sodium-ethylxanthate and Sarcoma

We have documented functional and psychosocial changes in patients with extremity soft tissue sarcomas who have undergone multimodality limb-sparing treatments. In 88 patients, parameters related to economic status, sexual activity, pain, limb function, and global quality of life (QOL) were recorded prior to surgery and every 6 months postoperatively. Changes from the preoperative assessment for every parameter were analyzed in each patient. Six months after surgery, there was a decrease in employment status, sexual activity, and in limb function in a significant number of patients. At 12 months, these decreases were still evident. Despite these changes, global QOL measured by a standardized test showed at least some improvement in a significant proportion of patients at 12 months. These findings highlight the difficulty in defining QOL. It could not be ascertained if radiation therapy and/or chemotherapy were causative factors in specific changes because of the small numbers of patients in each subgroup. However, among 60 patients with high-grade sarcomas, significant wound problems developed in 10 of 33 who received postoperative radiation therapy in combination with adjuvant doxorubicin and cyclophosphamide chemotherapy compared with one of 27 patients who received adjuvant chemotherapy alone (P = .016). Also, among high-grade sarcoma patients with 12-month follow-up, six of 19 patients who received radiation therapy and chemotherapy developed joint contractures compared with zero of 15 patients who received chemotherapy alone (P less than .04). The combination of postoperative radiation therapy and chemotherapy appeared to be associated with significantly more tissue-related injury in patients with high-grade sarcomas compared with chemotherapy alone.

Topics: Adolescent; Adult; Aged; Arm; Clinical Trials as Topic; Combined Modality Therapy; Employment; Female; Humans; Leg; Male; Middle Aged; Psychological Tests; Quality of Life; Random Allocation; Sarcoma; Sex; Social Support; Soft Tissue Neoplasms; Statistics as Topic; Surveys and Questionnaires; Wound Healing

Topics: Adolescent; Aging; Bone Neoplasms; Burkitt Lymphoma; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Leukemia; Lymphoma; Male; Melanoma; Neoplasms; Neoplasms, Connective Tissue; Neoplasms, Germ Cell and Embryonal; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue; Sarcoma; Sex; Uganda; United States

Topics: Adenocarcinoma; Animals; Female; Hemangioendothelioma; Humans; Male; Mammary Neoplasms, Experimental; Mammary Tumor Virus, Mouse; Maternal Age; Mice; Pregnancy; Pregnancy, Animal; Sarcoma; Sex

Topics: Adolescent; Adult; Aged; Child; Dysgerminoma; Female; Fibrosarcoma; Hemangiopericytoma; Humans; Leiomyosarcoma; Liposarcoma; Male; Middle Aged; Pregnancy; Pregnancy Complications; Prognosis; Rhabdomyosarcoma; Sarcoma; Sarcoma, Synovial; Sex

Topics: Animals; Benz(a)Anthracenes; Carcinoma; Castration; Diethylstilbestrol; Female; Male; Methylthiouracil; Neoplasms, Experimental; Rats; Salivary Gland Neoplasms; Sarcoma; Sex; Thyroxine

Topics: Adenocarcinoma; Asian People; Black People; Carcinoma; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Chordoma; Ethnology; Geriatrics; Lymphatic Metastasis; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Nasopharyngeal Neoplasms; Neoplasms; New York; Rhabdomyosarcoma; Sarcoma; Sex; Surgical Procedures, Operative

Topics: Brain; Brain Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Humans; Neoplasm Metastasis; Neoplasms; Neoplastic Cells, Circulating; Prognosis; Sarcoma; Sex

Topics: Adolescent; Adult; Aged; Cerebrospinal Fluid Proteins; Child; Child, Preschool; Female; Humans; Male; Middle Aged; Sarcoma; Sex; Spinal Cord Neoplasms

Topics: Aging; Animals; Brain Abscess; Brain Neoplasms; Carcinoma, Squamous Cell; Glioblastoma; Glioma; Methylcholanthrene; Mice; Neoplasms; Neoplasms, Experimental; Research; Sarcoma; Sarcoma, Experimental; Sex; Sex Factors; Toxicology

Topics: Adolescent; Antineoplastic Agents; Brain Neoplasms; Child; Head; Head and Neck Neoplasms; Humans; Infant; Lymphoma; Neoplasms; Palliative Care; Prognosis; Rhabdomyosarcoma; Sarcoma; Sex; Surgical Procedures, Operative; Thyroid Neoplasms

Topics: Animals; Avian Leukosis; Chickens; Coloring Agents; Disease Susceptibility; Meat; Neoplasms; Poultry; Research; Sarcoma; Sarcoma, Avian; Sarcoma, Experimental; Sex

Topics: Animals; Antibodies; Fluorescent Antibody Technique; Immune Sera; Immunization; Methylcholanthrene; Mice; Neoplasms; Research; Sarcoma; Sarcoma, Experimental; Sex; Toxicology

Topics: Adenocarcinoma; Adolescent; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Carcinosarcoma; Child; Ethnology; Geriatrics; Humans; Incidence; Kidney; Neoplasm Metastasis; Neoplasms; Pathology; Sarcoma; Sex; Singapore; Wilms Tumor

Topics: Aging; Astrocytoma; Cerebellar Neoplasms; Glioma; Humans; Medulloblastoma; Neoplasms; Neurosurgery; Sarcoma; Sex