sodium-ethylxanthate and Sjogren-s-Syndrome

Sjögren syndrome (SS) is an immunologically complex, chronic autoimmune disease targeting lacrimal and salivary glands. Nonobese diabetic (NOD) mice spontaneously develop inflammation of lacrimal and salivary glands with histopathological features similar to SS in humans including focal lymphocytic infiltrates in the affected glands. The innate immune signals driving lymphocytic infiltration of these glands are not well-defined. Here we evaluate the role of Toll-like receptor (TLR) 7 in the development of SS-like manifestations in NOD mice. We created a

Topics: Animals; Autoimmunity; B-Lymphocytes; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Female; Gene Expression Regulation; Inflammation; Interferon Type I; Lacrimal Apparatus; Male; Membrane Glycoproteins; Mice; Mice, Inbred NOD; Mice, Knockout; RNA-Seq; Salivary Glands; Sex; Sjogren's Syndrome; Toll-Like Receptor 7

Topics: Adult; Aged; Aging; Antibodies; Antibodies, Antinuclear; Autoantibodies; Blood Chemical Analysis; Blood Glucose; Deglutition Disorders; Dental Caries; Female; Hemoglobins; Humans; Lacrimal Apparatus; Lupus Erythematosus, Systemic; Male; Middle Aged; Saliva; Salivary Glands; Secretory Rate; Sex; Sjogren's Syndrome; Stomatitis; Tongue Diseases; Xerostomia

Topics: Achlorhydria; Arthritis; Arthritis, Rheumatoid; Deglutition Disorders; Esophagus; Humans; Radiography; Sex; Sjogren's Syndrome; Xerostomia