sodium-ethylxanthate and Uremia

Twenty-four uremic patients on hemodialysis who had never been treated with vitamin E or related drugs and 12 control patients with normal renal function were studied. Hemodialysis patients were randomly divided into two groups; 12 were treated with oral vitamin E (300 mg/day) for eight weeks and 12 uremic patients and 12 controls were given placebo. Serum vitamin E, prolactin, FSH, LH, and free testosterone levels were measured in all patients before and after treatment. After the vitamin E treatment serum prolactin levels were significantly decreased (50.8 vs 15.4 ng/ml, p < 0.01). Vitamin E levels were significantly increased (1.11 vs 1.22 mg/dl, p < 0.05). Serum FSH, LH and free testosterone were not affected. In the other two groups there were no significant changes. These results show that vitamin E treatment lowers prolactin levels in uremic hemodialysis patients. This might be due to inhibition of central prolactin secretion. Vitamin E inhibits pituitary gland hypertrophy in vitamin E-deficient rats.

Topics: Adolescent; Adult; Double-Blind Method; Follicle Stimulating Hormone; Gonadal Steroid Hormones; Humans; Luteinizing Hormone; Male; Middle Aged; Prolactin; Radioimmunoassay; Renal Dialysis; Sex; Testosterone; Uremia; Vitamin E

The purpose of this study was to evaluate whether levels of sex hormones and sexual function differ in renal failure patients with and without uremia and the effect of treatment with recombinant human erythropoietin (rhuEPO).. Fifteen males with chronic renal failure who were not receiving hemodialysis and 25 male renal failure patients with uremia who were undergoing hemodialysis were enrolled before and after rhuEPO therapy. Fifteen male volunteers matched for age and weight were also studied. Levels of various blood biochemicals were measured in all patients before and 1 week after rhuEPO treatment. Sexual function was also studied in all patients before and 6 months after rhuEPO treatment.. The control group had significantly higher levels of testosterone (6.21 +/- 1.21 ng/ml) and hematocrit (Hct) (43.2 +/- 2.1%) and significantly lower levels of prolactin (5.27 +/- 1.21 ng/ml), follicular-stimulating hormone (FSH) (7.51 +/- 2.36 mIU/ml) and leutinizing hormone (LH) (4.23 +/- 2.10 mIU/ml) than the two patient groups (p < 0.05 for all comparisons). Patients with renal failure only had significantly lower levels of testosterone and Hct (2.54 +/- 0.53 ng/ml and 21.4 +/- 1.4%, respectively) than those with uremia (3.65 +/- 0.52 ng/ml and 24.3 +/- 2.5%, respectively; p < 0.001 for both comparisons). After rhuEPO therapy, the testosterone and Hct levels of the two patient groups did not reach the level of the control subjects (p < 0.05 for both comparisons). Similarly, the levels of prolactin, FSH and LH were significantly higher in both patient groups than those of control subjects after rhuEPO therapy (p < 0.001 for both comparisons). However, after rhuEPO therapy, significant increases in testosterone and Hct levels were found in both patient groups (p < 0.001 for both comparisons). Sexual function was also markedly improved in the hemodialysis patient group. While 20/25 (80%) male hemodialysis patients reported improved sexual function after rhuEPO treatment, only 3/15 (20%) chronic renal failure patients reported improvement.. In patients with advanced uremia, rhuEPO therapy may result in improved gonadotropic hormone levels and sexual function. Good dialysis quality may contribute to the increase in the incidence of patients with better sexual function.

Topics: Erythropoietin; Gonadal Steroid Hormones; Gonadotropins; Humans; Kidney Failure, Chronic; Male; Middle Aged; Recombinant Proteins; Renal Dialysis; Sex; Uremia

Topics: Adult; Aged; Aging; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Male; Middle Aged; Renal Dialysis; Sex; Testosterone; Uremia

Topics: Female; Humans; Infant, Newborn; Kidney Failure, Chronic; Libido; Male; Menstruation; Menstruation Disturbances; Pregnancy; Renal Dialysis; Sex; Sex Factors; Spermatogenesis; Testis; Uremia

Topics: Female; Humans; Kidney Failure, Chronic; Male; Pituitary Gland; Pregnancy; Renal Dialysis; Sex; Testis; Uremia

Topics: Aging; Blood Pressure Determination; Cardiomegaly; Electrocardiography; Female; Follow-Up Studies; Humans; Hypertension; Male; Middle Aged; Obesity; Ophthalmoscopy; Prognosis; Proteinuria; Sex; Uremia

Topics: Adolescent; Blood Proteins; Child; Child, Preschool; Female; Hematuria; Humans; Hypertension, Renal; Infant; Infant, Newborn; Male; Nephrotic Syndrome; Prognosis; Sex; Uremia

Topics: Adolescent; Child; Deafness; Glomerulonephritis; Humans; Kidney Diseases; Life Expectancy; Nephritis; Nephritis, Hereditary; Pyelonephritis; Sex; Uremia

Topics: Animals; Aspergillus; Dogs; Endotoxins; Haplorhini; Hemolysin Proteins; Hot Temperature; Hydrogen-Ion Concentration; Kidney Diseases; Nephrectomy; Pathology; Rabbits; Rats; Research; Sex; Uremia; Urologic Diseases