radiographic pattern and the underlying trabecular structure. This corresponds to the coarseness or fineness of the radiographic texture pattern. A high level of FMP indicates thin and closely spaced trabecular structure. Low FMP indicates widely spaced dark areas usually corresponding to a strong, thick trabecular structure. (NCT00145977)
Timeframe: Baseline to Month 24

Changes in Radiographic Texture Analysis (RTA) Feature Standard Deviation of Root Mean Square (sdRMS) From Baseline to Month 24

Intervention	Percent Change (Mean)
Alendronate	0.09
Control	1.04

"Root Mean Square (RMS) is a measure of the variability in the radiographic texture pattern, the relative difference in the contrast between light and dark areas is expressed in a grayscale level. In practical terms, a bone image with a washed-out appearance due to loss of trabecular structure such as that seen in osteoporosis, will have a low value for RMS because there will be relatively little contrast between lighter and darker areas of the image. An image of a bone with strong trabecular structure will have a high RMS value because the contrast between the lighter and darker areas of the image will be greater.~To derive a measure of variability in the RMS in the region of interest of the bone image, the power spectrum is divided into 24 angular sectors at 15 degree intervals, and RMS is calculated for each segment. We use sdRMS (standard deviation of the RMS across the segments) as a measure of the direction dependence (anisotropy) of the trabeculae in the bone image." (NCT00145977)
Timeframe: Baseline to Month 24

Changes in Radiographic Texture Analysis (RTA) Integrated Root Mean Square (iRMS) From Baseline to Month 24

Intervention	Percent Change (Mean)
Alendronate	6.85
Control	1.08

"Root Mean Square (RMS) is a measure of the variability in the radiographic texture pattern, the relative difference in the contrast between light and dark areas is expressed in a grayscale level. In practical terms, a bone image with a washed-out appearance due to loss of trabecular structure such as that seen in osteoporosis, will have a low value for RMS because there will be relatively little contrast between lighter and darker areas of the image. An image of a bone with strong trabecular structure will have a high RMS value because the contrast between the lighter and darker areas of the image will be greater.~To derive a measure of variability in the RMS in the region of interest in the bone image, the power spectrum is divided into 24 angular sectors at 15 degree intervals, and RMS is calculated for each segment. The iRMS (integrated RMS) roughly corresponds to RMS averaged across all 24 angular sectors" (NCT00145977)
Timeframe: Baseline to Month 24

Changes in Radiographic Texture Analysis (RTA) Minimum First Moment of the Power Spectrum (minFMP) From Baseline to Month 24

Intervention	Percent Change (Mean)
Alendronate	-3.70
Control	-0.53

To derive a measure of variability and directionality in the first moment of the power spectrum (FMP) in the region of interest of the bone image, the power spectrum is divided into 24 angular sectors at 15 degree intervals and FMP is calculated for each segment. We use minFMP (minimum FMP) to represent the lowest value of FMP across the 24 angular sectors corresponding to the special frequency in the most washed-out direction. FMP characterizes spatial frequency in the radiographic pattern and the underlying trabecular structure. This corresponds to the coarseness or fineness of the radiographic texture pattern. A high level of FMP indicates thin and closely spaced trabecular structure. Low FMP indicates widely spaced dark areas usually corresponding to a strong, thick trabecular structure. (NCT00145977)
Timeframe: Baseline to Month 24

Changes in Radiographic Texture Analysis (RTA) Minkowski Fractal Dimension (MINK) From Baseline to Month 24

Intervention	Percent Change (Mean)
Alendronate	-3.61
Control	-0.18

The Percent Change in Radiographic Texture Analysis (RTA) Minkowski Fractal Dimension (MINK) from Baseline to Month 24 is a description of the similarity of texture of the images at different magnifications. The Minkowski fractal dimension is calculated from the slope of the least -square fitted line relating log volume and log magnification. (NCT00145977)
Timeframe: Baseline to Month 24

Changes in Radiographic Texture Analysis (RTA) Spectral Density Coefficient Beta (BETA) From Baseline to Month 24

Intervention	Percent Change (Mean)
Alendronate	-0.06
Control	0.12

The Percent Change in Radiographic Texture Analysis (RTA) spectral density coefficient beta (BETA) from Baseline to Month 24 is an analysis of spectral density vs. the spacial frequency on a log-log plot. BETA is the coefficient (slope) of this plot. Higher values of beta correspond to rougher (strong bone) and lower values to smoother, higher-frequency texture pattern (washed out bone). (NCT00145977)
Timeframe: Baseline to Month 24

Changes in Total Hip BMD +/- Treatment With Alendronate

Intervention	Percent Change (Mean)
Alendronate	3.09
Control	6.53

Percent Change in total hip BMD from Baseline to Month 24 (NCT00145977)
Timeframe: Baseline to Month 24

Article	Year
Emerging Role of PET clinics, 2023, Volume: 18, Issue:1 Topics: Fractures, Bone; Humans; Osteoporosis; Positron Emission Tomography Computed Tomography; Sodium Fluo	2023
Emerging Role of PET clinics, 2023, Volume: 18, Issue:1 Topics: Fractures, Bone; Humans; Osteoporosis; Positron Emission Tomography Computed Tomography; Sodium Fluo	2023
Emerging Role of PET clinics, 2023, Volume: 18, Issue:1 Topics: Fractures, Bone; Humans; Osteoporosis; Positron Emission Tomography Computed Tomography; Sodium Fluo	2023
Emerging Role of PET clinics, 2023, Volume: 18, Issue:1 Topics: Fractures, Bone; Humans; Osteoporosis; Positron Emission Tomography Computed Tomography; Sodium Fluo	2023
Diagnosis and Monitoring of Osteoporosis with Total-Body PET clinics, 2020, Volume: 15, Issue:4 Topics: Bone and Bones; Fluorine Radioisotopes; Humans; Osteoporosis; Positron Emission Tomography Computed	2020
Diagnosis and Monitoring of Osteoporosis With Seminars in nuclear medicine, 2018, Volume: 48, Issue:6 Topics: Bone Remodeling; Fluorine Radioisotopes; Humans; Multimodal Imaging; Osteoporosis; Positron-Emission	2018
Evolving Role of Molecular Imaging with (18)F-Sodium Fluoride PET as a Biomarker for Calcium Metabolism. Current osteoporosis reports, 2016, Volume: 14, Issue:4 Topics: Arthritis, Rheumatoid; Back Pain; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone and Bones	2016
Management of osteoporosis in patients with gastrointestinal diseases. European journal of gastroenterology & hepatology, 2003, Volume: 15, Issue:8 Topics: Bone and Bones; Calcitonin; Calcium; Celiac Disease; Dietary Supplements; Diphosphonates; Female; Ga	2003
New anabolic agents in the treatment of osteoporosis. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2003, Volume: 93, Issue:10 Topics: Anabolic Agents; Bone Density; Bone Remodeling; Growth Hormone; Humans; Hydroxymethylglutaryl-CoA Re	2003
Osteoporosis. Clinics in geriatric medicine, 2005, Volume: 21, Issue:3 Topics: Alkaline Phosphatase; Androgens; Bone Remodeling; Calcitonin; Calcium; Diagnosis, Differential; Diph	2005
[Anabolic therapy in osteoporosis--part 1]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2005, Volume: 18, Issue:108 Topics: Human Growth Hormone; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin-Like Growth Fa	2005
[Anabolic therapy of osteoporosis]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2005, Volume: 19, Issue:109 Topics: Anabolic Agents; Clinical Trials as Topic; Human Growth Hormone; Humans; Hydroxymethylglutaryl-CoA R	2005
[Prevention and treatment of osteoporosis]. Polskie Archiwum Medycyny Wewnetrznej, 2005, Volume: 114, Issue:6 Topics: Absorptiometry, Photon; Anticholesteremic Agents; Bone Density; Bone Density Conservation Agents; Ca	2005
Osteoporosis--a review and update. Archives of physical medicine and rehabilitation, 1982, Volume: 63, Issue:10 Topics: Aged; Back Pain; Calcium, Dietary; Dietary Proteins; Endocrine System Diseases; Estrogens; Exercise	1982
Osteoporosis. The Journal of bone and joint surgery. American volume, 1983, Volume: 65, Issue:2 Topics: Aged; Biopsy; Bone and Bones; Calcium; Densitometry; Estrogens; Female; Humans; Male; Middle Aged; N	1983
Monofluorophosphate physiology: the effects of fluoride on bone. Caries research, 1983, Volume: 17 Suppl 1 Topics: Animals; Bone and Bones; Cell Count; Female; Fluorides; Humans; Male; Osteoblasts; Osteogenesis; Ost	1983
[Diagnosis and treatment of osteoporosis]. Polskie Archiwum Medycyny Wewnetrznej, 1983, Volume: 69, Issue:6 Topics: Adult; Age Factors; Aged; Bone and Bones; Calcium; Drug Therapy, Combination; Female; Humans; Lumbar	1983
Should we use fluoride to treat osteoporosis? A review. The Quarterly journal of medicine, 1984,Spring, Volume: 53, Issue:210 Topics: Aged; Bone and Bones; Bone Diseases; Child; Female; Fractures, Bone; Humans; Minerals; Osteoporosis;	1984
Osteoporosis. The Orthopedic clinics of North America, 1984, Volume: 15, Issue:4 Topics: Calcium; Calcium, Dietary; Diagnosis, Differential; Estrogens; Female; Humans; Male; Menopause; Oste	1984
[Histological effects of the treatment of osteoporosis with the combination of sodium fluoride, vitamin D and calcium]. Revue du rhumatisme et des maladies osteo-articulaires, 1980, Volume: 47, Issue:12 Topics: Bone and Bones; Calcium; Drug Therapy, Combination; Ergocalciferols; Fluorides; Humans; Ilium; Osteo	1980
Diagnosis of bone disease by core biopsies. Seminars in hematology, 1981, Volume: 18, Issue:4 Topics: Adult; Aged; Biopsy; Bone and Bones; Bone Diseases; Bone Neoplasms; Breast Neoplasms; Female; Humans	1981
[Bone manifestations of multiple myeloma and therapeutic possibilities]. Acta medica Austriaca, 1994, Volume: 21, Issue:5 Topics: Calcitonin; Diphosphonates; Humans; Multiple Myeloma; Osteoporosis; Randomized Controlled Trials as	1994
Ultrasound study of bone in vitro. Calcified tissue international, 1993, Volume: 53 Suppl 1 Topics: Aging; Biomechanical Phenomena; Bone and Bones; Bone Density; Humans; In Vitro Techniques; Osteoporo	1993
Osteoporosis. British journal of rheumatology, 1993, Volume: 32 Suppl 4 Topics: Accidental Falls; Age Factors; Aged; Bone Density; Calcitonin; Calcium, Dietary; Cost of Illness; Di	1993
Osteoporotic fractures: background and prevention strategies. Maturitas, 1996, Volume: 23, Issue:2 Topics: Absorptiometry, Photon; Aged; Aged, 80 and over; Alcoholism; Biomarkers; Bone and Bones; Bone Densit	1996
Fluoride and the skeleton. Critical reviews in clinical laboratory sciences, 1996, Volume: 33, Issue:2 Topics: Bone and Bones; Fluoridation; Fluorides; Humans; Osteoporosis; Sodium Fluoride	1996
Fluoride therapy of type I osteoporosis. Clinical rheumatology, 1995, Volume: 14 Suppl 3 Topics: Aged; Biological Availability; Clinical Trials as Topic; Female; Humans; Male; Osteoporosis; Osteopo	1995
Update on pharmacologic therapies for osteoporosis. The Nurse practitioner, 1996, Volume: 21, Issue:8 Topics: Alendronate; Bone Density; Calcitonin; Estrogen Replacement Therapy; Humans; Osteoporosis; Sodium Fl	1996
Water fluoridation and osteoporotic fracture. Community dental health, 1996, Volume: 13 Suppl 2 Topics: Aged; Bone and Bones; Bone Density; Female; Finland; Fluoridation; Fluorides; Fractures, Bone; Hip F	1996
Alternatives to estrogen replacement therapy for preventing osteoporosis. Journal of the American Pharmaceutical Association (Washington, D.C. : 1996), 1996, Volume: NS36, Issue:12 Topics: Calcitonin; Calcium, Dietary; Diphosphonates; Estrogen Replacement Therapy; Female; Humans; Male; Os	1996
Sustained-release sodium fluoride in the management of established postmenopausal osteoporosis. The American journal of the medical sciences, 1997, Volume: 313, Issue:1 Topics: Biological Availability; Controlled Clinical Trials as Topic; Delayed-Action Preparations; Female; H	1997
Corticosteroid-induced osteoporosis. The American journal of the medical sciences, 1997, Volume: 313, Issue:1 Topics: Adrenal Cortex Hormones; Anabolic Agents; Bone Development; Bone Resorption; Calcitonin; Diphosphona	1997
Osteoporosis: prevention, diagnosis, and management. The American journal of medicine, 1997, Jan-27, Volume: 102, Issue:1A Topics: Bone Density; Calcitonin; Diphosphonates; Drug Therapy, Combination; Estrogen Replacement Therapy; F	1997
Prevention and treatment of osteoporosis: does the future belong to hormone replacement therapy? Journal of clinical pharmacology, 1997, Volume: 37, Issue:12 Topics: Alendronate; Alzheimer Disease; Calcitonin; Calcium; Coronary Disease; Diphosphonates; Endometrial N	1997
Osteoporosis: a focus on treatment. Maryland medical journal (Baltimore, Md. : 1985), 1997, Volume: 46, Issue:6 Topics: Accidental Falls; Aged; Aging; Alendronate; Bone Density; Calcitonin; Contraindications; Estrogen Re	1997
The role of fluoride in the prevention of osteoporosis. Endocrinology and metabolism clinics of North America, 1998, Volume: 27, Issue:2 Topics: Bone Density; Humans; Osteoporosis; Sodium Fluoride	1998
A review of clinical trials of therapies for osteoporosis using fracture as an end point. Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry, 1999,Winter, Volume: 2, Issue:4 Topics: Calcitonin; Diphosphonates; Estrogen Replacement Therapy; Female; Fractures, Bone; Humans; Male; Ost	1999
Management of osteoporosis in primary biliary cirrhosis. Bailliere's best practice & research. Clinical gastroenterology, 2000, Volume: 14, Issue:4 Topics: Absorptiometry, Photon; Bone Density; Calcitonin; Diphosphonates; Female; Hormone Replacement Therap	2000
Past and future of anabolic agents. Annales de medecine interne, 2000, Volume: 151, Issue:6 Topics: Animals; Calcium; Female; Fluorides; Fractures, Bone; Human Growth Hormone; Humans; Insulin-Like Gro	2000
Clinical review 123: Anabolic therapy for osteoporosis. The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:3 Topics: Drug Therapy, Combination; Female; Human Growth Hormone; Humans; Insulin-Like Growth Factor I; Osteo	2001
An update on glucocorticoid-induced osteoporosis. Rheumatic diseases clinics of North America, 2001, Volume: 27, Issue:1 Topics: Animals; Bone Density; Bone Remodeling; Diphosphonates; Drug Therapy, Combination; Estrogens; Fractu	2001
Anabolic effects of fluoride on bone. Trends in endocrinology and metabolism: TEM, 1995, Volume: 6, Issue:7 Topics: Antioxidants; Bone and Bones; Bone Density; Bone Matrix; Calcium Citrate; Delayed-Action Preparation	1995
Mechanisms of bone loss and gain in untreated and treated osteoporosis. Endocrine, 2002, Volume: 17, Issue:1 Topics: Bone and Bones; Bone Remodeling; Bone Resorption; Calcification, Physiologic; Female; Humans; Osteop	2002
[Therapy of old-age osteoporosis]. Deutsche medizinische Wochenschrift (1946), 1977, Aug-19, Volume: 102, Issue:33 Topics: Aged; Aging; Anabolic Agents; Analgesics; Calcitonin; Calcium; Diphosphonates; Femoral Neck Fracture	1977
[Osteoporosis]. Fortschritte der Medizin, 1978, Dec-01, Volume: 96, Issue:45 Topics: Alkaline Phosphatase; Anabolic Agents; Analgesics; Bone and Bones; Calcium; Diagnosis, Differential;	1978
Prevention and treatment of osteoporosis. One of the most frequent disorders in American women: a review. Journal of medicine, 1992, Volume: 23, Issue:6 Topics: Calcitonin; Calcium; Estrogens; Etidronic Acid; Female; Humans; Osteoporosis; Sodium Fluoride	1992
Treatment of osteoporosis with sodium fluoride or parathyroid hormone. The American journal of medicine, 1991, Nov-25, Volume: 91, Issue:5B Topics: Bone Density; Fractures, Bone; Humans; Osteoporosis; Parathyroid Hormone; Sodium Fluoride	1991
[Conclusive evaluation of osteoporosis therapy with fluorides]. Der Internist, 1991, Volume: 32, Issue:12 Topics: Bone Density; Dose-Response Relationship, Drug; Female; Fluorides; Fractures, Spontaneous; Humans; O	1991
Do we have any alternative to sex steroids in the prevention and treatment of osteoporosis? Bailliere's clinical obstetrics and gynaecology, 1991, Volume: 5, Issue:4 Topics: Adult; Bone Regeneration; Bone Remodeling; Bone Resorption; Calcitonin; Calcium; Diphosphonates; Exe	1991
Treatment of osteoporosis and Paget's disease. Current opinion in rheumatology, 1991, Volume: 3, Issue:3 Topics: Calcitonin; Calcium, Dietary; Diphosphonates; Estrogens; Female; Glucocorticoids; Humans; Osteitis D	1991
[Involutional osteoporosis--pathogenesis, diagnosis, prevention and therapy]. Postepy higieny i medycyny doswiadczalnej, 1991, Volume: 45, Issue:1-2 Topics: Aged; Bone Density; Bone Resorption; Calcium, Dietary; Estrogen Replacement Therapy; Female; Humans;	1991
Therapies for symptomatic primary osteoporosis. Geriatrics, 1991, Volume: 46, Issue:11 Topics: Aged; Calcitonin; Diagnosis, Differential; Etidronic Acid; Female; Humans; Male; Osteoporosis; Sodiu	1991
New treatments for osteoporosis. Lancet (London, England), 1990, May-05, Volume: 335, Issue:8697 Topics: Bone Density; Bone Development; Bone Resorption; Drug Administration Schedule; Etidronic Acid; Femal	1990
[Stress fractures during treatment of osteoporosis with sodium fluoride. Apropos of a case and a critical review of the literature]. Revue du rhumatisme et des maladies osteo-articulaires, 1990, Volume: 57, Issue:2 Topics: Aged; Female; Fractures, Stress; Humans; Osteoporosis; Sodium Fluoride	1990
Osteoporosis in men: diagnosis, pathophysiology, and prevention. Medicine, 1990, Volume: 69, Issue:3 Topics: Anabolic Agents; Bone and Bones; Calcitonin; Calcium; Diagnosis, Differential; Humans; Male; Osteopo	1990
Review: sodium fluoride: too late and too toxic for the elderly osteoporotic patient? Age and ageing, 1990, Volume: 19, Issue:3 Topics: Aged; Calcium; Femoral Neck Fractures; Humans; Osteoporosis; Sodium Fluoride; Vitamin D	1990
Modern therapeutic approaches to osteoporosis. Rheumatic diseases clinics of North America, 1989, Volume: 15, Issue:3 Topics: Animals; Bone Regeneration; Calcitonin; Calcium, Dietary; Combined Modality Therapy; Estrogens; Exer	1989
[Effective methods in the medical treatment of osteoporosis]. Therapeutische Umschau. Revue therapeutique, 1985, Volume: 42, Issue:6 Topics: Calcitonin; Calcium; Cholecalciferol; Estrogens; Female; Humans; Menopause; Middle Aged; Osteoporosi	1985
[Drug therapy of osteoporosis]. Der Orthopade, 1988, Volume: 17, Issue:5 Topics: Aged; Calcitonin; Calcium; Estradiol Congeners; Humans; Middle Aged; Osteoporosis; Progesterone Cong	1988
Osteoporosis. American family physician, 1988, Volume: 38, Issue:5 Topics: Aged; Bone Resorption; Densitometry; Diagnostic Imaging; Estrogens; Female; Humans; Middle Aged; Ost	1988
Fluoride and osteoporosis. Annales chirurgiae et gynaecologiae, 1988, Volume: 77, Issue:5-6 Topics: Bone and Bones; Europe; Female; Fluorides; History, 20th Century; Humans; Male; Osteoporosis; Sodium	1988
Treatment of osteoporosis. Obstetrics and gynecology clinics of North America, 1987, Volume: 14, Issue:1 Topics: Aged; Calcitonin; Calcium; Estrogens; Female; Fractures, Spontaneous; Humans; Middle Aged; Osteoporo	1987
New approaches to the treatment of osteoporosis. Clinical obstetrics and gynecology, 1987, Volume: 30, Issue:4 Topics: Benzothiadiazines; Calcitonin; Diphosphonates; Diuretics; Growth Hormone; Humans; Osteoporosis; Para	1987
The treatment of osteoporosis. The Medical journal of Australia, 1986, Jun-09, Volume: 144, Issue:12 Topics: Adult; Age Factors; Aged; Anabolic Agents; Calcitriol; Calcium; Drug Therapy, Combination; Estrogens	1986
Metabolic bone disease and Paget's disease in the elderly. Part I: Metabolic bone disease. Clinics in rheumatic diseases, 1986, Volume: 12, Issue:1 Topics: Aged; Bone and Bones; Bone Development; Bone Diseases, Metabolic; Calcium; Estrogens; Female; Humans	1986
Postmenopausal osteoporosis. The Medical clinics of North America, 1987, Volume: 71, Issue:1 Topics: Bone Resorption; Calcium; Diagnosis, Differential; Estradiol Congeners; Estrogens; Exercise Therapy;	1987
Trabecular bone architecture in the pathogenesis and prevention of fracture. The American journal of medicine, 1987, Jan-26, Volume: 82, Issue:1B Topics: Bone and Bones; Estrogens; Female; Fractures, Bone; Humans; Menopause; Osteoporosis; Sodium Fluoride	1987
Primary osteoporosis. American family physician, 1985, Volume: 31, Issue:1 Topics: Aged; Calcium; Estrogens; Female; Fractures, Bone; Humans; Male; Middle Aged; Osteoporosis; Risk; So	1985
Osteoporosis: calcium, fluoride, and aluminum interactions. Journal of the American College of Nutrition, 1985, Volume: 4, Issue:1 Topics: Aluminum; Aluminum Hydroxide; Calcium; Fluorides; Humans; Intestinal Absorption; Osteoporosis; Phosp	1985

Article	Year
Intravenous ibandronate or sodium-fluoride--a 3.5 years study on bone density and fractures in Crohn's disease patients with osteoporosis. Journal of gastrointestinal and liver diseases : JGLD, 2011, Volume: 20, Issue:2 Topics: Absorptiometry, Photon; Adult; Bone Density; Bone Density Conservation Agents; Calcium Citrate; Chol	2011
Therapy of osteoporosis in patients with Crohn's disease: a randomized study comparing sodium fluoride and ibandronate. Alimentary pharmacology & therapeutics, 2003, Mar-15, Volume: 17, Issue:6 Topics: Bone Density; Crohn Disease; Diphosphonates; Female; Follow-Up Studies; Humans; Ibandronic Acid; Lum	2003
Treatment of osteoporotic fracture. Lancet (London, England), 1984, Jan-07, Volume: 1, Issue:8367 Topics: Bone Development; Calcium; Clinical Trials as Topic; Double-Blind Method; Estrogens; Follow-Up Studi	1984
New evidence for sodium fluoride in osteoporosis. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1984, Volume: 25, Issue:6 Topics: Clinical Trials as Topic; Diphosphonates; Humans; Osteoporosis; Radionuclide Imaging; Sodium Fluorid	1984
Effect of the fluoride/calcium regimen on vertebral fracture occurrence in postmenopausal osteoporosis. Comparison with conventional therapy. The New England journal of medicine, 1982, Feb-25, Volume: 306, Issue:8 Topics: Aged; Calcium; Clinical Trials as Topic; Drug Therapy, Combination; Estrogens, Conjugated (USP); Fem	1982
Relief of osteoporotic backache with fluoride, calcium, and calciferol. Acta medica Scandinavica, 1981, Volume: 209, Issue:6 Topics: Aged; Back Pain; Calcium; Clinical Trials as Topic; Drug Therapy, Combination; Ergocalciferols; Fema	1981
Extended treatment of primary osteoporosis by sodium fluoride combined with 25 hydroxycholecalciferol. Clinical rheumatology, 1984, Volume: 3, Issue:2 Topics: Aged; Bone and Bones; Calcifediol; Calcium; Drug Therapy, Combination; Female; Humans; Male; Middle	1984
[Experiences with Ossin]. Medicinski pregled, 1980, Volume: 33, Issue:7-8 Topics: Calcium; Clinical Trials as Topic; Drug Therapy, Combination; Female; Fluorides; Humans; Male; Middl	1980
Fluoride balance studies in healthy men during bed rest with and without a fluoride supplement.. The American journal of clinical nutrition, 1982, Volume: 36, Issue:2 Topics: Adult; Bed Rest; Calcium; Fluorides; Food, Fortified; Homeostasis; Humans; Locomotion; Male; Osteopo	1982
Treatment of osteoporosis after liver transplantation. Transplantation proceedings, 1995, Volume: 27, Issue:1 Topics: Adult; Bone Density; Calcitriol; Calcium; Female; Humans; Liver Failure; Liver Transplantation; Male	1995
Fluoride treatment of osteoporosis: cyclical non-blinded or continuous blinded studies? Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 1993, Volume: 3 Suppl 1 Topics: Aged; Bone and Bones; Bone Resorption; Diphosphonates; Drug Administration Schedule; Drug Therapy, C	1993
New drugs for osteoporosis. The Medical letter on drugs and therapeutics, 1996, Jan-05, Volume: 38, Issue:965 Topics: Administration, Intranasal; Aged; Alendronate; Calcitonin; Calcium; Costs and Cost Analysis; Delayed	1996
Is addition of sodium fluoride to cyclical etidronate beneficial in the treatment of corticosteroid induced osteoporosis? Annals of the rheumatic diseases, 1997, Volume: 56, Issue:6 Topics: Adult; Aged; Bone Density; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combinat	1997
Reflection ultrasound velocities and histomorphometric and connectivity analyses: correlations and effect of slow-release sodium fluoride. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1997, Volume: 12, Issue:12 Topics: Adult; Aged; Biomechanical Phenomena; Bone and Bones; Bone Density; Data Interpretation, Statistical	1997
Effect of sodium fluoride on the prevention of corticosteroid-induced osteoporosis. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 1997, Volume: 7, Issue:6 Topics: Adrenal Cortex Hormones; Adult; Aged; Bone Density; Double-Blind Method; Female; Hip Joint; Humans;	1997
Effects of different regimens of sodium fluoride treatment for osteoporosis on the structure, remodeling and mineralization of bone. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 1998, Volume: 8, Issue:5 Topics: Aged; Bone and Bones; Bone Remodeling; Calcification, Physiologic; Calcium; Dose-Response Relationsh	1998
Increase of bone mineral density with sodium fluoride in patients with Crohn's disease. European journal of gastroenterology & hepatology, 2000, Volume: 12, Issue:1 Topics: Adult; Bone Density; Calcium; Cholecalciferol; Crohn Disease; Drug Therapy, Combination; Female; Hum	2000
Past and future of anabolic agents. Annales de medecine interne, 2000, Volume: 151, Issue:6 Topics: Animals; Calcium; Female; Fluorides; Fractures, Bone; Human Growth Hormone; Humans; Insulin-Like Gro	2000
[Therapy of senile osteoporosis using sodium fluoride--continuous and intermittent long-term therapy]. Schweizerische medizinische Wochenschrift, 1979, May-05, Volume: 109, Issue:18 Topics: Age Factors; Aged; Densitometry; Female; Fluorides; Humans; Hydroxyproline; Long-Term Care; Male; Me	1979
Effect of sodium fluoride, inorganic phosphate, and oxymetholone therapies in osteoporosis: a six-year progress report. Journal of gerontology, 1978, Volume: 33, Issue:2 Topics: Aged; Densitometry; Fluorides; Follow-Up Studies; Humans; Male; Middle Aged; Osteoporosis; Oxymethol	1978
Sodium fluoride prevents bone loss in primary biliary cirrhosis. Journal of hepatology, 1992, Volume: 15, Issue:3 Topics: Absorptiometry, Photon; Adult; Aged; Bone Density; Calcium; Double-Blind Method; Female; Food, Forti	1992
Fluoride therapy and parathyroid hormone activity in osteoporosis. Clinical science (London, England : 1979), 1990, Volume: 79, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Calcium; Female; Humans; Male; Middle Aged; Osteoporosis; Parathyroi	1990
New doubts about benefits of sodium fluoride. JAMA, 1990, Apr-04, Volume: 263, Issue:13 Topics: Bone Density; Clinical Trials as Topic; Female; Fractures, Bone; Humans; Osteoporosis; Sodium Fluori	1990
Treatment of the vertebral crush fracture syndrome with enteric-coated sodium fluoride tablets and calcium supplements. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1990, Volume: 5 Suppl 1 Topics: Aged; Bone Density; Calcium; Clinical Trials as Topic; Densitometry; Double-Blind Method; Estrogen R	1990
Effect of intermittent therapy with a slow-release fluoride preparation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1990, Volume: 5 Suppl 1 Topics: Bone Density; Calcitriol; Delayed-Action Preparations; Drug Administration Schedule; Female; Fractur	1990
Increased incidence of hip fracture in osteoporotic women treated with sodium fluoride. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1989, Volume: 4, Issue:2 Topics: Aged; Aged, 80 and over; Calcitriol; Calcium; Drug Therapy, Combination; Female; Hip Fractures; Huma	1989
Risk-benefit ratio of sodium fluoride treatment in primary vertebral osteoporosis. Lancet (London, England), 1988, Aug-13, Volume: 2, Issue:8607 Topics: Administration, Oral; Aged; Aged, 80 and over; Ankle; Calcium; Clinical Trials as Topic; Drug Admini	1988
Safe and effective treatment of osteoporosis with intermittent slow release sodium fluoride: augmentation of vertebral bone mass and inhibition of fractures. The Journal of clinical endocrinology and metabolism, 1989, Volume: 68, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Bone and Bones; Calcium; Delayed-Action Preparations; Dose-Response	1989
Fluoride and osteoporosis. Annales chirurgiae et gynaecologiae, 1988, Volume: 77, Issue:5-6 Topics: Bone and Bones; Europe; Female; Fluorides; History, 20th Century; Humans; Male; Osteoporosis; Sodium	1988
The effect of fluoride and calcium on spinal bone mineral content: a controlled, prospective (3 years) study. Calcified tissue international, 1987, Volume: 40, Issue:6 Topics: Aged; Calcium; Clinical Trials as Topic; Female; Humans; Middle Aged; Minerals; Osteoporosis; Prospe	1987

Article	Year
The Utility of 18 F-NaF-Positron Emission Tomography/Computed Tomography in Measuring the Metabolic Activity of the Aging Spine : Implications for Osteoporosis. Spine, 2023, Aug-01, Volume: 48, Issue:15 Topics: Adult; Aging; Cross-Sectional Studies; Female; Fluorine Radioisotopes; Humans; Male; Osteoporosis; P	2023
Preliminary evaluation of different biomaterials for defect healing in an experimental osteoporotic rat model with dynamic PET-CT (dPET-CT) using F-18-sodium fluoride (NaF). Injury, 2014, Volume: 45, Issue:3 Topics: Animals; Biocompatible Materials; Bone Cements; Calcium; Calcium Phosphates; Female; Femoral Fractur	2014
Application of F-18-sodium fluoride (NaF) dynamic PET-CT (dPET-CT) for defect healing: a comparison of biomaterials in an experimental osteoporotic rat model. Medical science monitor : international medical journal of experimental and clinical research, 2014, Oct-15, Volume: 20 Topics: Animals; Biocompatible Materials; Disease Models, Animal; Female; Multimodal Imaging; Osteoporosis;	2014
Effect of Sodium Fluoride on Bone Biomechanical and Histomorphometric Parameters and on Insulin Signaling and Insulin Sensitivity in Ovariectomized Rats. Biological trace element research, 2016, Volume: 173, Issue:1 Topics: Animals; Bone Density; Female; Insulin; Insulin Resistance; Osteoporosis; Ovariectomy; Rats; Rats, W	2016
Oral bone loss induced by mineral deficiency in a rat model: effect of a synthetic bone mineral (SBM) preparation. Archives of oral biology, 2012, Volume: 57, Issue:9 Topics: Alveolar Bone Loss; Animals; Apatites; Bone Density; Bone Density Conservation Agents; Calcium Carbo	2012
PLASMA FLUORIDE CONCENTRATIONS ON PATIENTS TREATED WITH SODIUM FLUORIDE. The Journal of clinical investigation, 1964, Volume: 43 Topics: Blood; Fluorides; Humans; Osteitis Deformans; Osteoporosis; Phosphates; Sodium; Sodium Fluoride; Sod	1964
SODIUM FLUORIDE AND OPTIC NEURITIS. British medical journal, 1964, Aug-08, Volume: 2, Issue:5405 Topics: Edema; Fluoride Poisoning; Humans; Macula Lutea; Optic Neuritis; Osteoporosis; Sodium Fluoride; Spin	1964
Influence of fluor salts, hormone replacement therapy and calcitonin on the concentration of insulin-like growth factor (IGF)-I, IGF-II and transforming growth factor-beta 1 in human iliac crest bone matrix from patients with primary osteoporosis. European journal of endocrinology, 2004, Volume: 150, Issue:1 Topics: Biopsy; Bone Density; Calcitonin; Estrogen Replacement Therapy; Female; Growth Substances; Humans; I	2004
[Biodistribution of (18)F-NaF as an imaging agent in osteoporotic rats for position emission tomography]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2008, Volume: 28, Issue:1 Topics: Adult; Animals; Bone and Bones; Female; Fluorine Radioisotopes; Humans; Male; Osteoporosis; Positron	2008
Cost effectiveness of ibandronate for the prevention of fractures in inflammatory bowel disease-related osteoporosis: cost-utility analysis using a Markov model. PharmacoEconomics, 2008, Volume: 26, Issue:4 Topics: Adult; Aged; Bone Density; Bone Density Conservation Agents; Calcium; Cholecalciferol; Cost-Benefit	2008
Sodium fluoride treatment of bone disease in multiple myeloma. Texas medicine, 1984, Volume: 80, Issue:12 Topics: Calcium Carbonate; Drug Therapy, Combination; Estrogens, Conjugated (USP); Humans; Multiple Myeloma;	1984
Treatment of osteoporotic fracture. Lancet (London, England), 1984, Feb-18, Volume: 1, Issue:8373 Topics: Female; Fractures, Bone; Humans; Osteoporosis; Parathyroid Hormone; Peptide Fragments; Sodium Fluori	1984
Osteoporosis, osteomalacia, rickets, and Paget's disease. Primary care, 1984, Volume: 11, Issue:2 Topics: Anti-Inflammatory Agents; Calcitonin; Calcium; Diet; Estrogens; Etidronic Acid; Humans; Osteitis Def	1984
Factors in response to treatment of early postmenopausal bone loss. Calcified tissue international, 1981, Volume: 33, Issue:6 Topics: Alkaline Phosphatase; Bendroflumethiazide; Bone and Bones; Calcium; Cholecalciferol; Estrogens; Fema	1981
Bilateral fractures of femoral neck in patients with moderate renal failure receiving fluoride for spinal osteoporosis. British medical journal (Clinical research ed.), 1983, Sep-10, Volume: 287, Issue:6394 Topics: Aged; Bone and Bones; Calcium; Cholecalciferol; Drug Therapy, Combination; Female; Femoral Neck Frac	1983
[Fractures of the calcaneus during fluoride therapy of osteoporosis]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1983, Dec-08, Volume: 59, Issue:45 Topics: Aged; Calcaneus; Female; Fractures, Bone; Fractures, Closed; Humans; Middle Aged; Osteoporosis; Radi	1983
Non-hormonal treatment of osteoporosis. British medical journal (Clinical research ed.), 1983, Mar-26, Volume: 286, Issue:6370 Topics: Adult; Aged; Calcium, Dietary; Female; Humans; Male; Menopause; Osteoporosis; Sodium Fluoride	1983
Treatment of postmenopausal osteoporosis: some current concepts. Scottish medical journal, 1981, Volume: 26, Issue:1 Topics: Aged; Calcitonin; Calcium Carbonate; Clodronic Acid; Ergocalciferols; Estrogens; Female; Humans; Men	1981
Increase of whole-body calcium and skeletal mass in normal and osteoporotic adult rats treated with parathyroid hormone. Clinical science (London, England : 1979), 1982, Volume: 62, Issue:4 Topics: Animals; Body Composition; Bone and Bones; Calcitriol; Calcium; Clodronic Acid; Female; Organ Size;	1982
Fluoride therapy in metabolic bone disease. Israel journal of medical sciences, 1984, Volume: 20, Issue:5 Topics: Calcium; Fluorides; Humans; Intestinal Absorption; Male; Osteitis Deformans; Osteogenesis Imperfecta	1984
Metabolic bone disease and the elderly: current approach to diagnosis and therapy. Nephron, 1984, Volume: 38, Issue:2 Topics: Age Factors; Aged; Anabolic Agents; Bone and Bones; Bone Diseases, Metabolic; Bone Resorption; Calci	1984
Treatment of osteoporosis with sodium fluoride and calcium: effects on vertebral fracture incidence and bone histomorphometry. The Orthopedic clinics of North America, 1984, Volume: 15, Issue:4 Topics: Aged; Biopsy; Calcium; Female; Fractures, Spontaneous; Humans; Ilium; Middle Aged; Osteoporosis; Sod	1984
[Longevity of a population exposed to fluorides for decades]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1984, Sep-15, Volume: 39, Issue:18 Topics: Aged; Female; Fractures, Bone; Germany, East; Humans; Longevity; Male; Osteoporosis; Population Dyna	1984
[Mechanism of action of sodium fluoride in patients with osteoporosis]. Polskie Archiwum Medycyny Wewnetrznej, 1984, Volume: 72, Issue:3 Topics: Aged; Female; Humans; Male; Middle Aged; Osteogenesis; Osteoporosis; Sodium Fluoride	1984
[Treatment of postmenopausal osteoporosis with sodium fluoride]. La Revue de medecine interne, 1983, Volume: 4, Issue:2 Topics: Female; Fluorides; Humans; Menopause; Middle Aged; Osteoporosis; Sodium Fluoride	1983
[Osteoporosis and prolonged administration of antialdosterone drugs. Histomorphometric study]. Revue du rhumatisme et des maladies osteo-articulaires, 1983, Volume: 50, Issue:7 Topics: Adult; Calcifediol; Calcium; Drug Administration Schedule; Female; Fractures, Spontaneous; Humans; H	1983
[Sodium fluoride loading test and the monitoring of fluoride levels in the urine during the treatment of osteoporosis with sodium fluoride]. Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca, 1983, Volume: 50, Issue:5 Topics: Fluorides; Humans; Osteoporosis; Sodium Fluoride	1983
[Clinical experience in the use of large doses of NaF in the treatment of osteoporosis]. Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca, 1983, Volume: 50, Issue:6 Topics: Female; Humans; Middle Aged; Osteoporosis; Sodium Fluoride	1983
Pathogenesis and treatment of postmenopausal osteoporosis. Calcified tissue international, 1983, Volume: 35, Issue:6 Topics: Aged; Calcitonin; Calcitriol; Female; Fractures, Bone; Hormones; Humans; Malabsorption Syndromes; Me	1983
Bone histomorphometry in corticosteroid-induced osteoporosis and Cushing's syndrome. Advances in experimental medicine and biology, 1984, Volume: 171 Topics: Adrenal Cortex Hormones; Adult; Aged; Biopsy; Bone and Bones; Calcium; Cushing Syndrome; Drug Therap	1984
Skeletal scintigraphic changes in osteoporosis treated with sodium fluoride: concise communication. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1984, Volume: 25, Issue:6 Topics: Aged; Alkaline Phosphatase; Bone and Bones; Bone Regeneration; Calcium Carbonate; Drug Evaluation; F	1984
Treatment of postmenopausal osteoporosis. Comprehensive therapy, 1984, Volume: 10, Issue:7 Topics: Aged; Anabolic Agents; Androgens; Calcitonin; Calcium; Diphosphonates; Estrogens; Female; Humans; Me	1984
Three-year changes in bone mineral mass of postmenopausal osteoporotic patients based on neutron activation analysis of the central third of the skeleton. The Journal of clinical endocrinology and metabolism, 1981, Volume: 52, Issue:4 Topics: Bone and Bones; Calcium; Ergocalciferols; Estrogens; Female; Fluorides; Follow-Up Studies; Humans; M	1981
Sodium fluoride treatment of osteoporosis: radiologic findings. AJR. American journal of roentgenology, 1982, Volume: 139, Issue:1 Topics: Aged; Bone Diseases; Female; Fluoride Poisoning; Humans; Male; Middle Aged; Osteoporosis; Radiograph	1982
Sodium fluoride in the treatment of osteoporosis. Clinical and investigative medicine. Medecine clinique et experimentale, 1982, Volume: 5, Issue:2-3 Topics: Aged; Bone and Bones; Calcium; Ergocalciferols; Estradiol Congeners; Female; Fluorides; Humans; Midd	1982
[Therapy of primary osteoporosis with sodium fluoride and calcium]. Medizinische Klinik, 1982, Jan-29, Volume: 77, Issue:3 Topics: Calcium; Fluorides; Humans; Osteoporosis; Prospective Studies; Sodium Fluoride; Vitamin D	1982
[Our experience in the treatment of post-menopausal osteoporosis (author's transl)]. Medicina clinica, 1982, Apr-16, Volume: 78, Issue:8 Topics: Adult; Aged; Calcitonin; Calcium; Drug Therapy, Combination; Female; Fluorides; Humans; Menopause; M	1982
Quantitative computed tomography of bone. Mayo Clinic proceedings, 1982, Volume: 57 Suppl Topics: Adult; Aged; Bone and Bones; Child; Child, Preschool; Female; Humans; Immobilization; Middle Aged; O	1982
Fluoride in serum and bone during treatment of osteoporosis with sodium fluoride, calcium and vitamin D. Metabolic bone disease & related research, 1982, Volume: 4, Issue:1 Topics: Adult; Aged; Bone and Bones; Calcium; Female; Fluorides; Humans; Male; Middle Aged; Osteoporosis; So	1982
Long-term fluoride and calcium therapy of postmenopausal osteoporosis. Journal of the Oslo city hospitals, 1982, Volume: 32, Issue:12 Topics: Aged; Calcium Carbonate; Delayed-Action Preparations; Female; Fluorides; Humans; Menopause; Middle A	1982
A subacute fluoride intoxication during treatment of osteoporosis with sodium fluoride (NaF): case report. The Netherlands journal of medicine, 1981, Volume: 24, Issue:1 Topics: Aged; Dose-Response Relationship, Drug; Female; Fluoride Poisoning; Fluorides; Humans; Osteoporosis;	1981
[Multiple bony fissures during treatment of osteoporosis with sodium fluoride]. Revue du rhumatisme et des maladies osteo-articulaires, 1980, Volume: 47, Issue:10 Topics: Aged; Bone Diseases; Female; Fluorides; Fractures, Spontaneous; Humans; Osteoporosis; Sodium Fluorid	1980
[Osteoporosis therapy and thyroid function. Influence of 6 months of sodium fluoride treatment on thyroid function and bone density]. Fortschritte der Medizin, 1981, Mar-12, Volume: 99, Issue:10 Topics: Alkaline Phosphatase; Bone and Bones; Female; Fluorides; Humans; Middle Aged; Osteoporosis; Sodium F	1981
[Diagnosis and therapy of osteoporosis]. Medizinische Klinik, 1981, Feb-27, Volume: 76, Issue:5 Topics: Bone and Bones; Calcium; Diagnosis, Differential; Female; Humans; Male; Minerals; Osteoporosis; Sodi	1981
Improved method for quantitative determination in serum of alkaline phosphatase of skeletal origin. Clinical chemistry, 1981, Volume: 27, Issue:12 Topics: Alkaline Phosphatase; Bone and Bones; Female; Hot Temperature; Humans; Intestines; Isoenzymes; Liver	1981
[Experience with treatment of osteoporosis with Ossin (author's transl)]. Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca, 1981, Volume: 48, Issue:6 Topics: Fluorides; Humans; Osteoporosis; Sodium Fluoride	1981
Treatment of primary osteoporosis with fluoride and calcium. Clinical tolerance and fracture occurrence. JAMA, 1980, Feb-01, Volume: 243, Issue:5 Topics: Adult; Aged; Anemia, Hypochromic; Calcium, Dietary; Drug Therapy, Combination; Female; Fluorides; Fr	1980
Sodium fluoride for osteoporosis--some unanswered questions. JAMA, 1980, Feb-01, Volume: 243, Issue:5 Topics: Calcium, Dietary; Drug Therapy, Combination; Drug Tolerance; Fluorides; Humans; Osteoporosis; Sodium	1980
Osteomalacia developing during treatment of osteoporosis with sodium fluoride and vitamin D. British medical journal, 1980, Oct-04, Volume: 281, Issue:6245 Topics: Drug Therapy, Combination; Female; Fluorides; Humans; Hydroxycholecalciferols; Middle Aged; Osteomal	1980
[Results of treatment of osteoporosis with sodium fluoride]. Chirurgia narzadow ruchu i ortopedia polska, 1980, Volume: 45, Issue:4 Topics: Female; Fluorides; Follow-Up Studies; Humans; Male; Middle Aged; Osteoporosis; Sodium Fluoride	1980
[The effect of sodium fluoride on calcium resorption during osteoporosis therapy]. Medicinski pregled, 1980, Volume: 33, Issue:5-6 Topics: Calcium; Drug Therapy, Combination; Fluorides; Humans; Osteoporosis; Sodium Fluoride	1980
[Change in the plasma and urine levels of ionized fluorine under the influence of low doses of niflumic acid. Possible application to the treatment of osteoporosis]. Revue du rhumatisme et des maladies osteo-articulaires, 1980, Volume: 47, Issue:11 Topics: Adult; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorine; Human	1980
Sodium fluoride in osteoporosis. The Netherlands journal of medicine, 1980, Volume: 23, Issue:4 Topics: Aged; Dihydrotachysterol; Female; Fluorides; Humans; Male; Middle Aged; Osteoporosis; Sodium Fluorid	1980
No bones about fluoride. Nature medicine, 1995, Volume: 1, Issue:11 Topics: Bone and Bones; Bone Density; Clinical Trials as Topic; Delayed-Action Preparations; Diphosphonates;	1995
[Loss of trabecular bone strength and bone quality after 5 years of fluoride therapy for osteoporosis]. Ugeskrift for laeger, 1995, Apr-03, Volume: 157, Issue:14 Topics: Aged; Biomechanical Phenomena; Bone and Bones; Bone Density; Female; Humans; Ilium; Longitudinal Stu	1995
[Comparative study of the in vitro effects of calcitonin, NaF and ipriflavone in cell culture]. Magyar traumatologia, ortopedia, kezsebeszet, plasztikai sebeszet, 1994, Volume: 37, Issue:3 Topics: Bone Density; Bone Resorption; Calcitonin; Cells, Cultured; Fibroblasts; Humans; In Vitro Techniques	1994
Reversal of vertebral deformities in osteoporosis: measurement error or "rebound"? Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1994, Volume: 9, Issue:7 Topics: Aged; Female; Humans; Male; Middle Aged; Osteoporosis; Radiography; Reproducibility of Results; Sens	1994
Measurement of intrinsic bone quality in vivo by reflection ultrasound: correction of impaired quality with slow-release sodium fluoride and calcium citrate. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1993, Volume: 8, Issue:3 Topics: Analysis of Variance; Bone and Bones; Bone Density; Citrates; Citric Acid; Delayed-Action Preparatio	1993
[The effect of sodium fluoride on bone mineral density and bone strength in ovariectomized rats]. Nihon Seikeigeka Gakkai zasshi, 1995, Volume: 69, Issue:11 Topics: Animals; Bone Density; Calcium, Dietary; Disease Models, Animal; Female; Femur; Fluorides, Topical;	1995
Fluoride and the FDA: a curious case. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1996, Volume: 11, Issue:9 Topics: Animals; Bone Density; Clinical Trials as Topic; Delayed-Action Preparations; Drug Evaluation; Guide	1996
Study of NaF effects on transiliac bone. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 1996, Volume: 6, Issue:5 Topics: Bone Density; Bone Matrix; Humans; Ilium; Osteoporosis; Sodium Fluoride	1996
Sodium fluoride treatment is a major protector against vertebral and nonvertebral fractures when compared with other common treatments of osteoporosis: a longitudinal, observational study. Calcified tissue international, 1997, Volume: 60, Issue:3 Topics: Administration, Oral; Aged; Female; Follow-Up Studies; Fractures, Bone; Humans; Longitudinal Studies	1997
Mineralization of cancellous bone after alendronate and sodium fluoride treatment: a quantitative backscattered electron imaging study on minipig ribs. Bone, 1997, Volume: 20, Issue:5 Topics: Alendronate; Animals; Biomechanical Phenomena; Bone Density; Bone Remodeling; Humans; Osteoporosis;	1997
Fewer bone histomorphometric abnormalities with intermittent than with continuous slow-release sodium fluoride therapy. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 1997, Volume: 7, Issue:4 Topics: Adult; Aged; Bone and Bones; Delayed-Action Preparations; Female; Fractures, Spontaneous; Humans; Ma	1997
[Osteoporosis: its diagnosis, its consequences]. Revue de stomatologie et de chirurgie maxillo-faciale, 1997, Volume: 98 Suppl 1 Topics: Absorptiometry, Photon; Adolescent; Adult; Aged; Bone Resorption; Calcium, Dietary; Diphosphonates;	1997
Outcomes assessment in osteoporosis: strategies for improvement. Medical interface, 1996, Volume: 9, Issue:7 Topics: Administration, Intranasal; Alendronate; Calcitonin; Cost of Illness; Diphosphonates; Estrogen Repla	1996
Treatment with fluoride or bisphosphonates prevents bone loss associated with colitis in the rat. Calcified tissue international, 2000, Volume: 67, Issue:5 Topics: Animals; Anti-Inflammatory Agents; Colitis; Diphosphonates; Disease Models, Animal; Inflammatory Bow	2000
[Effect of sodium fluoride on bone turnover and bone loss of vertebrae and tibia in ovariectomized rats]. Zhonghua bing li xue za zhi = Chinese journal of pathology, 2000, Volume: 29, Issue:1 Topics: Animals; Bone Resorption; Female; Lumbar Vertebrae; Osteogenesis; Osteoporosis; Ovariectomy; Rats; R	2000
Advances in osteoporosis. Lancet (London, England), 1976, Sep-04, Volume: 1, Issue:7984 Topics: Calcium; Fluorides; Humans; Middle Aged; Osteoporosis; Sodium Fluoride	1976
[Sodium fluoride in the therapy of osteoporosis]. Fortschritte der Medizin, 1979, Oct-04, Volume: 97, Issue:37 Topics: Adult; Aged; Back Pain; Calcium; Female; Fluorides; Humans; Hydroxyapatites; Intestinal Absorption;	1979
[Effect on continuous and periodic treatment with fluor on the bone density in senile osteoporosis]. Acta medica Austriaca. Supplement, 1977, Issue:4 Topics: Age Factors; Aged; Densitometry; Female; Fluorides; Humans; Male; Osteoporosis; Sodium Fluoride; Tim	1977
Iatrogenic fluorosis. Australian and New Zealand journal of medicine, 1978, Volume: 8, Issue:5 Topics: Aged; Calcium; Drug Therapy, Combination; Female; Fluorides; Humans; Iatrogenic Disease; Osteoporosi	1978
[Problems of high-dose sodium fluoride therapy in osteoporosis. 3. Practice of osteoporosis therapy with sodium fluoride]. Zeitschrift fur arztliche Fortbildung, 1979, Jun-15, Volume: 73, Issue:12 Topics: Calcium; Calcium Fluoride; Dose-Response Relationship, Drug; Exercise Therapy; Fluoridation; Fluorid	1979
Bone remodeling and calcium metabolism: a correlated histomorphometric, calcium kinetic, and biochemical study in patients with osteoporosis and Paget's Disease. Metabolism: clinical and experimental, 1977, Volume: 26, Issue:6 Topics: Adult; Aged; Bone and Bones; Bone Resorption; Calcium; Etidronic Acid; Female; Histocytochemistry; H	1977
Treatment of osteoporosis with large doses of sodium fluoride. Review of Czechoslovak medicine, 1977, Volume: 23, Issue:2 Topics: Adult; Female; Fluorides; Humans; Male; Osteoporosis; Sodium Fluoride	1977
[Is calcium therapy for osteoporosis still justified?]. Medizinische Klinik, 1979, Mar-02, Volume: 74, Issue:9 Topics: Calcium; Fluorides; Humans; Osteoporosis; Sodium Fluoride	1979
[Treatment of osteoporosis with a new retard-preparation of sodium fluoride (author's transl)]. Wiener medizinische Wochenschrift (1946), 1979, May-15, Volume: 129, Issue:9 Topics: Aged; Delayed-Action Preparations; Female; Fluorides; Humans; Middle Aged; Osteoporosis; Radiography	1979
[Problems of high dose sodium fluoride treatment in osteoporosis. 2. The effect of fluorides on the human skeleton]. Zeitschrift fur arztliche Fortbildung, 1979, Jun-01, Volume: 73, Issue:11 Topics: Age Factors; Bone and Bones; Dose-Response Relationship, Drug; Fluorides; Humans; Osteoblasts; Osteo	1979
[Effects of the treatment of active osteoporosis on the urinary excretion of hydroxyproline]. Revista clinica espanola, 1979, Apr-30, Volume: 153, Issue:2 Topics: Adult; Calcium Carbonate; Calcium Gluconate; Drug Therapy, Combination; Female; Humans; Hydroxyproli	1979
[Problems of large dose therapy with sodium fluoride in osteoporosis]. Zeitschrift fur arztliche Fortbildung, 1979, May-01, Volume: 73, Issue:9 Topics: Antacids; Biological Availability; Dose-Response Relationship, Drug; Fluoridation; Fluorides; Gastri	1979
[Results of long-term treatment of primary osteoporosis with sodium fluoride (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1978, Feb-10, Volume: 103, Issue:6 Topics: Body Height; Female; Fluorides; Humans; Ilium; Male; Middle Aged; Minerals; Osteoporosis; Radiograph	1978
[Effect of fluorine on calcium absorption in the treatment of osteoporosis]. Casopis lekaru ceskych, 1978, May-19, Volume: 117, Issue:20 Topics: Calcium; Fluorides; Humans; Intestinal Absorption; Osteoporosis; Sodium Fluoride	1978
Management of osteoporosis. Hospital practice, 1978, Volume: 13, Issue:12 Topics: Aged; Androgens; Calcitonin; Estrogens; Ethnicity; Female; Humans; Male; Menopause; Middle Aged; Ost	1978
What to do with "postmenopausal osteoporosis?". The American journal of medicine, 1978, Volume: 65, Issue:6 Topics: Aged; Androgens; Biopsy; Bone and Bones; Calcium, Dietary; Estrogens; Female; Growth Hormone; Humans	1978
[Juvenile osteoporosis]. Deutsche medizinische Wochenschrift (1946), 1979, Jan-12, Volume: 104, Issue:2 Topics: Adolescent; Adult; Age Factors; Humans; Male; Osteoporosis; Sodium Fluoride	1979
[Biological availability of Ossin, a sodium-fluoride dragee for osteoporosis therapy]. Fortschritte der Medizin, 1979, Jan-04, Volume: 97, Issue:1 Topics: Biological Availability; Fluorides; Humans; Osteoporosis; Sodium Fluoride; Tablets	1979
[Results of animal experimental studies on rabbits with sodium fluoride and the effect of antidotes]. Zeitschrift fur die gesamte Hygiene und ihre Grenzgebiete, 1977, Volume: 23, Issue:1 Topics: Animals; Boron Compounds; Fluoride Poisoning; Iron; Osteoporosis; Rabbits; Sodium Fluoride	1977
[Principles in the therapy of osteoporosis. 2. Therapy]. Fortschritte der Medizin, 1977, Feb-24, Volume: 95, Issue:8 Topics: Anabolic Agents; Calcium; Cortisone; Estrogens; Female; Growth Hormone; Humans; Male; Menopause; Ost	1977
Senile osteoporosis. Radiologic clinics of North America, 1977, Volume: 15, Issue:2 Topics: Aged; Calcium; Estrogens; Female; Humans; Male; Middle Aged; Osteoporosis; Phosphates; Sodium Fluori	1977
Effect of fluoride therapy on nondialyzable urinary hydroxyproline, serum alkaline phosphatase, parathyroid hormone, and 25-hydroxyvitamin D. Metabolism: clinical and experimental, 1977, Volume: 26, Issue:9 Topics: Aged; Alkaline Phosphatase; Bone and Bones; Calcium; Dialysis; Fluorides; Humans; Hydroxycholecalcif	1977
[Drug treatment of osteoporosis]. Therapeutische Umschau. Revue therapeutique, 1977, Volume: 34, Issue:9 Topics: Aged; Calcitonin; Estrogens; Female; Humans; Male; Middle Aged; Osteoporosis; Sodium Fluoride	1977
Magnesium-fluoride interrelationships in man. I. Effect of fluoride on magnesium metabolism. The American journal of physiology, 1977, Volume: 233, Issue:3 Topics: Calcium, Dietary; Diet; Dose-Response Relationship, Drug; Fluorides; Humans; Magnesium; Male; Osteop	1977
[Treatment of osteoporosis (author's transl)]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1976, Sep-14, Volume: 65, Issue:37 Topics: Calcium; Female; Fractures, Bone; Humans; Male; Osteoporosis; Physical Therapy Modalities; Sodium Fl	1976
[Experiences with sodium fluoride in the treatment of osteoporosis]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1976, Dec-01, Volume: 31, Issue:23 Topics: Adult; Aged; Aging; Alkaline Phosphatase; Female; Fluorides; Glucocorticoids; Humans; Male; Middle A	1976
[Serum fluoride level in the NaF treatment of osteoporosis]. Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1976, Volume: 82 Pt 1 Topics: Calcium; Drug Therapy, Combination; Fluorides; Humans; Osteoporosis; Sodium Fluoride	1976
[Osteoporotic vertebral fractures in systemic mastocytosis without skin involvement]. Deutsche medizinische Wochenschrift (1946), 1992, Nov-06, Volume: 117, Issue:45 Topics: Aspirin; Bone Marrow Examination; Calcitonin; Calcium; Cholecalciferol; Diagnosis, Differential; Fem	1992
Corticosteroid-induced osteoporosis: effects of a treatment with slow-release sodium fluoride. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 1992, Volume: 2, Issue:6 Topics: Adrenal Cortex Hormones; Aged; Bone Density; Delayed-Action Preparations; Female; Humans; Male; Midd	1992
Lack of deleterious effect of slow-release sodium fluoride treatment on cortical bone histology and quality in osteoporotic patients. Bone and mineral, 1992, Volume: 18, Issue:1 Topics: Adult; Aged; Bone Density; Bone Remodeling; Citrates; Citric Acid; Delayed-Action Preparations; Drug	1992
Adolescent osteoporosis disclosing familial osteopenia. Clinical rheumatology, 1992, Volume: 11, Issue:4 Topics: Adolescent; Bone Density; Bone Diseases, Metabolic; Calcifediol; Calcium Carbonate; Drug Therapy, Co	1992
[The effects of long-term intake of a low concentration of sodium fluoride on bone loss in the growing senescence-accelerated mouse (SAM-P/6)]. Nihon eiseigaku zasshi. Japanese journal of hygiene, 1992, Volume: 47, Issue:2 Topics: Animals; Body Weight; Bone and Bones; Bone Density; Calcium; Disease Models, Animal; Female; Male; M	1992
[Comparison of the effects of sodium fluoride and calcidiol on the remodeling of the endosteal surface of the rib cortex in dogs after administration of prednisone]. Polskie Archiwum Medycyny Wewnetrznej, 1992, Volume: 87, Issue:2 Topics: Animals; Bone Remodeling; Calcifediol; Disease Models, Animal; Dogs; Drug Synergism; Osteoporosis; P	1992
Thalassemia minor: a risk factor for osteoporosis? Bone and mineral, 1992, Volume: 16, Issue:1 Topics: Adult; Bone Density; Calcitriol; Female; Humans; Ilium; Male; Middle Aged; Osteoporosis; Radiography	1992
Bone hypertrophy and trabecular generation in Paget's disease and in fluoride-treated osteoporosis. Bone and mineral, 1992, Volume: 17, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Biopsy; Bone Matrix; Female; Humans; Hyperostosis; Middle Aged; Oste	1992
Spontaneous calcaneal fracture in osteoporosis without fluoride therapy. Clinical nuclear medicine, 1991, Volume: 16, Issue:11 Topics: Calcaneus; Female; Fractures, Spontaneous; Humans; Middle Aged; Osteoporosis; Radionuclide Imaging;	1991
The effect of sodium fluoride on trabecular architecture. Bone, 1991, Volume: 12, Issue:5 Topics: Adult; Aged; Bone Density; Female; Fractures, Bone; Humans; Longitudinal Studies; Male; Middle Aged;	1991
The prevention of osteoporosis. Hospital practice (Office ed.), 1991, May-15, Volume: 26, Issue:5 Topics: Aged; Back Pain; Bone Density; Calcitonin; Calcium, Dietary; Diphosphonates; Estradiol Congeners; Fe	1991
Current treatment concepts for osteoporosis. Nurse practitioner forum, 1991, Volume: 2, Issue:4 Topics: Calcitonin; Calcium; Diphosphonates; Estrogens; Humans; Osteoporosis; Sodium Fluoride; Vitamin D	1991
Fluoride treatment for osteoporosis. Lancet (London, England), 1990, Jul-07, Volume: 336, Issue:8706 Topics: Biological Availability; Bone Density; Bone Resorption; Drug Administration Schedule; Humans; Osteop	1990
Fluoride and vertebral fractures. Lancet (London, England), 1990, Jul-28, Volume: 336, Issue:8709 Topics: Fractures, Spontaneous; Humans; Osteoporosis; Risk Factors; Sodium Fluoride; Time Factors	1990
Periostitis due to low-dose fluoride intoxication demonstrated by bone scanning. Clinical nuclear medicine, 1991, Volume: 16, Issue:1 Topics: Aged; Bone and Bones; Female; Humans; Osteoporosis; Periostitis; Radionuclide Imaging; Sodium Fluori	1991
Exacerbation of rheumatoid arthritis by sodium fluoride treatment of osteoporosis. Archives of internal medicine, 1991, Volume: 151, Issue:4 Topics: Aged; Arthritis, Rheumatoid; Female; Humans; Osteoporosis; Sodium Fluoride	1991
Assessment by reflection ultrasound method of the effect of intermittent slow-release sodium fluoride-calcium citrate therapy on material strength of bone. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1991, Volume: 6, Issue:3 Topics: Adult; Aged; Bone and Bones; Citrates; Citric Acid; Delayed-Action Preparations; Drug Administration	1991
Marrow space star volume in the iliac crest decreases in osteoporotic patients after continuous treatment with fluoride, calcium, and vitamin D2 for five years. Bone, 1991, Volume: 12, Issue:1 Topics: Aged; Aged, 80 and over; Biopsy; Calcium; Drug Therapy, Combination; Ergocalciferols; Female; Humans	1991
[Treatment of osteoporosis]. Nihon rinsho. Japanese journal of clinical medicine, 1990, Volume: 48, Issue:12 Topics: Calcitonin; Calcium; Drug Therapy, Combination; Estrogens; Humans; Osteoporosis; Physical Therapy Mo	1990
Designing clinical trials of treatment for osteoporosis: recruitment and follow-up. Calcified tissue international, 1990, Volume: 47, Issue:6 Topics: Aged; Clinical Trials as Topic; Female; Follow-Up Studies; Fractures, Spontaneous; Humans; Middle Ag	1990
Iliac bone biopsies at the time of periarticular stress fractures during fluoride therapy: comparison with pretreatment biopsies. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1990, Volume: 5, Issue:2 Topics: Biopsy; Creatinine; Female; Fractures, Stress; Hip Fractures; Humans; Ilium; Osteoporosis; Parathyro	1990
The long-term treatment of steroid osteoporosis with fluoride. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1990, Volume: 5 Suppl 1 Topics: Adult; Aged; Bone Density; Female; Fractures, Bone; Humans; Male; Middle Aged; Osteoporosis; Prednis	1990
Risk factors for the development of stress fractures during fluoride therapy for osteoporosis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1990, Volume: 5 Suppl 1 Topics: Aged; Alkaline Phosphatase; Biopsy; Creatinine; Female; Fractures, Stress; Humans; Leg Injuries; Mal	1990
Stress fractures of the lower limbs in osteoporotic patients treated with fluoride. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1990, Volume: 5 Suppl 1 Topics: Aged; Aged, 80 and over; Female; Fluorides; Fractures, Stress; Humans; Leg Injuries; Male; Middle Ag	1990
The causes of bone scintigram hot spots in fluoride-treated osteoporotic patients. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1990, Volume: 5 Suppl 1 Topics: Adult; Aged; Aged, 80 and over; Bone Density; Female; Femur; Fractures, Stress; Humans; Middle Aged;	1990
Fluoride pharmacokinetics: its implications in the fluoride treatment of osteoporosis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1990, Volume: 5 Suppl 1 Topics: Biological Availability; Calcium; Delayed-Action Preparations; Drug Therapy, Combination; Fasting; F	1990
The value of local 99mTc(Sn)-MDP bone to soft tissue uptake ratio in osteoporosis, before and during fluoride therapy. European journal of nuclear medicine, 1990, Volume: 16, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Bone and Bones; Connective Tissue; Female; Humans; Male; Middle Aged	1990
Treatment of osteoporosis with human parathyroid peptide and observations on effect of sodium fluoride. BMJ (Clinical research ed.), 1990, Aug-11, Volume: 301, Issue:6747 Topics: Bone Density; Calcium; Drug Therapy, Combination; Estrogen Replacement Therapy; Female; Fractures, B	1990
[Treatment of patients with postmenopausal and steroid-induced osteoporosis using sodium fluoride combined with vitamin D2 and calcium gluconate]. Vutreshni bolesti, 1990, Volume: 29, Issue:1 Topics: Adrenal Cortex Hormones; Adult; Aged; Body Height; Calcium Gluconate; Chronic Disease; Drug Evaluati	1990
Effects of sodium fluoride, vitamin D, and calcium on cortical bone remodeling in osteoporotic patients. Calcified tissue international, 1989, Volume: 45, Issue:6 Topics: Aged; Bone and Bones; Bone Regeneration; Bone Resorption; Calcium; Female; Humans; Middle Aged; Oste	1989
[Value of bone fluoride determination in osteoporotic patients treated with sodium fluoride]. Presse medicale (Paris, France : 1983), 1989, Apr-01, Volume: 18, Issue:13 Topics: Adult; Aged; Biopsy; Bone and Bones; Bone Development; Female; Humans; Male; Middle Aged; Osteoporos	1989
Fluoride and osteoblasts. Lancet (London, England), 1989, Feb-25, Volume: 1, Issue:8635 Topics: Calcium-Binding Proteins; Humans; Osteoblasts; Osteocalcin; Osteogenesis; Osteoporosis; Sodium Fluor	1989
The effect of prolonged fluoride therapy for osteoporosis: bone composition and histology. Bone, 1989, Volume: 10, Issue:5 Topics: Alkaline Phosphatase; Biopsy; Bone and Bones; Bone Density; Female; Humans; Male; Osteoporosis; Sodi	1989
[Microradiographic study of iliac bone biopsies taken after treatment of postmenopausal osteoporosis with sodium fluoride. Histomorphometric correlations]. Revue du rhumatisme et des maladies osteo-articulaires, 1989, Volume: 56, Issue:5 Topics: Adult; Aged; Biopsy; Calcifediol; Calcium; Female; Fluoride Poisoning; Humans; Ilium; Menopause; Mic	1989
[Treatment of postmenopausal with sodium fluoride. Effect on mineral bone content of the radius]. Revue du rhumatisme et des maladies osteo-articulaires, 1989, Volume: 56, Issue:6 Topics: Aged; Female; Humans; Menopause; Minerals; Osteoporosis; Radionuclide Imaging; Radius; Sodium Fluori	1989
Fluoride and the therapy of osteoporosis. The Journal of clinical endocrinology and metabolism, 1989, Volume: 69, Issue:5 Topics: Absorptiometry, Photon; Bone Density; Female; Humans; Osteoporosis; Sodium Fluoride; Spine	1989
[Stress fractures and fluorosis-like osseous changes during long-term cortisone therapy and prevention of osteoporosis using sodium fluoride]. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1987, Volume: 147, Issue:5 Topics: Adolescent; Bone and Bones; Cortisone; Fractures, Spontaneous; Humans; Male; Osteoporosis; Polyradic	1987
Postmenopausal osteoporosis: treatment with low-dose sodium fluoride and estrogen. Southern medical journal, 1988, Volume: 81, Issue:5 Topics: Aged; Bone and Bones; Calcium Carbonate; Drug Therapy, Combination; Estrogens, Conjugated (USP); Fem	1988
A newly developed spine deformity index (SDI) to quantitate vertebral crush fractures in patients with osteoporosis. Bone and mineral, 1988, Volume: 3, Issue:4 Topics: Adult; Aged; Anthropometry; Body Height; Calcium; Cholecalciferol; Female; Fractures, Bone; Humans;	1988
Treatment of bone weakness in patients with femoral neck fracture by fluoride, calcium and vitamin D. The Journal of bone and joint surgery. British volume, 1989, Volume: 71, Issue:1 Topics: Aged; Aged, 80 and over; Bone and Bones; Calcium Carbonate; Drug Therapy, Combination; Female; Femor	1989
[Risks and benefits of treatment with sodium fluoride of osteoporosis with vertebral collapse]. La Revue du praticien, 1989, Feb-02, Volume: 39, Issue:3 Topics: Aged; Female; Humans; Male; Osteoporosis; Prospective Studies; Sodium Fluoride; Spinal Diseases	1989
From the National Institutes of Health. JAMA, 1989, Apr-07, Volume: 261, Issue:13 Topics: Arthritis, Rheumatoid; Caffeine; Cyclosporins; Female; Fertility; Humans; Osteoporosis; Sodium Fluor	1989
[Spontaneous fissures and fractures of the legs in patients with osteoporosis treated with sodium fluoride]. Presse medicale (Paris, France : 1983), 1987, Apr-04, Volume: 16, Issue:12 Topics: Aged; Aged, 80 and over; Bone Diseases; Female; Fractures, Spontaneous; Humans; Leg; Male; Middle Ag	1987
[Fractures caused by bone insufficiency in osteoporotic patients treated with sodium fluoride]. Presse medicale (Paris, France : 1983), 1987, Jun-06, Volume: 16, Issue:21 Topics: Aged; Female; Fractures, Spontaneous; Humans; Leg Injuries; Osteoporosis; Sodium Fluoride	1987
[Fluorosis following the long-term treatment of osteoporosis with sodium fluoride]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1986, Jan-01, Volume: 41, Issue:1 Topics: Bone and Bones; Glucocorticoids; Humans; Long-Term Care; Male; Middle Aged; Osteoporosis; Osteoscler	1986
Osteoporosis: cause and management. British medical journal (Clinical research ed.), 1987, Apr-18, Volume: 294, Issue:6578 Topics: Estrogens; Female; Humans; Osteoporosis; Parathyroid Hormone; Peptide Fragments; Sodium Fluoride; Te	1987
[Skeletal fluorosis following uncontrolled use of sodium fluoride]. Zeitschrift fur arztliche Fortbildung, 1988, Volume: 82, Issue:10 Topics: Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Female; Humans; Long-Term Care; Osteoporo	1988
[Contribution to the study of the treatment of osteoporosis using fluoride. Long-term sequelae following discontinuation of fluoride]. Schweizerische medizinische Wochenschrift, 1988, Aug-27, Volume: 118, Issue:34 Topics: Aged; Calcium; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Oste	1988
[Role of hyperthyroidism in bone complications of fluoride treatment of osteoporosis]. Revue du rhumatisme et des maladies osteo-articulaires, 1988, Volume: 55, Issue:11 Topics: Aged; Female; Fractures, Spontaneous; Humans; Hyperthyroidism; Middle Aged; Osteoporosis; Sodium Flu	1988
The effect of fluoride on bone histology in postmenopausal osteoporosis depends on adequate fluoride absorption and retention. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1988, Volume: 3, Issue:2 Topics: Biopsy; Bone and Bones; Female; Humans; Intestinal Absorption; Menopause; Middle Aged; Osteoporosis;	1988
[Tendinosis calcarea--progression after NaF treatment of osteoporosis. Case report]. Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca, 1988, Volume: 55, Issue:1 Topics: Adult; Bursitis; Calcinosis; Female; Humans; Osteoporosis; Shoulder Joint; Sodium Fluoride	1988
Fluoride therapy in osteoporosis: acute effects on parathyroid and mineral homoeostasis. Clinical science (London, England : 1979), 1988, Volume: 75, Issue:2 Topics: Aged; Calcium; Dihydroxycholecalciferols; Female; Homeostasis; Humans; Hydroxyapatites; Male; Middle	1988
Sodium fluoride treatment in osteoporosis. Acta Universitatis Carolinae. Medica, 1986, Volume: 32, Issue:5-6 Topics: Humans; Osteoporosis; Radiography; Sodium Fluoride	1986
[Reversibility of skeletal fluorosis]. Beitrage zur Orthopadie und Traumatologie, 1987, Volume: 34, Issue:11 Topics: Aged; Female; Follow-Up Studies; Humans; Male; Middle Aged; Osteoporosis; Osteosclerosis; Sodium Flu	1987
Incidence of hip fractures in osteoporotic women treated with sodium fluoride. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1987, Volume: 2, Issue:2 Topics: Aged; Aged, 80 and over; Female; Hip Fractures; Humans; Middle Aged; Osteoporosis; Sodium Fluoride	1987
[Treatment with sodium fluoride, calcium phosphate and vitamin D2 in spinal osteoporosis. Effect on calcium balance, calcium metabolism, bone remodelling, and side effects]. Ugeskrift for laeger, 1986, Dec-15, Volume: 148, Issue:51 Topics: Aged; Bone Regeneration; Calcium; Calcium Phosphates; Ergocalciferols; Female; Humans; Middle Aged;	1986
Attainment of therapeutic fluoride levels in serum without major side effects using a slow-release preparation of sodium fluoride in postmenopausal osteoporosis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1986, Volume: 1, Issue:6 Topics: Aged; Aged, 80 and over; Biological Availability; Circadian Rhythm; Delayed-Action Preparations; Fem	1986
The relationship between fluoride effects on bone histology and on bone mass in patients with postmenopausal osteoporosis. Bone and mineral, 1986, Volume: 1, Issue:4 Topics: Aged; Bone and Bones; Calcium; Female; Fluorides; Humans; Middle Aged; Minerals; Osteoporosis; Sodiu	1986
The effect of exercise on bone mass of osteoporotic patients on fluoride treatment. Clinical and investigative medicine. Medecine clinique et experimentale, 1987, Volume: 10, Issue:2 Topics: Aged; Bone and Bones; Female; Humans; Middle Aged; Osteoporosis; Physical Exertion; Sodium Fluoride	1987
In vivo analysis of bone fluoride content via NMR. Physics in medicine and biology, 1987, Volume: 32, Issue:4 Topics: Bone and Bones; Fluorides; Humans; Magnetic Resonance Spectroscopy; Osteoporosis; Sodium Fluoride	1987
Responders and non-responders after fluoride therapy in osteoporosis. Bone, 1987, Volume: 8, Issue:3 Topics: Aged; Alkaline Phosphatase; Drug Resistance; Female; Humans; Middle Aged; Osteoporosis; Sodium Fluor	1987
Monitoring fluoride therapy in osteoporosis by dual photon absorptiometry. Bone, 1987, Volume: 8, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Bone and Bones; Estrogens; Female; Humans; Male; Middle Aged; Minera	1987
Prevention and treatment of postmenopausal osteoporosis. The Medical letter on drugs and therapeutics, 1987, Aug-14, Volume: 29, Issue:746 Topics: Calcitonin; Calcium; Estrogens; Female; Humans; Osteoporosis; Physical Exertion; Risk; Sodium Fluori	1987
When your patient asks you about osteoporosis. American pharmacy, 1987, Volume: NS27, Issue:7 Topics: Adult; Aged; Calcitonin; Calcium; Female; Humans; Male; Middle Aged; Osteoporosis; Sodium Fluoride	1987
Supraacetabular and femoral head stress fracture during fluoride treatment. Gerontology, 1987, Volume: 33, Issue:5 Topics: Acetabulum; Aged; Female; Femoral Neck Fractures; Fractures, Spontaneous; Humans; Osteoporosis; Pred	1987
Safety of osteoporosis treatment with sodium fluoride, calcium phosphate and vitamin D. Mineral and electrolyte metabolism, 1987, Volume: 13, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bone and Bones; Calcium Phosphates; Female; Humans; Live	1987
Osteoporosis: significance, risk factors and treatment. The Nurse practitioner, 1986, Volume: 11, Issue:9 Topics: Aged; Biomechanical Phenomena; Calcitonin; Calcium; Estrogens; Female; Humans; Menopause; Middle Age	1986
[Methods of study in the therapy of osteoporosis--clinical aspects, roentgenology, biochemistry]. Zeitschrift fur arztliche Fortbildung, 1986, Volume: 80, Issue:11 Topics: Aged; Bone and Bones; Enzymes; Follow-Up Studies; Humans; Hydroxyproline; Middle Aged; Osteomalacia;	1986
Histomorphometric analysis of a calcaneal stress fracture: a possible complication of fluoride therapy for osteoporosis. Bone, 1986, Volume: 7, Issue:3 Topics: Bone Resorption; Calcaneus; Female; Fractures, Spontaneous; Humans; Middle Aged; Osteogenesis; Osteo	1986
Long-term fluoride therapy of postmenopausal osteoporosis. Bone, 1986, Volume: 7, Issue:3 Topics: Aged; Alkaline Phosphatase; Female; Fractures, Spontaneous; Humans; Menopause; Middle Aged; Osteopor	1986
[Therapy-induced fluorosis--damage or goal?]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1986, Sep-15, Volume: 41, Issue:18 Topics: Adult; Aged; Dose-Response Relationship, Drug; Female; Fractures, Spontaneous; Humans; Osteoporosis;	1986
Fluoride treatment in corticosteroid induced osteoporosis. Archives of disease in childhood, 1986, Volume: 61, Issue:12 Topics: Child; Dermatomyositis; Female; Glucocorticoids; Humans; Osteoporosis; Sodium Fluoride	1986
[Pathogenesis and therapy of osteoporosis in the postmenopausal period]. Der Gynakologe, 1986, Volume: 19, Issue:4 Topics: Bone and Bones; Calcium; Estradiol Congeners; Estrogens; Female; Fractures, Spontaneous; Humans; Men	1986
Radiographic features of the spine in fluoride therapy for osteoporosis. The Journal of bone and joint surgery. British volume, 1987, Volume: 69, Issue:2 Topics: Adult; Aged; Calcium; Drug Evaluation; Drug Therapy, Combination; Female; Fractures, Spontaneous; Hu	1987
[Therapeutic choices in osteoporosis]. Schweizerische medizinische Wochenschrift, 1987, Jan-17, Volume: 117, Issue:3 Topics: Aged; Aging; Bone and Bones; Bone Regeneration; Bone Resorption; Calcitonin; Calcium; Densitometry;	1987
The effects of sodium fluoride, calcium phosphate, and vitamin D2 for one to two years on calcium and phosphorus metabolism in postmenopausal women with spinal crush fracture osteoporosis. Bone, 1985, Volume: 6, Issue:4 Topics: Aged; Bone and Bones; Bone Resorption; Calcium; Calcium Phosphates; Ergocalciferols; Female; Fractur	1985
Effect of sodium fluoride, calcium, phosphate, and vitamin D2 on trabecular bone balance and remodeling in osteoporotics. Bone, 1985, Volume: 6, Issue:5 Topics: Aged; Bone and Bones; Bone Resorption; Calcification, Physiologic; Calcium; Cell Division; Ergocalci	1985
[Medicamentous skeletal fluorosis]. Beitrage zur Orthopadie und Traumatologie, 1985, Volume: 32, Issue:2 Topics: Aged; Dose-Response Relationship, Drug; Humans; Long-Term Care; Male; Middle Aged; Osteopetrosis; Os	1985
Osteoporosis. Postmenopausal or secondary? Hospital practice (Office ed.), 1985, Oct-30, Volume: 20, Issue:10A Topics: Adult; Biopsy; Bone and Bones; Bone Resorption; Estrogens; Female; Humans; Menopause; Middle Aged; O	1985
[Osteomalacia caused by sodium fluoride]. Deutsche medizinische Wochenschrift (1946), 1986, Jan-10, Volume: 111, Issue:2 Topics: Aged; Female; Humans; Osteomalacia; Osteoporosis; Sodium Fluoride	1986
Sodium fluoride in the treatment of osteoporosis. Clinical and investigative medicine. Medecine clinique et experimentale, 1986, Volume: 9, Issue:1 Topics: Calcium; Female; Fractures, Bone; Humans; Menopause; Osteoporosis; Sodium Fluoride	1986
Preventing osteoporosis: current practices and problems. Geriatrics, 1986, Volume: 41, Issue:5 Topics: Adult; Aged; Bone and Bones; Bone Resorption; Calcium; Diet; Estrogens; Female; Humans; Middle Aged;	1986
Osteoporosis: radiographic detection of fluoride-induced extra-axial bone formation. Radiology, 1986, Volume: 159, Issue:2 Topics: Bone and Bones; Bone Development; Female; Humans; Male; Osteoporosis; Pain; Radiography; Radionuclid	1986
[The osteoporosis disease in menopausal women. Physiopathology and therapeutic impact]. Revue francaise de gynecologie et d'obstetrique, 1985, Volume: 80, Issue:4 Topics: Calcium; Estrogens; Exercise Therapy; Female; Humans; Menopause; Middle Aged; Osteoporosis; Radius F	1985
Fluoride in the treatment of osteoporosis: risk of adverse effects on bone. Alabama medicine : journal of the Medical Association of the State of Alabama, 1985, Volume: 54, Issue:12 Topics: Aged; Bone Resorption; Calcium; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Osteop	1985
[Multidisciplinary study of the prolonged treatment of involution osteoporosis using sodium fluoride with calcium, phosphate and vitamin D]. Schweizerische medizinische Wochenschrift, 1985, Jul-09, Volume: 115, Issue:27-28 Topics: Aged; Biopsy; Bone and Bones; Calcium; Drug Therapy, Combination; Female; Fractures, Bone; Humans; M	1985
Osteoporosis. American family physician, 1985, Volume: 32, Issue:5 Topics: Aged; Bone and Bones; Calcium; Estrogens; Female; Forearm Injuries; Fractures, Bone; Hip Fractures;	1985
Prevention and therapy of osteoporosis. Rational drug therapy, 1985, Volume: 19, Issue:8 Topics: Aged; Calcitonin; Calcium; Estrogens; Female; Humans; Male; Osteoporosis; Physical Exertion; Risk; S	1985
Studies of fluoride and calcium metabolism in patients with osteoporosis. The American journal of medicine, 1970, Volume: 49, Issue:6 Topics: Adult; Aged; Calcium, Dietary; Humans; Male; Osteoporosis; Sodium Fluoride	1970

sodium fluoride and Age-Related Osteoporosis