sodium-ethylxanthate and Syphilis

Despite reports of unusual clinical presentations and therapeutic responses among HIV-infected patients with syphilis, syphilis has not been regarded as a serious opportunistic infection that predictably progresses among most HIV-coinfected patients.. To define and describe differences in the presentation and response to treatment of early syphilis among HIV-infected and HIV-uninfected patients, to describe any differences by gender, and to determine if clinical presentation of central nervous system involvement predicted serologic failure.. A prospective, multicenter, randomized, controlled trial of enhanced versus standard therapy to compare the benefit of enhanced therapy, the clinical importance of central nervous system involvement, and the clinical manifestations of early syphilis infection among HIV-infected and HIV-uninfected patients.. The median number of ulcers was significantly greater among HIV-infected and HIV-uninfected patients, as was the percent of HIV-infected patients with multiple ulcers. Among patients diagnosed with secondary syphilis, a higher percentage of HIV-infected patients presented with genital ulcers [13/53 (25%)] than did HIV-uninfected patients [27/200 (14%)]. No differences between HIV-infected and HIV-uninfected patients were detected for other secondary syphilis manifestations. Although women presented more frequently with secondary syphilis than did men, no other gender differences in clinical manifestations were noted. Neurologic complaints were reported most frequently among patients with secondary syphilis [103/248 patients (42%)] compared with patients with primary syphilis [32/136 (24%)] and early latent syphilis [48/ 142, (34%)] (P < 0.05), but no differences in neurologic complaints were apparent by HIV status or CSF abnormalities. No neurologic complaints were significantly associated with serologic treatment failures at 6 months.. Overall, HIV infection had a small effect on the clinical manifestations of primary and secondary syphilis. Compared with HIV-uninfected patients, HIV-infected patients with primary syphilis tended to present more frequently with multiple ulcers, and HIV-infected patients with secondary syphilis presented with concomitant genitals ulcers more frequently.

Topics: Adult; Female; HIV Infections; Humans; Male; Neurosyphilis; Prospective Studies; Randomized Controlled Trials as Topic; Severity of Illness Index; Sex; Syphilis; Syphilis Serodiagnosis; United States

Although recent increases in the incidence of syphilis are well known to public health officials, the general medical community is less well informed regarding the dramatic rise in cases. We present trend data from Nashville and Tennessee over the past decade. These statistics emphasize specific factors, such as drug abuse, that contribute to new difficulties in controlling this sexually transmitted disease.

Topics: Contact Tracing; Crack Cocaine; Disease Outbreaks; Female; Humans; Incidence; Male; Sex; Sex Work; Sexual Partners; Substance-Related Disorders; Syphilis; Syphilis, Latent; Tennessee; White People

Thirty-four-year-old George Talbot was admitted to your medical/surgical unit with deep vein thrombosis of his left leg, probably related to intravenous drug abuse. So it's no surprise that Mr. Talbot is receiving heparin IV. Today, however, you notice that his physician has prescribed one dose (2.4 million units) of benzathine penicillin IM. You're not sure why until you check the patient's lab work. Mr. Talbot's rapid plasma reagin (RPR) test was reactive. The physician is treating Mr. Talbot for syphilis.

Topics: Adult; Humans; Male; Patient Education as Topic; Penicillin G; Penicillin G Benzathine; Risk Factors; Sex; Substance Abuse, Intravenous; Syphilis; United States

Topics: Acquired Immunodeficiency Syndrome; Attitude; Female; History, 19th Century; History, 20th Century; Humans; Male; Physicians, Women; Sex; Sweden; Syphilis

Topics: Female; Gonorrhea; Herpes Genitalis; Humans; Male; Sex; Sexually Transmitted Diseases; Syphilis; Urethritis

Topics: Ainhum; Child, Preschool; Diabetes Mellitus; Diagnosis, Differential; Female; Hallux; Humans; Leprosy; Sex; Spinal Cord Diseases; Syphilis

Topics: Aging; Blood Cell Count; Blood Chemical Analysis; Clinical Enzyme Tests; Diabetes Mellitus; Geriatrics; Humans; Japan; Leukocyte Count; Leukocytes; Muramidase; Nuclear Warfare; Radiation Injuries; Respiratory Tract Diseases; Sex; Syphilis; Tuberculosis

Topics: Greenland; Habits; Humans; Male; Sex; Sexual Behavior; Syphilis