sodium-ethylxanthate and Metabolic-Syndrome

Metabolic syndrome (MetS) and hyperuricemia are important risk factors for cardiovascular disease, hypertension and renal disease. The relationship between serum uric acid (UA) levels and MetS remains unclear. In the present study we determined the presence of MetS and measured UA levels among personnel at the Thai Red Cross Society and Chulalongkorn University to evaluate the possible presence of an association between the two. We conducted this cross sectional study in 2009. A total of 2,804 persons, aged 35-60 years (628 men and 2176 women) filled out questionnaires, had laboratory testing and were included in the study. MetS was defined by criteria harmonized from six international expert groups. The association between MetS and UA levels was determined using multivariable logistic regression. The overall prevalences of MetS were 25.1, 21.1, and 18.2% when a BMI > or = 23 kg/m2, a BMI > or = 25 kg/m2 or waist circumference were used to classify abdominal obesity, respectively. Body mass index, waist circumference, blood pressure, and triglycerides significantly elevated in both men and women with elevated UA levels (all a p-value < 0.005). After adjustment for potential confounders, the odds ratio of having MetS in the fourth quartile compared with the first quartile of a UA level was 2.77 times for men (95% CI 1.60-4.79) and 8.04 times for women (95% CI 5.43-11.91). There wes a stronger association between the presence of MetS and UA in women than men. UA levels were associated with the presence of MetS.

Topics: Adult; Blood Pressure; Body Weights and Measures; Cross-Sectional Studies; Female; Humans; Hyperuricemia; Lipids; Male; Metabolic Syndrome; Middle Aged; Prevalence; Sex; Thailand; Uric Acid

The present paper describes a nutritional survey carried out among Japanese-Brazilian subjects living in Bauru, south-eastern Brazil. Data were from a cross-sectional population-based study of 1283 first-generation Japanese-Brazilian subjects (Japan-born; 127 men and 121 women) and second-generation Japanese-Brazilian subjects (Brazil-born; 456 men and 573 women) aged 30-90 years. Anthropometric measurements and % body fat were measured and BMI and waist:hip ratio calculated. Dietary assessment was performed using a validated food-frequency questionnaire. A considerable proportion of men (51 %) and women (47 %) had excess weight (BMI>24.9 kg/m2). A greater waist circumference in men and women (age-adjusted by covariance analysis) was observed among Brazil-born participants. In general, only 10 % of the participants reported current practice of sports or other vigorous physical activity. Age-adjusted mean energy intakes and % energy from macronutrients were found to be similar across generations. The age-adjusted mean daily % energy intake from fat were similar across generations: among Japan-born participants, they were 31.5 (95 % CI 30.6, 32.4) % for men and 32.6 (95 % CI 31.7, 33.5) % for women. The respective figures for Brazil-born subjects were 32.1 (95 % CI 31.6, 32.6) % and 33.2 (95 % CI 32.7, 33.5) %. These values are quite different from the usual intakes reported in Japan during the last decades (about 25 %). Taking into account the traditional Japanese diet, a high energy density diet and a sedentary lifestyle may be implicated in the high prevalence of central obesity and metabolic syndrome observed among Japanese-Brazilian subjects across gender and generations.

Topics: Adult; Aged; Aged, 80 and over; Aging; Alcohol Drinking; Body Composition; Body Mass Index; Brazil; Cross-Sectional Studies; Diet; Exercise; Female; Glucose Tolerance Test; Health Surveys; Humans; Japan; Male; Metabolic Syndrome; Middle Aged; Nutritional Status; Risk; Sex