sodium fluoride has been researched along with Ache in 13 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "During an 8-year period, 163 consecutive patients with spinal crush fracture osteoporosis started a 5-year treatment with a combination of sodium fluoride (60 mg/day), calcium phosphate (45 mmol/day) and vitamin D2 (18,000 IU/day), and were followed in the outpatient clinic every 3 months." | 7.67 | Safety of osteoporosis treatment with sodium fluoride, calcium phosphate and vitamin D. ( Hasling, C; Melsen, F; Mosekilde, L; Nielsen, HE, 1987) |
| "During an 8-year period, 163 consecutive patients with spinal crush fracture osteoporosis started a 5-year treatment with a combination of sodium fluoride (60 mg/day), calcium phosphate (45 mmol/day) and vitamin D2 (18,000 IU/day), and were followed in the outpatient clinic every 3 months." | 3.67 | Safety of osteoporosis treatment with sodium fluoride, calcium phosphate and vitamin D. ( Hasling, C; Melsen, F; Mosekilde, L; Nielsen, HE, 1987) |
| "Sodium fluoride was given orally in water to male Sprague-Dawley (75 and 150 ppm) and Lou rats (150 ppm) for 15 and 27 weeks, respectively." | 1.31 | Absence of painful neuropathy after chronic oral fluoride intake in Sprague-Dawley and Lou/C rats. ( Authier, N; Balayssac, D; Coudoré, F; Eschalier, A; Jourdan, D; Nicolay, A; Richard, D, 2002) |
| "Four other patients had stress fractures associated with trauma." | 1.28 | Fluoride-induced fractures: relation to osteogenic effect. ( Bayley, TA; Goodwin, S; Harrison, JE; Josse, RG; Murray, TM; Pritzker, KP; Strauss, A; Sturtridge, W; Vieth, R, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (38.46) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 3 (23.08) | 2.80 |
| Authors | Studies |
|---|---|
| Butera, A | 1 |
| Gallo, S | 1 |
| Pascadopoli, M | 1 |
| Montasser, MA | 1 |
| Abd El Latief, MH | 1 |
| Modica, GG | 1 |
| Scribante, A | 1 |
| Seong, J | 2 |
| Newcombe, RG | 1 |
| Matheson, JR | 1 |
| Weddell, L | 1 |
| Edwards, M | 1 |
| West, NX | 1 |
| McLarty, E | 1 |
| Spriet, M | 1 |
| Beylin, D | 1 |
| Chou, PY | 1 |
| Filliquist, B | 1 |
| Marcellin-Little, DJ | 1 |
| Kapatkin, AS | 1 |
| Bahal, P | 1 |
| He, T | 1 |
| Zou, Y | 1 |
| Davies, M | 1 |
| Chapman, N | 1 |
| West, N | 1 |
| Balayssac, D | 1 |
| Richard, D | 1 |
| Authier, N | 1 |
| Nicolay, A | 1 |
| Jourdan, D | 1 |
| Eschalier, A | 1 |
| Coudoré, F | 1 |
| Czukor, J | 1 |
| Heidelmann, G | 2 |
| Gips, S | 1 |
| Cohen, L | 1 |
| Hardoff, R | 1 |
| Bayley, TA | 1 |
| Harrison, JE | 1 |
| Murray, TM | 1 |
| Josse, RG | 1 |
| Sturtridge, W | 1 |
| Pritzker, KP | 1 |
| Strauss, A | 1 |
| Vieth, R | 1 |
| Goodwin, S | 1 |
| Mamelle, N | 1 |
| Meunier, PJ | 1 |
| Dusan, R | 1 |
| Guillaume, M | 1 |
| Martin, JL | 1 |
| Gaucher, A | 1 |
| Prost, A | 1 |
| Zeigler, G | 1 |
| Netter, P | 1 |
| Hasling, C | 1 |
| Nielsen, HE | 1 |
| Melsen, F | 1 |
| Mosekilde, L | 1 |
| Schulz, EE | 1 |
| Engstrom, H | 1 |
| Sauser, DD | 1 |
| Baylink, DJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Comparison Between a Toothpaste With Micro Crystals of Hydroxyapatite and a Toothpaste With 1450 Ppm of Fluoride in the Home Remineralization of White Spot Lesions: a Clinical Trial.[NCT04908293] | 40 participants (Actual) | Interventional | 2021-05-28 | Completed | |||
| A Medical Device Study to Measure the Efficacy of a Toothpaste Containing Calcium-silicate/Phosphate on Dentinal Hypersensitivity Compared to a Control Toothpaste Containing Fluoride.[NCT03244618] | 272 participants (Actual) | Interventional | 2017-06-19 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The Yeaple score is recorded in terms of quantified reproducible force (range 10-60 grams with higher values indicating a better outcome). The Yeaple probe tip with a force of 10 grams is passed over the exposed dentin on the buccal surface of the selected teeth, apical to the cementenamel junction and the applied force in increased each time by 10 grams until the participant indicates that he/she is experiencing discomfort, or until 20 grams (baseline) or 60 grams (post product use) of force is reached. A higher value indicates lower levels of dentinal hypersensitivity. Each subject will be characterised at each visit by the average of the relevant scores for the two indicator teeth. (NCT03244618)
Timeframe: 4-weeks of product use (Day 28)
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Baseline | Week 4 | |
| CSSP Toothpaste | 17.5 | 38.2 |
| Fluoride Toothpaste | 16.6 | 27.5 |
The Yeaple score is recorded in terms of quantified reproducible force (range 10-60 grams with higher values indicating a better outcome). The Yeaple probe tip with a force of 10 grams is passed over the exposed dentin on the buccal surface of the selected teeth, apical to the cementenamel junction and the applied force in increased each time by 10 grams until the participant indicates that he/she is experiencing discomfort, or until 20 grams (baseline) or 60 grams (post product use) of force is reached. A higher value indicates lower levels of dentinal hypersensitivity. Each subject will be characterised at each visit by the average of the relevant scores for the two indicator teeth. (NCT03244618)
Timeframe: Day 29, 12 hours after product use has ceased
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Baseline | Day 29, 12hr after last product use | |
| CSSP Toothpaste | 17.5 | 41.5 |
| Fluoride Toothpaste | 16.6 | 29.7 |
Air blast sensitivity assessed by directing a one-second blast of air onto the exposed buccal root surface of sensitive tooth. Sensitivity recorded: 0 = Tooth/Subject does not respond; 1 Tooth/subject responds but does not request discontinuation; 2 Tooth/subject responds and requests discontinuation or moves;3 Tooth/subject responds, considers stimulus to be painful, and requests discontinuation. Each subject will be characterised at each visit by the average of the relevant scores for the two indicator teeth. HIgher score is worse outcome. (NCT03244618)
Timeframe: 4-weeks of product use (Day 28)
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Baseline | Week 4 | |
| CSSP Toothpaste | 2.188 | 1.268 |
| Fluoride Toothpaste | 2.246 | 1.811 |
Air blast sensitivity assessed by directing a one-second blast of air onto the exposed buccal root surface of sensitive tooth. Sensitivity will be recorded: 0 = Tooth/Subject does not respond; 1 Tooth/subject responds but does not request discontinuation; 2 Tooth/subject responds and requests discontinuation or moves;3 Tooth/subject responds, considers stimulus to be painful, and requests discontinuation. Each subject will be characterised at each visit by the average of the relevant scores for the two indicator teeth. (NCT03244618)
Timeframe: Day 29, 12 hours after product use has ceased
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Baseline | Day 29, 12hr after last product use | |
| CSSP Toothpaste | 2.188 | 1.044 |
| Fluoride Toothpaste | 2.246 | 1.713 |
Visual Analogue Scale values of the same teeth will be also be recorded to give the outcome variable per subject at the same time of Schiff assessment. The VAS values will be assigned a numerical value in the conventional order from 0 (no pain) to 100 (extremely pain). (NCT03244618)
Timeframe: Day 29, 12 hours after product use has ceased
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Baseline | Day 29, 12hr after last product use | |
| CSSP Toothpaste | 48.1 | 27.2 |
| Fluoride Toothpaste | 49.9 | 38.1 |
Visual Analogue Scale values were recorded to give the outcome variable per subject at the same time asSchiff assessment. The VAS values were assigned a numerical value in the conventional order from 0 (no pain) to 100 (extremely pain). (NCT03244618)
Timeframe: 4-weeks of product use (Day 28)
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Baseline | Week 4 | |
| CSSP Toothpaste | 48.1 | 31.1 |
| Fluoride Toothpaste | 49.9 | 42.0 |
4 trials available for sodium fluoride and Ache
| Article | Year |
|---|---|
Home Oral Care with Biomimetic Hydroxyapatite vs. Conventional Fluoridated Toothpaste for the Remineralization and Desensitizing of White Spot Lesions: Randomized Clinical Trial.
Topics: Biomimetics; Dental Caries; Durapatite; Fluorides; Humans; Pain; Sodium Fluoride; Toothpastes | 2022 |
A randomised controlled trial investigating efficacy of a novel toothpaste containing calcium silicate and sodium phosphate in dentine hypersensitivity pain reduction compared to a fluoride control toothpaste.
Topics: Adult; Arginine; Calcium Carbonate; Calcium Compounds; Dentin Desensitizing Agents; Dentin Sensitivi | 2020 |
A randomised controlled trial to investigate the efficacy of an oxalate strip for the management of dentine hypersensitivity pain.
Topics: Adult; Calcium Carbonate; Dentin Desensitizing Agents; Dentin Sensitivity; Double-Blind Method; Fluo | 2019 |
Risk-benefit ratio of sodium fluoride treatment in primary vertebral osteoporosis.
Topics: Administration, Oral; Aged; Aged, 80 and over; Ankle; Calcium; Clinical Trials as Topic; Drug Admini | 1988 |
9 other studies available for sodium fluoride and Ache
| Article | Year |
|---|---|
Comparison of 18F-sodium fluoride positron emission tomography and CT: An exploratory study in 12 dogs with elbow pain.
Topics: Animals; Dog Diseases; Dogs; Fluorine Radioisotopes; Forelimb; Male; Pain; Positron Emission Tomogra | 2021 |
Absence of painful neuropathy after chronic oral fluoride intake in Sprague-Dawley and Lou/C rats.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Animals; Male; Pain; Pain Measurement; Pain Threshol | 2002 |
[The use of iontophoresis in dental practice].
Topics: Dental Caries; Dentin Sensitivity; Gels; Gingival Diseases; Humans; Iontophoresis; Pain; Periodontal | 1993 |
[Problems of high-dose sodium fluoride therapy in osteoporosis. 3. Practice of osteoporosis therapy with sodium fluoride].
Topics: Calcium; Calcium Fluoride; Dose-Response Relationship, Drug; Exercise Therapy; Fluoridation; Fluorid | 1979 |
[Problems of high dose sodium fluoride treatment in osteoporosis. 2. The effect of fluorides on the human skeleton].
Topics: Age Factors; Bone and Bones; Dose-Response Relationship, Drug; Fluorides; Humans; Osteoblasts; Osteo | 1979 |
'Stress fracture' in osteoporosis treated with sodium fluoride.
Topics: Calcaneus; Diagnosis, Differential; Female; Fractures, Stress; Humans; Middle Aged; Osteoporosis, Po | 1991 |
Fluoride-induced fractures: relation to osteogenic effect.
Topics: Aged; Drug Therapy, Combination; Female; Femoral Neck Fractures; Fractures, Bone; Fractures, Stress; | 1990 |
Safety of osteoporosis treatment with sodium fluoride, calcium phosphate and vitamin D.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bone and Bones; Calcium Phosphates; Female; Humans; Live | 1987 |
Osteoporosis: radiographic detection of fluoride-induced extra-axial bone formation.
Topics: Bone and Bones; Bone Development; Female; Humans; Male; Osteoporosis; Pain; Radiography; Radionuclid | 1986 |